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Article ; Online: Post-cardiac arrest patients with epileptiform EEG: Better selection for better treatment.

Beretta, Simone / Coppo, Anna

2020 Volume 94, Issue 16, Page(s) 685–686

MeSH term(s)	Coma ; Consciousness ; Electroencephalography ; Heart Arrest ; Humans
Language	English
Publishing date	2020-03-25
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000009282
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Article ; Online: Transthoracic impedance variability to assess quality of chest compression in out-of-hospital cardiac arrest.

Magliocca, Aurora / Castagna, Valentina / Fornari, Carla / Zimei, Gabriele / Merigo, Giulia / Penna, Alessio / Carlson, Jonas / Fumagalli, Francesca / Stirparo, Giuseppe / Migliari, Maurizio / Coppo, Anna / Sechi, Giuseppe Maria / Grasselli, Giacomo / Hardig, Bjarne Madsen / Ristagno, Giuseppe

Acta anaesthesiologica Scandinavica

2024 Volume 68, Issue 4, Page(s) 556–566

Abstract: Background: Chest compression is a lifesaving intervention in out-of-hospital cardiac arrest (OHCA), but the optimal metrics to assess its quality have yet to be identified. The objective of this study was to investigate whether a new parameter, that is, ...

Abstract	Background: Chest compression is a lifesaving intervention in out-of-hospital cardiac arrest (OHCA), but the optimal metrics to assess its quality have yet to be identified. The objective of this study was to investigate whether a new parameter, that is, the variability of the chest compression-generated transthoracic impedance (TTI), namely Imp Methods: This multicenter observational, retrospective study included OHCAs with shockable rhythm. Imp Results: Among 835 treated OHCAs, 680 met inclusion criteria and 565 matched long-term outcomes. Imp Conclusions: In this population, consistency of chest compression maneuver, measured by variability in TTI, was an independent predictor of defibrillation outcome. Imp
MeSH term(s)	Humans ; Cardiopulmonary Resuscitation ; Out-of-Hospital Cardiac Arrest/therapy ; Cardiography, Impedance ; Retrospective Studies ; Respiration, Artificial ; Emergency Medical Services
Language	English
Publishing date	2024-01-14
Publishing country	England
Document type	Observational Study ; Multicenter Study ; Journal Article
ZDB-ID	80002-8
ISSN	1399-6576 ; 0001-5172
ISSN (online)	1399-6576
ISSN	0001-5172
DOI	10.1111/aas.14374
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Article ; Online: Rodin's Thinker: An Alternative Position in Awake Patients with COVID-19.

Coppo, Anna / Winterton, Dario / Benini, Annalisa / Monzani, Anna / Aletti, Gabriele / Cadore, Barbara / Isgrò, Stefano / Pizzagalli, Jonata / Bellani, Giacomo / Foti, Giuseppe

American journal of respiratory and critical care medicine

2021 Volume 204, Issue 6, Page(s) 728–730

MeSH term(s)	Aged ; COVID-19/physiopathology ; COVID-19/therapy ; Continuous Positive Airway Pressure/methods ; Female ; Humans ; Italy ; Male ; Middle Aged ; Prone Position ; Retrospective Studies ; SARS-CoV-2 ; Sitting Position ; Supine Position ; Treatment Outcome ; Wakefulness/physiology
Language	English
Publishing date	2021-08-04
Publishing country	United States
Document type	Comparative Study ; Letter
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202104-0915LE
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Article: Double antiglutamatergic therapy in a case of postanoxic super-refractory status epilepticus.

Stabile, Andrea / Beretta, Simone / Coppo, Anna / Padovano, Giada / Bogliun, Graziella / Ferrarese, Carlo / Avalli, Leonello

Neurology. Clinical practice

2020 Volume 10, Issue 5, Page(s) e44–e46

Language	English
Publishing date	2020-11-18
Publishing country	United States
Document type	Case Reports
ZDB-ID	2645818-4
ISSN	2163-0933 ; 2163-0402
ISSN (online)	2163-0933
ISSN	2163-0402
DOI	10.1212/CPJ.0000000000000740
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Article: Absence and reappearance of N20 response after thiopental withdrawal in postanoxic coma.

Coppo, Anna / Beretta, Simone / Migliari, Maurizio / Ferrarese, Carlo / Avalli, Leonello

Neurology. Clinical practice

2018 Volume 5, Issue 6, Page(s) 488–490

Language	English
Publishing date	2018-06-18
Publishing country	United States
Document type	Case Reports
ZDB-ID	2645818-4
ISSN	2163-0933 ; 2163-0402
ISSN (online)	2163-0933
ISSN	2163-0402
DOI	10.1212/CPJ.0000000000000135
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Article ; Online: Management of possible stroke by laypeople in pre-hospital setting: who should we train?

Stirparo, Giuseppe / Kacerik, Erika / Ristagno, Giuseppe / Andreassi, Aida / Coppo, Anna / Migliari, Maurizio / Albonico, Andrea / Sechi, Giuseppe Maria / Zoli, Alberto / Signorelli, Carlo

Acta bio-medica : Atenei Parmensis

2023 Volume 94, Issue 5, Page(s) e2023203

Abstract: Background and aim: The pre-hospital management of a possible stroke is fundamental for the transport of patients to the correct HUB facility; thus, they must be transported to the Emergency Department (ED) by EMS vehicles. Our study aims to analyze the ...

Abstract	Background and aim: The pre-hospital management of a possible stroke is fundamental for the transport of patients to the correct HUB facility; thus, they must be transported to the Emergency Department (ED) by EMS vehicles. Our study aims to analyze the factors correlated with a higher probability of accessing the ED through the EMS in this event. Methods: This is a retrospective observational study. All accesses in the 120 EDs of the Lombardy region, with a diagnosis of discharge whose symptoms could resemble CPSS, were analyzed between 1 January 2019 and 31 December 2019. Results: We identified an increased probability of using the EMS vehicles of 0,05% (I.C. 95%: 0.04% - 0.06%; p<0.0001) for each additional year of age, considering patients aged 20 to 100 years and the percentage was significantly higher in the female population (58% vs 49%; p<0.001). Moreover, we calculated that the incidence of stroke was approximately 140 cases per 100,000 inhabitants. Conclusions: Only half of the citizens in the Lombardy region use the EMS in case of suspicion of stroke; further information campaigns are essential to educate citizens. Information strategies should be directed especially at men between 30 and 59 years old.
MeSH term(s)	Male ; Humans ; Female ; Young Adult ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Emergency Medical Services ; Stroke/epidemiology ; Stroke/therapy ; Stroke/diagnosis ; Emergency Service, Hospital ; Hospitals ; Retrospective Studies
Language	English
Publishing date	2023-10-17
Publishing country	Italy
Document type	Observational Study ; Journal Article
ZDB-ID	2114240-3
ISSN	2531-6745 ; 0392-4203
ISSN (online)	2531-6745
ISSN	0392-4203
DOI	10.23750/abm.v94i5.14261
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Article ; Online: Emergency Department waiting-time in the post pandemic era: new organizational models, a challenge for the future.

Stirparo, Giuseppe / Kacerik, Erika / Andreassi, Aida / Pausilli, Paolo / Cortellaro, Francesca / Coppo, Anna / Migliari, Maurizio / Albonico, Andrea / Sechi, Giuseppe Maria / Zoli, Alberto / Signorelli, Carlo

Acta bio-medica : Atenei Parmensis

2023 Volume 94, Issue S3, Page(s) e2023122

Abstract: Background and aim: Covid-19 has profoundly changed the Emergency Department system in Lombardy, especially for the type of accesses and the number of diagnoses. Accordingly, the pre-hospital rescue system has undergone heavy changes, in particular ... ...

Abstract	Background and aim: Covid-19 has profoundly changed the Emergency Department system in Lombardy, especially for the type of accesses and the number of diagnoses. Accordingly, the pre-hospital rescue system has undergone heavy changes, in particular regarding the times of rescue. Despite this, studies concerning the post-pandemic phase are lacking to understand whether the conditions of the emergency systems has resumed to the pre-pandemic period. The aim of the study is to evaluate the length of stay (LOS) phenomenon in the emergency departments (EDs) in the post-pandemic era. Methods: a retrospective observational study was conducted, which analyzed the first six months of the years 2019, 2021 and 2022. The pandemic peak phase, corresponding to the first months of 2020, wasn't included. The investigated area included the provinces of Milan and Monza, a metropolitan area with 4 million inhabitants. Results: The average time spent by patients in the ED increased by +3.8 hours in 2022 and by +1.3 hours in 2021 compared to 2019. The average time from ED access to hospitalization also increased by +4.8 hours in 2022 and +5.0 hours in 2021 compared to 2019. The percentage of time in ED recorded in a National Emergency Department Overcrowding Study (NEDOCS) in black code in 2022 reached 5.4% against 1.7% in 2021 and 0.5 % in 2019. Conclusions: data show an increase in the time spent in the EDs and an increase in the overcrowding, according to the NEDOCS index. New management models and a reorganization of EDs are needed as the workload has increased significantly.
MeSH term(s)	Humans ; COVID-19/epidemiology ; Models, Organizational ; Pandemics ; Waiting Lists ; Emergency Service, Hospital
Language	English
Publishing date	2023-08-30
Publishing country	Italy
Document type	Observational Study ; Journal Article
ZDB-ID	2114240-3
ISSN	2531-6745 ; 0392-4203
ISSN (online)	2531-6745
ISSN	0392-4203
DOI	10.23750/abm.v94iS3.14262
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Article ; Online: 'It's tough. It is hard': A qualitative interview study of staff and volunteers caring for hospice in-patients with delirium.

Featherstone, Imogen / Siddiqi, Najma / Jones, Lesley / Coppo, Eleonora / Sheldon, Trevor / Hosie, Annmarie / Wolkowski, Anna / Bush, Shirley H / Taylor, Johanna / Teodorczuk, Andrew / Johnson, Miriam J

Palliative medicine

2023 Volume 37, Issue 7, Page(s) 993–1005

Abstract: Background: Delirium is a distressing condition often experienced by hospice in-patients. Increased understanding of current multidisciplinary care of delirium is needed to develop interventions in this setting.: Aim(s): To explore hospice staff and ... ...

Abstract	Background: Delirium is a distressing condition often experienced by hospice in-patients. Increased understanding of current multidisciplinary care of delirium is needed to develop interventions in this setting. Aim(s): To explore hospice staff and volunteers' practice, its influences and what may need to change to improve hospice delirium care. Design: Qualitative interview study using behaviour change theory from a critical realist stance. Setting/participants: Thirty-seven staff, including different professional groups and roles, and volunteers were purposively sampled from two in-patient hospices. Results: We found that participants' practice focus was on managing hyperactive symptoms of delirium, through medication use and non-pharmacological strategies. Delirium prevention, early recognition and hypoactive delirium received less attention. Our theoretically-informed analysis identified this focus was influenced by staff and volunteers' emotional responses to the distress associated with hyperactive symptoms of delirium as well as understanding of delirium prevention, recognition and care, which varied between staff groups. Non-pharmacological delirium management was supported by adequate staffing levels, supportive team working and a culture of person-centred and family-centred care, although behaviours that disrupted the calm hospice environment challenged this. Conclusions: Our findings can inform hospice-tailored behaviour change interventions that develop a shared team understanding and engage staff's emotional responses to improve delirium care. Reflective learning opportunities are needed that increase understanding of the potential to reduce patient distress through prevention and early recognition of delirium, as well as person-centred management. Organisational support for adequate, flexible staffing levels and supportive team working is required to support person-centred delirium care.
MeSH term(s)	Humans ; Hospices ; Palliative Care/psychology ; Hospice Care ; Qualitative Research ; Volunteers ; Delirium/therapy
Language	English
Publishing date	2023-05-02
Publishing country	England
Document type	Journal Article
ZDB-ID	639247-7
ISSN	1477-030X ; 0269-2163
ISSN (online)	1477-030X
ISSN	0269-2163
DOI	10.1177/02692163231170655
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Article ; Online: Functional features of KPC-109, a novel 270-loop KPC-3 mutant mediating resistance to avibactam-based β-lactamase inhibitor combinations and cefiderocol.

Di Pilato, Vincenzo / Codda, Giulia / Niccolai, Claudia / Willison, Edward / Wong, Joshua L C / Coppo, Erika / Frankel, Gad / Marchese, Anna / Rossolini, Gian Maria

International journal of antimicrobial agents

2023 Volume 63, Issue 1, Page(s) 107030

Abstract: Objectives: To investigate a ceftazidime/avibactam (CZA)-resistant Klebsiella pneumoniae (NE368), isolated from a patient exposed to CZA, expressing a novel K. pneumoniae carbapenemase (KPC)-3 variant (KPC-109).: Methods: Antimicrobial susceptibility ...

Abstract	Objectives: To investigate a ceftazidime/avibactam (CZA)-resistant Klebsiella pneumoniae (NE368), isolated from a patient exposed to CZA, expressing a novel K. pneumoniae carbapenemase (KPC)-3 variant (KPC-109). Methods: Antimicrobial susceptibility testing was performed by reference broth microdilution. Whole-genome sequencing (WGS) analysis of NE368 was performed combining a short- and long-reads approach (Illumina and Oxford Nanopore Technologies). Functional characterization of KPC-109 was performed to investigate the impact of KPC-109 production on the β-lactam resistance phenotype of various Escherichia coli and Klebsiella pneumoniae strains, including derivatives of K. pneumoniae with OmpK35 and OmpK36 porin alterations. Horizontal transfer of the KPC-109-encoding plasmid was investigated by conjugation and transformation experiments. Results: K. pneumoniae NE368 was isolated from a patient after repeated CZA exposure, and showed resistance to CZA, fluoroquinolones, piperacillin/tazobactam, expanded-spectrum cephalosporins, amikacin, carbapenems and cefiderocol. WGS revealed the presence of a large chimeric plasmid of original structure (pKPN-NE368), encoding a novel 270-loop mutated KPC-3 variant (KPC-109; ins_270_KYNKDD). KPC-109 production mediated resistance/decreased susceptibility to avibactam-based combinations (with ceftazidime, cefepime and aztreonam) and cefiderocol, with a trade-off on carbapenem resistance. However, in the presence of porin alterations commonly encountered in high-risk clonal lineages of K. pneumoniae, KPC-109 was also able to confer clinical-level resistance to carbapenems. Resistance of NE368 to cefiderocol was likely contributed by KPC-109 production acting in concert with a mutated EnvZ sensor kinase. The KPC-109-encoding plasmid did not appear to be conjugative. Conclusions: These findings expand current knowledge about the diversity of emerging KPC enzyme variants with 270-loop alterations that can be encountered in the clinical setting.
MeSH term(s)	Humans ; Ceftazidime/pharmacology ; Anti-Bacterial Agents/pharmacology ; beta-Lactamase Inhibitors/pharmacology ; Cefiderocol ; Klebsiella pneumoniae ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; beta-Lactamases/genetics ; beta-Lactamases/metabolism ; Azabicyclo Compounds/pharmacology ; Carbapenems/pharmacology ; Drug Combinations ; Porins/genetics ; Microbial Sensitivity Tests
Chemical Substances	Ceftazidime (9M416Z9QNR) ; carbapenemase (EC 3.5.2.6) ; Anti-Bacterial Agents ; beta-Lactamase Inhibitors ; Cefiderocol (SZ34OMG6E8) ; avibactam (7352665165) ; Bacterial Proteins ; beta-Lactamases (EC 3.5.2.6) ; Azabicyclo Compounds ; Carbapenems ; Drug Combinations ; Porins
Language	English
Publishing date	2023-11-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2023.107030
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Article ; Online: Antibacterial activity of polyphenols.

Coppo, Erika / Marchese, Anna

Current pharmaceutical biotechnology

2014 Volume 15, Issue 4, Page(s) 380–390

Abstract: Polyphenols are a widely distributed group of natural products found in fruits, vegetables, nuts, seeds, stems and flowers. Such compounds, especially dietary flavonoids and tannins, have been shown to exert antioxidant, antiinflammatory, anti-cancer and ...

Abstract	Polyphenols are a widely distributed group of natural products found in fruits, vegetables, nuts, seeds, stems and flowers. Such compounds, especially dietary flavonoids and tannins, have been shown to exert antioxidant, antiinflammatory, anti-cancer and antibacterial effects and may have beneficial effects on human health. The antimicrobial activity of polyphenols has been widely studied and hundreds of publications reporting the antimicrobial activity of polyphenols have been recently published. In an era of increasing antibiotic resistance, the development of new strategies to fight bacteria is welcome. Further studies are needed to evaluate the therapeutic potential of polyphenols alone or in combination with currently available antibiotics.
MeSH term(s)	Animals ; Anti-Bacterial Agents/pharmacology ; Bacteria/drug effects ; Carboxylic Acids/pharmacology ; Flavonoids/pharmacology ; Tannins/pharmacology
Chemical Substances	Anti-Bacterial Agents ; Carboxylic Acids ; Flavonoids ; Tannins
Language	English
Publishing date	2014-10-11
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2132197-8
ISSN	1873-4316 ; 1389-2010
ISSN (online)	1873-4316
ISSN	1389-2010
DOI	10.2174/138920101504140825121142
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