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Article ; Online: Framing as a Concept for Health Communication: A Systematic Review.

Guenther, Lars / Gaertner, Maria / Zeitz, Jessica

2020 Volume 36, Issue 7, Page(s) 891–899

Abstract: Over the past decades, research in the fields of both framing and health communication has grown exponentially. However, to date, no systematic review has been conducted about how framing - as a concept - has been used in health communication. The ... ...

Abstract	Over the past decades, research in the fields of both framing and health communication has grown exponentially. However, to date, no systematic review has been conducted about how framing - as a concept - has been used in health communication. The present study provides a systematic review of the current research, applying a quantitative content analysis to the published literature on framing in health communication. Articles published in peer-reviewed scientific journals (
MeSH term(s)	Communication ; Health Communication ; Humans ; Vaccination
Language	English
Publishing date	2020-01-29
Publishing country	England
Document type	Journal Article ; Systematic Review
ZDB-ID	1038723-7
ISSN	1532-7027 ; 1041-0236
ISSN (online)	1532-7027
ISSN	1041-0236
DOI	10.1080/10410236.2020.1723048
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Article ; Online: Thrifty energy phenotype predicts weight regain in postmenopausal women with overweight or obesity and is related to FGFR1 signaling.

Spranger, Leonard / Weiner, January / Bredow, Josephine / Zeitz, Ulrike / Grittner, Ulrike / Boschmann, Michael / Dickmann, Sophia / Stobäus, Nicole / Schwartzenberg, Reiner Jumpertz-von / Brachs, Maria / Spranger, Joachim / Mai, Knut

Clinical nutrition (Edinburgh, Scotland)

2023 Volume 42, Issue 4, Page(s) 559–567

Abstract: Background&aims: Long term improvement of body weight and metabolism is highly requested in obesity. The specific impact of weight loss associated temporary negative energy balance or modified body composition on metabolism and weight regain is unclear.! ...

Abstract	Background&aims: Long term improvement of body weight and metabolism is highly requested in obesity. The specific impact of weight loss associated temporary negative energy balance or modified body composition on metabolism and weight regain is unclear. Methods: We randomly assigned 80 post-menopausal women (BMI 33.9 (32.2-36.8)kg/m Results: Between March 2012 and July 2015, 479 subjects were screened for eligibility. 80 subjects were randomly assigned to IG (n = 40) or CG (n = 40). The total number of dropouts was 18 (IG: n = 13, CG: n = 5). LBM and ISI Conclusion: Negative energy balance had no additional effect on insulin sensitivity. FGFR1 signaling might be involved in the adaption of energy expenditure to temporary negative energy balance, which indicates a thrifty phenotype susceptible to weight regain. Trial registration: ClinicalTrials.gov number: NCT01105143, https://clinicaltrials.gov/ct2/show/NCT01105143, date of registration: April 16th, 2010.
MeSH term(s)	Female ; Humans ; Overweight ; Insulin Resistance ; Postmenopause ; Obesity/metabolism ; Body Composition ; Energy Metabolism ; Weight Gain ; Weight Loss ; Receptor, Fibroblast Growth Factor, Type 1/metabolism
Chemical Substances	FGFR1 protein, human (EC 2.7.10.1) ; Receptor, Fibroblast Growth Factor, Type 1 (EC 2.7.10.1)
Language	English
Publishing date	2023-02-24
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604812-2
ISSN	1532-1983 ; 0261-5614
ISSN (online)	1532-1983
ISSN	0261-5614
DOI	10.1016/j.clnu.2023.02.020
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Zs.A 1774: Show issues

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Book ; Online: Sensitivity of ice flow to uncertainty in flow law parameters in an idealized one-dimensional geometry

Zeitz, Maria / Levermann, Anders / Winkelmann, Ricarda

eISSN: 1994-0424

2020

Abstract: The flow of ice drives mass losses in both, the Antarctic and the Greenland Ice Sheet. The projections of possible future sea-level rise rely on numerical ice-sheet models, which solve the physics of ice flow and melt. While a number of important ... ...

Abstract	The flow of ice drives mass losses in both, the Antarctic and the Greenland Ice Sheet. The projections of possible future sea-level rise rely on numerical ice-sheet models, which solve the physics of ice flow and melt. While a number of important uncertainties have been addressed by the ice-sheet modeling community, the flow law, which is at the center of most process-based ice-sheet models, has so far been assumed certain. Unfortunately, recent studies show that the parameters in the flow law might be uncertain and different from the widely accepted standard values. Here, we use an idealized flowline setup to investigate how uncertainties in the flow law translate into uncertainties in flow-driven mass loss given a step-wise increase of surface temperatures. We find that the measured range of flow parameters can double the flow-driven mass loss within the first centuries of warming, compared to a setting with standard parameters. The spread of ice loss due to an uncertainty in flow parameters is of the same order as the increase in mass loss due to increasing surface temperatures. While this study focuses on an idealized setting in order to disentangle the effect of the flow law from other effects, it is likely that this uncertainty carries over to realistic three-dimensional simulations of Greenland and Antarctica.
Subject code	621
Language	English
Publishing date	2020-04-07
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Sensitivity of ice loss to uncertainty in flow law parameters in an idealized one-dimensional geometry

Zeitz, Maria / Levermann, Anders / Winkelmann, Ricarda

eISSN: 1994-0424

2020

Abstract: Acceleration of the flow of ice drives mass losses in both the Antarctic and the Greenland Ice Sheet. The projections of possible future sea-level rise rely on numerical ice-sheet models, which solve the physics of ice flow, melt, and calving. While ... ...

Abstract	Acceleration of the flow of ice drives mass losses in both the Antarctic and the Greenland Ice Sheet. The projections of possible future sea-level rise rely on numerical ice-sheet models, which solve the physics of ice flow, melt, and calving. While major advancements have been made by the ice-sheet modeling community in addressing several of the related uncertainties, the flow law, which is at the center of most process-based ice-sheet models, is not in the focus of the current scientific debate. However, recent studies show that the flow law parameters are highly uncertain and might be different from the widely accepted standard values. Here, we use an idealized flow-line setup to investigate how these uncertainties in the flow law translate into uncertainties in flow-driven mass loss. In order to disentangle the effect of future warming on the ice flow from other effects, we perform a suite of experiments with the Parallel Ice Sheet Model (PISM), deliberately excluding changes in the surface mass balance. We find that changes in the flow parameters within the observed range can lead up to a doubling of the flow-driven mass loss within the first centuries of warming, compared to standard parameters. The spread of ice loss due to the uncertainty in flow parameters is on the same order of magnitude as the increase in mass loss due to surface warming. While this study focuses on an idealized flow-line geometry, it is likely that this uncertainty carries over to realistic three-dimensional simulations of Greenland and Antarctica.
Subject code	621
Language	English
Publishing date	2020-10-27
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Active Brownian particles moving in a random Lorentz gas.

Zeitz, Maria / Wolff, Katrin / Stark, Holger

The European physical journal. E, Soft matter

2017 Volume 40, Issue 2, Page(s) 23

Abstract: Biological microswimmers often inhabit a porous or crowded environment such as soil. In order to understand how such a complex environment influences their spreading, we numerically study non-interacting active Brownian particles (ABPs) in a two- ... ...

Abstract	Biological microswimmers often inhabit a porous or crowded environment such as soil. In order to understand how such a complex environment influences their spreading, we numerically study non-interacting active Brownian particles (ABPs) in a two-dimensional random Lorentz gas. Close to the percolation transition in the Lorentz gas, they perform the same subdiffusive motion as ballistic and diffusive particles. However, due to their persistent motion they reach their long-time dynamics faster than passive particles and also show superdiffusive motion at intermediate times. While above the critical obstacle density [Formula: see text] the ABPs are trapped, their long-time diffusion below [Formula: see text] is strongly influenced by the propulsion speed v
Language	English
Publishing date	2017
Publishing country	France
Document type	Journal Article
ZDB-ID	2004003-9
ISSN	1292-895X ; 1292-8941
ISSN (online)	1292-895X
ISSN	1292-8941
DOI	10.1140/epje/i2017-11510-0
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Article ; Online: Dynamic regimes of the Greenland Ice Sheet emerging from interacting melt–elevation and glacial isostatic adjustment feedbacks

Zeitz, Maria / Haacker, Jan M. / Donges, Jonathan F. / Albrecht, Torsten / Winkelmann, Ricarda

2022

Abstract: The stability of the Greenland Ice Sheet under global warming is governed by a number of dynamic processes and interacting feedback mechanisms in the ice sheet, atmosphere and solid Earth. Here we study the long-term effects due to the interplay of the ... ...

Abstract	The stability of the Greenland Ice Sheet under global warming is governed by a number of dynamic processes and interacting feedback mechanisms in the ice sheet, atmosphere and solid Earth. Here we study the long-term effects due to the interplay of the competing melt–elevation and glacial isostatic adjustment (GIA) feedbacks for different temperature step forcing experiments with a coupled ice-sheet and solid-Earth model. Our model results show that for warming levels above 2 ∘C, Greenland could become essentially ice-free within several millennia, mainly as a result of surface melting and acceleration of ice flow. These ice losses are mitigated, however, in some cases with strong GIA feedback even promoting an incomplete recovery of the Greenland ice volume. We further explore the full-factorial parameter space determining the relative strengths of the two feedbacks: our findings suggest distinct dynamic regimes of the Greenland Ice Sheets on the route to destabilization under global warming – from incomplete recovery, via quasi-periodic oscillations in ice volume to ice-sheet collapse. In the incomplete recovery regime, the initial ice loss due to warming is essentially reversed within 50 000 years, and the ice volume stabilizes at 61 %–93 % of the present-day volume. For certain combinations of temperature increase, atmospheric lapse rate and mantle viscosity, the interaction of the GIA feedback and the melt–elevation feedback leads to self-sustained, long-term oscillations in ice-sheet volume with oscillation periods between 74 000 and over 300 000 years and oscillation amplitudes between 15 %–70 % of present-day ice volume. This oscillatory regime reveals a possible mode of internal climatic variability in the Earth system on timescales on the order of 100 000 years that may be excited by or synchronized with orbital forcing or interact with glacial cycles and other slow modes of variability. Our findings are not meant as scenario-based near-term projections of ice losses but rather providing insight into ...
Subject code	290
Language	English
Publishing date	2022-07-22
Publisher	Copernicus Publications (EGU)
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Feedback mechanism for microtubule length regulation by stathmin gradients.

Zeitz, Maria / Kierfeld, Jan

Biophysical journal

2014 Volume 107, Issue 12, Page(s) 2860–2871

Abstract: We formulate and analyze a theoretical model for the regulation of microtubule (MT) polymerization dynamics by the signaling proteins Rac1 and stathmin. In cells, the MT growth rate is inhibited by cytosolic stathmin, which, in turn, is inactivated by ... ...

Abstract	We formulate and analyze a theoretical model for the regulation of microtubule (MT) polymerization dynamics by the signaling proteins Rac1 and stathmin. In cells, the MT growth rate is inhibited by cytosolic stathmin, which, in turn, is inactivated by Rac1. Growing MTs activate Rac1 at the cell edge, which closes a positive feedback loop. We investigate both tubulin sequestering and catastrophe promotion as mechanisms for MT growth inhibition by stathmin. For a homogeneous stathmin concentration in the absence of Rac1, we find a switchlike regulation of the MT mean length by stathmin. For constitutively active Rac1 at the cell edge, stathmin is deactivated locally, which establishes a spatial gradient of active stathmin. In this gradient, we find a stationary bimodal MT-length distribution for both mechanisms of MT growth inhibition by stathmin. One subpopulation of the bimodal length distribution can be identified with fast-growing and long pioneering MTs in the region near the cell edge, which have been observed experimentally. The feedback loop is closed through Rac1 activation by MTs. For tubulin sequestering by stathmin, this establishes a bistable switch with two stable states: one stable state corresponds to upregulated MT mean length and bimodal MT length distributions, i.e., pioneering MTs; the other stable state corresponds to an interrupted feedback with short MTs. Stochastic effects as well as external perturbations can trigger switching events. For catastrophe-promoting stathmin, we do not find bistability.
MeSH term(s)	Feedback, Physiological ; Microtubules/chemistry ; Microtubules/metabolism ; Models, Biological ; Polymerization ; Stathmin/metabolism ; rac1 GTP-Binding Protein/metabolism
Chemical Substances	Stathmin ; rac1 GTP-Binding Protein (EC 3.6.5.2)
Language	English
Publishing date	2014-12-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218078-9
ISSN	1542-0086 ; 0006-3495
ISSN (online)	1542-0086
ISSN	0006-3495
DOI	10.1016/j.bpj.2014.10.056
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Zs.A 235: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Exploring risks and benefits of overshooting a 1.5 °C carbon budget over space and time

Nico Bauer / David P Keller / Julius Garbe / Kristine Karstens / Franziska Piontek / Werner von Bloh / Wim Thiery / Maria Zeitz / Matthias Mengel / Jessica Strefler / Kirsten Thonicke / Ricarda Winkelmann

Environmental Research Letters, Vol 18, Iss 5, p

2023 Volume 054015

Abstract: Temperature targets of the Paris Agreement limit global net cumulative emissions to very tight carbon budgets. The possibility to overshoot the budget and offset near-term excess emissions by net-negative emissions is considered economically attractive ... ...

Abstract	Temperature targets of the Paris Agreement limit global net cumulative emissions to very tight carbon budgets. The possibility to overshoot the budget and offset near-term excess emissions by net-negative emissions is considered economically attractive as it eases near-term mitigation pressure. While potential side effects of carbon removal deployment are discussed extensively, the additional climate risks and the impacts and damages have attracted less attention. We link six models for an integrative analysis of the climatic, environmental and socio-economic consequences of temporarily overshooting a carbon budget consistent with the 1.5 °C temperature target along the cause-effect chain from emissions and carbon removals to climate risks and impact. Global climatic indicators such as CO _2 -concentration and mean temperature closely follow the carbon budget overshoot with mid-century peaks of 50 ppmv and 0.35 °C, respectively. Our findings highlight that investigating overshoot scenarios requires temporally and spatially differentiated analysis of climate, environmental and socioeconomic systems. We find persistent and spatially heterogeneous differences in the distribution of carbon across various pools, ocean heat content, sea-level rise as well as economic damages. Moreover, we find that key impacts, including degradation of marine ecosystem, heat wave exposure and economic damages, are more severe in equatorial areas than in higher latitudes, although absolute temperature changes being stronger in higher latitudes. The detrimental effects of a 1.5 °C warming and the additional effects due to overshoots are strongest in non-OECD countries (Organization for Economic Cooperation and Development). Constraining the overshoot inflates CO _2 prices, thus shifting carbon removal towards early afforestation while reducing the total cumulative deployment only slightly, while mitigation costs increase sharply in developing countries. Thus, scenarios with carbon budget overshoots can reverse global mean temperature ...
Keywords	carbon dioxide removal ; mitigation and impacts ; integrated assessment models ; Earth system model of intermediate complexity ; global south ; carbon budget overshoot ; Environmental technology. Sanitary engineering ; TD1-1066 ; Environmental sciences ; GE1-350 ; Science ; Q ; Physics ; QC1-999
Subject code	333
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	IOP Publishing
Document type	Article ; Online
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Article ; Online: Reversibility of red blood cell deformation.

Zeitz, Maria / Sens, P

Physical review. E, Statistical, nonlinear, and soft matter physics

2012 Volume 85, Issue 5 Pt 1, Page(s) 51904

Abstract: The ability of cells to undergo reversible shape changes is often crucial to their survival. For red blood cells (RBCs), irreversible alteration of the cell shape and flexibility often causes anemia. Here we show theoretically that RBCs may react ... ...

Abstract	The ability of cells to undergo reversible shape changes is often crucial to their survival. For red blood cells (RBCs), irreversible alteration of the cell shape and flexibility often causes anemia. Here we show theoretically that RBCs may react irreversibly to mechanical perturbations because of tensile stress in their cytoskeleton. The transient polymerization of protein fibers inside the cell seen in sickle cell anemia or a transient external force can trigger the formation of a cytoskeleton-free membrane protrusion of μm dimensions. The complex relaxation kinetics of the cell shape is shown to be responsible for selecting the final state once the perturbation is removed, thereby controlling the reversibility of the deformation. In some case, tubular protrusion are expected to relax via a peculiar "pearling instability."
MeSH term(s)	Biomechanical Phenomena ; Cell Membrane/metabolism ; Cell Shape ; Cell Surface Extensions/metabolism ; Cytoskeleton/metabolism ; Erythrocytes/cytology ; Erythrocytes/metabolism ; Kinetics ; Models, Biological ; Protein Multimerization ; Protein Structure, Quaternary
Language	English
Publishing date	2012-05
Publishing country	United States
Document type	Journal Article
ISSN	1550-2376
ISSN (online)	1550-2376
DOI	10.1103/PhysRevE.85.051904
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Article ; Online: Feedback control of flow vorticity at low Reynolds numbers.

Zeitz, Maria / Gurevich, Pavel / Stark, Holger

The European physical journal. E, Soft matter

2015 Volume 38, Issue 3, Page(s) 22

Abstract: Our aim is to explore strategies of feedback control to design and stabilize novel dynamic flow patterns in model systems of complex fluids. To introduce the control strategies, we investigate the simple Newtonian fluid at low Reynolds number in a ... ...

Abstract	Our aim is to explore strategies of feedback control to design and stabilize novel dynamic flow patterns in model systems of complex fluids. To introduce the control strategies, we investigate the simple Newtonian fluid at low Reynolds number in a circular geometry. Then, the fluid vorticity satisfies a diffusion equation. We determine the mean vorticity in the sensing area and use two control strategies to feed it back into the system by controlling the angular velocity of the circular boundary. Hysteretic feedback control generates self-regulated stable oscillations in time, the frequency of which can be adjusted over several orders of magnitude by tuning the relevant feedback parameters. Time-delayed feedback control initiates unstable vorticity modes for sufficiently large feedback strength. For increasing delay time, we first observe oscillations with beats and then regular trains of narrow pulses. Close to the transition line between the resting fluid and the unstable modes, these patterns are relatively stable over long times.
Language	English
Publishing date	2015-03
Publishing country	France
Document type	Journal Article
ZDB-ID	2004003-9
ISSN	1292-895X ; 1292-8941
ISSN (online)	1292-895X
ISSN	1292-8941
DOI	10.1140/epje/i2015-15022-7
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