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  1. Article ; Online: East Antarctic warming forced by ice loss during the Last Interglacial.

    Hutchinson, David K / Menviel, Laurie / Meissner, Katrin J / Hogg, Andrew McC

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1026

    Abstract: ... surface warming over East Antarctica of 2 to 4 °C, and sea surface temperature (SST) increases ... in the Weddell and Ross Seas by up to 2 °C. Meltwater forcing causes a high latitude SST decrease and ... a subsurface (100-500 m) ocean temperature increase by up to 2 °C in the Ross Sea. Our results suggest ...

    Abstract During the Last Interglacial (LIG; 129-116 thousand years before present), the Antarctic ice sheet (AIS) was 1 to 7 m sea level equivalent smaller than at pre-industrial. Here, we assess the climatic impact of partial AIS melting at the LIG by forcing a coupled climate model with a smaller AIS and the equivalent meltwater input around the Antarctic coast. We find that changes in surface elevation induce surface warming over East Antarctica of 2 to 4 °C, and sea surface temperature (SST) increases in the Weddell and Ross Seas by up to 2 °C. Meltwater forcing causes a high latitude SST decrease and a subsurface (100-500 m) ocean temperature increase by up to 2 °C in the Ross Sea. Our results suggest that the combination of a smaller AIS and enhanced meltwater input leads to a larger sub-surface warming than meltwater alone and induces further Antarctic warming than each perturbation separately.
    Language English
    Publishing date 2024-02-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-45501-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Classifying Future Healthcare Utilization in COPD Using Quantitative CT Lung Imaging and Two-Step Feature Selection via Sparse Subspace Learning with the CanCOLD Study.

    Moslemi, Amir / Hague, Cameron J / Hogg, James C / Bourbeau, Jean / Tan, Wan C / Kirby, Miranda

    Academic radiology

    2024  

    Abstract: Rationale: Although numerous candidate features exist for predicting risk of higher risk of healthcare utilization in patients with chronic obstructive pulmonary disease (COPD), the process for selecting the most discriminative features remains unclear.! ...

    Abstract Rationale: Although numerous candidate features exist for predicting risk of higher risk of healthcare utilization in patients with chronic obstructive pulmonary disease (COPD), the process for selecting the most discriminative features remains unclear.
    Objective: The objective of this study was to develop a robust feature selection method to identify the most discriminative candidate features for predicting healthcare utilization in COPD, and compare the model performance with other common feature selection methods.
    Materials and methods: In this retrospective study, demographic, lung function measurements and CT images were collected from 454 COPD participants from the Canadian Cohort Obstructive Lung Disease study from 2010-2017. A follow-up visit was completed approximately 1.5 years later and participants reported healthcare utilization. CT analysis was performed for feature extraction. A two-step hybrid feature selection method was proposed that utilized: (1) sparse subspace learning with nonnegative matrix factorization, and, (2) genetic algorithm. Seven commonly used feature selection methods were also implemented that reported the top 10 or 20 features for comparison. Performance was evaluated using accuracy.
    Results: Of the 454 COPD participants evaluated, 161 (35%) utilized healthcare services at follow-up. The accuracy for predicting subsequent healthcare utilization for the seven commonly used feature selection methods ranged from 72%-76% with the top 10 features, and 77%-80% with the top 20 features. Relative to these methods, hybrid feature selection obtained significantly higher accuracy for predicting subsequent healthcare utilization at 82% ± 3% (p < 0.05). Selected features with the proposed method included: DL
    Conclusion: The hybrid feature selection method identified the most discriminative features for classifying individuals with and without future healthcare utilization, and increased the accuracy compared to other state-of-the-art approaches.
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1355509-1
    ISSN 1878-4046 ; 1076-6332
    ISSN (online) 1878-4046
    ISSN 1076-6332
    DOI 10.1016/j.acra.2024.03.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4594: Show issues Location:
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  3. Article ; Online: UPF1 ATPase autoinhibition and activation modulate RNA binding kinetics and NMD efficiency.

    Chapman, Joseph H / Youle, Alice M / Grimme, Acadia L / Neuman, Keir C / Hogg, J Robert

    Nucleic acids research

    2024  

    Abstract: The RNA helicase UPF1 interacts with mRNAs, mRNA decay machinery, and the terminating ribosome to promote nonsense-mediated mRNA decay (NMD). Structural and biochemical data have revealed that UPF1 exists in an enzymatically autoinhibited 'closed' state. ...

    Abstract The RNA helicase UPF1 interacts with mRNAs, mRNA decay machinery, and the terminating ribosome to promote nonsense-mediated mRNA decay (NMD). Structural and biochemical data have revealed that UPF1 exists in an enzymatically autoinhibited 'closed' state. Upon binding the NMD protein UPF2, UPF1 undergoes an extensive conformational change into a more enzymatically active 'open' state, which exhibits enhanced ATPase and helicase activity. However, mechanically deficient UPF1 mutants (i.e. poorly processive, slow, and mechanochemically uncoupled) can support efficient NMD, bringing into question the roles of UPF1 enzymatic autoinhibition and activation in NMD. Here, we identify two additional important features of the activated open state: slower RNA binding kinetics and enhanced ATP-stimulated RNA dissociation kinetics. Computational modeling based on empirical measurements of UPF1, UPF2 and RNA interaction kinetics predicts that the majority of UPF1-RNA binding and dissociation events in cells occur independently of UPF2 binding. We find that UPF1 mutants with either reduced or accelerated dissociation from RNA have NMD defects, whereas UPF1 mutants that are more dependent on UPF2 for catalytic activity remain active on well-established NMD targets. These findings support a model in which the kinetics of UPF1-mRNA interactions are important determinants of cellular NMD efficiency.
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkae136
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1067: Show issues Location:
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  4. Article: Automated Growth Rate Measurement of the Facet Surfaces of Single Crystals of the β-Form of l-Glutamic Acid Using Machine Learning Image Processing.

    Jiang, Chen / Ma, Cai Y / Hazlehurst, Thomas A / Ilett, Thomas P / Jackson, Alexander S M / Hogg, David C / Roberts, Kevin J

    Crystal growth & design

    2024  Volume 24, Issue 8, Page(s) 3277–3288

    Abstract: Precision measurement of the growth rate of individual single crystal facets ( ...

    Abstract Precision measurement of the growth rate of individual single crystal facets (
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ISSN 1528-7483
    ISSN 1528-7483
    DOI 10.1021/acs.cgd.3c01548
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  5. Article: Nonoperative management of degenerative cervical radiculopathy: protocol of a systematic review.

    Plener, Joshua / Ammendolia, Carlo / Hogg-Johnson, Sheilah

    The Journal of the Canadian Chiropractic Association

    2022  Volume 66, Issue 1, Page(s) 74–84

    Abstract: Background: Degenerative cervical radiculopathy (DCR) is a common condition which, due to the aging global population, is expected to worsen over time. For the majority of patients with DCR, surgical intervention is not required as nonoperative ... ...

    Abstract Background: Degenerative cervical radiculopathy (DCR) is a common condition which, due to the aging global population, is expected to worsen over time. For the majority of patients with DCR, surgical intervention is not required as nonoperative management is sufficient for symptom improvement. However, there are significant gaps within the literature as the majority of past systematic reviews assessing conservative interventions are outdated, or omit relevant studies due to strict inclusion/exclusion criteria. Therefore, an updated understanding of the effectiveness of noninvasive nonoperative management for DCR is required.
    Methods: We will search MEDLINE, CENTRAL, Embase, PsycINFO, and CINAHL from inception, as well as hand-search reference lists of included studies and previous systematic reviews, to identify peer-reviewed randomized controlled trials on this topic.
    Discussion: The results of this review will provide an understanding of the effectiveness of various nonoperative interventions. The quality of evidence will also be assessed using the GRADE approach.
    Systematic review registration: PROSPERO CRD42021249699.
    Language English
    Publishing date 2022-03-02
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2093945-0
    ISSN 1715-6181 ; 0008-3194
    ISSN (online) 1715-6181
    ISSN 0008-3194
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  6. Article: UPF1 ATPase autoinhibition and activation modulate RNA binding kinetics and NMD efficiency.

    Chapman, Joseph H / Youle, Alice M / Grimme, Acadia L / Neuman, Keir C / Hogg, J Robert

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The RNA helicase UPF1 interacts with mRNAs, mRNA decay machinery, and the terminating ribosome to promote nonsense-mediated mRNA decay (NMD). Structural and biochemical data have revealed that UPF1 exists in an enzymatically autoinhibited "closed" state. ...

    Abstract The RNA helicase UPF1 interacts with mRNAs, mRNA decay machinery, and the terminating ribosome to promote nonsense-mediated mRNA decay (NMD). Structural and biochemical data have revealed that UPF1 exists in an enzymatically autoinhibited "closed" state. Upon binding the NMD protein UPF2, UPF1 undergoes an extensive conformational change into a more enzymatically active "open" state, which exhibits enhanced ATPase and helicase activity. However, mechanically deficient UPF1 mutants can support efficient NMD, bringing into question the roles of UPF1 enzymatic autoinhibition and activation in NMD. Here, we identify two additional important features of the activated open state: slower nucleic acid binding kinetics and enhanced ATP-stimulated nucleic acid dissociation kinetics. Computational modeling based on empirical measurements of UPF1, UPF2, and RNA interaction kinetics predicts that the majority of UPF1-RNA binding and dissociation events in cells occur independently of UPF2 binding. We find that UPF1 mutants with either reduced or accelerated dissociation from RNA have NMD defects, whereas UPF1 mutants that are more dependent on UPF2 for catalytic activity remain active on well-established NMD targets. These findings support a model in which the kinetics of UPF1-mRNA interactions are important determinants of cellular NMD efficiency.
    Language English
    Publishing date 2023-11-03
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.11.03.565554
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  7. Article ; Conference proceedings: Die Effekte eines intensiven Ganzkörpervibrationstrainings auf die Muskulatur und Körperzusammensetzung bei immobilisierten Intensivpatienten

    Böselt, T / Kütting, H / Högg, K / Kroenig, J / Alter, P / Spielmanns, M / Vogelmeier, C / Beutel, B / Koczulla, A

    Pneumologie

    2023  Volume 77, Issue S 01

    Event/congress 63. Kongress der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e. V., Düsseldorf, 2023-03-29
    Language German
    Publishing date 2023-03-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 607630-0
    ISSN 1438-8790 ; 0934-8387
    ISSN (online) 1438-8790
    ISSN 0934-8387
    DOI 10.1055/s-0043-1761133
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    Uh II Zs.142: Show issues Location:
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  8. Article ; Online: Multi-omics resources for the Australian southern stuttering frog (Mixophyes australis) reveal assorted antimicrobial peptides.

    Tang, Simon / Peel, Emma / Belov, Katherine / Hogg, Carolyn J / Farquharson, Katherine A

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 3991

    Abstract: ... naturally vegetated riverbanks in south-eastern Australia. Using PacBio HiFi long-read sequencing and Hi-C ...

    Abstract The number of genome-level resources for non-model species continues to rapidly expand. However, frog species remain underrepresented, with up to 90% of frog genera having no genomic or transcriptomic data. Here, we assemble the first genomic and transcriptomic resources for the recently described southern stuttering frog (Mixophyes australis). The southern stuttering frog is ground-dwelling, inhabiting naturally vegetated riverbanks in south-eastern Australia. Using PacBio HiFi long-read sequencing and Hi-C scaffolding, we generated a high-quality genome assembly, with a scaffold N50 of 369.3 Mb and 95.1% of the genome contained in twelve scaffolds. Using this assembly, we identified the mitochondrial genome, and assembled six tissue-specific transcriptomes. We also bioinformatically characterised novel sequences of two families of antimicrobial peptides (AMPs) in the southern stuttering frog, the cathelicidins and β-defensins. While traditional peptidomic approaches to peptide discovery have typically identified one or two AMPs in a frog species from skin secretions, our bioinformatic approach discovered 12 cathelicidins and two β-defensins that were expressed in a range of tissues. We investigated the novelty of the peptides and found diverse predicted activities. Our bioinformatic approach highlights the benefits of multi-omics resources in peptide discovery and contributes valuable genomic resources in an under-represented taxon.
    MeSH term(s) Animals ; Antimicrobial Peptides ; beta-Defensins/genetics ; Multiomics ; Stuttering ; Australia ; Cathelicidins/genetics ; Anura/genetics ; Chromosomes
    Chemical Substances Antimicrobial Peptides ; beta-Defensins ; Cathelicidins
    Language English
    Publishing date 2024-02-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-54522-x
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  9. Article: Improving the sustainability of the ruthenium-catalysed

    Findlay, Michael T / Hogg, Ashley S / Douglas, James J / Larrosa, Igor

    Green chemistry : an international journal and green chemistry resource : GC

    2023  Volume 25, Issue 6, Page(s) 2394–2400

    Abstract: Direct C-H functionalisation methodologies represent an opportunity to improve the overall 'green' ... we describe a recent advance in our ruthenium-catalysed C-H arylation methodology that aims to address ...

    Abstract Direct C-H functionalisation methodologies represent an opportunity to improve the overall 'green' credentials of organic coupling reactions, improving atom economy and reducing overall step count. Despite this, these reactions frequently run under reaction conditions that leave room for improved sustainability. Herein, we describe a recent advance in our ruthenium-catalysed C-H arylation methodology that aims to address some of the environmental impacts associated with this procedure, including solvent choice, reaction temperature, reaction time, and loading of the ruthenium catalyst. We believe that our findings demonstrate a reaction with improved environmental credentials and showcase it on a multi-gram scale within an industrial setting.
    Language English
    Publishing date 2023-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2006274-6
    ISSN 1463-9270 ; 1463-9262
    ISSN (online) 1463-9270
    ISSN 1463-9262
    DOI 10.1039/d2gc03860a
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  10. Article: Quantitative computed tomography and visual emphysema scores: association with lung function decline.

    Koo, Meghan C / Tan, Wan C / Hogg, Jim C / Bourbeau, Jean / Hague, Cameron J / Leipsic, Jonathon A / Kirby, Miranda

    ERJ open research

    2023  Volume 9, Issue 2

    Abstract: Background: Computed tomography (CT) visual emphysema score is a better predictor of mortality than single quantitative CT emphysema measurements in COPD, but there are numerous CT measurements that reflect COPD-related disease features. The purpose of ... ...

    Abstract Background: Computed tomography (CT) visual emphysema score is a better predictor of mortality than single quantitative CT emphysema measurements in COPD, but there are numerous CT measurements that reflect COPD-related disease features. The purpose of this study was to determine if linear combinations of quantitative CT measurements by principal component analysis (PCA) have a greater association with forced expiratory volume in 1 s (FEV
    Methods: In this retrospective, longitudinal study, demographic, spirometry and CT images were acquired. CT visual emphysema score and quantitative analysis were performed; low attenuation area <950 HU (LAA
    Results: Quantitative CT measures (LAA
    Conclusions: PCA with a combination of CT measurements reflecting several different COPD-related disease features independently predicted baseline lung function and increased the relative importance of quantitative CT compared with visual emphysema score for predicting lung function decline.
    Language English
    Publishing date 2023-04-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00523-2022
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