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  1. Article: Exploring Anti-Breast Cancer Effects of Live

    Adumuah, Naa N / Quarshie, Jude T / Danwonno, Harry / Aikins, Anastasia R / Ametefe, Elmer N

    International journal of breast cancer

    2024  Volume 2024, Page(s) 1841909

    Abstract: Current breast cancer treatment options are limited by drug resistance and adverse side effects, which calls for the need for alternatives or complementary remedies. Probiotic bacteria isolated from human breast milk have been shown to possess ... ...

    Abstract Current breast cancer treatment options are limited by drug resistance and adverse side effects, which calls for the need for alternatives or complementary remedies. Probiotic bacteria isolated from human breast milk have been shown to possess proapoptotic and anti-inflammatory properties against breast mastitis in breastfeeding mothers and are being studied as possible anticancer regimens. Thus, this study aimed at exploring the effect of lactic acid bacteria isolated from human breast milk on MDA-MB 231 breast cancer cells. A total of twenty-two bacteria were isolated from four human breast milk samples. The isolates were characterized and identified using biochemical tests and Sanger sequencing, respectively. For in vitro experiments, we used isolated
    Language English
    Publishing date 2024-01-27
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2603566-2
    ISSN 2090-3189 ; 2090-3170
    ISSN (online) 2090-3189
    ISSN 2090-3170
    DOI 10.1155/2024/1841909
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The Current State of Parkinsonism in West Africa: A Systematic Review.

    Quarshie, Jude T / Mensah, Esther N / Quaye, Osbourne / Aikins, Anastasia R

    Parkinson's disease

    2021  Volume 2021, Page(s) 7479423

    Abstract: Parkinsonism is one of the most common neurodegenerative diseases among the elderly. Africa is experiencing an increasing burden of age-related conditions including parkinsonism. However, there is not enough data on the prevalence, symptoms, and ... ...

    Abstract Parkinsonism is one of the most common neurodegenerative diseases among the elderly. Africa is experiencing an increasing burden of age-related conditions including parkinsonism. However, there is not enough data on the prevalence, symptoms, and management of the disorder in West African patients. This systematic review examines the current state of parkinsonism in West Africa by discussing its epidemiology, symptomatology, and treatment. We searched PubMed, BioMed Central, and AJOL databases from January 2000 to December 2020 for studies on parkinsonism conducted in West African countries. We included 32 studies in this review: 23 from Nigeria, 5 from Ghana, and 1 each from Benin, Mali, Niger, and Senegal. Out of the 32 reviewed studies, 11 focused on the prevalence of parkinsonism, 4 examined the genetics of Parkinson's disease (PD), and 17 described the symptomatology and therapy of parkinsonism. The prevalence of parkinsonism in West Africa ranges from 6.0% to 8.3% of neurologic admissions/consultations. The estimated crude prevalence of PD in West Africa varies from 15 to 572 per 100,000 people. Thus far, no pathogenic genetic variants have been associated with PD in the region. Levodopa is frequently used singly or in combination with other medications to manage parkinsonian symptoms, which is consistent with reports from other African regions. Most of the reviewed studies focused only on PD, limiting assessment of other forms of parkinsonism. Almost all the prevalence studies were hospital-based and monocentric, making it impossible to accurately estimate the true prevalence of parkinsonism in West Africa. Larger community-based prevalence studies are recommended to enable accurate quantification of disease burden. Future genetic investigations should consider a wider array of gene mutations associated with parkinsonism. Moreover, public health surveillance strategies should be established to monitor the epidemiology of the disorder.
    Language English
    Publishing date 2021-09-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2573854-9
    ISSN 2042-0080 ; 2090-8083
    ISSN (online) 2042-0080
    ISSN 2090-8083
    DOI 10.1155/2021/7479423
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: High atherogenic index of plasma and cardiovascular risk factors among Ghanaian breast cancer patients.

    Tagoe, Emmanuel A / Dwamena-Akoto, Eric / Nsaful, Josephine / Aikins, Anastasia R / Clegg-Lamptey, Joe-Nat / Quaye, Osbourne

    Experimental biology and medicine (Maywood, N.J.)

    2020  Volume 245, Issue 18, Page(s) 1648–1655

    Abstract: Comorbidities impact negatively on breast cancer prognosis, especially in developing countries where cases are usually presented to clinics at advanced stages. This study aimed to determine the atherogenic index of plasma (AIP) and cardiovascular risk ... ...

    Abstract Comorbidities impact negatively on breast cancer prognosis, especially in developing countries where cases are usually presented to clinics at advanced stages. This study aimed to determine the atherogenic index of plasma (AIP) and cardiovascular risk factors among Ghanaian women diagnosed with breast cancer. A total of 52 breast cancer patients were age-matched with 52 healthy controls. Sociodemographics of participants were obtained using a well-structured questionnaire. Pathological data of patients were obtained from medical records, and all clinical and anthropometric measurements were done using standard instruments. Lipid profile was determined from serum using enzymatic assays, and cardiovascular risk factors were calculated from estimated lipid parameters. Blood pressure, AIP, total cholesterol (T. chol), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-c) were significantly elevated (
    MeSH term(s) Atherosclerosis/blood ; Atherosclerosis/complications ; Breast Neoplasms/blood ; Breast Neoplasms/complications ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/epidemiology ; Female ; Ghana/epidemiology ; Humans ; Lipids/blood ; Middle Aged ; Neoplasm Staging ; Regression Analysis ; Risk Factors
    Chemical Substances Lipids
    Language English
    Publishing date 2020-07-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 4015-0
    ISSN 1535-3699 ; 1525-1373 ; 0037-9727
    ISSN (online) 1535-3699 ; 1525-1373
    ISSN 0037-9727
    DOI 10.1177/1535370220940992
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.111: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Downregulation of transgelin blocks interleukin-8 utilization and suppresses vasculogenic mimicry in breast cancer cells.

    Aikins, Anastasia R / Kim, MiJung / Raymundo, Bernardo / Kim, Chan-Wha

    Experimental biology and medicine (Maywood, N.J.)

    2017  Volume 242, Issue 6, Page(s) 573–583

    Abstract: Vasculogenic mimicry (VM) is a non-classical mechanism recently described in many tumors, whereby cancer cells, rather than endothelial cells, form blood vessels. Transgelin is an actin-binding protein that has been implicated in multiple stages of ... ...

    Abstract Vasculogenic mimicry (VM) is a non-classical mechanism recently described in many tumors, whereby cancer cells, rather than endothelial cells, form blood vessels. Transgelin is an actin-binding protein that has been implicated in multiple stages of cancer development. In this study, we investigated the role of transgelin in VM and assessed its effect on the expression of endothelial and angiogenesis-related genes during VM in MDA-MB-231 breast cancer cells. We confirmed the ability of MDA-MB-231 cells to undergo VM through a tube formation assay. Flow cytometry analysis revealed an increase in the expression of the endothelial-related markers VE-cadherin and CD34 in cells that underwent VM, compared with those growing in a monolayer, which was confirmed by immunocytochemistry. We employed siRNA to silence transgelin, and knockdown efficiency was determined by western blot analyses. Downregulation of transgelin suppressed cell proliferation and tube formation, but increased IL-8 levels in Matrigel cultures. RT-PCR analyses revealed that the expression of IL-8, VE-cadherin, and CD34 was unaffected by transgelin knockdown, indicating that increased IL-8 expression was not due to enhanced transcriptional activity. More importantly, the inhibition of IL-8/CXCR2 signaling also resulted in suppression of VM with increased IL-8 levels, confirming that increased IL-8 levels after transgelin knockdown was due to inhibition of IL-8 uptake. Our findings indicate that transgelin regulates VM by enhancing IL uptake. These observations are relevant to the future development of efficient antivascular agents. Impact statement Vasculogenic mimicry (VM) is an angiogenic-independent mechanism of blood vessel formation whereby aggressive tumor cells undergo formation of capillary-like structures. Thus, interventions aimed at angiogenesis might not target the entire tumor vasculature. A more holistic approach is therefore needed in the development of improved antivascular agents. Transgelin, an actin-binding protein, has been associated with multiple stages of cancer development such as proliferation, migration and invasion, but little is known about its role in vasculogenic mimicry. We present here, an additional mechanism by which transgelin promotes malignancy by way of its association with the occurrence of VM. Although transgelin knockdown did not affect the transcript levels of most of the angiogenesis-related genes in this study, it was associated with the inhibition of the uptake of IL-8, accompanied by suppressed VM, indicating that transgelin is required for VM. These observations are relevant to the future development of efficient antivascular agents.
    MeSH term(s) Antigens, CD/physiology ; Blotting, Western ; Breast Neoplasms/physiopathology ; Cadherins/physiology ; Cell Line, Tumor ; Down-Regulation ; Female ; Flow Cytometry ; Humans ; Interleukin-8/physiology ; MCF-7 Cells/physiology ; Microfilament Proteins/physiology ; Muscle Proteins/physiology ; Neovascularization, Pathologic/physiopathology ; Neovascularization, Pathologic/prevention & control ; Polymerase Chain Reaction
    Chemical Substances Antigens, CD ; Cadherins ; Interleukin-8 ; Microfilament Proteins ; Muscle Proteins ; cadherin 5 ; transgelin
    Language English
    Publishing date 2017-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 4015-0
    ISSN 1535-3699 ; 1525-1373 ; 0037-9727
    ISSN (online) 1535-3699 ; 1525-1373
    ISSN 0037-9727
    DOI 10.1177/1535370216685435
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.111: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Antiproliferative Activities of Methanolic Extract and Fractions of

    Aikins, Anastasia Rosebud / Birikorang, Peggy Afua / Chama, Mary / Dotse, Eunice / Anning, Abigail / Appiah-Opong, Regina

    Evidence-based complementary and alternative medicine : eCAM

    2021  Volume 2021, Page(s) 4051555

    Abstract: Most of the current cancer chemotherapeutics are associated with harsh and undesirable side effects, including toxicity and chemoresistance, driving the need for safer and more effective alternatives. In this study, the antiproliferative activities of ... ...

    Abstract Most of the current cancer chemotherapeutics are associated with harsh and undesirable side effects, including toxicity and chemoresistance, driving the need for safer and more effective alternatives. In this study, the antiproliferative activities of the methanolic extract of
    Language English
    Publishing date 2021-07-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2021/4051555
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5995: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Cohort study of the association of antibody levels to AMA1, MSP119, MSP3 and GLURP with protection from clinical malaria in Ghanaian children.

    Dodoo, Daniel / Aikins, Anastasia / Kusi, Kwadwo Asamoah / Lamptey, Helena / Remarque, Ed / Milligan, Paul / Bosomprah, Samuel / Chilengi, Roma / Osei, Yaa Difie / Akanmori, Bartholomew Dicky / Theisen, Michael

    Malaria journal

    2008  Volume 7, Page(s) 142

    Abstract: Background: Antigen-specific antibody-mediated immune responses play an important role in natural protection against clinical malaria, but conflicting estimates of this association have emerged from immuno-epidemiological studies in different ... ...

    Abstract Background: Antigen-specific antibody-mediated immune responses play an important role in natural protection against clinical malaria, but conflicting estimates of this association have emerged from immuno-epidemiological studies in different geographical settings. This study was aimed at assessing in a standardized manner the relationship between the antibody responses to four malaria vaccine candidate antigens and protection from clinical malaria, in a cohort of Ghanaian children.
    Methods: Standardized ELISA protocols were used to measure isotype and IgG subclass levels to Apical Membrane Antigen 1 (AMA1), Merozoite Surface Protein 1-19 (MSP119), Merozoite Surface Protein 3 (MSP3) and Glutamate Rich Protein (GLURP) antigens in plasma samples from 352 Ghanaian children, aged three to 10 years with subsequent malaria surveillance for nine months. This is one of a series of studies in different epidemiological settings using the same standardized ELISA protocols to permit comparisons of results from different laboratories.
    Results: The incidence rate of malaria was 0.35 episodes per child per year. Isotype and IgG subclasses for all antigens investigated increased with age, while the risk of malaria decreased with age. After adjusting for age, higher levels of IgG to GLURP, MSP119, MSP3 and IgM to MSP119, MSP3 and AMA1 were associated with decreased malaria incidence. Of the IgG subclasses, only IgG1 to MSP119 was associated with reduced incidence of clinical malaria. A previous study in the same location failed to find an association of antibodies to MSP119 with clinical malaria. The disagreement may be due to differences in reagents, ELISA and analytical procedures used in the two studies. When IgG, IgM and IgG subclass levels for all four antigens were included in a combined model, only IgG1 [(0.80 (0.67-0.97), p = 0.018)] and IgM [(0.48 (0.32-0.72), p < 0.001)] to MSP119 were independently associated with protection from malaria.
    Conclusion: Using standardized procedures, the study has confirmed the importance of antibodies to MSP119 in reducing the risk of clinical malaria in Ghanaian children, thus substantiating its potential as a malaria vaccine candidate.
    MeSH term(s) Animals ; Antibodies, Protozoan/blood ; Antigens, Protozoan/blood ; Antigens, Protozoan/immunology ; Child ; Child, Preschool ; Cohort Studies ; Enzyme-Linked Immunosorbent Assay ; Female ; Ghana ; Humans ; Immunoglobulin G/blood ; Immunoglobulin Isotypes/blood ; Malaria, Falciparum/blood ; Malaria, Falciparum/immunology ; Male ; Merozoite Surface Protein 1/immunology ; Peptide Fragments/immunology ; Protozoan Proteins/immunology
    Chemical Substances Antibodies, Protozoan ; Antigens, Protozoan ; Immunoglobulin G ; Immunoglobulin Isotypes ; MSP3 protein, Plasmodium falciparum (181-276) ; Merozoite Surface Protein 1 ; Peptide Fragments ; Protozoan Proteins ; glutamate-rich protein, Plasmodium (145112-81-8)
    Language English
    Publishing date 2008-07-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1475-2875
    ISSN (online) 1475-2875
    DOI 10.1186/1475-2875-7-142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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