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  1. Article: Sir John Vivian Dacie: 20 July 1912 - 12 February 2005.

    Lewis, Mitchell / Mollison, Patrick / Weatherall, David

    Biographical memoirs of fellows of the Royal Society. Royal Society (Great Britain)

    2008  Volume 52, Page(s) 67–82

    Abstract: John Dacie was the leading figure in haematology in this country during its period of major expansion after World War II. By his meticulous approach to the study of patients in haematological disorders in the laboratory he was able accurately to define ... ...

    Abstract John Dacie was the leading figure in haematology in this country during its period of major expansion after World War II. By his meticulous approach to the study of patients in haematological disorders in the laboratory he was able accurately to define many new diseases, particularly haemolytic anaemias, so laying a firm foundation for their further definition by the tools of the protein chemistry and molecular biology eras. And by establishing the haematology laboratory at the Royal Postgraduate Medical School as an international centre of excellence, where many future leaders of the field were trained, he had a critical role in the development of the clinical and laboratory aspects of haematology, both in the UK and internationally.
    MeSH term(s) Hematology/history ; History, 20th Century ; History, 21st Century ; Research/history ; United Kingdom
    Language English
    Publishing date 2008-05-13
    Publishing country England
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 3485-x
    ISSN 0080-4606
    ISSN 0080-4606
    DOI 10.1098/rsbm.2006.0006
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    Zs.A 5067: Show issues Location:
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  2. Article ; Online: Association of COVID-19 Vaccinations With Flares of Systemic Rheumatic Disease: A Case-Crossover Study.

    Braverman, Genna / Barbhaiya, Medha / Nong, Minerva / Bykerk, Vivian P / Hupert, Nathaniel / Lewis, Colby / Mandl, Lisa A

    Arthritis care & research

    2024  Volume 76, Issue 5, Page(s) 733–742

    Abstract: Objective: We aimed to determine the association of COVID-19 vaccination with flares of systemic rheumatic disease (SRD).: Methods: Adults with systemic rheumatic disease (SRD) in a single-center COVID-19 Rheumatology Registry were invited to enroll ... ...

    Abstract Objective: We aimed to determine the association of COVID-19 vaccination with flares of systemic rheumatic disease (SRD).
    Methods: Adults with systemic rheumatic disease (SRD) in a single-center COVID-19 Rheumatology Registry were invited to enroll in a study of flares. COVID-19 vaccine information from March 5, 2021, to September 6, 2022, was obtained from chart review and self-report. Participants self-reported periods of SRD flare and periods without SRD flare. "Hazard periods" were defined as the time before a self-report of flare and "control periods" as the time before a self-report of no flare. The association between flare and COVID-19 vaccination was evaluated during hazard and control periods through univariate conditional logistic regression stratified by participant, using lookback windows of 2, 7, and 14 days.
    Results: A total of 434 participants (mean ± SD age 59 ± 13 years, 84.1% female, 81.8% White, 64.5% with inflammatory arthritis, and 27.0% with connective tissue diseases) contributed to both the hazard and control periods and were included in analysis. A total of 1,316 COVID-19 vaccinations were identified (58.5% Pfizer-BioNTech, 39.5% Moderna, and 1.4% Johnson & Johnson); 96.1% of participants received at least one dose and 93.1% at least two doses. There was no association between COVID-19 vaccination and flares in the subsequent 2, 7, or 14 days (odds ratio [OR] 1.46, 95% confidence interval [CI] 0.86-2.46; OR 1.09, 95% CI 0.76-1.55; and OR 0.85, 95% CI 0.64-1.13, respectively). Analyses stratified on sex, age, SRD subtype, and vaccine manufacturer similarly showed no association between vaccination and flare.
    Conclusion: COVID-19 vaccination was not associated with flares in this cohort of participants with SRD. These data are reassuring and can inform shared decision-making on COVID-19 immunization.
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645059-3
    ISSN 2151-4658 ; 0893-7524 ; 2151-464X
    ISSN (online) 2151-4658
    ISSN 0893-7524 ; 2151-464X
    DOI 10.1002/acr.25288
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  3. Article ; Online: A prospective, double-blinded cohort study using quantitative fetal fibronectin testing in symptomatic women for the prediction of spontaneous preterm delivery.

    Ng, Vivian Wai Yan / Seto, Mimi Tin Yan / Lewis, Holly / Cheung, Ka Wang

    BMC pregnancy and childbirth

    2023  Volume 23, Issue 1, Page(s) 225

    Abstract: Background: Spontaneous preterm birth (PTB) affects 6.5% of deliveries in Hong Kong. Quantitative fetal fibronectin (fFN) is under-utilised as a test for PTB prediction in Hong Kong. Our objective was to evaluate the effectiveness of quantitative fFN in ...

    Abstract Background: Spontaneous preterm birth (PTB) affects 6.5% of deliveries in Hong Kong. Quantitative fetal fibronectin (fFN) is under-utilised as a test for PTB prediction in Hong Kong. Our objective was to evaluate the effectiveness of quantitative fFN in predicting spontaneous PTB in women with symptoms of threatened preterm labour (TPTL) in our population.
    Methods: A prospective, double-blinded cohort study of women with a singleton gestation and TPTL symptoms presenting to a tertiary hospital in Hong Kong between 24 + 0 to 33 + 6 weeks was performed from 1st October 2020 and 31st October 2021. Women with vaginal bleeding, ruptured membranes, and cervical dilation > 3 cm were excluded. The primary outcome was to test the characteristics of quantitative fFN in predicting spontaneous PTB < 37 weeks. Secondary outcome was to investigate the relationship between fFN value and time to PTB. Test characteristics of quantitative fFN at different thresholds were evaluated.
    Results: 48 women with TPTL were recruited. All had fFN testing at admission with the results being concealed from the obstetrician managing the patient. 10 mothers had PTB (< 37 weeks' gestation). 7/48 (15%) had a subsequent PTB within 14 days from testing and 5 (10%) delivered within 48 h. The negative predictive value (NPV) of predicting delivery within 14 days was 97.3% and 100% when using a cut-off of < 50ng/ml and < 10ng/ml respectively. Using > 200 ng/ml as cut-off can also reliably predict delivery within 48 h - 7 days with positive predictive value PPV of 100%; as well as PTB before 37 weeks.
    Conclusions: Quantitative fFN has predictive value for spontaneous PTB prediction in symptomatic women in a Hong Kong population. fFN concentration could help clinicians rule out PTB and avoid unnecessary interventions and hospitalisation.
    MeSH term(s) Female ; Humans ; Infant, Newborn ; Cohort Studies ; Fibronectins ; Obstetric Labor, Premature/diagnosis ; Predictive Value of Tests ; Premature Birth/diagnosis ; Premature Birth/epidemiology ; Prospective Studies ; Double-Blind Method
    Chemical Substances Fibronectins
    Language English
    Publishing date 2023-04-04
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2059869-5
    ISSN 1471-2393 ; 1471-2393
    ISSN (online) 1471-2393
    ISSN 1471-2393
    DOI 10.1186/s12884-023-05543-3
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  4. Article ; Online: Pregnancy After Concussion: A Clarion Call for Attention?

    Anto-Ocrah, Martina / Cafferky, Virginia / Lewis, Vivian

    The Journal of head trauma rehabilitation

    2021  Volume 37, Issue 4, Page(s) E268–E279

    Abstract: Objective: Emerging research shows that women who sustain a mild traumatic brain injury, also termed concussion, have a higher risk of menstrual irregularities and sexual dysfunctions. However, no research exists on how these reproductive disruptions ... ...

    Abstract Objective: Emerging research shows that women who sustain a mild traumatic brain injury, also termed concussion, have a higher risk of menstrual irregularities and sexual dysfunctions. However, no research exists on how these reproductive disruptions affect women's subsequent pregnancies. The objective of this study was to evaluate pregnancy outcomes after concussion in a cohort of reproductive-aged women (aged 18-45 years), 24 months post-injury. We hypothesized that, compared with their extremity-injured peers in the same cohort, women with concussion will have lower incidence of pregnancies.
    Setting: Emergency department of a level 1 trauma center.
    Participants: Women of reproductive age (aged 18-45 years) seeking care for concussion or extremity injury.
    Design: Longitudinal cohort study that used data collected at 3 distinct time points: t0, baseline: an original cohort of 245 women recruited in January to July 2017 for exposure assessment; t1, 6(+4) weeks post-injury: evaluation of self-reported postinjury menstrual and sexual changes for subgroup analyses-data collected in March to September 2017 ( n = 135); t2, 24 months post-injury: March 2020 chart review for documentation of pregnancies/pregnancy-related events ( N = 245).
    Main measure: Poisson regression estimates used to model the incidence rate (IR) of pregnancies, comparing concussion with extremity injury.
    Results: We reviewed the charts of 254 women from the t0 cohort. After excluding 9 patients who were either deceased or missing relevant data, we had the 245 (96.5%) charts of 102 concussed and 143 extremity-injured study participants. After adjusting for race and obstetric history, women with concussion had 80% lower incidence of pregnancies than their extremity-injured peers (adjusted [adj] IR = 0.20; 95% CI: 0.07-0.59; P = .003). When we excluded women who were using birth control, the IR of pregnancy for women with concussions was 76% lower than for those who had sustained extremity injuries (adj IR = 0.24; 95% CI: 0.07-0.81; P = .02). Pregnancy incidence remained consistently lower for concussed women in additional sensitivity analyses excluding assault/domestic violence victims and those with a prior/new concussion at t0 and t2. Subgroup analyses of the 135 women who had experienced menstrual and/or sexual dysfunctions at t1 showed 84% reduced incidence of pregnancy for women with concussions compared with those who had sustained an extremity injury (adj IR = 0.16; 95% CI: 0.04-0.73; P = .02).
    Conclusion and relevance: Our study potentially serves as a clarion call to understand the long-term reproductive effects of female concussions.
    MeSH term(s) Adult ; Athletic Injuries/epidemiology ; Brain Concussion/epidemiology ; Female ; Humans ; Incidence ; Longitudinal Studies ; Pregnancy ; Risk Factors
    Language English
    Publishing date 2021-09-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 639221-0
    ISSN 1550-509X ; 0885-9701
    ISSN (online) 1550-509X
    ISSN 0885-9701
    DOI 10.1097/HTR.0000000000000723
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  5. Article ; Online: High hydroxyurea usage in sickle cell anemia regardless of patient demographics.

    Phan, Vivian / Park, Ju Ae / Dulman, Robin / Lewis, Angela / Briere, Noravy / Notarangelo, Bailey / Yang, Elizabeth

    Pediatric blood & cancer

    2023  Volume 71, Issue 2, Page(s) e30728

    Abstract: Hydroxyurea is highly effective in sickle cell disease, but it is still underutilized. Reports of hydroxyurea utilization largely use Medicaid data, and socioeconomics is often cited as a barrier. To address whether patient demographics influenced the ... ...

    Abstract Hydroxyurea is highly effective in sickle cell disease, but it is still underutilized. Reports of hydroxyurea utilization largely use Medicaid data, and socioeconomics is often cited as a barrier. To address whether patient demographics influenced the high hydroxyurea usage rate recently reported for the pediatric sickle cell program of Northern Virginia, analysis of data from 2011 to 2021 revealed no statistical difference in hydroxyurea usage rate between Medicaid and non-Medicaid, African American and African, or age less than 13 and age greater than or equal to 13 years cohorts, demonstrating that hydroxyurea can be successfully implemented across demographic groups.
    MeSH term(s) United States/epidemiology ; Humans ; Child ; Hydroxyurea/therapeutic use ; Hospitalization ; Anemia, Sickle Cell/drug therapy ; Medicaid ; Demography ; Antisickling Agents/therapeutic use
    Chemical Substances Hydroxyurea (X6Q56QN5QC) ; Antisickling Agents
    Language English
    Publishing date 2023-12-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.30728
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  6. Article ; Online: Becoming by doing: How women in academic health sciences build a leadership identity through project experiences.

    Baldwin, Constance D / Lewis, Vivian / Thorndyke, Luanne E / Morahan, Page S / Gusic, Maryellen E

    Medical teacher

    2022  Volume 45, Issue 1, Page(s) 73–79

    Abstract: Purpose: Leadership development programs often use institutional projects to activate learning. We explored how project work shaped leadership identity formation in senior women leaders from one academic health science center who enrolled in The Hedwig ... ...

    Abstract Purpose: Leadership development programs often use institutional projects to activate learning. We explored how project work shaped leadership identity formation in senior women leaders from one academic health science center who enrolled in The Hedwig von Ameringen Executive Leadership in Academic Medicine (ELAM
    Materials and methods: We interviewed ELAM Fellows and conducted a qualitative analysis of transcripts. Our primary analysis focused on the influences of projects on Fellows and institutions. Leadership identity formation emerged as a distinct pattern, so this narrative content was separated for secondary analysis. All authors approved the final assignment of themes and codes.
    Results: Participants described a multi-dimensional process for developing a leadership identity. Themes encompassed participants'
    Conclusions: We examined the process of leadership identity formation from the perspective of women leaders in academic health sciences who completed an institutional project during a leadership development program. Findings illustrate how internal and external forces, experienced in the context of project work, combine to influence leadership identity formation in women.
    MeSH term(s) Humans ; Female ; Leadership ; Health Facilities ; Learning ; Interpersonal Relations ; Motivation
    Language English
    Publishing date 2022-08-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 424426-6
    ISSN 1466-187X ; 0142-159X
    ISSN (online) 1466-187X
    ISSN 0142-159X
    DOI 10.1080/0142159X.2022.2102469
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  7. Article ; Online: Elevated CO2 concentration enhances Oryza sativa seed shattering and affects seed shattering gene expression

    Balbinot, Andrisa / Viana, Vívian E. / Feijó, Anderson R. / Fipke, Marcus V. / Heck, Tamara / Ziska, Lewis H. / Markus, Catarine / Merotto, Aldo, Jr / Avila, Luis A.

    Weed Research. 2023 Aug., v. 63, no. 4 p.207-217

    2023  

    Abstract: Weedy rice (Oryza spp.) is widely recognised as a major constraint in cultivated rice systems globally. Seed shattering is related to the invasiveness and persistence of weedy ecotypes in field and exacerbates control of weedy rice in cultivated rice ... ...

    Abstract Weedy rice (Oryza spp.) is widely recognised as a major constraint in cultivated rice systems globally. Seed shattering is related to the invasiveness and persistence of weedy ecotypes in field and exacerbates control of weedy rice in cultivated rice systems. Shattering traits are controlled genetically and by different environmental conditions. At present, a rapidly changing environment, including rising levels of atmospheric carbon dioxide, could alter shattering frequency, with subsequent effects on weed seed input and competition. The study aimed to evaluate the interaction between weedy rice seed shattering and transcriptional seed shattering‐regulation genes as affected by weedy rice genotypes and atmospheric CO₂ concentrations. We examined seven biotypes and two levels of atmospheric [CO₂]: ambient {a[CO₂]} and enhanced {e[CO₂]} concentrations of 400 and 700 μmol mol⁻¹ respectively. Our results indicate that e[CO₂] increases weedy rice seed shattering. The gene expression analysis demonstrates that in most genotypes the e[CO₂] increased the expression of all shattering‐related genes (OsCPL1, qSH1, Sh4, SHAT1, OsXTH8, OSH15 and SH5). Atmospheric [CO₂] greatly affects seed shattering in weedy rice and has a minor effect on cultivated rice, by modulation of seed shattering‐related gene expression. Weedy rice genotypes had the highest upregulation of these genes.
    Keywords Oryza sativa ; carbon dioxide ; carbon dioxide enrichment ; ecotypes ; gene expression ; research ; rice ; transcription (genetics) ; weeds
    Language English
    Dates of publication 2023-08
    Size p. 207-217.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 281281-2
    ISSN 1365-3180 ; 0043-1737
    ISSN (online) 1365-3180
    ISSN 0043-1737
    DOI 10.1111/wre.12587
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Antibody titrations are critical for microflow cytometric analysis of extracellular vesicles.

    Pink, Desmond / Basu, Arghya / Wong, Michael / Pham, Diana / Valencia, Juliana / Triana, Vivian / Beatty, Perrin H / Rieger, Aja M / Lewis, John D

    Cytometry. Part A : the journal of the International Society for Analytical Cytology

    2023  Volume 103, Issue 8, Page(s) 670–683

    Abstract: Optimization of flow cytometry assays for extracellular vesicles (EVs) often fail to include appropriate reagent titrations - the most critically antibody titration is either not performed or is incomplete. Using nonoptimal antibody concentration is one ... ...

    Abstract Optimization of flow cytometry assays for extracellular vesicles (EVs) often fail to include appropriate reagent titrations - the most critically antibody titration is either not performed or is incomplete. Using nonoptimal antibody concentration is one of the main sources of error leading to a lack of reproducible data. Antibody titration for the analysis of antigens on the surface of EVs is challenging for a variety of technical reasons. Using platelets as surrogates for cells and platelet-derived particles as surrogates for EV populations, we demonstrate our process for antibody titration, highlighting some of the key analysis parameters that may confound and surprise new researchers moving into the field of EV research. Additional care must be exercised to ensure instrument and reagent controls are utilized appropriately. Complete graphical analysis of positive and negative signal intensities, concentration, and separation or stain index data is highly beneficial when paired with visual analysis of the cytometry data. Using analytical flow cytometry procedures optimized for cells for EV analysis can lead to misleading and nonreproducible results.
    MeSH term(s) Extracellular Vesicles ; Blood Platelets ; Flow Cytometry/methods ; Coloring Agents
    Chemical Substances Coloring Agents
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2099868-5
    ISSN 1552-4930 ; 0196-4763 ; 1552-4922
    ISSN (online) 1552-4930
    ISSN 0196-4763 ; 1552-4922
    DOI 10.1002/cyto.a.24733
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  9. Article ; Online: Formation of Biomolecular Condensates in Bacteria by Tuning Protein Electrostatics

    Vivian Yeong / Emily G. Werth / Lewis M. Brown / Allie C. Obermeyer

    ACS Central Science, Vol 6, Iss 12, Pp 2301-

    2020  Volume 2310

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Formation of Biomolecular Condensates in Bacteria by Tuning Protein Electrostatics.

    Yeong, Vivian / Werth, Emily G / Brown, Lewis M / Obermeyer, Allie C

    ACS central science

    2020  Volume 6, Issue 12, Page(s) 2301–2310

    Abstract: While eukaryotic cells have a myriad of membrane-bound organelles enabling the isolation of different chemical environments, prokaryotic cells lack these defined reaction vessels. Biomolecular condensates-organelles that lack a membrane-provide a ... ...

    Abstract While eukaryotic cells have a myriad of membrane-bound organelles enabling the isolation of different chemical environments, prokaryotic cells lack these defined reaction vessels. Biomolecular condensates-organelles that lack a membrane-provide a strategy for cellular organization without a physical barrier while allowing for the dynamic, responsive organization of the cell. It is well established that intrinsically disordered protein domains drive condensate formation via liquid-liquid phase separation; however, the role of globular protein domains on intracellular phase separation remains poorly understood. We hypothesized that the overall charge of globular proteins would dictate the formation and concentration of condensates and systematically probed this hypothesis with supercharged proteins and nucleic acids in
    Language English
    Publishing date 2020-11-12
    Publishing country United States
    Document type Journal Article
    ISSN 2374-7943
    ISSN 2374-7943
    DOI 10.1021/acscentsci.0c01146
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