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  1. Book: Was tun bei Parkinson?

    George, Sabine / Manke, Julia / Peter, Sina / Pichler, Katharina / Schroeteler, Frauke / Sporrer, Wiebke / Ziegler, Kerstin / Ceballos-Bauman, Andreas

    ein Ratgeber für Betroffene und Angehörige

    (Ratgeber für Angehörige, Betroffene und Fachleute)

    2023  

    Author's details Sabine George/Julia Manke/Sina Peter/Katharina Pichler/Frauke Schroeteler [und weitere]
    Series title Ratgeber für Angehörige, Betroffene und Fachleute
    Keywords Tremor ; Stürze ; Gehfähigkeit ; Akinese ; Rigor ; Zittern ; Hardcover, Softcover / Medizin/Pflege ; Parkinson-Krankheit ; Alternative Medizin
    Subject Schüttellähmung ; Paralysis agitans ; Idiopathischer Parkinsonismus ; Morbus Parkinson ; Außerschulische Medizin ; Außenseitermedizin ; Außenseiterverfahren ; Alternativmedizin ; Komplementärmedizin ; Komplementäre Medizin ; Alternative Therapie
    Subject code 616.83306
    Language German
    Size 80 Seiten, Illustrationen, 21 cm, 212 g
    Edition 4., vollständig überarbeitete und aktualisierte Auflage
    Publisher Schulz-Kirchner
    Publishing place Idstein
    Publishing country Germany
    Document type Book
    Old title Vorangegangen ist
    HBZ-ID HT030396077
    ISBN 978-3-8248-1323-0 ; 3-8248-1323-8 ; 9783824898718 ; 3824898713
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Vet available for loan (reading room) Lesesaal EG Gesundheitsliteratur

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  2. Book ; Thesis: Simultaneous PET-MR hybrid imaging

    Ziegler, Susanne

    phantom measurement strategies

    2013  

    Author's details vorgelegt von Susanne Ziegler
    Language English
    Size 79 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Erlangen, Nürnberg, Univ., Diss., 2013
    HBZ-ID HT018252570
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 E 575 order for loan Magazin

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  3. Article: Zum 60. Geburtstag von Professor Dr. med. Peter Marquardt.

    Ziegler, E

    Arzneimittel-Forschung

    1970  Volume 20, Issue 10, Page(s) 1610–1612

    Title translation On the 60th birthday of Professor Dr. med. Peter Marquardt.
    MeSH term(s) Germany, West ; History, 20th Century ; Therapeutics/history
    Language German
    Publishing date 1970-10
    Publishing country Germany
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 502081-5
    ISSN 1616-7066 ; 0004-4172
    ISSN (online) 1616-7066
    ISSN 0004-4172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    ab Jg. 2022: Lesesaal (EG)
    1990 A 260: Show issues

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  4. Book ; Online: Carbon and oxygen isotope ratios, and geochemistry of the Precambrian-Cambrian Sukharikha River section, northwestern Siberian platform, supplementary data to: Kouchinsky, Artem; Bengtson, Stefan; Pavlov, Vladimir; Runnegar, Bruce; Torssander, Peter; Young, Edward; Ziegler, Karen (2007): Carbon isotope stratigraphy of the Precambrian-Cambrian Sukharikha River section, northwestern Siberian platform. Geological Magazine, 144(3), 1-10

    Kouchinsky, Artem / Bengtson, Stefan / Pavlov, Vladimir / Runnegar, Bruce / Torssander, Peter / Young, Edward / Ziegler, Karen

    2007  

    Abstract: A high-resolution carbon isotope profile through the uppermost Neoproterozoic-Lower Cambrian part of the Sukharikha section at the northwestern margin of the Siberian platform shows prominent secular oscillations of d13C with peak-to-peak range of 6-10 ?. ...

    Abstract A high-resolution carbon isotope profile through the uppermost Neoproterozoic-Lower Cambrian part of the Sukharikha section at the northwestern margin of the Siberian platform shows prominent secular oscillations of d13C with peak-to-peak range of 6-10 ?. There are six minima, 1n-6n, and seven maxima 1p-7p, in the Sukharikha Formation and a rising trend of d13C from the minimum 1n of -8.6 ? to maximum 6p of +6.4 ?. The trough 1n probably coincides with the isotopic minimum at the Precambrian-Cambrian boundary worldwide. Highly positive d13C values of peaks 5p and 6p are typical of the upper portion of the Precambrian-Cambrian transitional beds just beneath the Tommotian Stage in Siberia. A second rising trend of d13C is observed through the Krasnoporog and lower Shumny formations. It consists of four excursions with four major maxima that can be cor related with Tommotian-Botomian peaks II, IV, V, and VII of the reference profile from the southeastern Siberian platform. According to the chemostratigraphic cor relation, the first appearances of the index forms of archaeocyaths are earlier in the Sukharikha section than in the Lena-Aldan region.
    Language English
    Dates of publication 2007-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Online
    Note This dataset is supplement to doi:10.1017/S0016756807003354
    DOI 10.1594/PANGAEA.526943
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  5. Article ; Online: Escherichia coli Leucine-Responsive Regulatory Protein Bridges DNA

    Ziegler, Christine A / Freddolino, Peter L

    mBio

    2023  Volume 14, Issue 2, Page(s) e0269022

    Abstract: Feast-famine response proteins are a widely conserved class of global regulators in prokaryotes, the most highly studied of which is the Escherichia coli leucine-responsive regulatory protein (Lrp). Lrp senses the environmental nutrition status and ... ...

    Abstract Feast-famine response proteins are a widely conserved class of global regulators in prokaryotes, the most highly studied of which is the Escherichia coli leucine-responsive regulatory protein (Lrp). Lrp senses the environmental nutrition status and subsequently regulates up to one-third of the genes in E. coli, either directly or indirectly. Lrp exists predominantly as octamers and hexadecamers (16mers), where leucine is believed to shift the equilibrium toward the octameric state. In this study, we analyzed the effects of three oligomerization state mutants of Lrp in terms of their ability to bind to DNA and regulate gene expression in response to exogenous leucine. We find that oligomerization beyond dimers is required for Lrp's regulatory activity and that, contrary to previous speculation, exogenous leucine modulates Lrp activity at its target promoters exclusively by inhibiting Lrp binding to DNA. We also show evidence that Lrp binding bridges DNA over length scales of multiple kilobases, revealing a new range of mechanisms for Lrp-mediated transcriptional regulation.
    MeSH term(s) Leucine-Responsive Regulatory Protein/genetics ; Leucine-Responsive Regulatory Protein/metabolism ; Escherichia coli/metabolism ; Transcription Factors/metabolism ; Leucine/metabolism ; DNA-Binding Proteins/metabolism ; Escherichia coli Proteins/metabolism ; DNA/metabolism ; Bacteria/genetics ; Gene Expression Regulation, Bacterial ; Bacterial Proteins/metabolism
    Chemical Substances Leucine-Responsive Regulatory Protein (138791-20-5) ; Transcription Factors ; Leucine (GMW67QNF9C) ; DNA-Binding Proteins ; Escherichia coli Proteins ; DNA (9007-49-2) ; Bacterial Proteins
    Language English
    Publishing date 2023-02-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.02690-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Thesis: 14 Wege in den psychiatrischen Langzeitbereich

    Ziegler, Peter

    2000  

    Title variant Vierzehn Wege in den psychiatrischen Langzeitbereich
    Author's details vorgelegt von Peter Ziegler
    Language German
    Size 172, [5] Bl., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Hannover, Med. Hochsch., Diss., 2000
    HBZ-ID HT012992124
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2001 E 1227 order for loan Magazin

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  7. Article ; Online: Photostability of sennosides and their aglycones in solution.

    Meier, Nadja / Meier, Beat / Schenk, Alexander / Ziegler, Le Nhung / Peter, Samuel / Wolfram, Evelyn

    Phytochemical analysis : PCA

    2024  Volume 35, Issue 3, Page(s) 521–529

    Abstract: Introduction: Sennosides are the main active constituents of the dried leaves and/or pods of Senna alexandrina Mill. that are used as laxatives. A hypothesis is that aglycones are formed during the degradation of sennosides. However, it is unknown, ... ...

    Abstract Introduction: Sennosides are the main active constituents of the dried leaves and/or pods of Senna alexandrina Mill. that are used as laxatives. A hypothesis is that aglycones are formed during the degradation of sennosides. However, it is unknown, whether this happens under visible light exposure and how photosensitive sennosides behave in solution.
    Objectives: Pure anthraquinone glycosides were tested on their behaviour during sample preparation in the lab under visible light exposure in dependence on the instability of the solvent.
    Materials and methods: Samples before and after exposure were analysed using UHPLC with UV/Vis and MS detection.
    Results: Under visible light protection, the solutions were stable for 14 days at room temperature whereas a loss of 20%-60% was measured after 1 day of light exposure. The loss of sennosides due to degradation can be as fast as up to 2%-2.5% per hour, which might have a tremendous impact on phytochemical analysis results during the course of an analysis. The formation of aglycones was not observed in the degradation of sennosides and rhein-8-O-glucoside.
    Conclusion: Aglycones could not be found as a result of the forced degradation. The solutions of sennosides clearly need to be protected from light to obtain reliable analytical results, and light protection is a major point for the stability of liquid preparations.
    MeSH term(s) Sennosides ; Senna Extract/analysis ; Anthraquinones ; Senna Plant/metabolism ; Glucosides ; Plant Leaves/chemistry
    Chemical Substances Sennosides ; Senna Extract (8013-11-4) ; Anthraquinones ; Glucosides
    Language English
    Publishing date 2024-01-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1073576-8
    ISSN 1099-1565 ; 0958-0344
    ISSN (online) 1099-1565
    ISSN 0958-0344
    DOI 10.1002/pca.3308
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4608: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: Investigating Thymic Epithelial Cell Diversity Using Systems Biology.

    Chiu, Honyin / Linsley, Peter S / Ziegler, Steven F

    Journal of immunology (Baltimore, Md. : 1950)

    2023  Volume 210, Issue 7, Page(s) 888–894

    Abstract: The thymus is an intricate organ consisting of a diverse population of thymic epithelial cells (TECs). Cortical and medullary TECs and their subpopulations have distinct roles in coordinating the development and selection of functionally competent and ... ...

    Abstract The thymus is an intricate organ consisting of a diverse population of thymic epithelial cells (TECs). Cortical and medullary TECs and their subpopulations have distinct roles in coordinating the development and selection of functionally competent and self-tolerant T cells. Recent advances made in technologies such as single-cell RNA sequencing have made it possible to investigate and resolve the heterogeneity in TECs. These findings have provided further understanding of the molecular mechanisms regulating TEC function and expression of tissue-restricted Ags. In this brief review, we focus on the newly characterized subsets of TECs and their diversity in relation to their functions in supporting T cell development. We also discuss recent discoveries in expression of self-antigens in the context of TEC development as well as the cellular and molecular changes occurring during embryonic development to thymic involution.
    MeSH term(s) Systems Biology ; T-Lymphocytes ; Thymus Gland ; Epithelial Cells ; Cell Differentiation
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2200610
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.37: Show issues Location:
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    Zs.MG 28: Show issues

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  9. Book ; Online ; E-Book: Antibiotika-Fibel 2021/22

    Huggett, Susanne / Döring, Stefanie / Hauber, Hans-Peter / Kreft, Isabel / Stoehr, Albrecht / Wenner-Ziegler, Susanne / Wulffen, Hinrik von

    Rationale Antibiotikatherapie

    (Die Asklepios Praxisbibliothek)

    2021  

    Abstract: Cover -- Titel -- Liebe Leserinnen und Leser -- Vorwort -- Inhalt -- Hinweise zur Antibiotikatherapie -- Therapieversagen -- Antibiotic Stewardship (ABS) - ein Instrument zur Reduktion der Resistenzentwicklung -- 1 Infektion der Atemwege -- 1.1 ... ...

    Author's details S. Huggett, S. Döring,H.-P. Hauber, I. Kreft, A. Stoehr, S. Wenner-Ziegler, H. von Wulffen
    Series title Die Asklepios Praxisbibliothek
    Abstract Cover -- Titel -- Liebe Leserinnen und Leser -- Vorwort -- Inhalt -- Hinweise zur Antibiotikatherapie -- Therapieversagen -- Antibiotic Stewardship (ABS) - ein Instrument zur Reduktion der Resistenzentwicklung -- 1 Infektion der Atemwege -- 1.1 Infektexazerbation bei COPD -- 1.2 Ambulant erworbene Pneumonie -- 1.3 Nosokomiale Pneumonie -- 2 Harnwegsinfekte -- 2.1 Asymptomatische Bakteriurie -- 2.2 Unkomplizierte Harnwegsinfekte -- 2.3 Komplizierte Harnwegsinfekte -- 2.4 Infektionen in Schwangerschaft und Stillzeit1 -- 3 Abdominelle Infektionen -- 4 Chirurgische Infektionen -- 4.1 Postoperative Wundinfektion -- 4.2 Weichgewebeinfektionen -- 4.3 Knocheninfektionen -- 5 Gynäkologische Infektionen -- 6 Bakterielle Meningitis -- 6.1 Initialtherapie -- 6.2 Umgebungsprophylaxe bei Meningitis -- 7 Endokarditis -- 7.1 ESC Guideline 2015 -- 7.2 Kalkulierte Therapie -- 7.3 Gezielte Therapie -- 7.4 Endokarditisprophylaxe -- 8 Sepsis -- 9 Neutropenisches Fieber -- 9.1 Definitionen -- 9.2 Antimikrobielle Therapie -- 10 Infektionen im HNO- und MKG-Bereich -- 10.1 Infektionen des Halses und der Mundregion -- 10.2 Infektionen der Ohren -- 10.3 Infektionen der Nase und deren Komplikationen -- 11 Mykosen -- 11.1 Pilzinfektionen - HIV-positive Patienten -- 11.2 Pilzinfektionen - neutropenische Patienten -- 12 Perioperative Antibiotikaprophylaxe (PAP) -- 13 HIV-Postexpositionsprophylaxe (PEP) -- 14 Gezielte Antibiotikatherapie und Infektionen mit multiresistenten Erregern -- 14.1 Gezielte Antibiotikatherapie -- 14.2 Infektionen mit multiresistenten Erregern -- 15 Verfügbare Antiinfektiva in den Kliniken der Asklepios Kliniken Hamburg GmbH (03/21) -- 15.1 Antibiotika (24-h-Dosis = für Erwachsene) -- 15.2 Antimykotika -- 15.3 Virustatika (außer antiretrovirale Substanzen) -- 16 Empfehlungen zur (Höchst-)Dosierung bei Niereninsuffizienz und Hämodialyse.
    Keywords Electronic books
    Language German
    Size 1 Online-Ressource (x, 98 Seiten)
    Edition 8. Auflage
    Publisher Medizinisch Wissenschaftliche Verlagsgesellschaft
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Note Description based on publisher supplied metadata and other sources
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021015886
    ISBN 978-3-95466-618-8 ; 9783954666171 ; 3-95466-618-9 ; 3954666170
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  10. Book ; Online: Vorschlag zur Umsetzung von Massnahme 1 "Ein Prozess zur Errichtung von Referenzzentren wird definiert"

    Meier-Abt, Peter / Kind, Christian / Amstad, Hermann / Ziegler, Rita / Tobler, Andreas / Bounameaux, Henri / Nienhaus, Agnes

    Bericht der SAMW zuhanden des Bundesamtes für Gesundheit : Nationales Konzept Seltene Krankheiten

    2016  

    Institution Schweizerische Akademie der Medizinischen Wissenschaften
    Author's details SAMW, Schweizerische Akademie der Medizinischen Wissenschaften ; Arbeitsgruppe: Peter Meier-Abt, Christian Kind, Hermann Amstad (SAMW); Rita Ziegler, Andreas Tobler, Henri Bounameaux, Agnes Nienhaus (Universitäre Medizin Schweiz)
    Subject code 610
    Language German
    Size 1 Online-Ressource (12 Seiten), Illustrationen
    Publisher Schweizerische Akademie der Medizinischen Wissenschaften (SAMW)
    Publishing place Bern
    Publishing country Switzerland
    Document type Book ; Online
    HBZ-ID HT019763755
    DOI 10.4126/FRL01-006409151
    Database Repository for Life Sciences

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