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  1. Article ; Online: Feasibility of Therapeutic Effects of the Cholinergic Anti-Inflammatory Pathway on COVID-19 Symptoms.

    Mazloom, Roham

    Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology

    2020  Volume 15, Issue 2, Page(s) 165–166

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Cytokines ; Feasibility Studies ; Humans ; Neuroimmunomodulation ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Syndrome
    Chemical Substances Cytokines
    Keywords covid19
    Language English
    Publishing date 2020-05-07
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2227405-4
    ISSN 1557-1904 ; 1557-1890
    ISSN (online) 1557-1904
    ISSN 1557-1890
    DOI 10.1007/s11481-020-09919-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Possibility of Assessing the Gastrointestinal Tract as a Complex System.

    Mazloom, Roham

    Journal of medical systems

    2019  Volume 43, Issue 3, Page(s) 65

    MeSH term(s) Electrodiagnosis/methods ; Gastrointestinal Tract
    Language English
    Publishing date 2019-02-07
    Publishing country United States
    Document type Letter
    ZDB-ID 423488-1
    ISSN 1573-689X ; 0148-5598
    ISSN (online) 1573-689X
    ISSN 0148-5598
    DOI 10.1007/s10916-019-1194-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1426: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: A new approach for digestive disease diagnosis: Dynamics of gastrointestinal electrical activity.

    Mazloom, Roham

    Medical hypotheses

    2019  Volume 128, Page(s) 64–68

    Abstract: Various methods are used for analyzing the status of the human body. In digestive system, myoelectrical activity is recorded from the abdominal surface. Frequency and power of Gastrointestinal (GI) activity is usually assessed using power spectral ... ...

    Abstract Various methods are used for analyzing the status of the human body. In digestive system, myoelectrical activity is recorded from the abdominal surface. Frequency and power of Gastrointestinal (GI) activity is usually assessed using power spectral analysis. However, spectral analysis of GI electrical activity is a nonspecific test, failing to distinguish diseases. Other dimensions of GI electrical waves may help identify diseases more precisely. Studying complex systems is one of the approaches that can be taken for research on body systems. The dynamic variability of a complex system is estimated by nonlinear methods. Previous studies have identified how functional dynamic variability of organs differ in normal and disease conditions. Variation of electroencephalogram, heart rate, and respiratory rate are known examples of system dynamic fluctuation. If we consider the digestive tract as a complex system, the dynamic variation of the waves in the GI system could be analyzed by nonlinear methods to possibly help clinicians assess various conditions of the GI system in healthy subjects and patients.
    MeSH term(s) Digestive System Diseases/diagnosis ; Electrodes ; Electrophysiology/methods ; Gastrointestinal Diseases/diagnosis ; Gastrointestinal Motility ; Gastrointestinal Tract/physiopathology ; Heart Rate ; Humans ; Male ; Models, Theoretical ; Nonlinear Dynamics ; Respiratory Rate ; Young Adult
    Language English
    Publishing date 2019-05-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2019.05.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1132: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Feasibility of Therapeutic Effects of the Cholinergic Anti-Inflammatory Pathway on COVID-19 Symptoms

    Mazloom, Roham

    Journal of Neuroimmune Pharmacology

    2020  Volume 15, Issue 2, Page(s) 165–166

    Keywords Immunology ; Immunology and Allergy ; Pharmacology ; Neuroscience (miscellaneous) ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2227405-4
    ISSN 1557-1904 ; 1557-1890
    ISSN (online) 1557-1904
    ISSN 1557-1890
    DOI 10.1007/s11481-020-09919-6
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Role of Farnesoid Receptors and Nrf2-mediated Genes in Gentamicin-induced Nephrotoxicity in Rat: A Time-course Study.

    Ashrafi, Mohammad Reza / Khalili, Azadeh / Hashemi, Seyed Ali / Mazloom, Roham / Changizi-Ashtiyani, Saeed / Bayat, Gholamreza

    Iranian journal of kidney diseases

    2023  Volume 17, Issue 6, Page(s) 294–305

    Abstract: Introduction: Farnesoid-X-activated receptor (FXR) is considered as an upstream controller which could influence the other key regulatory genes encoding cellular antioxidant defense system.: Methods: Thirty-five male Wistar rats (240 ± 20 g) were ... ...

    Abstract Introduction: Farnesoid-X-activated receptor (FXR) is considered as an upstream controller which could influence the other key regulatory genes encoding cellular antioxidant defense system.
    Methods: Thirty-five male Wistar rats (240 ± 20 g) were randomly allocated into five groups: 1) control, 2) received gentamicin (100 mg/kg/d) for three days (GM-3d), 3) seven days (GM-7d), 4) 10 days (GM-10d), and 5) 14 consecutive days (GM-14d). Biochemical measurements of BUN and serum creatinine (SCr), histological assessment of renal samples as well as molecular analysis using real-time qRT-PCR were used to investigate the pattern of changes in different levels.
    Results: Administration of gentamicin was associated with a significant increase in the BUN and SCr until the 10th day, which then suddenly dropped at the day 14. Meantime, the maximum histological distortion was also seen on the 10th day but in a similar pattern, 14th day was associated with clear improvement. Compared to the control value, the maximum reduction in the mRNA expression of Farnesoid X-activated receptor (FXR), nuclear factor erythroid 2-related factor 2 (Nrf2) and Glutathione cysteine ligase-modulatory subunit (GCLM), occurred at the 3rd and 7th days, respectively. Compared to the control, the mRNA expression of the mentioned genes significantly increased up to day 14. Apart from the 3rd day, the mRNA expression of alpha-glutathione S-transferase (α-GST) and superoxide dismutase (SOD) showed a similar descending and ascending pattern at 7th and 10th days, respectively.
    Conclusion: The expression of FXR, as an upstream controller gene and its downstream pathways mediated by Nrf2, could play a role in gentamicin-induced nephrotoxicity but the pattern of expression was rather biphasic at the acute phase or the subacute ones.  DOI: 10.52547/ijkd.7523.
    MeSH term(s) Rats ; Male ; Animals ; Gentamicins/toxicity ; Gentamicins/metabolism ; Rats, Wistar ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Kidney/pathology ; Renal Insufficiency ; Drug-Related Side Effects and Adverse Reactions ; RNA, Messenger/metabolism ; Oxidative Stress
    Chemical Substances Gentamicins ; NF-E2-Related Factor 2 ; RNA, Messenger
    Language English
    Publishing date 2023-12-03
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2388271-2
    ISSN 1735-8604 ; 1735-8582
    ISSN (online) 1735-8604
    ISSN 1735-8582
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The time interval between injection of nicotine and tremor initiation: a new index for evaluating nicotine efficacy in rodents.

    Esmaeeli Dehaj, Helia / Maleki Dehnavi, Saeideh / Zahedi Nejad, Mohadese / Akbarzadeh Kolahi, Saeid / Abdolghaffari, Amir Hossein / Khalili, Azadeh / Mazloom, Roham

    Toxicology mechanisms and methods

    2023  Volume 34, Issue 4, Page(s) 408–412

    Abstract: Tremor is one of the effects of nicotine as a toxic substance, especially in animal models. The intensity and duration of tremors were used to evaluate the effect of nicotine on locomotor activity in laboratory animals. In our observations, the time ... ...

    Abstract Tremor is one of the effects of nicotine as a toxic substance, especially in animal models. The intensity and duration of tremors were used to evaluate the effect of nicotine on locomotor activity in laboratory animals. In our observations, the time interval between nicotine injection and the onset of tremor changed depending on the dose. Therefore, by increasing the dose of nicotine in rats, the time interval of tremor onset was also shortened. These results suggest that the time interval between nicotine injection and the onset of tremors can be used as a complementary index for better evaluation of nicotine-derived motor disturbances.
    MeSH term(s) Rats ; Animals ; Nicotine ; Tremor/chemically induced ; Rodentia
    Chemical Substances Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2023-12-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2081252-8
    ISSN 1537-6524 ; 1537-6516 ; 1051-7235
    ISSN (online) 1537-6524
    ISSN 1537-6516 ; 1051-7235
    DOI 10.1080/15376516.2023.2294822
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3215: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Silymarin Administration Attenuates Cirrhotic-induced Cardiac Abnormality in the Rats: A Possible Role of β

    Bayat, Gholamreza / Mazloom, Roham / Hashemi, Seyed Ali / Pourkhalili, Khalil / Fallah, Parviz / Shams, Alireza / Esmaeili, Parvaneh / Khalili, Azadeh

    Iranian journal of medical sciences

    2022  Volume 47, Issue 4, Page(s) 367–378

    Abstract: Background: Cirrhotic cardiomyopathy is a well-recognized cardiac dysfunction in cirrhotic patients. Studies have confirmed the protective effects of silymarin in different types of cardiac injury. This study aimed to examine the effectiveness and ... ...

    Abstract Background: Cirrhotic cardiomyopathy is a well-recognized cardiac dysfunction in cirrhotic patients. Studies have confirmed the protective effects of silymarin in different types of cardiac injury. This study aimed to examine the effectiveness and molecular mechanism of silymarin against myocardial dysfunction and hypertrophy in a rat model of cirrhosis.
    Methods: The experiment was performed at Alborz University of Medical Sciences (Karaj, Iran) during 2020-2021. Thirty-two male Wistar rats were randomly divided into four groups of Sham-operated (control group for surgical procedures), Bile Duct Ligated (BDL), and two Silymarin extract (SE)-treated groups of 300 and 600 mg/Kg/day. After 28 days, serum levels of AST, ALT, GGT, and ALP, liver histopathological status, as well as cardiac mechanical function, were assessed. Cardiac β
    Results: BDL was associated with a significant elevation in serum AST, ALT, GGT, and ALP, development of necrosis and fibrosis of the liver texture, increased Heart Weight and Heart Weight to Body Weight ratio, enhanced cardiac mechanical function as well as a significant up-regulation of ventricular β
    Conclusion: Silymarin treatment in higher dose attenuated cirrhosis-associated cardiac remodeling and reduced cardiac mechanical dysfunctions.
    MeSH term(s) Animals ; Calcium Channels, L-Type ; Cardiomyopathies/drug therapy ; Cardiomyopathies/metabolism ; Liver Cirrhosis/complications ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/metabolism ; Male ; Necrosis/drug therapy ; Rats ; Rats, Wistar ; Receptors, Adrenergic, beta-1/metabolism ; Silymarin/pharmacology ; Silymarin/therapeutic use
    Chemical Substances Calcium Channels, L-Type ; Receptors, Adrenergic, beta-1 ; Silymarin
    Language English
    Publishing date 2022-08-02
    Publishing country Iran
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603872-4
    ISSN 1735-3688 ; 0253-0716
    ISSN (online) 1735-3688
    ISSN 0253-0716
    DOI 10.30476/IJMS.2021.90750.2172
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    Zs.B 1634: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Body temperature fluctuation analysis in cirrhosis.

    Mani, Ali R / Mazloom, Roham / Haddadian, Zahra / Montagnese, Sara

    Liver international : official journal of the International Association for the Study of the Liver

    2017  Volume 38, Issue 2, Page(s) 378–379

    MeSH term(s) Animals ; Body Temperature Regulation ; Liver Cirrhosis, Experimental/physiopathology ; Multiple Organ Failure/physiopathology ; Rats ; Time Factors
    Language English
    Publishing date 2017-08-24
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.13539
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1632: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Saffron offers hepatoprotection via up-regulation of hepatic farnesoid-X-activated receptors in a rat model of acetaminophen-induced hepatotoxicity.

    Jamshidi, Vahid / Hashemi, Seyed Ali / Khalili, Azadeh / Fallah, Parviz / Ahmadian-Attari, Mohammad Mahdi / Beikzadeh, Leila / Mazloom, Roham / Najafizadeh, Parvaneh / Bayat, Gholamreza

    Avicenna journal of phytomedicine

    2021  Volume 11, Issue 6, Page(s) 622–632

    Abstract: Objectives: The most important toxicity of acetaminophen is hepatotoxicity. Farnesoid X-activated receptors (: Methods: Male Wister rats were randomly allocated into five groups including a control, vehicle, acetaminophen and two saffron extract ... ...

    Abstract Objectives: The most important toxicity of acetaminophen is hepatotoxicity. Farnesoid X-activated receptors (
    Methods: Male Wister rats were randomly allocated into five groups including a control, vehicle, acetaminophen and two saffron extract groups of 150 and 300 mg/kg/day. The liver function and hepatic
    Results: Levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) of the acetaminophen group were significantly higher than the control group whereas those of the extract-treated groups were significantly lower than those of the acetaminophen group. The real time RT-PCR findings showed a non-significant down-regulation of
    Conclusion: The main finding of the present study was that the hepatic
    Language English
    Publishing date 2021-11-04
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2658672-1
    ISSN 2228-7949 ; 2228-7930
    ISSN (online) 2228-7949
    ISSN 2228-7930
    DOI 10.22038/AJP.2021.18227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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