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Article ; Online: Facioscapulohumeral Muscular Dystrophy and Poliomyelitis followed by Multiple Sclerosis: A "triple trouble" case report and review of the literature on the association of MS and muscle disorders.

Ziccone, Vanessa / Rodolico, Carmelo / Rizzo, Vincenzo / Tupler, Rossella / Buccafusca, Maria / Toscano, Antonio

2021 Volume 31, Issue 11, Page(s) 1179–1185

Abstract: We describe herein a "triple trouble" case of a patient affected by Facioscapulohumeral muscular dystrophy type 1 (FSHD1), with a previous history of poliomyelitis, who later developed multiple sclerosis (MS). Association of muscle disorders and MS is ... ...

Abstract	We describe herein a "triple trouble" case of a patient affected by Facioscapulohumeral muscular dystrophy type 1 (FSHD1), with a previous history of poliomyelitis, who later developed multiple sclerosis (MS). Association of muscle disorders and MS is uncommon; in fact, there are only three case reports of this unusual co-occurrence. As regard as this combination, some hypotheses have been raised about the role of immunological factors. Genetic basis of FSHD1 is a deletion of a critical number of macrosatellite repeats (D4Z4) in the subtelomeric region of chromosome 4q35, resulting in transcriptional de-repression of a gene DUX4. This molecular change could induce an alteration of immune responses, likely conferring susceptibility to both diseases. In this case, poliomyelitis could have delayed the FSHD1 diagnosis and likely acted as a trigger for MS onset. Association of multiple neurological disorders has to be kept in mind to avoid misinterpretation of symptoms and diagnostic delays.
MeSH term(s)	Adolescent ; Epigenesis, Genetic ; Female ; Gene Expression ; Humans ; Male ; Multiple Sclerosis/complications ; Muscular Dystrophy, Facioscapulohumeral/complications ; Poliomyelitis/complications ; Young Adult
Language	English
Publishing date	2021-06-18
Publishing country	England
Document type	Case Reports
ZDB-ID	1077681-3
ISSN	1873-2364 ; 0960-8966
ISSN (online)	1873-2364
ISSN	0960-8966
DOI	10.1016/j.nmd.2021.06.006
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Article ; Online: Favourable course in a cohort of Parkinson's disease patients infected by SARS-CoV-2: a single-centre experience.

Buccafusca, Maria / Micali, Cristina / Autunno, Massimo / Versace, Antonio Giovanni / Nunnari, Giuseppe / Musumeci, Olimpia

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2021 Volume 42, Issue 3, Page(s) 811–816

Abstract: The COVID-19 outbreak has had a dramatic impact on the healthcare system due to the rapid, worldwide spread of the virus, highlighting several considerations on the best management of infected patients and also potential risks and prognostic factors in ... ...

Abstract	The COVID-19 outbreak has had a dramatic impact on the healthcare system due to the rapid, worldwide spread of the virus, highlighting several considerations on the best management of infected patients and also potential risks and prognostic factors in patients with pre-existing chronic diseases exposed to the virus. Neurodegenerative disorders are known to be chronic, disabling diseases that imply a higher vulnerability to infections, and for this reason, it has been suggested that SARS-CoV-2 infection may have a worse course in these patients. In the present study, we report our experience with 12 patients affected by Parkinson's disease (PD) who became infected with SARS-Cov-2 due to a COVID-19 outbreak in a care residency, and thus hospitalised in our COVID hospital. Most of the PD patients had a long disease duration and multiple comorbidities even though SARS-CoV-2 manifestations were mild, and none required intensive care. Despite lung conditions, most of our PD patients had mild symptoms: 7 patients were clinically asymptomatic (58.3%); 3 patients had fever, cough, and myalgia (25%) and 2 patients had dyspnoea (16%) that needed high-flow oxygen therapy. Few complications related to PD were seen. All patients were discharged after a mean hospitalisation period of 30 days. Mortality rate during hospitalisation was zero. Our findings suggest that SARS-CoV-2 infection does not have a poor prognosis in patients with PD. More extensive data and evaluations, however, are needed to confirm our data, and caution is warranted.
MeSH term(s)	Aged ; Aged, 80 and over ; COVID-19/complications ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Nursing Homes ; Parkinson Disease/virology ; Rehabilitation Centers ; Retrospective Studies ; SARS-CoV-2
Language	English
Publishing date	2021-01-13
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-020-05001-4
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Article ; Online: A thiol redox sensor in soluble epoxide hydrolase enables oxidative activation by intra-protein disulfide bond formation.

Charles, Rebecca L / Abis, Giancarlo / Fernandez, Beatriz F / Guttzeit, Sebastian / Buccafusca, Roberto / Conte, Maria R / Eaton, Philip

Redox biology

2021 Volume 46, Page(s) 102107

Abstract: Soluble epoxide hydrolase (sEH), an enzyme that broadly regulates the cardiovascular system, hydrolyses epoxyeicosatrienoic acids (EETs) to their corresponding dihydroxyeicosatrienoic acids (DHETs). We previously showed that endogenous lipid ... ...

Abstract	Soluble epoxide hydrolase (sEH), an enzyme that broadly regulates the cardiovascular system, hydrolyses epoxyeicosatrienoic acids (EETs) to their corresponding dihydroxyeicosatrienoic acids (DHETs). We previously showed that endogenous lipid electrophiles adduct within the catalytic domain, inhibiting sEH to lower blood pressure in angiotensin II-induced hypertensive mice. As angiotensin II increases vascular H
MeSH term(s)	Animals ; Disulfides ; Epoxide Hydrolases/genetics ; Epoxide Hydrolases/metabolism ; Hydrogen Peroxide ; Mice ; Oxidation-Reduction ; Oxidative Stress ; Sulfhydryl Compounds
Chemical Substances	Disulfides ; Sulfhydryl Compounds ; Hydrogen Peroxide (BBX060AN9V) ; Epoxide Hydrolases (EC 3.3.2.-)
Language	English
Publishing date	2021-08-18
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701011-9
ISSN	2213-2317 ; 2213-2317
ISSN (online)	2213-2317
ISSN	2213-2317
DOI	10.1016/j.redox.2021.102107
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Article ; Online: Clinicians' and Patients' Perceptions and Use of the Word "Cured" in Cancer Care: An Italian Survey.

Tralongo, Paolo / Cappuccio, Francesco / Gori, Stefania / Donato, Vittorio / Beretta, Giordano / Elia, Ausilia / Romano, Fabrizio / Iacono, Margherita / Tralongo, Antonino Carmelo / Bordonaro, Sebastiano / Di Mari, Annamaria / Giuliano, Sebastiano Rametta / Buccafusca, Gabriella / Careri, Maria Carmela / Santoro, Armando

Current oncology (Toronto, Ont.)

2023 Volume 30, Issue 2, Page(s) 1332–1353

Abstract: Background: The words "hope" and "cure" were used in a greater number of articles and sentences in narrative and editorial papers than in primary research. Despite concomitant improvements in cancer outcomes, the related reluctance to use these terms in ...

Abstract	Background: The words "hope" and "cure" were used in a greater number of articles and sentences in narrative and editorial papers than in primary research. Despite concomitant improvements in cancer outcomes, the related reluctance to use these terms in more scientifically oriented original reports may reflect a bias worthy of future exploration. This study aims to survey a group of physicians and cancer patients regarding their perception and use of the word cure. Materials and method: An anonymous online and print survey was conducted to explore Italian clinicians' (the sample includes medical oncologists, radiotherapists, and oncological surgeons) and cancer patients' approach to the perception and use of the word "cure" in cancer care. The participants received an email informing them of the study's purpose and were invited to participate in the survey via a linked form. A portion, two-thirds, of questionnaires were also administered to patients in the traditional paper form. Results: The survey was completed by 224 clinicians (54 oncologists, 78 radiotherapists, and 92 cancer surgeons) and 249 patients. The results indicate a favourable attitude for patients in favour of a new language ("cured" vs. "complete remission") of the disease experience. Conclusions: The use of the word cured is substantially accepted and equally shared by doctors and patients. Its use can facilitate the elimination of metaphoric implications and toxic cancer-related connotations registered in all cultures that discourage patients from viewing cancer as a disease with varied outcomes, including cure.
MeSH term(s)	Humans ; Surveys and Questionnaires ; Neoplasms ; Physicians ; Attitude ; Language
Language	English
Publishing date	2023-01-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol30020103
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Article ; Online: Unmet needs and gaps in the identification of secondary progression in multiple sclerosis: a Southern Italy healthcare professionals' perspective.

Lus, Giacomo / Bassano, Marco André / Brescia Morra, Vincenzo / Bonavita, Simona / Gallo, Antonio / Maimone, Davide / Malerba, Laura / Maniscalco, Giorgia Teresa / Saccà, Francesco / Salemi, Giuseppe / Turrini, Renato / Cottone, Salvatore / Sessa, Edoardo / Buccafusca, Maria / Grimaldi, Luigi Maria Edoardo

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2022

Abstract: Objective: Multiple sclerosis (MS) is a chronic disease with different clinical courses and a tendency to worsening. The relapsing-remitting MS presents acute onset and relapses of neurological symptoms, followed by their remission. This form can ... ...

Abstract	Objective: Multiple sclerosis (MS) is a chronic disease with different clinical courses and a tendency to worsening. The relapsing-remitting MS presents acute onset and relapses of neurological symptoms, followed by their remission. This form can convert to secondary progressive MS (SPMS) with irreversible neurological worsening and disability. The identification of signs, symptoms, markers of progression, and strategies to manage MS patients is mandatory to allow early identification of those at higher risk of conversion to SPMS, for prompt intervention to cope with the progression of the disease. Methods: A panel of Italian experts from Southern Italy have reviewed the current knowledge on MS and its management and identified the crucial tools for SPMS recognition. Results: More effective communication between patients and clinicians should be established, with the support of digital tools. Moreover, the improvement in the clinical use of biomarkers for progression (cellular structures and tissue organization, such as neurofilaments and chitinase 3-like 1, axonal and neurons density) and of instrumental analyses for recognition of whole-brain atrophy, chronic active lesions, spinal cord lesions and atrophy, and the improvement the combination of the Expanded Disability Status Scale and the evaluation of cognitive dysfunction are discussed. Conclusion: Given the availability of a pharmacological option, adequate education both for patients, regarding the evolution of the disease and the specific treatment, and for professionals, to allow more effective and sensitive communication and the best use of diagnostic and management tools, could represent a strategy to improve patient management and their quality of life.
Language	English
Publishing date	2022-09-17
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-022-06402-3
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Article ; Online: The role of ethnicity and native-country income in multiple sclerosis: the Italian multicentre study (MS-MigIT).

Bianchi, Alessia / Matranga, Domenica / Patti, Francesco / Maniscalco, Laura / Pilotto, Silvy / Di Filippo, Massimiliano / Zaffaroni, Mauro / Annovazzi, Pietro / Bertolotto, Antonio / Gasperini, Claudio / Quartuccio, Esmeralda / Centonze, Diego / Fantozzi, Roberta / Gajofatto, Alberto / Gobbin, Francesca / Landi, Doriana / Granella, Franco / Buccafusca, Maria / Marfia, Girolama Alessandra /

Chisari, Clara / Naldi, Paola / Bergamaschi, Roberto / Greco, Giacomo / Zarbo, Ignazio Roberto / Rizzo, Vincenzo / Ulivelli, Monica / Bezzini, Daiana / Florio, Lucia / Turazzini, Michelangelo / Di Gregorio, Maria / Pugliatti, Maura / Salemi, Giuseppe / Ragonese, Paolo

Journal of neurology

2024 Volume 271, Issue 5, Page(s) 2182–2194

Abstract: Objective: Multiple sclerosis (MS) is a complex disorder in which environmental and genetic factors interact modifying disease risk and course. This multicentre, case-control study involving 18 Italian MS Centres investigated MS course by ethnicity and ... ...

Abstract	Objective: Multiple sclerosis (MS) is a complex disorder in which environmental and genetic factors interact modifying disease risk and course. This multicentre, case-control study involving 18 Italian MS Centres investigated MS course by ethnicity and native-country economic status in foreign-born patients living in Italy. Methods: We identified 457 MS patients who migrated to Italy and 893 age- and sex-matched native-born Italian patients. In our population, 1225 (93.2%) subjects were White Europeans and White Northern Americans (WENA) and 89 (6.8%) patients were from other ethnical groups (OEG); 1109 (82.1%) patients were born in a high-income (HI) Country and 241 (17.9%) in a low-middle-income (LMI) Country. Medical records and patients interviews were used to collect demographic and disease data. Results: We included 1350 individuals (973 women and 377 men); mean (SD) age was 45.0 (11.7) years. At onset, 25.45% OEG patients vs 12.47% WENA (p = 0.039) had > 3 STIR spine lesions. At recruitment, the same group featured mean (SD) EDSS score of 2.85 (2.23) vs 2.64 (2.28) (p = 0.044) reached in 8.9 (9.0) vs 12.0 (9.0) years (p = 0.018) and underwent 1.10 (4.44) vs. 0.99 (0.40) annual MRI examinations (p = 0.035). At disease onset, patients from LMI countries had higher EDSS score than HI patients (2.40 (1.43) vs 1.99 (1.17); p = 0.032). Discussion: Our results suggested that both ethnicity and socio-economic status of native country shape MS presentation and course and should be considered for an appropriate management of patients. To the best of our knowledge, this is the first study reporting on the impact of ethnicity in MS at an individual level and beyond an ecological population-perspective.
MeSH term(s)	Humans ; Male ; Female ; Italy/ethnology ; Middle Aged ; Adult ; Multiple Sclerosis/ethnology ; Case-Control Studies ; Income ; Ethnicity
Language	English
Publishing date	2024-02-16
Publishing country	Germany
Document type	Journal Article ; Multicenter Study
ZDB-ID	187050-6
ISSN	1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
ISSN (online)	1432-1459
ISSN	0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
DOI	10.1007/s00415-024-12214-6
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Article ; Online: A thiol redox sensor in soluble epoxide hydrolase enables oxidative activation by intra-protein disulfide bond formation

Rebecca L. Charles / Giancarlo Abis / Beatriz F. Fernandez / Sebastian Guttzeit / Roberto Buccafusca / Maria R. Conte / Philip Eaton

Redox Biology, Vol 46, Iss , Pp 102107- (2021)

2021

Abstract	Soluble epoxide hydrolase (sEH), an enzyme that broadly regulates the cardiovascular system, hydrolyses epoxyeicosatrienoic acids (EETs) to their corresponding dihydroxyeicosatrienoic acids (DHETs). We previously showed that endogenous lipid electrophiles adduct within the catalytic domain, inhibiting sEH to lower blood pressure in angiotensin II-induced hypertensive mice. As angiotensin II increases vascular H2O2, we explored sEH redox regulation by this oxidant and how this integrates with inhibition by lipid electrophiles to regulate vasotone. Kinetics analyses revealed that H2O2 not only increased the specific activity of sEH but increased its affinity for substrate and increased its catalytic efficiency. This oxidative activation was mediated by formation of an intra-disulfide bond between C262 and C264, as determined by mass spectrometry and substantiated by biotin-phenylarsinate and thioredoxin-trapping mutant assays. C262S/264S sEH mutants were resistant to peroxide-induced activation, corroborating the disulfide-activation mechanism. The physiological impact of sEH redox state was determined in isolated arteries and the effect of the pro-oxidant vasopressor angiotensin II on arterial sEH redox state and vasodilatory EETs indexed in mice. Angiotensin II induced the activating intra-disulfide in sEH, causing a decrease in plasma EET/DHET ratios that is consistent with the pressor response to this hormone. Although sEH C262–C264 disulfide formation enhances hydrolysis of vasodilatory EETs, this modification also sensitized sEH to inhibition by lipid electrophiles. This explains why angiotensin II decreases EETs and increases blood pressure, but when lipid electrophiles are also present, that EETs are increased and blood pressure lowered.
Keywords	Redox regulation ; Oxidation ; Angiotensin II ; Disulfide ; Soluble epoxide hydrolase ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
Subject code	500
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Germline thymidylate synthase deficiency impacts nucleotide metabolism and causes dyskeratosis congenita.

Tummala, Hemanth / Walne, Amanda / Buccafusca, Roberto / Alnajar, Jenna / Szabo, Anita / Robinson, Peter / McConkie-Rosell, Allyn / Wilson, Meredith / Crowley, Suzanne / Kinsler, Veronica / Ewins, Anna-Maria / Madapura, Pradeepa M / Patel, Manthan / Pontikos, Nikolas / Codd, Veryan / Vulliamy, Tom / Dokal, Inderjeet

American journal of human genetics

2022 Volume 109, Issue 8, Page(s) 1472–1483

Abstract: Dyskeratosis congenita (DC) is an inherited bone-marrow-failure disorder characterized by a triad of mucocutaneous features that include abnormal skin pigmentation, nail dystrophy, and oral leucoplakia. Despite the identification of several genetic ... ...

Abstract	Dyskeratosis congenita (DC) is an inherited bone-marrow-failure disorder characterized by a triad of mucocutaneous features that include abnormal skin pigmentation, nail dystrophy, and oral leucoplakia. Despite the identification of several genetic variants that cause DC, a significant proportion of probands remain without a molecular diagnosis. In a cohort of eight independent DC-affected families, we have identified a remarkable series of heterozygous germline variants in the gene encoding thymidylate synthase (TYMS). Although the inheritance appeared to be autosomal recessive, one parent in each family had a wild-type TYMS coding sequence. Targeted genomic sequencing identified a specific haplotype and rare variants in the naturally occurring TYMS antisense regulator ENOSF1 (enolase super family 1) inherited from the other parent. Lymphoblastoid cells from affected probands have severe TYMS deficiency, altered cellular deoxyribonucleotide triphosphate pools, and hypersensitivity to the TYMS-specific inhibitor 5-fluorouracil. These defects in the nucleotide metabolism pathway resulted in genotoxic stress, defective transcription, and abnormal telomere maintenance. Gene-rescue studies in cells from affected probands revealed that post-transcriptional epistatic silencing of TYMS is occurring via elevated ENOSF1. These cell and molecular abnormalities generated by the combination of germline digenic variants at the TYMS-ENOSF1 locus represent a unique pathogenetic pathway for DC causation in these affected individuals, whereas the parents who are carriers of either of these variants in a singular fashion remain unaffected.
MeSH term(s)	Dyskeratosis Congenita/genetics ; Germ Cells ; Heterozygote ; Humans ; Nucleotides ; Thymidylate Synthase/deficiency ; Thymidylate Synthase/genetics
Chemical Substances	Nucleotides ; Thymidylate Synthase (EC 2.1.1.45)
Language	English
Publishing date	2022-08-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	219384-x
ISSN	1537-6605 ; 0002-9297
ISSN (online)	1537-6605
ISSN	0002-9297
DOI	10.1016/j.ajhg.2022.06.014
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Article ; Online: A method to compare prospective and historical cohorts to evaluate drug effects. Application to the analysis of early treatment effectiveness of intramuscular interferon-β1a in multiple sclerosis patients.

Mallucci, Giulia / Patti, Francesco / Brescia Morra, Vincenzo / Buccafusca, Maria / Moiola, Lucia / Amato, Maria Pia / Ferraro, Elisabetta / Trojano, Maria / Zaffaroni, Mauro / Mirabella, Massimiliano / Moscato, Gianluca / Plewnia, Katrin / Zipoli, Valentina / Puma, Elisa / Bergamaschi, Roberto

Multiple sclerosis and related disorders

2020 Volume 40, Page(s) 101952

Abstract: Background: Disease modifying therapy have changed the natural evolution of multiple sclerosis (MS), with efficacy demonstrated in randomized clinical trials. Standard-of-care effectiveness is needed to complement clinical trial data and highlight ... ...

Abstract	Background: Disease modifying therapy have changed the natural evolution of multiple sclerosis (MS), with efficacy demonstrated in randomized clinical trials. Standard-of-care effectiveness is needed to complement clinical trial data and highlight outcomes in real-world practice, but comparing prospective patients with historical cohorts likely introduces biases. To address these potential biases, assigning a patient with a score that expresses his/her disease prognosis before starting a therapy may make it possible to evaluate the unbiased ability of the therapy to modify disease natural history. Thus, we aimed at analyzing the effectiveness of intramuscular interferon-β1a (im IFN-β1a) matching by BREMSO score (Bayesian Risk Estimate for Multiple Sclerosis at Onset) a prospective real-world cohort of treated patients with a historical cohort of untreated patients. Material and methods: We observed 108 newly diagnosed, treatment naïve MS patients over 12 months of treatment with im IFN-β1a. BREMSO score was used to assign a value to each patient, giving the real-world treated patients comparable with the Historical untreated patients, on the basis of the same risk to have unfavorable evolution. Results: A significantly higher percentage of relapse-free patients is observed in IFN-β1a treated cohort vs. Historical untreated cohort (79.6% vs. 59.3%, p < 0.01). Clinical relapses risk is reduced by 2.2 times in treated patients (p = 0.01). Conclusions: We propose a promising method to manage observational data in a relatively unbiased way, in order to analyze real-world treatment effectiveness.
MeSH term(s)	Adult ; Bayes Theorem ; Cohort Studies ; Female ; Humans ; Immunologic Factors/administration & dosage ; Immunologic Factors/pharmacology ; Injections, Intramuscular ; Interferon beta-1a/administration & dosage ; Interferon beta-1a/pharmacology ; Male ; Middle Aged ; Multiple Sclerosis/diagnosis ; Multiple Sclerosis/drug therapy ; Observational Studies as Topic ; Outcome Assessment, Health Care/methods ; Prognosis ; Prospective Studies ; Risk Assessment
Chemical Substances	Immunologic Factors ; Interferon beta-1a (XRO4566Q4R)
Language	English
Publishing date	2020-01-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2645330-7
ISSN	2211-0356 ; 2211-0348
ISSN (online)	2211-0356
ISSN	2211-0348
DOI	10.1016/j.msard.2020.101952
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Article: A case of lung injury resembling diffuse pulmonary hemorrhage after the first administration of alemtuzumab in a patient with multiple sclerosis. Role of the HRCT.

Cipolla, Gaia / Relo, Rosalba / Pasciuta, Elisa / Catalano, Domenica / Lo Bello, Federica / Coppolino, Irene / Ruggeri, Paolo / Proietto, Alfio / Buccafusca, Maria / Cutroneo, Paola Maria / Trifirò, Gianluca / Caramori, Gaetano

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace

2020 Volume 90, Issue 3

Abstract: Diffuse alveolar hemorrhage (DAH) is an acute often life-threatening condition characterized by a variable combination of hemoptysis, dyspnoea, diffuse and bilateral ground glass pulmonary opacities, anemia and hypoxemia, that can be induced by different ...

Abstract	Diffuse alveolar hemorrhage (DAH) is an acute often life-threatening condition characterized by a variable combination of hemoptysis, dyspnoea, diffuse and bilateral ground glass pulmonary opacities, anemia and hypoxemia, that can be induced by different causes, including several drugs. We report here the case of a 25-year-old woman who has been admitted to our pulmonary clinic for the onset of chest pain, cough and haemoptysis, started one week after her first treatment with alemtuzumab for multiple sclerosis. Computed tomography (CT) scan of the chest at the admission showed diffuse and bilateral ground glass pulmonary opacities. Her symptoms resolved completely without any treatment, after the interruption of alemtuzumab, and CT scan of the chest performed one month later showed total disappearance of the pulmonary opacities.
MeSH term(s)	Adult ; Alemtuzumab/administration & dosage ; Alemtuzumab/adverse effects ; Alemtuzumab/therapeutic use ; Antineoplastic Agents, Immunological/administration & dosage ; Antineoplastic Agents, Immunological/adverse effects ; Antineoplastic Agents, Immunological/therapeutic use ; Drug-Related Side Effects and Adverse Reactions/complications ; Dyspnea/chemically induced ; Dyspnea/diagnosis ; Female ; Hemoptysis/chemically induced ; Hemoptysis/diagnosis ; Hemorrhage/chemically induced ; Hemorrhage/diagnosis ; Humans ; Lung Diseases/diagnostic imaging ; Lung Diseases/pathology ; Lung Injury/chemically induced ; Lung Injury/complications ; Multiple Sclerosis/drug therapy ; Tomography, X-Ray Computed/methods ; Withholding Treatment
Chemical Substances	Antineoplastic Agents, Immunological ; Alemtuzumab (3A189DH42V)
Language	English
Publishing date	2020-07-24
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	1160940-0
ISSN	1122-0643 ; 1120-0391
ISSN	1122-0643 ; 1120-0391
DOI	10.4081/monaldi.2020.1352
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In stock of ZB MED Cologne/Königswinter

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Full text online

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Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito