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  1. Book: Wo zuo Jiang Jieshi "yu yi" 40 nian

    Xiong, Wan

    Xiong Wan xian sheng fang tan lu

    (Qin li li shi)

    2006  

    Title variant Reminiscences of Doctor Xiong Wan
    Author's details Chen Sanjing fang wen ; Li Yuqing ji lu
    Series title Qin li li shi
    MeSH term(s) Physicians ; History, 20th Century
    Keywords China ; Taiwan
    Language Chinese
    Size 3, 6, 214 p., [36] p. of plates :, ill. (some col.), ports. ;, 23 cm.
    Edition Di 1 ban.
    Publisher Tuan jie chu ban she
    Publishing place Beijing Shi
    Document type Book
    ISBN 9787802141094 ; 7802141095
    Database Catalogue of the US National Library of Medicine (NLM)

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  2. Article ; Online: Psychophysical determination of boundaries and smoothness of color gradients.

    Xiong, Nian / Shamey, Renzo

    Journal of the Optical Society of America. A, Optics, image science, and vision

    2024  Volume 41, Issue 3, Page(s) 572–580

    Abstract: Color gradients constitute an important component in the evaluation of the color quality of multicolored patterns that contain color transitions. A two-part psychophysical study was designed and employed to test the appearance of a set of hue-, chroma-, ... ...

    Abstract Color gradients constitute an important component in the evaluation of the color quality of multicolored patterns that contain color transitions. A two-part psychophysical study was designed and employed to test the appearance of a set of hue-, chroma-, or lightness-based color gradients. The influence of several parameters on the visual determination of gradients' boundaries and perceived smoothness was tested. These parameters included gradient type, e.g., transitions based on hue, chroma, lightness or their combination, orientation, slope, and quantization step size of color transitions. The influence of these parameters on intra- and interobserver variability in responses was calculated using the standardized residual sum of squares metric. In the first part of the experiment, the perceived boundaries of color gradient stimuli as well as observer confidence ratings in performing these visual tasks were determined. In the second part, the perceived smoothness ratings of the stimuli and visual confidence ratings in assessments were examined. Four binary color transition images, i.e., brown-green, brown-tan, green-olive, and light sage-olive, were generated. Three different linear-gradient slopes were applied to each transition, and each stimulus was shown to observers, separately, in four orientations: horizontal, vertical, right diagonal, and left diagonal. Results indicate that the gradient slopes influence perceived boundaries and smoothness ratings. When determining smoothness ratings, observers were found to be more tolerant to changes in chroma and lightness than in hue.
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 283633-6
    ISSN 1520-8532 ; 1084-7529 ; 0740-3232
    ISSN (online) 1520-8532
    ISSN 1084-7529 ; 0740-3232
    DOI 10.1364/JOSAA.509530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2689: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: High-capacity and multi-dimensional orbital angular momentum multiplexing holography.

    Zhang, Nian / Xiong, Baoxing / Zhang, Xiang / Yuan, Xiao

    Optics express

    2023  Volume 31, Issue 20, Page(s) 31884–31897

    Abstract: Optical holography has been investigated for enhancing information capacity and encryption. Here, the multi-vortex geometric orbital angular momentum (MVG-OAM) multiplexing holography is proposed and experimentally implemented, which encodes information ... ...

    Abstract Optical holography has been investigated for enhancing information capacity and encryption. Here, the multi-vortex geometric orbital angular momentum (MVG-OAM) multiplexing holography is proposed and experimentally implemented, which encodes information into MVG beams with different central OAM, sub-beam OAM, and coherent-state phase. The orthogonality of the above three parameters are analyzed, respectively, which point out the feasibility of using them for holographic multiplexing. A three-dimensional multiplexing holography is realized by combining these three parameters, which offers potential applications for information storage, optical encryption, and display.
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.499899
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Pachymic acid activates TP53INP2/TRAF6/caspase-8 pathway to promote apoptosis in renal cell carcinoma cells.

    Li, Xunjia / He, An / Liu, Chengxuan / Li, Ying / Luo, Yan / Xiong, Weijian / Nian, Weiqi / Zuo, Deyu

    Environmental toxicology

    2024  

    Abstract: While pachymic acid (PA), a key component of Poria cocos (Schw.), has demonstrated anti-tumor effects in lung, breast, and pancreatic cancers, its impact on renal cell carcinoma (RCC) is unclear. This study evaluated the effect of PA on proliferation, ... ...

    Abstract While pachymic acid (PA), a key component of Poria cocos (Schw.), has demonstrated anti-tumor effects in lung, breast, and pancreatic cancers, its impact on renal cell carcinoma (RCC) is unclear. This study evaluated the effect of PA on proliferation, migration, and apoptosis in human renal cancer A498 and ACHN cells as well as in cancer xenograft mice using wound scratch test, Western blotting, and co-immunoprecipitation assays. In a dose- and time-dependent manner, PA exhibited significant inhibition of RCC cell proliferation, migration, and invasion, accompanied by the induction of apoptosis. Additionally, PA upregulated the expression of tumor protein p53-inducible nuclear protein 2 (TP53INP2) and tumor necrosis factor receptor-associated factor 6 (TRAF6), which were downregulated in renal papillary and chromophobe carcinoma, resulting in inhibited tumor growth in mice. PA treatment elevated cleaved-caspase 3 and 8, and PARP levels, and facilitated TP53INP2 and TRAF6 binding to caspase 8, promoting its ubiquitination. Molecular docking revealed interactions between PA and TP53INP2, TRAF6. In summary, PA inhibits RCC development by upregulating TP53INP2 and promoting TRAF6-induced caspase 8 ubiquitination, activating apoptotic pathways.
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1463449-1
    ISSN 1522-7278 ; 1520-4081
    ISSN (online) 1522-7278
    ISSN 1520-4081
    DOI 10.1002/tox.24195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2676: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Identification of a lipid homeostasis-related gene signature for predicting prognosis, immunity, and chemotherapeutic effect in patients with gastric cancer.

    Li, Chao / Xiong, Zhen / Han, Jinxin / Nian, Weiqi / Wang, Zheng / Cai, Kailin / Gao, Jinbo / Wang, Guobin / Tao, Kaixiong / Cai, Ming

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 2895

    Abstract: Gastric cancer (GC) is one of the most common and deadliest cancers worldwide. Lipid homeostasis is essential for tumour development because lipid metabolism is one of the most important metabolic reprogramming pathways within tumours. Elucidating the ... ...

    Abstract Gastric cancer (GC) is one of the most common and deadliest cancers worldwide. Lipid homeostasis is essential for tumour development because lipid metabolism is one of the most important metabolic reprogramming pathways within tumours. Elucidating the mechanism of lipid homeostasis in GC might significantly improve treatment strategies and patient prognosis. GSE62254 was applied to construct a lipid homeostasis-related gene signature score (HGSscore) by multiple bioinformatic algorithms including weighted gene coexpression network analysis (WGCNA) and LASSO-Cox regression. A nomogram based on HGSscore and relevant clinical characteristics was constructed to predict the survival of patients with GC. TIMER and xCell were used to evaluate immune and stromal cell infiltration in the tumour microenvironment. Correlations between lipid homeostasis-related genes and chemotherapeutic efficacy were analysed in GSCAlite. RT‒qPCR and cell viability assays were applied to verify the findings in this study. HGSscore was constructed based on eighteen lipid homeostasis-related genes that were selected by WGCNA and LASSO-Cox regression. HGSscore was strongly associated with advanced TNM stage and showed satisfactory value in predicting GC prognosis in three independent cohorts. Furthermore, we found that HGSscore was associated with the tumour mutation burden (TMB) and immune/stromal cell infiltration, which are related to GC prognosis, indicating that lipid homeostasis impacts the formation of the tumour microenvironment (TME). With respect to the GSCAlite platform, PLOD2 and TGFB2 were shown to be positively related to chemotherapeutic resistance, while SLC10A7 was a favourable factor for chemotherapy efficacy. Cell viability assays showed that disrupted lipid homeostasis could attenuate GC cell viability. Moreover, RT‒qPCR revealed that lipid homeostasis could influence expression of specific genes. We identified a lipid homeostasis-related gene signature that correlated with survival, clinical characteristics, the TME, and chemotherapeutic efficacy in GC patients. This research provides a new perspective for improving prognosis and guiding individualized chemotherapy for patients with GC.
    MeSH term(s) Humans ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/genetics ; Prognosis ; Nomograms ; Homeostasis/genetics ; Lipids ; Tumor Microenvironment/genetics
    Chemical Substances Lipids
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-52647-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Feasibility of controlling COVID-19.

    Xiong, Nian / Lin, Zhicheng

    The Lancet. Global health

    2020  Volume 8, Issue 6, Page(s) e774

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Feasibility Studies ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-30
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2723488-5
    ISSN 2214-109X ; 2214-109X
    ISSN (online) 2214-109X
    ISSN 2214-109X
    DOI 10.1016/S2214-109X(20)30129-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Feasibility of controlling COVID-19

    Nian Xiong / Zhicheng Lin

    The Lancet Global Health, Vol 8, Iss 6, Pp e774- (2020)

    2020  

    Keywords Public aspects of medicine ; RA1-1270 ; covid19
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Article ; Online: Chromosome-level genome assembly of navel orange cv. Gannanzao (Citrus sinensis Osbeck cv. Gannanzao).

    Xiong, Zhiwei / Yin, Hui / Wang, Nian / Han, Guanzhu / Gao, Yuxia

    G3 (Bethesda, Md.)

    2023  Volume 14, Issue 2

    Abstract: Navel orange cv. Gannanzao is a variant of the navel orange cv. Newhall (Citrus sinensis Osbeck cv. Newhall) that exhibits an earlier maturation, making it commercially valuable. However, the mechanisms underlying its early maturation remain obscure. To ... ...

    Abstract Navel orange cv. Gannanzao is a variant of the navel orange cv. Newhall (Citrus sinensis Osbeck cv. Newhall) that exhibits an earlier maturation, making it commercially valuable. However, the mechanisms underlying its early maturation remain obscure. To address this question, we conducted genome sequencing and de novo assembly of navel orange cv. Gannanzao. The assembled genome sequence is 334.57 Mb in length with a GC content of 31.48%. It comprises 318 contigs (N50 = 3.23 Mb) and 187 scaffolds (N50 = 31.86 Mb). The Benchmarking Universal Single-Copy Orthologs test demonstrates 94.6% completeness. The annotation revealed 23,037 gene models, 164.95 Mb of repetitive sequences, and 2,554 noncoding RNAs. A comparative analysis identified 323 fruit ripening-related genes in navel orange cv. Gannanzao genome, while navel orange cv. Newhall genome contained 345 such genes. These genes were organized into 320 orthologous gene families, with 30.3% of them exhibiting differences in gene copy numbers between the 2 genomes. Additionally, we identified 15 fruit ripening-related genes that have undergone adaptive evolution, suggesting their potential role in advancing fruit maturation in navel orange cv. Gannanzao. Whole-genome sequencing and annotation of navel orange cv. Gannanzao provides a valuable resource to unravel the early maturation mechanism of citrus and enriches the genomic resources for citrus research.
    MeSH term(s) Citrus sinensis/genetics ; Fruit ; Chromosomes
    Language English
    Publishing date 2023-11-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2629978-1
    ISSN 2160-1836 ; 2160-1836
    ISSN (online) 2160-1836
    ISSN 2160-1836
    DOI 10.1093/g3journal/jkad268
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Effect of Ferulic Acid on Semen Quality of Goat Bucks during Liquid Storage at 17 °C.

    Zhang, Feng / Han, Shichang / Zhang, Nian / Chai, Jin / Xiong, Qi

    Animals : an open access journal from MDPI

    2023  Volume 13, Issue 15

    Abstract: This study investigated the effect of different concentrations of ferulic acid (FA) on the quality of goat semen preserved at 17 °C. First, semen was collected from three black-headed goat bucks using an artificial vagina. Then, the mixed semen was ... ...

    Abstract This study investigated the effect of different concentrations of ferulic acid (FA) on the quality of goat semen preserved at 17 °C. First, semen was collected from three black-headed goat bucks using an artificial vagina. Then, the mixed semen was diluted with basal dilutions containing different concentrations of FA (0, 25, 50, 100, and 200 μmol/L) and stored at 17 °C. Sperm total motility, plasma membrane integrity, acrosome integrity, reactive oxygen species (ROS) levels, malondialdehyde (MDA) content, and total antioxidant capacity (T-AOC) were measured during semen storage. The results showed that sperm total motility, plasma membrane integrity, and acrosome integrity were significantly improved in the 50 μmol/L FA group compared with the control group (0 μmol/L) on days 1-5, and the level of T-AOC significantly increased, while the contents of ROS and MDA significantly reduced. Meanwhile, the goats' conception rate showed that supplementing semen with 50 μmol/L FA preserved at 17 °C for 3 days had no significant effect on fertility. Taken together, our findings suggest that adding 50 μmol/L FA in dilution at 17 °C can improve goat bucks' semen quality.
    Language English
    Publishing date 2023-07-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13152469
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Overexpression of

    Xian, Peiqi / Yang, Yuan / Xiong, Chuwen / Guo, Zhibin / Alam, Intikhab / He, Zihang / Zhang, Yakun / Cai, Zhandong / Nian, Hai

    Frontiers in plant science

    2023  Volume 14, Page(s) 1133892

    Abstract: Introduction: Cadmium (Cd) stress is a significant threat to soybean production, and enhancing Cd tolerance in soybean is the focus of this study. The WRKY transcription factor family is associated with abiotic stress response processes. In this study, ... ...

    Abstract Introduction: Cadmium (Cd) stress is a significant threat to soybean production, and enhancing Cd tolerance in soybean is the focus of this study. The WRKY transcription factor family is associated with abiotic stress response processes. In this study, we aimed to identify a Cd-responsive WRKY transcription factor
    Methods: The characterization of
    Results: GmWRKY172
    Discussion: Our findings demonstrated that GmWRKY172 enhances Cd tolerance and reduces seed Cd accumulation in soybean by regulating multiple stress-related pathways, and could be a promising candidate for breeding Cd-tolerant and low Cd soybean varieties.
    Language English
    Publishing date 2023-03-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1133892
    Database MEDical Literature Analysis and Retrieval System OnLINE

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