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Book ; Online: La lingua italiana in una prospettiva di genere

Monaco, Maria Paola

Atti del Seminario online promosso dagli Atenei di Firenze e Udine con il patrocinio dell'Accademia della Crusca (1° marzo 2022)

(Proceedings e report)

2023

Series title	Proceedings e report
Keywords	Literature & literary studies ; gender ; equality ; language
Language	Italian
Size	1 electronic resource (98 pages)
Publisher	Firenze University Press
Publishing place	Florence
Document type	Book ; Online
Note	Italian
HBZ-ID	HT030382131
ISBN	9791221501407
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: ACSL4: biomarker, mediator and target in quadruple negative breast cancer.

Monaco, Marie E

Oncotarget

2023 Volume 14, Page(s) 563–575

Abstract: Breast cancer is a heterogeneous disease for which effective treatment depends on correct categorization of its molecular subtype. For the last several decades this determination has relied on hormone receptor status for estrogen, progesterone and HER2. ... ...

Abstract	Breast cancer is a heterogeneous disease for which effective treatment depends on correct categorization of its molecular subtype. For the last several decades this determination has relied on hormone receptor status for estrogen, progesterone and HER2. More recently, gene expression data have been generated that further stratify both receptor-positive and receptor-negative cancers. The fatty acid-activating enzyme, ACSL4, has been demonstrated to play a role in the malignant phenotype of a variety of cancers, including breast. This lipid metabolic enzyme is differentially expressed as a function of subtype in breast tumors, with highest expression observed in the mesenchymal (claudin low) and basal-like subtypes. Here we review data that support the potential of utilizing ACSL4 status as both a biomarker of molecular subtype and a predictor of response to a variety of targeted and non-targeted treatment regimens. Based on these findings, we suggest 3 expanded roles for ACSL4: 1. as a biomarker for classification of breast cancer subtypes; 2. as a predictor of sensitivity to hormone-based and certain other therapies; and 3. as a target for the development of new treatment modalities.
MeSH term(s)	Humans ; Animals ; Triple Negative Breast Neoplasms ; Biomarkers ; Estrogens ; Progesterone ; Mammary Neoplasms, Animal
Chemical Substances	Biomarkers ; Estrogens ; Progesterone (4G7DS2Q64Y)
Language	English
Publishing date	2023-06-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.28453
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Fatty acid metabolism in breast cancer subtypes.

Monaco, Marie E

Oncotarget

2017 Volume 8, Issue 17, Page(s) 29487–29500

Abstract: Dysregulation of fatty acid metabolism is recognized as a component of malignant transformation in many different cancers, including breast; yet the potential for targeting this pathway for prevention and/or treatment of cancer remains unrealized. ... ...

Abstract	Dysregulation of fatty acid metabolism is recognized as a component of malignant transformation in many different cancers, including breast; yet the potential for targeting this pathway for prevention and/or treatment of cancer remains unrealized. Evidence indicates that proteins involved in both synthesis and oxidation of fatty acids play a pivotal role in the proliferation, migration and invasion of breast cancer cells. The following essay summarizes data implicating specific fatty acid metabolic enzymes in the genesis and progression of breast cancer, and further categorizes the relevance of specific metabolic pathways to individual intrinsic molecular subtypes of breast cancer. Based on mRNA expression data, the less aggressive luminal subtypes appear to rely on a balance between de novo fatty acid synthesis and oxidation as sources for both biomass and energy requirements, while basal-like, receptor negative subtypes overexpress genes involved in the utilization of exogenous fatty acids. With these differences in mind, treatments may need to be tailored to individual subtypes.
Language	English
Publishing date	2017-04-25
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.15494
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Comparison of quantitative internal and external measures of performance for trainees in cytopathology fellowships.

Xing, Juan / Khader, Samer N / Ohori, N Paul / DeFrances, Marie / Cuda, Jackie / Monaco, Sara E

Journal of the American Society of Cytopathology

2021 Volume 10, Issue 5, Page(s) 495–503

Abstract: Introduction: Cytopathology fellowships need measures to assess performance of fellows. We sought to compare several internal quantitative assessment metrics in our fellowship with external metrics, such as performance on the American Society of ... ...

Abstract	Introduction: Cytopathology fellowships need measures to assess performance of fellows. We sought to compare several internal quantitative assessment metrics in our fellowship with external metrics, such as performance on the American Society of Cytopathology (ASC) Progressive Evaluation of Competency (PEC) examination and United States Medical Licensing Examination (USMLE). Methods: Quantitative parameters generated from our laboratory information system (LIS) on cytopathology fellows were evaluated over 6 years, including case volume and diagnostic discrepancies, in addition to ASC PEC and USMLE scores. For discrepancy reports, interpretations made by the fellow were compared with that of the cytopathologist, and classified as none (concordant), minor (<2-levels) or major (≥2-levels). Results: We evaluated internal and external metrics on 13 fellows over 6 years. The program average diagnostic concordance rate was 89.9%, with an average major discrepancy rate of 1.5%, and an average monthly case volume of 260 cases. More fellows with above-average ASC PEC performance showed above-average concordant diagnoses and lower case volume, while below-average PEC scores were seen more often with higher major discrepancy rates. More fellows with above-average USMLE scores had higher case volumes, while low USMLE scores showed a trend towards higher major discrepancy rates. Conclusion: Our fellowship program has used a variety of internal and external measures of performance for cytopathology fellows. Although the findings show no statistically significant finding correlating performance, these quantitative parameters generated from our LIS were helpful to identify areas of improvement, facilitate comparison to peers, and provide case volume documentation.
MeSH term(s)	Biopsy ; Cell Biology/education ; Certification ; Clinical Competence ; Curriculum ; Cytological Techniques ; Education, Medical, Graduate ; Educational Measurement ; Educational Status ; Fellowships and Scholarships ; Humans ; Pathologists/education ; Pathology/education ; Program Evaluation ; Specialization
Language	English
Publishing date	2021-05-19
Publishing country	United States
Document type	Comparative Study ; Journal Article
ISSN	2213-2945
ISSN	2213-2945
DOI	10.1016/j.jasc.2021.05.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: First and Second Language at Hand: A Chronometric Transcranial-Magnetic Stimulation Study on Semantic and Motor Resonance.

Monaco, Elisa / Jost, Lea B / Lancheros, Monica / Harquel, Sylvain / Schmidlin, Eric / Annoni, Jean-Marie

Journal of cognitive neuroscience

2021 Volume 33, Issue 8, Page(s) 1563–1580

Abstract: According to embodied theories, motor and language processing bidirectionally interact: Motor activation modulates behavior in lexico-semantic tasks (semantic resonance), and understanding motor-related words entails activation of the corresponding motor ...

Abstract	According to embodied theories, motor and language processing bidirectionally interact: Motor activation modulates behavior in lexico-semantic tasks (semantic resonance), and understanding motor-related words entails activation of the corresponding motor brain areas (motor resonance). Whereas many studies investigated such interaction in the first language (L1), only few did so in a second language (L2), focusing on motor resonance. Here, we directly compared L1 and a late L2, for the first time both in terms of semantic and motor resonance and both in terms of magnitude and timing, by taking advantage of single-pulse TMS. Twenty-five bilinguals judged, in each language, whether hand motor-related ("grasp") and non-motor-related verbs ("believe"), were physical or mental. Meanwhile, we applied TMS on the hand motor cortex at 125, 275, 350, and 500 msec post verb onset, and recorded behavioral responses and TMS-induced motor evoked potentials. TMS induced faster responses for L1 versus L2 motor and nonmotor verbs at 125 msec (three-way interaction β = -0.0442, 95% CI [0.0814, -0.0070]), showing a semantic resonance effect at an early stage of word processing in L1 but not in L2. Concerning motor resonance, TMS-induced motor evoked potentials at 275 msec revealed higher motor cortex excitability for L2 versus L1 processing (two-way interaction β = 0.095, 95% CI [0.017, 0.173]). These findings confirm action-language interaction at early stages of word recognition, provide further evidence that L1 and L2 are differently embodied, and call for an update of existing models of bilingualism and embodiment, concerning both language representations and processing.
MeSH term(s)	Language ; Magnetic Phenomena ; Multilingualism ; Semantics ; Transcranial Magnetic Stimulation
Language	English
Publishing date	2021-10-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1007410-7
ISSN	1530-8898 ; 0898-929X ; 1096-8857
ISSN (online)	1530-8898
ISSN	0898-929X ; 1096-8857
DOI	10.1162/jocn_a_01736
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: Materiali per lo studio del diritto antidiscriminatorio

FAVILLI, CHIARA / MONACO, MARIA PAOLA

(Strumenti per la didattica e la ricerca)

2008

Series title	Strumenti per la didattica e la ricerca
Keywords	International law ; Laws of Specific jurisdictions ; Diritto ; Diritti civili ; Discriminazioni ; Società ; Unione europea
Language	0\|i
Size	1 electronic resource (224 pages)
Publisher	Firenze University Press
Publishing place	Florence
Document type	Book ; Online
Note	Italian ; Open Access
HBZ-ID	HT021614095
ISBN	9788892738560 ; 8892738569
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Embodied Semantics in a Second Language: Critical Review and Clinical Implications.

Monaco, Elisa / Jost, Lea B / Gygax, Pascal M / Annoni, Jean-Marie

Frontiers in human neuroscience

2019 Volume 13, Page(s) 110

Abstract: The role of the sensorimotor system in second language (L2) semantic processing as well as its clinical implications for bilingual patients has hitherto been neglected. We offer an overview of the issues at stake in this under-investigated field, ... ...

Abstract	The role of the sensorimotor system in second language (L2) semantic processing as well as its clinical implications for bilingual patients has hitherto been neglected. We offer an overview of the issues at stake in this under-investigated field, presenting the theoretical and clinical relevance of studying L2 embodiment and reviewing the few studies on this topic. We highlight that (a) the sensorimotor network is involved in L2 processing, and that (b) in most studies, L2 is differently embodied than L1, reflected in a lower degree or in a different pattern of L2 embodiment. Importantly, we outline critical issues to be addressed in order to guide future research. We also delineate the subsequent steps needed to confirm or dismiss the value of language therapeutic approaches based on embodiment theories as a complement of speech and language therapies in adult bilinguals.
Language	English
Publishing date	2019-03-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2425477-0
ISSN	1662-5161
ISSN	1662-5161
DOI	10.3389/fnhum.2019.00110
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Lipid-associated macrophages transition to an inflammatory state in human atherosclerosis increasing the risk of cerebrovascular complications.

Dib, Lea / Koneva, Lada A / Edsfeldt, Andreas / Zurke, Yasemin-Xiomara / Sun, Jiangming / Nitulescu, Mihaela / Attar, Moustafa / Lutgens, Esther / Schmidt, Steffen / Lindholm, Marie W / Choudhury, Robin P / Cassimjee, Ismail / Lee, Regent / Handa, Ashok / Goncalves, Isabel / Sansom, Stephen N / Monaco, Claudia

Nature cardiovascular research

2024 Volume 2, Issue 7, Page(s) 656–672

Abstract: The immune system is integral to cardiovascular health and disease. Targeting inflammation ameliorates adverse cardiovascular outcomes. Atherosclerosis, a major underlying cause of cardiovascular disease (CVD), is conceptualised as a lipid-driven ... ...

Abstract	The immune system is integral to cardiovascular health and disease. Targeting inflammation ameliorates adverse cardiovascular outcomes. Atherosclerosis, a major underlying cause of cardiovascular disease (CVD), is conceptualised as a lipid-driven inflammation where macrophages play a non-redundant role. However, evidence emerging so far from single cell atlases suggests a dichotomy between lipid associated and inflammatory macrophage states. Here, we present an inclusive reference atlas of human intraplaque immune cell communities. Combining scRNASeq of human surgical carotid endarterectomies in a discovery cohort with bulk RNASeq and immunohistochemistry in a validation cohort (the Carotid Plaque Imaging Project-CPIP), we reveal the existence of PLIN2
Language	English
Publishing date	2024-02-15
Publishing country	England
Document type	Journal Article
ISSN	2731-0590
ISSN (online)	2731-0590
DOI	10.1038/s44161-023-00295-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Lysines Acetylome and Methylome Profiling of H3 and H4 Histones in Trichostatin A-Treated Stem Cells.

Cozzolino, Flora / Iacobucci, Ilaria / Monaco, Vittoria / Angrisano, Tiziana / Monti, Maria

International journal of molecular sciences

2021 Volume 22, Issue 4

Abstract: Trichostatin A ([R-(E,E)]-7-[4-(dimethylamino) phenyl]-N-hydroxy- 4,6-dimethyl- 7-oxo-2,4 ... histones to probe the optimized conditions in terms of enzyme:substrate (E:S) ratio and time of proteolysis ...

Abstract	Trichostatin A ([R-(E,E)]-7-[4-(dimethylamino) phenyl]-N-hydroxy- 4,6-dimethyl- 7-oxo-2,4-heptadienamide, TSA) affects chromatin state through its potent histone deacetylase inhibitory activity. Interfering with the removal of acetyl groups from lysine residues in histones is one of many epigenetic regulatory processes that control gene expression. Histone deacetylase inhibition drives cells toward the differentiation stage, favoring the activation of specific genes. In this paper, we investigated the effects of TSA on H3 and H4 lysine acetylome and methylome profiling in mice embryonic stem cells (ES14), treated with trichostatin A (TSA) by using a new, untargeted approach, consisting of trypsin-limited proteolysis experiments coupled with MALDI-MS and LC-MS/MS analyses. The method was firstly set up on standard chicken core histones to probe the optimized conditions in terms of enzyme:substrate (E:S) ratio and time of proteolysis and, then, applied to investigate the global variations of the acetylation and methylation state of lysine residues of H3 and H4 histone in the embryonic stem cells (ES14) stimulated by TSA and addressed to differentiation. The proposed strategy was found in its simplicity to be extremely effective in achieving the identification and relative quantification of some of the most significant epigenetic modifications, such as acetylation and lysine methylation. Therefore, we believe that it can be used with equal success in wider studies concerning the characterization of all epigenetic modifications.
MeSH term(s)	Acetylation/drug effects ; Amino Acid Sequence ; Animals ; Dimethyl Sulfoxide/pharmacology ; Embryonic Stem Cells/cytology ; Embryonic Stem Cells/drug effects ; Embryonic Stem Cells/metabolism ; Gene Expression Regulation/drug effects ; Histones/chemistry ; Histones/metabolism ; Hydroxamic Acids/pharmacology ; Lysine/metabolism ; Methylation/drug effects ; Mice ; Octamer Transcription Factor-3/genetics ; Octamer Transcription Factor-3/metabolism ; Peptides/chemistry ; Peroxiredoxins/genetics ; Peroxiredoxins/metabolism ; Protein Processing, Post-Translational/drug effects ; Proteolysis/drug effects
Chemical Substances	Histones ; Hydroxamic Acids ; Octamer Transcription Factor-3 ; Peptides ; Pou5f1 protein, mouse ; trichostatin A (3X2S926L3Z) ; Peroxiredoxins (EC 1.11.1.15) ; Prdx1 protein, mouse (EC 1.11.1.15) ; Lysine (K3Z4F929H6) ; Dimethyl Sulfoxide (YOW8V9698H)
Language	English
Publishing date	2021-02-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22042063
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Lipid metabolism in prostate cancer.

Wu, Xinyu / Daniels, Garrett / Lee, Peng / Monaco, Marie E

American journal of clinical and experimental urology

2014 Volume 2, Issue 2, Page(s) 111–120

Abstract: The malignant transformation of cells requires adaptations across multiple metabolic processes to satisfy the energy required for their increased rate of proliferation. Dysregulation of lipid metabolism has been a hallmark of the malignant phenotype; ... ...

Abstract	The malignant transformation of cells requires adaptations across multiple metabolic processes to satisfy the energy required for their increased rate of proliferation. Dysregulation of lipid metabolism has been a hallmark of the malignant phenotype; increased lipid accumulation secondary to changes in the levels of a variety of lipid metabolic enzymes has been documented in a variety of tumors, including prostate. Alterations in prostate lipid metabolism include upregulation of several lipogenic enzymes as well as of enzymes that function to oxidize fatty acids as an energy source. Cholesterol metabolism and phospholipid metabolism are also affected. With respect to lipogenesis, most studies have concentrated on increased expression and activity ofthe de novo fatty acid synthesis enzyme, fatty acid synthase (FASN), with suggestions that FASN might function as an oncogene. A central role for fatty acid oxidation in supplying energy to the prostate cancer cell is supported by the observation that the peroxisomal enzyme, α-methylacyl-CoA racemase (AMACR), which facilitates the transformation of branched chain fatty acids to a form suitable for β-oxidation, is highly overexpressed in prostate cancer compared with normal prostate. Exploitation of the alterations in lipid metabolic pathways in prostate cancer could result in the development of new therapeutic modalities as well as provide candidates for new prognostic and predictive biomarkers. AMACR has already proven to be a valuable biomarker in distinguishing normal from malignant prostate tissue, and is used routinely in clinical practice.
Language	English
Publishing date	2014-07-12
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2330-1910
ISSN	2330-1910
Database	MEDical Literature Analysis and Retrieval System OnLINE

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