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  1. Article: Ferrets (

    Khvatov, Ivan A / Sokolov, Alexey Yu / Kharitonov, Alexander N

    Animals : an open access journal from MDPI

    2023  Volume 13, Issue 3

    Abstract: Self-awareness is a complex phenomenon expressed as the ability of an individual to separate "self-entity" from "other entity". One of its earliest evolutionary components is body size awareness, namely, the ability to consider the boundaries of one's ... ...

    Abstract Self-awareness is a complex phenomenon expressed as the ability of an individual to separate "self-entity" from "other entity". One of its earliest evolutionary components is body size awareness, namely, the ability to consider the boundaries of one's own body as factors influencing interaction with surrounding objects. For ferrets,
    Language English
    Publishing date 2023-01-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13030444
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  2. Article ; Online: Ceruloplasmin Reduces the Lactoferrin/Oleic Acid Antitumor Complex-Mediated Release of Heme-Containing Proteins from Blood Cells.

    Elizarova, Anna Yu / Sokolov, Alexey V / Vasilyev, Vadim B

    International journal of molecular sciences

    2023  Volume 24, Issue 23

    Abstract: Our previous study showed that not only bovine lactoferrin (LF), the protein of milk and neutrophils, but also the human species forms complexes with oleic acid (OA) that inhibit tumor growth. Repeated injections of human LF in complex with OA (LF/8OA) ... ...

    Abstract Our previous study showed that not only bovine lactoferrin (LF), the protein of milk and neutrophils, but also the human species forms complexes with oleic acid (OA) that inhibit tumor growth. Repeated injections of human LF in complex with OA (LF/8OA) to hepatoma-carrying mice decelerated tumor growth and increased animals' longevity. However, whether the effect of the LF/8OA complex is directed exclusively against malignant cells was not studied. Hence, its effect on normal blood cells was assayed, along with its possible modulation of ceruloplasmin (CP), the preferred partner of LF among plasma proteins. The complex LF/8OA (6 μM) caused hemolysis, unlike LF alone or BSA/8OA (250 μM). The activation of neutrophils with exocytosis of myeloperoxidase (MPO), a potent oxidant, was induced by 1 μM LF/8OA, whereas BSA/8OA had a similar effect at a concentration increased by an order. The egress of heme-containing proteins, i.e., MPO and hemoglobin, from blood cells affected by LF/8OA was followed by a pronounced oxidative/halogenating stress. CP, which is the natural inhibitor of MPO, added at a concentration of 2 mol per 1 mol of LF/8OA abrogated its cytotoxic effect. It seems likely that CP can be used effectively in regulating the LF/8OA complex's antitumor activity.
    MeSH term(s) Mice ; Humans ; Animals ; Ceruloplasmin/metabolism ; Oleic Acid/pharmacology ; Lactoferrin/pharmacology ; Lactoferrin/metabolism ; Hemeproteins/metabolism ; Carcinoma, Hepatocellular ; Heme/metabolism
    Chemical Substances Ceruloplasmin (EC 1.16.3.1) ; Oleic Acid (2UMI9U37CP) ; Lactoferrin (EC 3.4.21.-) ; Hemeproteins ; Heme (42VZT0U6YR)
    Language English
    Publishing date 2023-11-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242316711
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  3. Article ; Online: Virtual Light Sensing Technology for Fast Calculation of Daylight Autonomy Metrics.

    Ershov, Sergey / Sokolov, Vadim / Galaktionov, Vladimir / Voloboy, Alexey

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 4

    Abstract: Virtual sensing technology uses mathematical calculations instead of natural measurements when the latter are too difficult or expensive. Nowadays, application of virtual light sensing technology becomes almost mandatory for daylight analysis at the ... ...

    Abstract Virtual sensing technology uses mathematical calculations instead of natural measurements when the latter are too difficult or expensive. Nowadays, application of virtual light sensing technology becomes almost mandatory for daylight analysis at the stage of architectural project development. Daylight Autonomy metrics should be calculated multiple times during the project. A properly designed building can reduce the necessity of artificial lighting, thus saving energy. There are two main daylight performance metrics: Spatial Daylight Autonomy (sDA) and Annual Sunlight Exposure (ASE). To obtain their values, we have to simulate global illumination for every hour of the year. A light simulation method should therefore be as efficient as possible for processing complex building models. In this paper we present a method for fast calculation of Daylight Autonomy metrics, allowing them to be calculated within a reasonable timescale. We compared our method with straightforward calculations and other existing solutions. This comparison demonstrates good agreement; this proves sufficient accuracy and higher efficiency of the method. Our method also contains an original algorithm for the automatic setting of the sensing area. The sDA metric is calculated considering blinds control, which should open or close them depending on overexposure to direct sunlight. Thus, we developed an optimization procedure to determine the blinds configuration at any time.
    Language English
    Publishing date 2023-02-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23042255
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  4. Article ; Online: Menthol dural application alters meningeal arteries tone and enhances excitability of trigeminocervical neurons in rats.

    Sokolov, Alexey Y / Mengal, Miran / Berkovich, Regina

    Brain research

    2023  Volume 1825, Page(s) 148725

    Abstract: Headaches, including migraines, can have a causal relationship to exposure to cold, and this relationship may be both positive and negative, as cold can both provoke and alleviate cephalgia. The role of thermoreceptors responsible for transduction of low ...

    Abstract Headaches, including migraines, can have a causal relationship to exposure to cold, and this relationship may be both positive and negative, as cold can both provoke and alleviate cephalgia. The role of thermoreceptors responsible for transduction of low temperatures belongs to the transient receptor potential cation channel subfamily melastatin member 8 (TRPM8). These channels mediate normal cooling sensation and have a role in both cold pain and cooling-mediated analgesia; they are seen as a potential target for principally new anti-migraine pharmaceuticals. Using a validated animal migraine models, we evaluated effects of menthol, the TRPM8-agonist, on trigeminovascular nociception. In acute experiments on male rats, effects of applied durally menthol solution in various concentrations on the neurogenic dural vasodilatation (NDV) and firing rate of dura-sensitive neurons of the trigeminocervical complex (TCC) were assessed. Application of menthol solution in concentrations of 5 % and 10 % was associated with NDV suppression, however amplitude reduction of the dilatation response caused not by the vascular dilatation degree decrease, but rather due to the significant increase of the meningeal arterioles' basal tone. In electrophysiological experiments the 1 % and 30 % menthol solutions intensified TCC neuron responses to the dural electrical stimulation while not changing their background activity. Revealed in our study excitatory effects of menthol related to the vascular as well as neuronal branches of the trigeminovascular system indicate pro-cephalalgic effects of TRPM8-activation and suggest feasibility of further search for new anti-migraine substances among TRPM8-antagonists.
    MeSH term(s) Rats ; Animals ; Male ; Female ; Menthol/pharmacology ; Meningeal Arteries ; TRPM Cation Channels ; Neurons ; Transient Receptor Potential Channels ; Caffeine ; Migraine Disorders ; Cold Temperature
    Chemical Substances Menthol (1490-04-6) ; TRPM Cation Channels ; Transient Receptor Potential Channels ; Caffeine (3G6A5W338E)
    Language English
    Publishing date 2023-12-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1200-2
    ISSN 1872-6240 ; 0006-8993
    ISSN (online) 1872-6240
    ISSN 0006-8993
    DOI 10.1016/j.brainres.2023.148725
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 161: Show issues Location:
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  5. Article: Membranes Based on PTMSP/PVTMS Blends for Membrane Contactor Applications.

    Kalmykov, Denis / Balynin, Alexey / Yushkin, Alexey / Grushevenko, Evgenia / Sokolov, Stepan / Malakhov, Alexander / Volkov, Alexey / Bazhenov, Stepan

    Membranes

    2022  Volume 12, Issue 11

    Abstract: In this work, perspective polymeric materials were developed for membrane contactor applications, e.g., for the dissolved oxygen removal from amine ... ...

    Abstract In this work, perspective polymeric materials were developed for membrane contactor applications, e.g., for the dissolved oxygen removal from amine CO
    Language English
    Publishing date 2022-11-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2614641-1
    ISSN 2077-0375
    ISSN 2077-0375
    DOI 10.3390/membranes12111160
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  6. Article: An Analysis of Medical Care Services for Children With Rare Diseases in the Russian Federation.

    Volgina, Svetlana Ya / Sokolov, Alexey A

    Frontiers in pharmacology

    2021  Volume 12, Page(s) 754073

    Abstract: Rare diseases continue to present numerous challenges for the medical field worldwide. Understanding innovative mechanisms of service provision for patients with rare conditions through shared communication across different healthcare systems should be ... ...

    Abstract Rare diseases continue to present numerous challenges for the medical field worldwide. Understanding innovative mechanisms of service provision for patients with rare conditions through shared communication across different healthcare systems should be encouraged. This study presents the organization of medical care for people with rare diseases in Russia, while also exploring the epidemiology of both life-threatening and chronic, progressive, rare diseases. Further, the regulation of medical care provision is examined, including the preferential provision of medicines in different Russian regions and potential role of compulsory medical insurance. The principles guiding patient referrals to appropriate specialist centres for rare diseases are outlined, including considering the increased role that public-patient organizations have in developing healthcare systems. In reviewing the specialized resources available for patients with rare diseases, medical genetics services offering diagnostics and counselling are discussed. Additionally, population-level preventive care necessitates significant investment, principally in diagnostic technology and screening programs. As seen elsewhere, these initiatives involve forming reference centres and tertiary-level pediatric departments staffed by multidisciplinary specialists in rare diseases. Numerous challenges are highlighted relating to Russian healthcare systems, including the financing of expensive treatments and ensuring equitable access to medical care for those patients with rare diseases outside of State-subsidized programs. Recommendations are made on creating international registries for knowledge sharing, quality appraisal, newborn screening, diagnostic challenges, available treatments and rehabilitation services. Given the high cost of rare diseases, cost-effective interventions are advisable, particularly developing preventive programs and targeting the most common and severe mutations in patients planning pregnancies.
    Language English
    Publishing date 2021-11-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.754073
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  7. Article ; Online: Mechanical Tensions Regulate Gene Expression in the

    Eroshkin, Fedor M / Fefelova, Elena A / Bredov, Denis V / Orlov, Eugeny E / Kolyupanova, Nataliya M / Mazur, Alexander M / Sokolov, Alexey S / Zhigalova, Nadezhda A / Prokhortchouk, Egor B / Nesterenko, Alexey M / Zaraisky, Andrey G

    International journal of molecular sciences

    2024  Volume 25, Issue 2

    Abstract: During gastrulation and neurulation, the chordamesoderm and overlying neuroectoderm of vertebrate embryos converge under the control of a specific genetic programme to the dorsal midline, simultaneously extending along it. However, whether mechanical ... ...

    Abstract During gastrulation and neurulation, the chordamesoderm and overlying neuroectoderm of vertebrate embryos converge under the control of a specific genetic programme to the dorsal midline, simultaneously extending along it. However, whether mechanical tensions resulting from these morphogenetic movements play a role in long-range feedback signaling that in turn regulates gene expression in the chordamesoderm and neuroectoderm is unclear. In the present work, by using a model of artificially stretched explants of
    MeSH term(s) Animals ; Stress, Mechanical ; Xenopus laevis/genetics ; 4-Butyrolactone ; Gene Expression
    Chemical Substances A-factor (Streptomyces) (51311-41-2) ; 4-Butyrolactone (OL659KIY4X)
    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25020870
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  8. Article ; Online: Guiding Self-Assembly of Active Colloids by Temporal Modulation of Activity.

    Zhang, Bo / Snezhko, Alexey / Sokolov, Andrey

    Physical review letters

    2022  Volume 128, Issue 1, Page(s) 18004

    Abstract: Self-organization phenomena in ensembles of self-propelled particles open pathways to the synthesis of new dynamic states not accessible by traditional equilibrium processes. The challenge is to develop a set of principles that facilitate the control and ...

    Abstract Self-organization phenomena in ensembles of self-propelled particles open pathways to the synthesis of new dynamic states not accessible by traditional equilibrium processes. The challenge is to develop a set of principles that facilitate the control and manipulation of emergent active states. Here, we report that dielectric rolling colloids energized by a pulsating electric field self-organize into alternating square lattices with a lattice constant controlled by the parameters of the field. We combine experiments and simulations to examine spatiotemporal properties of the emergent collective patterns and investigate the underlying dynamics of the self-organization.We reveal the resistance of the dynamic lattices to compression and expansion stresses leading to a hysteretic behavior of the lattice constant. The general mechanism of pattern synthesis and control in active ensembles via temporal modulation of activity can be applied to other active colloidal systems.
    Language English
    Publishing date 2022-01-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.128.018004
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    In stock of ZB MED Bonn / Germany

    Z 4' 58/153: Show issues

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  9. Article ; Online: Motility of acoustically powered micro-swimmers in a liquid crystalline environment.

    Katuri, Jaideep / Snezhko, Alexey / Sokolov, Andrey

    Soft matter

    2022  Volume 18, Issue 45, Page(s) 8641–8646

    Abstract: Suspensions of microswimmers in liquid crystals demonstrate remarkably complex dynamics and serve as a model system for studying active nematics. So far, experimental realization of microswimmers suspended in liquid crystalline media has relied on ... ...

    Abstract Suspensions of microswimmers in liquid crystals demonstrate remarkably complex dynamics and serve as a model system for studying active nematics. So far, experimental realization of microswimmers suspended in liquid crystalline media has relied on biological microorganisms that impose strict limitations on the compatible media and makes it difficult to regulate activity. Here, we demonstrate that acoustically powered bubble microswimmers can efficiently self-propel in a lyotropic liquid crystal. The velocity of the swimmers is controlled by the amplitude of the acoustic field. Histograms of swimming directions with respect to the local nematic field reveal a bimodal distribution: the swimmers tend to either fully align with or swim perpendicular to the director field of the liquid crystal, occasionally switching between these two states. The bubble-induced streaming from a swimmer locally melts the liquid crystal and produces topological defects at the tail of the swimmer. We show that the defect proliferation rate increases with the angle between the swimmer's velocity and the local orientation of the director field.
    MeSH term(s) Liquid Crystals/chemistry ; Models, Biological ; Swimming ; Acoustics ; Suspensions
    Chemical Substances Suspensions
    Language English
    Publishing date 2022-11-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2191476-X
    ISSN 1744-6848 ; 1744-683X
    ISSN (online) 1744-6848
    ISSN 1744-683X
    DOI 10.1039/d2sm01171a
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  10. Article ; Online: Influence of Type of Cross-Linking Agent on Structure and Transport Properties of Polydecylmethylsiloxane.

    Grushevenko, Evgenia / Rokhmanka, Tatiana / Sokolov, Stepan / Basko, Andrey / Borisov, Ilya / Pochivalov, Konstantin / Volkov, Alexey

    Polymers

    2023  Volume 15, Issue 22

    Abstract: The development of membrane materials with high transport and separation properties for the removal of higher hydrocarbons from gas mixtures is an important and complex task. This work examines the effect of a cross-linking agent on the structure and ... ...

    Abstract The development of membrane materials with high transport and separation properties for the removal of higher hydrocarbons from gas mixtures is an important and complex task. This work examines the effect of a cross-linking agent on the structure and transport properties of polydecylmethylsiloxane (C10), a material characterized by high selectivity towards C
    Language English
    Publishing date 2023-11-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15224436
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