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Article ; Online: Seizures in autoimmune-associated epilepsy: a long-term video-EEG monitoring study.

Fonte, Joana / Stabile, Andrea / de Curtis, Marco / Di Giacomo, Roberta / Pastori, Chiara / Didato, Giuseppe / Andreetta, Francesca / Del Sole, Angelo / Doniselli, Fabio / Deleo, Francesco

Journal of neurology

2024

Language	English
Publishing date	2024-04-24
Publishing country	Germany
Document type	Letter
ZDB-ID	187050-6
ISSN	1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
ISSN (online)	1432-1459
ISSN	0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
DOI	10.1007/s00415-024-12385-2
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Article: Efficacy and Safety of Combination Therapy with Low-Dose Rivaroxaban in Patients with Cardiovascular Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Bucci, Tommaso / Del Sole, Francesco / Menichelli, Danilo / Galardo, Gioacchino / Biccirè, Flavio Giuseppe / Farcomeni, Alessio / Lip, Gregory Y H / Pignatelli, Pasquale / Pastori, Daniele

Journal of clinical medicine

2024 Volume 13, Issue 7

Abstract: ... ...

Abstract	Objectives
Language	English
Publishing date	2024-03-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13072033
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Article ; Online: Atmospheric Pressure Plasma Deposition of Hybrid Nanocomposite Coatings Containing TiO

Del Sole, Regina / Lo Porto, Chiara / Lotito, Sara / Ingrosso, Chiara / Comparelli, Roberto / Curri, Maria Lucia / Barucca, Gianni / Fracassi, Francesco / Palumbo, Fabio / Milella, Antonella

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 13

Abstract: Among the different applications of ... ...

Abstract	Among the different applications of TiO
MeSH term(s)	Carbon ; Spectroscopy, Fourier Transform Infrared ; Titanium/chemistry ; Nanocomposites/chemistry ; Methylene Blue/chemistry ; Catalysis
Chemical Substances	graphene oxide ; titanium dioxide (15FIX9V2JP) ; Carbon (7440-44-0) ; Titanium (D1JT611TNE) ; Methylene Blue (T42P99266K)
Language	English
Publishing date	2023-06-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28135131
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Article ; Online: Risk of venous thromboembolism in autoimmune diseases: A comprehensive review.

Menichelli, Danilo / Cormaci, Vito Maria / Marucci, Silvia / Franchino, Giovanni / Del Sole, Francesco / Capozza, Alessandro / Fallarino, Alessia / Valeriani, Emanuele / Violi, Francesco / Pignatelli, Pasquale / Pastori, Daniele

Autoimmunity reviews

2023 Volume 22, Issue 11, Page(s) 103447

Abstract: Autoimmune diseases have specific pathophysiologic mechanisms leading to an increased risk of arterial and venous thrombosis. The risk of venous thromboembolism (VTE) varies according to the type and stage of the disease, and to concomitant treatments. ... ...

Abstract	Autoimmune diseases have specific pathophysiologic mechanisms leading to an increased risk of arterial and venous thrombosis. The risk of venous thromboembolism (VTE) varies according to the type and stage of the disease, and to concomitant treatments. In this review, we revise the most common autoimmune disease such as antiphospholipid syndrome, inflammatory myositis, polymyositis and dermatomyositis, rheumatoid arthritis, sarcoidosis, Sjogren syndrome, autoimmune haemolytic anaemia, systemic lupus erythematosus, systemic sclerosis, vasculitis and inflammatory bowel disease. We also provide an overview of pathophysiology responsible for the risk of VTE in each autoimmune disorder, and report current indications to anticoagulant treatment for primary and secondary prevention of VTE.
MeSH term(s)	Humans ; Venous Thromboembolism/complications ; Venous Thromboembolism/epidemiology ; Autoimmune Diseases/complications ; Autoimmune Diseases/epidemiology ; Arthritis, Rheumatoid/complications ; Antiphospholipid Syndrome/complications ; Lupus Erythematosus, Systemic/complications
Language	English
Publishing date	2023-09-14
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2144145-5
ISSN	1873-0183 ; 1568-9972
ISSN (online)	1873-0183
ISSN	1568-9972
DOI	10.1016/j.autrev.2023.103447
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Article ; Online: Coronary microvascular dysfunction in patients undergoing transcatheter aortic valve implantation.

Scarsini, Roberto / Portolan, Leonardo / Della Mora, Francesco / Fabroni, Margherita / Andreaggi, Stefano / Mainardi, Andrea / Springhetti, Paolo / Dotto, Alberto / Del Sole, Paolo Alberto / Fezzi, Simone / Pazzi, Sara / Tavella, Domenico / Mammone, Concetta / Lunardi, Mattia / Pesarini, Gabriele / Benfari, Giovanni / Ribichini, Flavio Luciano

Heart (British Cardiac Society)

2024 Volume 110, Issue 8, Page(s) 603–612

Abstract: Objectives: This study aimed to evaluate the prognostic value of coronary microvascular dysfunction (CMD) at long term after transcatheter aortic valve implantation (TAVI) and to explore its relationship with extravalvular cardiac damage (EVCD). ... ...

Abstract	Objectives: This study aimed to evaluate the prognostic value of coronary microvascular dysfunction (CMD) at long term after transcatheter aortic valve implantation (TAVI) and to explore its relationship with extravalvular cardiac damage (EVCD). Moreover, we sought to test the correlation between angiography-derived index of microcirculatory resistance (IMR Methods: This was a retrospective analysis of the Verona Valvular Heart Disease Registry (Italy) including 250 patients (83 (80-86) years, 53% female) with severe AS who underwent TAVI between 2019 and 2021. IMR Results: The primary endpoint occurred in 28 (11.2%) patients at a median follow-up of 22 (IQR 12-30) months. Patients with CMD met the primary endpoint more frequently than those without CMD (22.9% vs 2.8%, p<0.0001). Patients with CMD were more frequently characterised by advanced EVCD (33 (31.4%) vs 27 (18.6%), p=0.024). CMD was an independent predictor of adverse outcomes (adjusted HR 6.672 (2.251 to 19.778), p=0.001) and provided incremental prognostic value compared with conventional clinical and imaging variables. IMR Conclusions: CMD is an independent predictor of cardiovascular mortality and HF after TAVI.
MeSH term(s)	Humans ; Female ; Male ; Transcatheter Aortic Valve Replacement/adverse effects ; Retrospective Studies ; Microcirculation ; Treatment Outcome ; Aortic Valve Stenosis/complications ; Aortic Valve Stenosis/surgery ; Myocardial Ischemia ; Aortic Valve/surgery
Language	English
Publishing date	2024-03-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1303417-0
ISSN	1468-201X ; 1355-6037
ISSN (online)	1468-201X
ISSN	1355-6037
DOI	10.1136/heartjnl-2023-323461
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Article ; Online: Long-Term Risk of Major Adverse Cardiac Events in Atrial Fibrillation Patients on Direct Oral Anticoagulants.

Pastori, Daniele / Menichelli, Danilo / Del Sole, Francesco / Pignatelli, Pasquale / Violi, Francesco

Mayo Clinic proceedings

2020 Volume 96, Issue 3, Page(s) 658–665

Abstract: Objective: To determine the association between direct oral anticoagulant (DOAC) use and risk of major adverse cardiac events (MACEs) in patients with atrial fibrillation (AF).: Patients and methods: This study is a single-center prospective ... ...

Abstract	Objective: To determine the association between direct oral anticoagulant (DOAC) use and risk of major adverse cardiac events (MACEs) in patients with atrial fibrillation (AF). Patients and methods: This study is a single-center prospective observational cohort study including 2366 outpatients with non-valvular AF on treatment with DOACs or vitamin K antagonists (VKAs) from February 2008 for patients on VKA and September 2013 for patients on novel oral anticoagulants. The primary endpoint was the incidence of MACE including fatal and non-fatal myocardial infarction (MI), cardiac revascularization, and cardiovascular death. Results: The mean age was 75.1±9.0 years; 44.7% were women. During a mean follow-up of 33.3±21.9 months (6567 patients/years) 133 MACEs occurred (2.03%/year): 79 MI/cardiac revascularization and 54 cardiovascular deaths. Of these, 101 were on VKAs (2.42%/year) and 32 on DOACs (1.34%/year; log-rank test P=.040). This difference was evident also considering MI alone (1.53%/year and 0.63%/year in the VKA and DOAC group, respectively, log-rank test P=.009). At multivariable Cox proportional hazard regression analysis, use of DOACs was associated with a lower risk of MACE (hazard ratio, 0.636; 95% CI, 0.417 to 0.970; P=.036) and MI (hazard ratio, 0.497; 95% CI, 0.276 to 0.896; p=.020). Sensitivity analysis showed that this association was consistent in younger patients (<75 years), in patients with anemia, and in those without chronic obstructive pulmonary disease and heart failure. We also found that both dabigatran and apixaban/rivaroxaban were associated with a lower rate of MACE, with similar efficacy between full and low doses. Conclusion: DOACs are associated with a lower risk of MACE in patients with AF independently from dosage.
MeSH term(s)	Administration, Oral ; Aged ; Aged, 80 and over ; Anticoagulants/therapeutic use ; Atrial Fibrillation/drug therapy ; Cohort Studies ; Dabigatran/therapeutic use ; Female ; Heart Failure/drug therapy ; Humans ; Male ; Medication Adherence/statistics & numerical data ; Middle Aged ; Myocardial Infarction/drug therapy ; Platelet Aggregation Inhibitors/therapeutic use ; Prospective Studies ; Rivaroxaban/therapeutic use
Chemical Substances	Anticoagulants ; Platelet Aggregation Inhibitors ; Rivaroxaban (9NDF7JZ4M3) ; Dabigatran (I0VM4M70GC)
Language	English
Publishing date	2020-12-09
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	124027-4
ISSN	1942-5546 ; 0025-6196
ISSN (online)	1942-5546
ISSN	0025-6196
DOI	10.1016/j.mayocp.2020.06.057
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Article ; Online: A Comprehensive Review of Risk Factors for Venous Thromboembolism: From Epidemiology to Pathophysiology.

Pastori, Daniele / Cormaci, Vito Maria / Marucci, Silvia / Franchino, Giovanni / Del Sole, Francesco / Capozza, Alessandro / Fallarino, Alessia / Corso, Chiara / Valeriani, Emanuele / Menichelli, Danilo / Pignatelli, Pasquale

International journal of molecular sciences

2023 Volume 24, Issue 4

Abstract: Venous thromboembolism (VTE) is the third most common cause of death worldwide. The incidence of VTE varies according to different countries, ranging from 1-2 per 1000 person-years in Western Countries, while it is lower in Eastern Countries (<1 per 1000 ...

Abstract	Venous thromboembolism (VTE) is the third most common cause of death worldwide. The incidence of VTE varies according to different countries, ranging from 1-2 per 1000 person-years in Western Countries, while it is lower in Eastern Countries (<1 per 1000 person-years). Many risk factors have been identified in patients developing VTE, but the relative contribution of each risk factor to thrombotic risk, as well as pathogenetic mechanisms, have not been fully described. Herewith, we provide a comprehensive review of the most common risk factors for VTE, including male sex, diabetes, obesity, smoking, Factor V Leiden, Prothrombin G20210A Gene Mutation, Plasminogen Activator Inhibitor-1, oral contraceptives and hormonal replacement, long-haul flight, residual venous thrombosis, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, trauma and fractures, pregnancy, immobilization, antiphospholipid syndrome, surgery and cancer. Regarding the latter, the incidence of VTE seems highest in pancreatic, liver and non-small cells lung cancer (>70 per 1000 person-years) and lowest in breast, melanoma and prostate cancer (<20 per 1000 person-years). In this comprehensive review, we summarized the prevalence of different risk factors for VTE and the potential molecular mechanisms/pathogenetic mediators leading to VTE.
MeSH term(s)	Female ; Humans ; Male ; Venous Thromboembolism/genetics ; COVID-19 ; SARS-CoV-2 ; Risk Factors ; Venous Thrombosis/genetics ; Thrombophilia/genetics
Language	English
Publishing date	2023-02-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24043169
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Article ; Online: Statins and Major Adverse Limb Events in Patients with Peripheral Artery Disease: A Systematic Review and Meta-Analysis.

Pastori, Daniele / Farcomeni, Alessio / Milanese, Alberto / Del Sole, Francesco / Menichelli, Danilo / Hiatt, William R / Violi, Francesco

Thrombosis and haemostasis

2020 Volume 120, Issue 5, Page(s) 866–875

Abstract: Background: Statins are guidelines recommended in patients with peripheral artery disease (PAD) for the prevention of cardiovascular (CV) events. Comprehensive meta-data on the impact of statins on major adverse limb events (MALE) in PAD patients are ... ...

Abstract	Background: Statins are guidelines recommended in patients with peripheral artery disease (PAD) for the prevention of cardiovascular (CV) events. Comprehensive meta-data on the impact of statins on major adverse limb events (MALE) in PAD patients are lacking. We examined the association of statin use with MALE in patients with PAD. Methods: We performed a systematic review (registered at PROSPERO: number CRD42019137111) and metanalysis of studies retrieved from PubMed (via MEDLINE) and Cochrane (CENTRAL) databases addressing the impact of statin on MALE including amputation and graft occlusion/revascularization. Secondary endpoints were all-cause death, composite CV endpoints, CV death, and stroke. Results: We included 51 studies with 138,060 PAD patients, of whom 48,459 (35.1%) were treated with statins. The analysis included 2 randomized controlled trials, 20 prospective, and 29 retrospective studies. Overall, 11,396 MALE events, 21,624 deaths, 4,852 composite CV endpoints, 4,609 CV deaths, and 860 strokes were used for the analysis. Statins reduced MALE incidence by 30% (pooled hazard ratio [HR]: 0.702; 95% confidence interval [CI]: 0.605-0.815) and amputations by 35% (HR: 0.654; 95% CI: 0.522-0.819), all-cause mortality by 39% (pooled HR: 0.608, 95% CI: 0.543-0.680), CV death by 41% (HR: 0.594; 95% CI: 0.455-0.777), composite CV endpoints by 34% (pooled HR: 0.662; 95% CI: 0.591-0.741) and ischemic stroke by 28% (pooled HR: 0.718; 95% CI: 0.620-0.831). Conclusion: Statins reduce the incidence of MALE, all-cause, and CV mortality in patients with PAD. In PAD, a high proportion of MALE events and deaths could be prevented by implementing a statin prescription in this patient population.
MeSH term(s)	Amputation ; Cause of Death ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Incidence ; Limb Salvage ; Peripheral Arterial Disease/diagnosis ; Peripheral Arterial Disease/epidemiology ; Peripheral Arterial Disease/mortality ; Peripheral Arterial Disease/therapy ; Risk Assessment ; Risk Factors ; Treatment Outcome ; Vascular Surgical Procedures/adverse effects ; Vascular Surgical Procedures/mortality
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors
Language	English
Publishing date	2020-05-05
Publishing country	Germany
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	518294-3
ISSN	2567-689X ; 0340-6245
ISSN (online)	2567-689X
ISSN	0340-6245
DOI	10.1055/s-0040-1709711
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Uh III Zs.192: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Atrial fibrillation pattern, left atrial diameter and risk of cardiovascular events and mortality. A prospective multicenter cohort study.

Menichelli, Danilo / Sciacqua, Angela / Cangemi, Roberto / Andreozzi, Paola / Del Sole, Francesco / Violi, Francesco / Pignatelli, Pasquale / Pastori, Daniele

International journal of clinical practice

2020 Volume 75, Issue 3, Page(s) e13771

Abstract: Background: There are conflicting evidence on the association between atrial fibrillation (AF) pattern, such as persistent/permanent (Pers/Perm) and paroxysmal (PAF) AF and risk of ischemic events. We investigated if left atrial diameter (LAd) may ... ...

Abstract	Background: There are conflicting evidence on the association between atrial fibrillation (AF) pattern, such as persistent/permanent (Pers/Perm) and paroxysmal (PAF) AF and risk of ischemic events. We investigated if left atrial diameter (LAd) may affect the risk of cardiovascular outcomes according to AF pattern. Methods: Prospective multicenter observational including 1,252 non-valvular AF patients (533 PAF and 719 Pers/Perm AF). Study endpoints were cardiovascular events (CVEs), major adverse cardiac events (MACE) and CV death. LA anteroposterior diameter (LAd) was obtained by transthoracic echocardiography. Results: Pers/Perm AF patients had a higher proportion of LAd above median than PAF (≥44 mm, 59.5% vs 37.5% respectively, P < .001). In a mean follow-up of 42.2 ± 31.0 months (4,315 patients/year) 179 CVEs (incidence rate [IR] 4.2%/year), 133 MACE (IR 3.1%/year), and 97 CV deaths (IR 2.2%/year) occurred. Compared to patients with LAd below median, those with LAd above the median had a higher rate of CVEs (log-rank test, P < .001), MACE (log-rank test P < .001), and CV death (log-rank test P < .001). Multivariable Cox regression analysis showed that LAd above the median was associated with CVEs, (HR 1.569, 95% CI 1.129-2.180, P = .007) MACE (HR 1.858, 95% CI 1.257-2.745, P = .002) and CV death (HR 2.106, 95% CI 1.308-3.390, P = .002). The association between LAd and outcomes was evident both in PAF and Pers/Perm AF patients. No association between AF pattern and outcomes was found. Conclusion: LAd is a simple parameter that can be obtained in virtually all AF patients and can provide prognostic information on the risk of CVEs, MACE and CV death regardless of AF pattern.
MeSH term(s)	Atrial Fibrillation/complications ; Echocardiography ; Heart Atria/diagnostic imaging ; Humans ; Incidence ; Prospective Studies ; Risk Factors
Language	English
Publishing date	2020-11-09
Publishing country	India
Document type	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	1386246-7
ISSN	1742-1241 ; 1368-5031
ISSN (online)	1742-1241
ISSN	1368-5031
DOI	10.1111/ijcp.13771
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Article ; Online: Atmospheric Pressure Plasma Deposition of Hybrid Nanocomposite Coatings Containing TiO 2 and Carbon-Based Nanomaterials

Regina Del Sole / Chiara Lo Porto / Sara Lotito / Chiara Ingrosso / Roberto Comparelli / Maria Lucia Curri / Gianni Barucca / Francesco Fracassi / Fabio Palumbo / Antonella Milella

Molecules, Vol 28, Iss 5131, p

2023 Volume 5131

Abstract: Among the different applications of TiO 2 , its use for the photocatalytic abatement of organic pollutants has been demonstrated particularly relevant. However, the wide band gap (3.2 eV), which requires UV irradiation for activation, and the fast ... ...

Abstract	Among the different applications of TiO 2 , its use for the photocatalytic abatement of organic pollutants has been demonstrated particularly relevant. However, the wide band gap (3.2 eV), which requires UV irradiation for activation, and the fast electron-hole recombination rate of this n-type semiconductor limit its photocatalytic performance. A strategy to overcome these limitations relies on the realization of a nanocomposite that combines TiO 2 nanoparticles with carbon-based nanomaterials, such as rGO (reduced graphene oxide) and fullerene (C 60 ). On the other hand, the design and realization of coatings formed of such TiO 2 -based nanocomposite coatings are essential to make them suitable for their technological applications, including those in the environmental field. In this work, aerosol-assisted atmospheric pressure plasma deposition of nanocomposite coatings containing both TiO 2 nanoparticles and carbon-based nanomaterials, as rGO or C 60 , in a siloxane matrix is reported. The chemical composition and morphology of the deposited films were investigated for the different types of prepared nanocomposites by means of FT-IR, FEG-SEM, and TEM analyses. The photocatalytic activity of the nanocomposite coatings was evaluated through monitoring the photodegradation of methylene blue (MB) as a model organic pollutant. Results demonstrate that the nanocomposite coatings embedding rGO or C 60 show enhanced photocatalytic performance with respect to the TiO 2 counterpart. In particular, TiO 2 /C 60 nanocomposites allow to achieve 85% MB degradation upon 180 min of UV irradiation.
Keywords	plasma deposition ; nanocomposite coating ; TiO 2 ; photocatalysis ; aerosol-assisted plasma ; carbon nanomaterials ; Organic chemistry ; QD241-441
Subject code	620
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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