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Article: Favipiravir in Therapy of Viral Infections.

Łagocka, Ryta / Dziedziejko, Violetta / Kłos, Patrycja / Pawlik, Andrzej

2021 Volume 10, Issue 2

Abstract: Favipiravir (FPV) is a novel antiviral drug acting as a competitive inhibitor of RNA-dependent RNA polymerase (RdRp), preventing viral transcription and replication. FPV was approved in Japan in 2014 for therapy of influenza unresponsive to standard ... ...

Abstract	Favipiravir (FPV) is a novel antiviral drug acting as a competitive inhibitor of RNA-dependent RNA polymerase (RdRp), preventing viral transcription and replication. FPV was approved in Japan in 2014 for therapy of influenza unresponsive to standard antiviral therapies. FPV was also used in the therapy of Ebola virus disease (EVD) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In this review, we discuss the mechanisms of action, pharmacokinetic parameters, toxicity, and adverse effects of FPV, as well as clinical studies evaluating the use of FPV in the therapy of influenza virus (IV) infection, EVD, and SARS-CoV-2 infection, along with its effectiveness in treating other human RNA infections.
Language	English
Publishing date	2021-01-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10020273
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Article ; Online: The Clinical Significance and Role of CXCL1 Chemokine in Gastrointestinal Cancers.

Korbecki, Jan / Bosiacki, Mateusz / Barczak, Katarzyna / Łagocka, Ryta / Chlubek, Dariusz / Baranowska-Bosiacka, Irena

Cells

2023 Volume 12, Issue 10

Abstract: One area of cancer research is the interaction between cancer cells and immune cells, in which chemokines play a vital role. Despite this, a comprehensive summary of the involvement of C-X-C motif ligand 1 (CXCL1) chemokine (also known as growth- ... ...

Abstract	One area of cancer research is the interaction between cancer cells and immune cells, in which chemokines play a vital role. Despite this, a comprehensive summary of the involvement of C-X-C motif ligand 1 (CXCL1) chemokine (also known as growth-regulated gene-α (GRO-α), melanoma growth-stimulatory activity (MGSA)) in cancer processes is lacking. To address this gap, this review provides a detailed analysis of CXCL1's role in gastrointestinal cancers, including head and neck cancer, esophageal cancer, gastric cancer, liver cancer (hepatocellular carcinoma (HCC)), cholangiocarcinoma, pancreatic cancer (pancreatic ductal adenocarcinoma), and colorectal cancer (colon cancer and rectal cancer). This paper presents the impact of CXCL1 on various molecular cancer processes, such as cancer cell proliferation, migration, and invasion, lymph node metastasis, angiogenesis, recruitment to the tumor microenvironment, and its effect on immune system cells, such as tumor-associated neutrophils (TAN), regulatory T (T
MeSH term(s)	Humans ; Chemokine CXCL1 ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/pathology ; Clinical Relevance ; Chemokines ; Pancreatic Neoplasms/pathology ; Gastrointestinal Neoplasms ; Tumor Microenvironment ; Pancreatic Neoplasms
Chemical Substances	Chemokine CXCL1 ; Chemokines ; CXCL1 protein, human
Language	English
Publishing date	2023-05-17
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12101406
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Article ; Online: Favipiravir in Therapy of Viral Infections

Ryta Łagocka / Violetta Dziedziejko / Patrycja Kłos / Andrzej Pawlik

Journal of Clinical Medicine, Vol 10, Iss 2, p

2021 Volume 273

Abstract	Favipiravir (FPV) is a novel antiviral drug acting as a competitive inhibitor of RNA-dependent RNA polymerase (RdRp), preventing viral transcription and replication. FPV was approved in Japan in 2014 for therapy of influenza unresponsive to standard antiviral therapies. FPV was also used in the therapy of Ebola virus disease (EVD) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In this review, we discuss the mechanisms of action, pharmacokinetic parameters, toxicity, and adverse effects of FPV, as well as clinical studies evaluating the use of FPV in the therapy of influenza virus (IV) infection, EVD, and SARS-CoV-2 infection, along with its effectiveness in treating other human RNA infections.
Keywords	favipiravir ; viral infection ; influenza ; Medicine ; R
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: CCL5's Role in Periodontal Disease: A Narrative Review.

Barczak, Katarzyna / Droździk, Agnieszka / Bosiacki, Mateusz / Łagocka, Ryta / Cenariu, Diana / Uriciuc, Willi Andrei / Baranowska-Bosiacka, Irena

International journal of molecular sciences

2023 Volume 24, Issue 24

Abstract: Persistent host inflammatory and immune responses to biofilm play a critical role in the mechanisms that govern soft and hard tissue destruction in periodontal disease. Among the less explored facets of these mechanisms are chemokines, including CCL5 (C- ... ...

Abstract	Persistent host inflammatory and immune responses to biofilm play a critical role in the mechanisms that govern soft and hard tissue destruction in periodontal disease. Among the less explored facets of these mechanisms are chemokines, including CCL5 (C-C motif chemokine ligand 5), also known as RANTES (regulated on activation, normal T cell expressed and secreted), a proinflammatory CC subfamily chemokine synthesized by T lymphocytes. Despite its importance, there is currently no comprehensive review of the role of CCL5 in periodontitis in the literature. Therefore, this paper aims to fill this gap by summarizing the existing knowledge on the involvement of CCL5 in the onset and progression of periodontitis. In addition, we aim to stimulate interest in this relatively overlooked factor among periodontitis researchers, potentially accelerating the development of drugs targeting CCL5 or its receptors. The review examines the association of CCL5 with periodontitis risk factors, including aging, cigarette smoking, diabetes, and obesity. It discusses the involvement of CCL5 in pathological processes during periodontitis, such as connective tissue and bone destruction. The data show that CCL5 expression is observed in affected gums and gingival crevicular fluid of periodontitis patients, with bacterial activity contributing significantly to this increase, but the reviewed studies of the association between CCL5 expression and periodontal disease have yielded inconclusive results. Although CCL5 has been implicated in the pathomechanism of periodontitis, a comprehensive understanding of its molecular mechanisms and significance remains elusive, hindering the development of drugs targeting this chemokine or its receptors.
MeSH term(s)	Humans ; Chemokine CCL5/metabolism ; Chemokines/analysis ; Chemokines, CC ; Gingival Crevicular Fluid ; Periodontitis/metabolism ; T-Lymphocytes/chemistry ; Animals
Chemical Substances	CCL5 protein, human ; Chemokine CCL5 ; Chemokines ; Chemokines, CC
Language	English
Publishing date	2023-12-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242417332
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Article ; Online: Involvement in Tumorigenesis and Clinical Significance of CXCL1 in Reproductive Cancers: Breast Cancer, Cervical Cancer, Endometrial Cancer, Ovarian Cancer and Prostate Cancer.

Korbecki, Jan / Bosiacki, Mateusz / Barczak, Katarzyna / Łagocka, Ryta / Brodowska, Agnieszka / Chlubek, Dariusz / Baranowska-Bosiacka, Irena

International journal of molecular sciences

2023 Volume 24, Issue 8

Abstract: C-X-C motif chemokine ligand 1 (CXCL1) is a member of the CXC chemokine subfamily and a ligand for CXCR2. Its main function in the immune system is the chemoattraction of neutrophils. However, there is a lack of comprehensive reviews summarizing the ... ...

Abstract	C-X-C motif chemokine ligand 1 (CXCL1) is a member of the CXC chemokine subfamily and a ligand for CXCR2. Its main function in the immune system is the chemoattraction of neutrophils. However, there is a lack of comprehensive reviews summarizing the significance of CXCL1 in cancer processes. To fill this gap, this work describes the clinical significance and participation of CXCL1 in cancer processes in the most important reproductive cancers: breast cancer, cervical cancer, endometrial cancer, ovarian cancer, and prostate cancer. The focus is on both clinical aspects and the significance of CXCL1 in molecular cancer processes. We describe the association of CXCL1 with clinical features of tumors, including prognosis, ER, PR and HER2 status, and TNM stage. We present the molecular contribution of CXCL1 to chemoresistance and radioresistance in selected tumors and its influence on the proliferation, migration, and invasion of tumor cells. Additionally, we present the impact of CXCL1 on the microenvironment of reproductive cancers, including its effect on angiogenesis, recruitment, and function of cancer-associated cells (macrophages, neutrophils, MDSC, and T
MeSH term(s)	Male ; Humans ; Female ; Breast Neoplasms ; Uterine Cervical Neoplasms/genetics ; Ligands ; Clinical Relevance ; Chemokine CXCL1/genetics ; Endometrial Neoplasms/genetics ; Prostatic Neoplasms ; Ovarian Neoplasms ; Carcinogenesis ; Cell Transformation, Neoplastic ; Receptors, Interleukin-8B ; Tumor Microenvironment
Chemical Substances	Ligands ; Chemokine CXCL1 ; Receptors, Interleukin-8B ; CXCL1 protein, human
Language	English
Publishing date	2023-04-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24087262
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Article ; Online: CCL5’s Role in Periodontal Disease

Katarzyna Barczak / Agnieszka Droździk / Mateusz Bosiacki / Ryta Łagocka / Diana Cenariu / Willi Andrei Uriciuc / Irena Baranowska-Bosiacka

International Journal of Molecular Sciences, Vol 24, Iss 24, p

A Narrative Review

2023 Volume 17332

Abstract	Persistent host inflammatory and immune responses to biofilm play a critical role in the mechanisms that govern soft and hard tissue destruction in periodontal disease. Among the less explored facets of these mechanisms are chemokines, including CCL5 (C-C motif chemokine ligand 5), also known as RANTES (regulated on activation, normal T cell expressed and secreted), a proinflammatory CC subfamily chemokine synthesized by T lymphocytes. Despite its importance, there is currently no comprehensive review of the role of CCL5 in periodontitis in the literature. Therefore, this paper aims to fill this gap by summarizing the existing knowledge on the involvement of CCL5 in the onset and progression of periodontitis. In addition, we aim to stimulate interest in this relatively overlooked factor among periodontitis researchers, potentially accelerating the development of drugs targeting CCL5 or its receptors. The review examines the association of CCL5 with periodontitis risk factors, including aging, cigarette smoking, diabetes, and obesity. It discusses the involvement of CCL5 in pathological processes during periodontitis, such as connective tissue and bone destruction. The data show that CCL5 expression is observed in affected gums and gingival crevicular fluid of periodontitis patients, with bacterial activity contributing significantly to this increase, but the reviewed studies of the association between CCL5 expression and periodontal disease have yielded inconclusive results. Although CCL5 has been implicated in the pathomechanism of periodontitis, a comprehensive understanding of its molecular mechanisms and significance remains elusive, hindering the development of drugs targeting this chemokine or its receptors.
Keywords	chemokine CCL5 ; periodontal diseases ; gingival crevicular fluid ; periodontitis ; gingivitis ; inflammation ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	616
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The influence of two forms of chlorhexidine on the accuracy of contemporary electronic apex locators.

Marek, Ewa / Łagocka, Ryta / Kot, Katarzyna / Woźniak, Krzysztof / Lipski, Mariusz

BMC oral health

2019 Volume 20, Issue 1, Page(s) 3

Abstract: Background: Accurate determination of working length (WL) is crucial for the success of endodontic therapy. The aim of this study was to determine the influence of 2% chlorhexidine digluconate solution, 2% chlorhexidine digluconate gel and 2% ... ...

Abstract	Background: Accurate determination of working length (WL) is crucial for the success of endodontic therapy. The aim of this study was to determine the influence of 2% chlorhexidine digluconate solution, 2% chlorhexidine digluconate gel and 2% hypochlorite solution on the accuracy of two devices: the Raypex 5 and the ApexDal. Methods: Twenty-nine single-rooted human teeth were used in this study. The crowns were cut horizontally and embedded in an alginate mass. In each tooth, six endodontic measurements were made using two electronic apex locators (EALs): a Raypex 5 and an ApexDal. For each EAL, measurements were taken with the following products: 2% chlorhexidine solution (CHX-S group), 2% chlorhexidine gel (CHX-G group) and 2% NaOCl (NaOCl group). After performing an endodontic measurement, the endodontic instruments were stabilized with flow resin composite. Afterwards, the roots were removed from the alginate mass, and the apical one-third of each root was cut lengthways to recover the canal system. Last, the distance between the file tip and the apical foramen was measured under a microscope at 60 x magnification. Results: Statistically significant differences were found between CHX-S and NaOCl and CHX-G and NaOCl, but no significant differences were detected between CHX-S and CHX-G during the testing of both devices. No statistically significant differences were observed between the Raypex 5 and ApexDal for all intracanal media tested. Conclusion: The EALs Raypex 5 and ApexDal had higher accuracy in the anatomical foramen of the root containing chlorhexidine in the gel or in the solution form than in the canal containing sodium hypochlorite.
MeSH term(s)	Anti-Infective Agents, Local/therapeutic use ; Chlorhexidine/pharmacology ; Dental Pulp Cavity/anatomy & histology ; Disinfectants/therapeutic use ; Electrical Equipment and Supplies ; Electronics, Medical/instrumentation ; Humans ; Mouthwashes/therapeutic use ; Odontometry/instrumentation ; Root Canal Preparation/instrumentation ; Sodium Hypochlorite/therapeutic use ; Tooth Apex/anatomy & histology
Chemical Substances	Anti-Infective Agents, Local ; Disinfectants ; Mouthwashes ; Sodium Hypochlorite (DY38VHM5OD) ; Chlorhexidine (R4KO0DY52L)
Language	English
Publishing date	2019-12-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2091511-1
ISSN	1472-6831 ; 1472-6831
ISSN (online)	1472-6831
ISSN	1472-6831
DOI	10.1186/s12903-019-0994-z
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Article ; Online: Surface Geometry of Four Conventional Nanohybrid Resin-Based Composites and Four Regular Viscosity Bulk Fill Resin-Based Composites after Two-Step Polishing Procedure.

Granat, Mateusz / Cieloszyk, Janusz / Kowalska, Urszula / Buczkowska-Radlińska, Jadwiga / Łagocka, Ryta

BioMed research international

2020 Volume 2020, Page(s) 6203053

Abstract: Objectives: The aim of the study was to determine the quantitative and qualitative surface structure of contemporary RBCs in posterior teeth reconstructions: regular viscosity bulk fill and conventional composites, obtained after two-stage polishing ... ...

Abstract	Objectives: The aim of the study was to determine the quantitative and qualitative surface structure of contemporary RBCs in posterior teeth reconstructions: regular viscosity bulk fill and conventional composites, obtained after two-stage polishing procedure. Materials and methods: Four conventional nanohybrid composites (Tetric EvoCeram, GrandioSO, Filtek Z550, and Ceram·X Mono) and four regular viscosity bulk fill composites (Tetric EvoCeram Bulk Fill, X-tra fil, Filtek Bulk Fill Posterior, and QuixFil) were tested. Samples of each RBC were prepared using PMMA cylindrical mold. After two-step polishing procedure, a surface geometry was evaluated under profilometry (Turbowave v. 7.36, Hommel-Etamic) and SEM (VEGA 3, Tescan Analytics). To evaluate differences between values, the following nonparametric tests were used: Friedman's ANOVA, Wilcoxon's matched-pair test, ANOVA Kruskal-Wallis, and Mann-Whitney Results: All conventional RBCs showed Ra values in the range of 0.20-0.26 Conclusions: Regular viscosity bulk fill composites do not constitute a homogeneous group regarding surface roughness after polishing. They obtain, for the most part, poorer smoothness values after polishing than conventional RBCs.
MeSH term(s)	Composite Resins/chemistry ; Composite Resins/therapeutic use ; Dental Materials/chemistry ; Dental Materials/therapeutic use ; Humans ; Materials Testing ; Nanostructures/chemistry ; Nanostructures/therapeutic use ; Surface Properties ; Viscosity/drug effects
Chemical Substances	CeramX ; Composite Resins ; Dental Materials ; Filtek Bulk Fill ; Filtek Z550 ; QuiXfil ; Tetric EvoCeram
Language	English
Publishing date	2020-08-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2020/6203053
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Article ; Online: Surface Geometry of Four Conventional Nanohybrid Resin-Based Composites and Four Regular Viscosity Bulk Fill Resin-Based Composites after Two-Step Polishing Procedure

Mateusz Granat / Janusz Cieloszyk / Urszula Kowalska / Jadwiga Buczkowska-Radlińska / Ryta Łagocka

BioMed Research International, Vol

2020 Volume 2020

Abstract: Objectives. The aim of the study was to determine the quantitative and qualitative surface structure of contemporary RBCs in posterior teeth reconstructions: regular viscosity bulk fill and conventional composites, obtained after two-stage polishing ... ...

Abstract	Objectives. The aim of the study was to determine the quantitative and qualitative surface structure of contemporary RBCs in posterior teeth reconstructions: regular viscosity bulk fill and conventional composites, obtained after two-stage polishing procedure. Materials and Methods. Four conventional nanohybrid composites (Tetric EvoCeram, GrandioSO, Filtek Z550, and Ceram·X Mono) and four regular viscosity bulk fill composites (Tetric EvoCeram Bulk Fill, X-tra fil, Filtek Bulk Fill Posterior, and QuixFil) were tested. Samples of each RBC were prepared using PMMA cylindrical mold. After two-step polishing procedure, a surface geometry was evaluated under profilometry (Turbowave v. 7.36, Hommel-Etamic) and SEM (VEGA 3, Tescan Analytics). To evaluate differences between values, the following nonparametric tests were used: Friedman’s ANOVA, Wilcoxon’s matched-pair test, ANOVA Kruskal-Wallis, and Mann-Whitney U. Results. All conventional RBCs showed Ra values in the range of 0.20-0.26 μm. Bulk fill showed higher values in range of 0.49-1.36 μm except for Filtek Bulk Fill Posterior, which achieved 0.23 μm Ra value. SEM images of conventional RBCs were described as smooth surfaces with slight damage except for TEC, which presented smooth surface with no damage. Bulk fill composites showed rough surface, except for TBF, which presented smooth surface with slight damage. Conclusions. Regular viscosity bulk fill composites do not constitute a homogeneous group regarding surface roughness after polishing. They obtain, for the most part, poorer smoothness values after polishing than conventional RBCs.
Keywords	Medicine ; R
Subject code	620
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Lack of Association Between the VEGFA Gene Rs699947 Polymorphism and Periodontal Disease.

Mazurek-Mochol, Małgorzata / Łagocka, Ryta / Dembowska, Elżbieta / Kozak, Małgorzata / Sawczuk, Marek / Maciejewska, Agnieszka / Malinowski, Damian / Safranow, Krzysztof / Pawlik, Andrzej

Oral health & preventive dentistry

2020 Volume 18, Page(s) 171–175

Abstract: Purpose: Periodontal disease is a chronic inflammatory disease characterised by the infiltration of inflammatory cells as well as activation of pathological angiogenesis in gingival tissues. Vascular endothelial growth factor (VEGF) plays a ... ...

Abstract	Purpose: Periodontal disease is a chronic inflammatory disease characterised by the infiltration of inflammatory cells as well as activation of pathological angiogenesis in gingival tissues. Vascular endothelial growth factor (VEGF) plays a statistically significant role in the regulation of angiogenesis and induction of an inflammatory response in periodontal tissues. Materials and methods: We examined the association between the VEGFA gene rs699947 polymorphism and periodontal disease. This study enrolled 200 patients with periodontal disease (130 non-smokers and 70 smokers) and 160 control subjects (126 non-smokers and 34 smokers). Results: There were no statistically significant differences in the distribution of VEGFA rs699947 genotypes and alleles between patients with periodontal disease and control subjects, also in the case when the analysis was performed in subgroups stratified according to smoking status. Conclusion: The results of this study suggest there is no association between the VEGFA gene rs699947 polymorphism and periodontal disease.
MeSH term(s)	Case-Control Studies ; Genotype ; Humans ; Periodontal Diseases ; Polymorphism, Single Nucleotide ; Vascular Endothelial Growth Factor A
Chemical Substances	VEGFA protein, human ; Vascular Endothelial Growth Factor A
Language	English
Publishing date	2020-04-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2136786-3
ISSN	1757-9996 ; 1602-1622
ISSN (online)	1757-9996
ISSN	1602-1622
DOI	10.3290/j.ohpd.a43493
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