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Article ; Online: Breaking Bad News in Cancer Patients: Voicing the Training Requirement.

Taheri, Zahra / Javadinia, Seyed Alireza / Ghahramani-Asl, Ruhollah

2023 Volume 41, Issue 6, Page(s) 568–570

MeSH term(s)	Humans ; Neoplasms/therapy ; Communication
Language	English
Publishing date	2023-05-04
Publishing country	England
Document type	Letter
ZDB-ID	604942-4
ISSN	1532-4192 ; 0735-7907
ISSN (online)	1532-4192
ISSN	0735-7907
DOI	10.1080/07357907.2023.2209182
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Article ; Online: Radiographers' Occupational Health Assessments and their Radiation Exposure during COVID-19 era; A Call for an Action.

Ghahramani-Asl, Ruhollah / Ravanbakhsh, Ensieh / Javadinia, Seyed Alireza

Asian Pacific journal of cancer prevention : APJCP

2023 Volume 24, Issue 1, Page(s) 9–11

MeSH term(s)	Humans ; Occupational Health ; COVID-19/epidemiology ; COVID-19/prevention & control ; Radiology ; Clinical Competence ; Radiation Exposure ; Allied Health Personnel
Language	English
Publishing date	2023-01-01
Publishing country	Thailand
Document type	Journal Article
ZDB-ID	2218955-5
ISSN	2476-762X ; 1513-7368
ISSN (online)	2476-762X
ISSN	1513-7368
DOI	10.31557/APJCP.2023.24.1.9
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Article: A systematic review of the therapeutic effects of resveratrol in combination with 5-fluorouracil during colorectal cancer treatment: with a special focus on the oxidant, apoptotic, and anti-inflammatory activities.

Moutabian, Hossein / Majdaeen, Mehrsa / Ghahramani-Asl, Ruhollah / Yadollahi, Masoumeh / Gharepapagh, Esmaeil / Ataei, Gholamreza / Falahatpour, Zahra / Bagheri, Hamed / Farhood, Bagher

Cancer cell international

2022 Volume 22, Issue 1, Page(s) 142

Abstract: Purpose: 5-fluorouracil (5-FU), an effective chemotherapy drug, is commonly applied for colorectal cancer treatment. Nevertheless, its toxicity to normal tissues and the development of tumor resistance are the main obstacles to successful cancer ... ...

Abstract	Purpose: 5-fluorouracil (5-FU), an effective chemotherapy drug, is commonly applied for colorectal cancer treatment. Nevertheless, its toxicity to normal tissues and the development of tumor resistance are the main obstacles to successful cancer chemotherapy and hence, its clinical application is limited. The use of resveratrol can increase 5-FU-induced cytotoxicity and mitigate the unwanted adverse effects. This study aimed to review the potential therapeutic effects of resveratrol in combination with 5-FU against colorectal cancer. Methods: According to the PRISMA guideline, a comprehensive systematic search was carried out for the identification of relevant literature in four electronic databases of PubMed, Web of Science, Embase, and Scopus up to May 2021 using a pre-defined set of keywords in their titles and abstracts. We screened 282 studies in accordance with our inclusion and exclusion criteria. Thirteen articles were finally included in this systematic review. Results: The in vitro findings showed that proliferation inhibition of colorectal cancer cells in the groups treated by 5-FU was remarkably higher than the untreated groups and the co-administration of resveratrol remarkably increased cytotoxicity induced by 5-FU. The in vivo results demonstrated a decrease in tumor growth of mice treated by 5-FU than the untreated group and a dramatic decrease was observed following combined treatment of resveratrol and 5-FU. It was also found that 5-FU alone and combined with resveratrol could regulate the cell cycle profile of colorectal cancer cells. Moreover, this chemotherapeutic agent induced the biochemical and histopathological changes in the cancerous cells/tissues and these alterations were synergized by resveratrol co-administration (for most of the cases), except for the inflammatory mediators. Conclusion: The results obtained from this systematic review demonstrated that co-administration of resveratrol could sensitize the colorectal cancer cells to 5-FU treatment via various mechanisms, including regulation of cell cycle distribution, oxidant, apoptosis, anti-inflammatory effects.
Language	English
Publishing date	2022-04-02
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2091573-1
ISSN	1475-2867
ISSN	1475-2867
DOI	10.1186/s12935-022-02561-7
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Article ; Online: Biomedical applications of PLGA nanoparticles in nanomedicine: advances in drug delivery systems and cancer therapy.

Narmani, Asghar / Jahedi, Roghayyeh / Bakhshian-Dehkordi, Ehsan / Ganji, Saeid / Nemati, Mahnaz / Ghahramani-Asl, Ruhollah / Moloudi, Kave / Hosseini, Seyed Mohammad / Bagheri, Hamed / Kesharwani, Prashant / Khani, Ali / Farhood, Bagher / Sahebkar, Amirhossein

Expert opinion on drug delivery

2023 Volume 20, Issue 7, Page(s) 937–954

Abstract: Introduction: During the last decades, the ever-increasing proportion of patients with cancer has been led to serious concerns worldwide. Therefore, the development and use of novel pharmaceuticals, like nanoparticles (NPs)-based drug delivery systems ( ... ...

Abstract	Introduction: During the last decades, the ever-increasing proportion of patients with cancer has been led to serious concerns worldwide. Therefore, the development and use of novel pharmaceuticals, like nanoparticles (NPs)-based drug delivery systems (DDSs), can be potentially effective in cancer therapy. Area covered: Poly lactic-co-glycolic acid (PLGA) NPs, as a kind of bioavailable, biocompatible, and biodegradable polymers, have approved by the Food and Drug Administration (FDA) for some biomedical and pharmaceutical applications. PLGA is comprised of lactic acid (LA) and glycolic acid (GA) and their ratio could be controlled during various syntheses and preparation approaches. LA/GA ratio determines the stability and degradation time of PLGA; lower content of GA results in fast degradation. There are several approaches for preparing PLGA NPs that can affect their various aspects, such as size, solubility, stability, drug loading, pharmacokinetics, and pharmacodynamics, and so on. Expert opinion: These NPs have indicated the controlled and sustained drug release in the cancer site and can use in passive and active (via surface modification) DDSs. This review aims to provide an overview of PLGA NPs, their preparation approach and physicochemical aspects, drug release mechanism and the cellular fate, DDSs for efficient cancer therapy, and status in the pharmaceutical industry and nanomedicine.
MeSH term(s)	Humans ; Polylactic Acid-Polyglycolic Acid Copolymer ; Polyglycolic Acid/chemistry ; Polyglycolic Acid/pharmacology ; Nanomedicine ; Glycols ; Drug Delivery Systems/methods ; Lactic Acid/chemistry ; Lactic Acid/pharmacology ; Neoplasms/drug therapy ; Nanoparticles/chemistry ; Drug Carriers/chemistry ; Particle Size
Chemical Substances	glycolic acid (0WT12SX38S) ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; Polyglycolic Acid (26009-03-0) ; Glycols ; Lactic Acid (33X04XA5AT) ; Drug Carriers
Language	English
Publishing date	2023-06-23
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2167286-6
ISSN	1744-7593 ; 1742-5247
ISSN (online)	1744-7593
ISSN	1742-5247
DOI	10.1080/17425247.2023.2223941
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Article ; Online: The cardioprotective effects of nano-curcumin against doxorubicin-induced cardiotoxicity: A systematic review.

Moutabian, Hossein / Ghahramani-Asl, Ruhollah / Mortezazadeh, Tohid / Laripour, Reza / Narmani, Asghar / Zamani, Hamed / Ataei, Gholamreza / Bagheri, Hamed / Farhood, Bagher / Sathyapalan, Thozhukat / Sahebkar, Amirhossein

BioFactors (Oxford, England)

2022 Volume 48, Issue 3, Page(s) 597–610

Abstract: Although the chemotherapeutic drug, doxorubicin, is commonly used to treat various malignant tumors, its clinical use is restricted because of its toxicity especially cardiotoxicity. The use of curcumin may alleviate some of the doxorubicin-induced ... ...

Abstract	Although the chemotherapeutic drug, doxorubicin, is commonly used to treat various malignant tumors, its clinical use is restricted because of its toxicity especially cardiotoxicity. The use of curcumin may alleviate some of the doxorubicin-induced cardiotoxic effects. Especially, using the nano-formulation of curcumin can overcome the poor bioavailability of curcumin and enhance its physicochemical properties regarding its efficacy. In this study, we systematically reviewed the potential cardioprotective effects of nano-curcumin against the doxorubicin-induced cardiotoxicity. A systematic search was accomplished based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for the identification of all relevant articles on "the role of nano-curcumin on doxorubicin-induced cardiotoxicity" in the electronic databases of Scopus, PubMed, and Web of Science up to July 2021. One hundred and sixty-nine articles were screened following a predefined set of inclusion and exclusion criteria. Ten eligible scientific papers were finally included in the present systematic review. The administration of doxorubicin reduced the body and heart weights of mice/rats compared to the control groups. In contrast, the combined treatment of doxorubicin and nano-curcumin increased the body and heart weights of animals compared with the doxorubicin-treated groups alone. Furthermore, doxorubicin could significantly induce the biochemical and histological changes in the cardiac tissue; however, coadministration of nano-curcumin formulation demonstrated a pattern opposite to the doxorubicin-induced changes. The coadministration of nano-curcumin alleviates the doxorubicin-induced cardiotoxicity through various mechanisms including antioxidant, anti-inflammatory, and antiapoptotic effects. Also, the cardioprotective effect of nano-curcumin formulation against doxorubicin-induced cardiotoxicity was higher than free curcumin.
MeSH term(s)	Animals ; Antioxidants/pharmacology ; Apoptosis ; Cardiotoxicity/drug therapy ; Cardiotoxicity/etiology ; Cardiotoxicity/prevention & control ; Curcumin/pharmacology ; Curcumin/therapeutic use ; Doxorubicin/toxicity ; Mice ; Rats
Chemical Substances	Antioxidants ; Doxorubicin (80168379AG) ; Curcumin (IT942ZTH98)
Language	English
Publishing date	2022-01-26
Publishing country	Netherlands
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	59230-4
ISSN	1872-8081 ; 0951-6433
ISSN (online)	1872-8081
ISSN	0951-6433
DOI	10.1002/biof.1823
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Article ; Online: Evaluation of Bremsstrahlung radiation dose in stereotactically radiocolloid therapy of cystic craniopharyngioma tumors with

Babaei, Maryam / Ghahramani-Asl, Ruhollah / Sadoughi, Hamid-Reza / Sardari, Dariush / Shahzadi, Sohrab

Australasian physical & engineering sciences in medicine

2018 Volume 41, Issue 3, Page(s) 697–711

Abstract: Over 90% of craniopharyngeal brain tumors are cystic, which enables the injection of beta emitters such as phosphorus-32 ( ...

Abstract	Over 90% of craniopharyngeal brain tumors are cystic, which enables the injection of beta emitters such as phosphorus-32 (
MeSH term(s)	Colloids ; Computer Simulation ; Craniopharyngioma/radiotherapy ; Cysts/radiotherapy ; Dose-Response Relationship, Radiation ; Gamma Cameras ; Humans ; Monte Carlo Method ; Phantoms, Imaging ; Phosphorus Radioisotopes/chemistry ; Radiation ; Radiometry ; Stereotaxic Techniques
Chemical Substances	Colloids ; Phosphorus Radioisotopes ; Phosphorus-32 (690284A407)
Language	English
Publishing date	2018-07-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	46226-3
ISSN	1879-5447 ; 0158-9938
ISSN (online)	1879-5447
ISSN	0158-9938
DOI	10.1007/s13246-018-0665-4
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Article: Feasibility of Treatment Planning System in Localizing the COVID-19 Pneumonia Lesions and Evaluation of Volume Indices of Lung Involvement.

Ghahramani-Asl, Ruhollah / Porouhan, Pejman / Mehrpouyan, Mohammad / Welsh, James S / Calabrese, Edward J / Kapoor, Rachna / Dhawan, Gaurav / Javadinia, Seyed Alireza

Dose-response : a publication of International Hormesis Society

2020 Volume 18, Issue 3, Page(s) 1559325820962600

Abstract: Background and purpose: To assess the feasibility of a treatment planning system in localizing, contouring, and targeting lung lesions along with an evaluation of volume indices of lung involvement in patients with COVID-19 pneumonia.: Methods: We ... ...

Abstract	Background and purpose: To assess the feasibility of a treatment planning system in localizing, contouring, and targeting lung lesions along with an evaluation of volume indices of lung involvement in patients with COVID-19 pneumonia. Methods: We evaluated 10 patients with PCR-confirmed COVID-19 pneumonia. The CT images were imported into the ISOgray® treatment planning system to anatomically define and contour the volumes of the pulmonary lesions, the lungs, and other nearby organs. Results: The ratio of lung lesion volume to lung volume in this study was 0.11 ± 0.13 (11.13%). The highest mean biosynthesis ratio of lung lesions was 0.36. The ratio of lesion volume in the left lung of patients with the highest volume of involvement, was 0.44, and the ratio of lesion volume in the right lung of these patients was 0.27 (approximately 1.5 times more in the left lung than the right lung). On average, CTDIvol and DLP for all patients studied in our study were 11.22 ± 2.47 mGy and 354.20 ± 65.11 mGy.cm. Conclusion: We reported the feasibility of using a treatment planning system in localizing COVID-19 pulmonary lesions and its validity in the volumetric assessment of infected lung regions.
Keywords	covid19
Language	English
Publishing date	2020-09-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2440820-7
ISSN	1559-3258
ISSN	1559-3258
DOI	10.1177/1559325820962600
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Article ; Online: Feasibility of Treatment Planning System in Localizing the COVID-19 Pneumonia Lesions and Evaluation of Volume Indices of Lung Involvement

Ruhollah Ghahramani-Asl / Pejman Porouhan / Mohammad Mehrpouyan / James S. Welsh / Edward J. Calabrese / Rachna Kapoor / Gaurav Dhawan / Seyed Alireza Javadinia

Dose-Response, Vol

2020 Volume 18

Abstract	Background and purpose: To assess the feasibility of a treatment planning system in localizing, contouring, and targeting lung lesions along with an evaluation of volume indices of lung involvement in patients with COVID-19 pneumonia. Methods: We evaluated 10 patients with PCR-confirmed COVID-19 pneumonia. The CT images were imported into the ISOgray® treatment planning system to anatomically define and contour the volumes of the pulmonary lesions, the lungs, and other nearby organs. Results: The ratio of lung lesion volume to lung volume in this study was 0.11 ± 0.13 (11.13%). The highest mean biosynthesis ratio of lung lesions was 0.36. The ratio of lesion volume in the left lung of patients with the highest volume of involvement, was 0.44, and the ratio of lesion volume in the right lung of these patients was 0.27 (approximately 1.5 times more in the left lung than the right lung). On average, CTDIvol and DLP for all patients studied in our study were 11.22 ± 2.47 mGy and 354.20 ± 65.11 mGy.cm Conclusion: We reported the feasibility of using a treatment planning system in localizing COVID-19 pulmonary lesions and its validity in the volumetric assessment of infected lung regions.
Keywords	Therapeutics. Pharmacology ; RM1-950 ; covid19
Subject code	610 ; 616
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
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Article ; Online: Low-dose radiation therapy for osteoarthritis and enthesopathies: a review of current data.

Javadinia, Seyed Alireza / Nazeminezhad, Nooshin / Ghahramani-Asl, Ruhollah / Soroosh, Davood / Fazilat-Panah, Danial / PeyroShabany, Babak / Saberhosseini, Seyedeh Naeimeh / Mehrabian, Arezoo / Taghizadeh-Hesary, Farzad / Nematshahi, Mohammad / Dhawan, Gaurav / Welsh, James S / Calabrese, Edward J / Kapoor, Rachna

International journal of radiation biology

2021 Volume 97, Issue 10, Page(s) 1352–1367

Abstract: Background: Osteoarthritis (OA), the most common degenerative joint disease, is associated with severe functional limitation and impairment of quality of life. Numerous reports have documented the clinical efficacy of low-dose radiotherapy (LD-RT) in ... ...

Abstract	Background: Osteoarthritis (OA), the most common degenerative joint disease, is associated with severe functional limitation and impairment of quality of life. Numerous reports have documented the clinical efficacy of low-dose radiotherapy (LD-RT) in the management of various inflammatory disorders, including OA. In this paper, we assessed the clinical literature involving the use of LD-RT in the treatment of OA, its dose-response features, possible underlying mechanistic features, and optimal therapeutic dose range. Methods: We carried out a systematic review based on the guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statements and evaluated articles meeting the inclusion criteria for this review. Results: A total of 361 articles were identified from databases, such as Scopus, PubMed, Embase, and Science Direct out of which 224 articles were duplicates and were discarded. Of the remaining 137 articles, 74 articles were un-related, 27 articles were review articles, eight were conference abstracts, three were letters, two were editorials, two were notes, and one was a book chapter. Finally, 20 articles met all the inclusion criteria and were included in this systematic review. Discussion: Several single-arm retrospective/prospective studies showed advantages for LD-RT in the management of OA in terms of pain relief, improvement of mobility and function, and showed minimal side effects. Mechanistic considerations involve positive subcellular effects mediated by the activation of a nuclear factor erythroid 2-related transcription factor (Nrf2) mediated antioxidant response. Further research on both the short- and long-term effects of LD-RT on OA and other inflammatory disorders is recommended.
MeSH term(s)	Enthesopathy ; Humans ; Osteoarthritis/radiotherapy ; Prospective Studies ; Quality of Life ; Retrospective Studies
Language	English
Publishing date	2021-07-29
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	3065-x
ISSN	1362-3095 ; 0020-7616 ; 0955-3002
ISSN (online)	1362-3095
ISSN	0020-7616 ; 0955-3002
DOI	10.1080/09553002.2021.1956000
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Article ; Online: Feasibility of Treatment Planning System in Localizing the COVID-19 Pneumonia Lesions and Evaluation of Volume Indices of Lung Involvement

Ghahramani-Asl, Ruhollah / Porouhan, Pejman / Mehrpouyan, Mohammad / Welsh, James S. / Calabrese, Edward J. / Kapoor, Rachna / Dhawan, Gaurav / Javadinia, Seyed Alireza

Dose-Response

2020 Volume 18, Issue 3, Page(s) 155932582096260

Abstract	Background and purpose: To assess the feasibility of a treatment planning system in localizing, contouring, and targeting lung lesions along with an evaluation of volume indices of lung involvement in patients with COVID-19 pneumonia. Methods: We evaluated 10 patients with PCR-confirmed COVID-19 pneumonia. The CT images were imported into the ISOgray® treatment planning system to anatomically define and contour the volumes of the pulmonary lesions, the lungs, and other nearby organs. Results: The ratio of lung lesion volume to lung volume in this study was 0.11 ± 0.13 (11.13%). The highest mean biosynthesis ratio of lung lesions was 0.36. The ratio of lesion volume in the left lung of patients with the highest volume of involvement, was 0.44, and the ratio of lesion volume in the right lung of these patients was 0.27 (approximately 1.5 times more in the left lung than the right lung). On average, CTDIvol and DLP for all patients studied in our study were 11.22 ± 2.47 mGy and 354.20 ± 65.11 mGy.cm Conclusion: We reported the feasibility of using a treatment planning system in localizing COVID-19 pulmonary lesions and its validity in the volumetric assessment of infected lung regions.
Keywords	Toxicology ; Public Health, Environmental and Occupational Health ; Health, Toxicology and Mutagenesis ; Chemical Health and Safety ; covid19
Language	English
Publisher	SAGE Publications
Publishing country	us
Document type	Article ; Online
ZDB-ID	2440820-7
ISSN	1559-3258 ; 1559-3258
ISSN (online)	1559-3258
ISSN	1559-3258
DOI	10.1177/1559325820962600
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