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Article: Very unusual symptoms consistent with a possible migraine immediately following the injection of recombinant follitropin beta.

Check, J H

Clinical and experimental obstetrics & gynecology

2018 Volume 43, Issue 4, Page(s) 484–485

Abstract: Purpose: To present a new side effect of follitropin beta not shared with highly purified urinary follicle stimulating honnone (FSH).: Materials and methods: Follitropin beta was administered for preparation of in vitro fertilization-embryo transfer ( ...

Abstract	Purpose: To present a new side effect of follitropin beta not shared with highly purified urinary follicle stimulating honnone (FSH). Materials and methods: Follitropin beta was administered for preparation of in vitro fertilization-embryo transfer (IVF-ET). Results: Within a few minutes of injection of subcutaneously of follitropin beta, a 27-year-old woman developed a feeling of fever, headache, nausea, vomiting dizziness, and a visual aura consistent with migraine syndrome. These side effects did not occur when switched to highly purified urinary FSH. Conclusions: Since this reaction did not occur when injected with FSH not made with recombinant DNA technology, it is concluded that recombinant FSH (at least with follitropin beta) can produce an immediate migraine-like syndrome.
MeSH term(s)	Adult ; Embryo Transfer ; Female ; Fertilization in Vitro ; Follicle Stimulating Hormone/administration & dosage ; Follicle Stimulating Hormone, Human/adverse effects ; Humans ; Migraine with Aura/chemically induced ; Migraine with Aura/diagnosis ; Ovulation Induction ; Recombinant Proteins/adverse effects
Chemical Substances	Follicle Stimulating Hormone, Human ; Recombinant Proteins ; follitropin beta ; Follicle Stimulating Hormone (9002-68-0)
Language	English
Publishing date	2018-04-30
Publishing country	China
Document type	Case Reports ; Journal Article
ZDB-ID	754459-5
ISSN	0390-6663
ISSN	0390-6663
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Sympathetic neural hyperalgesia edema syndrome as a cause of autoimmune hearing loss.

Check, J H

Clinical and experimental obstetrics & gynecology

2018 Volume 44, Issue 1, Page(s) 133–134

Abstract: Purpose: To describe another previous unreported manifestation of the sympathetic neural hyperalgesia edema syndrome - autoimmune hearing loss.: Materials and methods: Dextroamphetamine sulfate 30 mg extended release capsules was given to a woman to ... ...

Abstract	Purpose: To describe another previous unreported manifestation of the sympathetic neural hyperalgesia edema syndrome - autoimmune hearing loss. Materials and methods: Dextroamphetamine sulfate 30 mg extended release capsules was given to a woman to try to help her conceive since, with her pelvic pain, chronic fatigue syndrome, and diarrhea, it was thought that an inflammatory condition related to permeation of unwanted chemicals into endometrial tissue related to the sympathetic neural hyperalgesia edema syndrome could be inhibiting her failure from conceiving despite three cycles of embryo transfer. Results: Not only did the symptoms mentioned above disappear, but she also noted marked improvement of hearing loss that had been present for several years. The improvement in hearing was documented by audiology tests and had not responded to many months of 15 mg/day prednisone. Conclusions: Autoimmune hearing loss (diagnosis established by her ear nose and throat specialist) should be added to the long list of manifestation of the sympathetic neural hyperalgesia edema syndrome.
MeSH term(s)	Adult ; Autoimmune Diseases/complications ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/drug therapy ; Autonomic Nervous System Diseases/complications ; Central Nervous System Stimulants/therapeutic use ; Dextroamphetamine/therapeutic use ; Edema/diagnosis ; Edema/etiology ; Female ; Hearing Loss/drug therapy ; Hearing Loss/etiology ; Humans ; Hyperalgesia/diagnosis ; Hyperalgesia/etiology ; Syndrome
Chemical Substances	Central Nervous System Stimulants ; Dextroamphetamine (TZ47U051FI)
Language	English
Publishing date	2018-11-07
Publishing country	China
Document type	Case Reports ; Journal Article
ZDB-ID	754459-5
ISSN	0390-6663
ISSN	0390-6663
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: An Editor's opinion of the recent committee opinion of the American Society for Reproductive Medicine that the luteal phase deficiency as a clinical entity causing infertility has not been proven.

Check, J H

Clinical and experimental obstetrics & gynecology

2018 Volume 43, Issue 4, Page(s) 479–483

Abstract: Purpose: To present an opposing view to the recent conclusions reached by the Practice Committee of the American Society for Reproductive Medicine and a recent review of the role of progesterone in subfertility by Sonntag and Ludwig that there is no ... ...

Abstract	Purpose: To present an opposing view to the recent conclusions reached by the Practice Committee of the American Society for Reproductive Medicine and a recent review of the role of progesterone in subfertility by Sonntag and Ludwig that there is no evidence to support using progesterone in the luteal phase as exclusive therapy. Materials and methods: A large quasi randomized study not mentioned by either review is presented. Results: In this study published in 1989 when women with luteal phase deficiencies and subfertil- ity were evaluated for follicular maturation, the majority seemed to form mature follicles. This majority group found far better with pregnancy outcome by taking exclusive progesterone in the luteal phase than follicle maturing drugs. A recent prospective series confirmed its beneficial effect. Conclusions: Physicians should not empirically treat with follicle maturing drugs but should use progesterone in the luteal phase, preferably in those women who seemingly create a mature follicle.
MeSH term(s)	Adult ; Female ; Humans ; Infertility, Female/etiology ; Luteal Phase ; Ovarian Diseases/complications ; Ovarian Diseases/drug therapy ; Ovarian Follicle/drug effects ; Pregnancy ; Progesterone/therapeutic use ; Prospective Studies ; Reproductive Medicine ; Societies, Medical ; United States
Chemical Substances	Progesterone (4G7DS2Q64Y)
Language	English
Publishing date	2018-04-30
Publishing country	China
Document type	Journal Article
ZDB-ID	754459-5
ISSN	0390-6663
ISSN	0390-6663
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1678: Show issues

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Article: A normal baby is possible despite twins following a single embryo transfer even if one twin is genetically defective.

Check, J H

Clinical and experimental obstetrics & gynecology

2018 Volume 44, Issue 2, Page(s) 185–186

Abstract: Purpose: To demonstrate that it is important to consider all possibilities when confronted with a decision to terminate a pregnancy because it is likely to be chromosomally abnormal.: Materials and methods: A cell free DNA test was performed on a ... ...

Abstract	Purpose: To demonstrate that it is important to consider all possibilities when confronted with a decision to terminate a pregnancy because it is likely to be chromosomally abnormal. Materials and methods: A cell free DNA test was performed on a woman with dichorionic diamniotic twins that followed the transfer of a single embryo. Results: The cell free DNA test was consistent with trisomy 21. Two perinatologists favored identical twins and thus suggested termination since both twins would be trisomy 21 and the couple did not want to raise a child with Down's syndrome. Our group suggested the possibility that these were fraternal twins with one occurring from natural conception. We suggested to forego termination by D&E but to undergo an amniocentesis at 16 weeks. One twin had obvious cardiac abnormalities by ultrasound and this one was reduced while amniocentesis with karyotype was performed on fetus 2. The results showed a normal male. Conclusions: One should consider all possibilities before suggesting termination of a very desired pregnancy. This woman had also been advised by other specialists in reproductive endocrinology that conception with her own oocytes (as did occur here) was not possible and she should consider donor oocytes based on her marked diminished oocyte reserve.
MeSH term(s)	Amniocentesis/methods ; Clinical Decision-Making ; Down Syndrome/diagnosis ; Down Syndrome/genetics ; Female ; Gestational Age ; Humans ; Karyotyping/methods ; Male ; Pregnancy ; Pregnancy Reduction, Multifetal/methods ; Single Embryo Transfer/methods ; Twins, Dizygotic/genetics ; Twins, Monozygotic/genetics
Language	English
Publishing date	2018-07-03
Publishing country	China
Document type	Journal Article
ZDB-ID	754459-5
ISSN	0390-6663
ISSN	0390-6663
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Clinical Effects of Inadvertent Increased Lipid Infusion in Neonates: Two Case Reports.

Hulgan, Christina Marie / Snow, Timothy / Check, Jennifer

Advances in neonatal care : official journal of the National Association of Neonatal Nurses

2022 Volume 23, Issue 1, Page(s) 23–30

Abstract: Background: Utility of total parenteral nutrition (TPN) with an intravenous lipid emulsion (IVLE) component is common in the neonatal intensive care unit; however, there are inherent risks to TPN use. With IVLE administered separate from other TPN ... ...

Abstract	Background: Utility of total parenteral nutrition (TPN) with an intravenous lipid emulsion (IVLE) component is common in the neonatal intensive care unit; however, there are inherent risks to TPN use. With IVLE administered separate from other TPN components, opportunities exist for additional error and subsequent potential harm. Clinical findings: We present 2 cases in term infants where IVLE infusions were noted to be inadvertently administered at higher than prescribed rates, prompting concern for lipemia and end-organ damage due to hyperviscosity. Primary diagnosis: Both infants developed iatrogenic hypertriglyceridemia and hyponatremia. Intervention: Upon recognition of the error, IVLE was immediately discontinued in each case. Triglyceride levels were serially monitored until they reached a normal level. Electrolyte panels and hepatic function panels were also drawn to assess for electrolyte derangements and function. Radiologic studies were performed for evaluation of end-organ effects of hyperviscosity. Outcomes: Triglyceride levels for both infants normalized within 7 hours. Both infants survived to discharge without any known effects related to the inadvertent excessive lipid infusion. Conclusion: It is helpful to perform a root-cause analysis for these types of events; have the exact amount of lipids in the bag needed and no overfill; consider having lipids in 4-hour dosage aliquots; require 2 nurses to verify infusion rates hourly; and educational sessions and unit protocols for any infusion may reduce the risk of administration error.
MeSH term(s)	Infant, Newborn ; Humans ; Fat Emulsions, Intravenous/adverse effects ; Parenteral Nutrition/adverse effects ; Lipids ; Triglycerides
Chemical Substances	Fat Emulsions, Intravenous ; Lipids ; Triglycerides
Language	English
Publishing date	2022-04-08
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2171013-2
ISSN	1536-0911 ; 1536-0903
ISSN (online)	1536-0911
ISSN	1536-0903
DOI	10.1097/ANC.0000000000000986
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 6005: Show issues

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Article: Chronic unremitting lower abdominal pain quickly abrogated following treatment with amphetamine.

Check, J H

Clinical and experimental obstetrics & gynecology

2016 Volume 43, Issue 1, Page(s) 109–111

Abstract: Purpose: To describe a cause and treatment for chronic unremitting lower abdominal pain of long duration with unknown origin.: Materials and methods: A 50-year-old woman with 30 years of unexplained right lower quadrant pain was treated with ... ...

Abstract	Purpose: To describe a cause and treatment for chronic unremitting lower abdominal pain of long duration with unknown origin. Materials and methods: A 50-year-old woman with 30 years of unexplained right lower quadrant pain was treated with dextroamphetamine sulfate. Results: Dramatic complete abrogation of the pain occurred within two weeks. The complete relief persisted for two years while she remains on therapy. Conclusions: Symphathetic neural hyperalgesia edema syndrome should be considered whenever there is refractory pelvic or abdominal pain.
MeSH term(s)	Abdominal Pain/drug therapy ; Amphetamine/therapeutic use ; Chronic Pain/drug therapy ; Female ; Humans ; Sympathomimetics/therapeutic use ; Time Factors ; Young Adult
Chemical Substances	Sympathomimetics ; Amphetamine (CK833KGX7E)
Language	English
Publishing date	2016-02-24
Publishing country	China
Document type	Case Reports ; Journal Article
ZDB-ID	754459-5
ISSN	0390-6663
ISSN	0390-6663
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Dextroamphetamine sulfate treatment eradicates long-term chronic severe headaches from temporomandibular joint syndrome--a case that emphasizes the role of the gynecologist in treating headaches in women.

Check, J H

Clinical and experimental obstetrics & gynecology

2016 Volume 43, Issue 1, Page(s) 119–122

Abstract: Purpose: To test sympathomimetic amine therapy on another type of chronic headache syndrome--headaches from temporal mandibular joint (TMJ) syndrome.: Materials and methods: A woman with 20 years of severe daily pain from TMJ refractory to all ... ...

Abstract	Purpose: To test sympathomimetic amine therapy on another type of chronic headache syndrome--headaches from temporal mandibular joint (TMJ) syndrome. Materials and methods: A woman with 20 years of severe daily pain from TMJ refractory to all therapies was treated with dextroamphetamine sulfate. Results: The woman showed immediate 100% relief from sympathomimetic amine treatment saving her from an expensive jaw breaking operation that was only given a slight chance of helping. Conclusions: Unfortunately most treating physicians are unaware of this defect of sympathetic nervous system hypofunction leading to the absorption of toxins, which when it involves brain tissue, leads to severe headaches. Thus, the gynecologist who is aware of this syndrome because sympathetic nervous system hypofunction is the most common cause of pelvic pain, may need to intervene in women with chronic headaches, even TMJ.
MeSH term(s)	Adult ; Central Nervous System Stimulants/administration & dosage ; Dextroamphetamine/administration & dosage ; Dose-Response Relationship, Drug ; Female ; Gynecology/methods ; Headache/drug therapy ; Headache/etiology ; Humans ; Physician's Role ; Temporomandibular Joint Dysfunction Syndrome/complications ; Temporomandibular Joint Dysfunction Syndrome/drug therapy
Chemical Substances	Central Nervous System Stimulants ; Dextroamphetamine (TZ47U051FI)
Language	English
Publishing date	2016-02-24
Publishing country	China
Document type	Case Reports ; Journal Article
ZDB-ID	754459-5
ISSN	0390-6663
ISSN	0390-6663
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

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Article: Increased tissue permeability and sympathetic nervous system hypofunction may be the common link between dysmenorrhea, chronic pelvic pain, Mittelschmerz, and Crohn's disease.

Check, J H

Clinical and experimental obstetrics & gynecology

2016 Volume 43, Issue 1, Page(s) 112–113

Abstract: Purpose: To determine if severe periovulatory diarrhea in a woman with Crohn's disease for just one day may be related to increased permeability of the large bowel related to hormonal changes that occur at this time of menstrual cycle.: Materials and ... ...

Abstract	Purpose: To determine if severe periovulatory diarrhea in a woman with Crohn's disease for just one day may be related to increased permeability of the large bowel related to hormonal changes that occur at this time of menstrual cycle. Materials and methods: Dextroamphetamine sulfate was given to a woman whose Crohn's disease was markedly improved by adalimumab but who still had one day of severe diarrhea at mid-cycle. Results: She did not have any diarrhea or frequent defecation for the first two periovulatory times before she achieved pregnancy. Previously for two years there had not been one month where she did not have the severe periovulatory diarrhea. Conclusions: This case helps support the concept that the classic symptoms of Mittelschmerz in women with endometriosis may be related to periovulatory events which either cause increased permeability of an already compromised tissue, whether it be pelvic or bowel or other tissues, or these periovulatory events impair sympathetic nervous system function, which is already impaired.
MeSH term(s)	Adult ; Autonomic Nervous System Diseases/complications ; Autonomic Nervous System Diseases/metabolism ; Autonomic Nervous System Diseases/physiopathology ; Chronic Pain/diagnosis ; Chronic Pain/etiology ; Chronic Pain/metabolism ; Dysmenorrhea/diagnosis ; Dysmenorrhea/etiology ; Dysmenorrhea/metabolism ; Female ; Humans ; Pelvic Pain/diagnosis ; Pelvic Pain/etiology ; Pelvic Pain/metabolism ; Permeability
Language	English
Publishing date	2016-02-24
Publishing country	China
Document type	Case Reports ; Journal Article
ZDB-ID	754459-5
ISSN	0390-6663
ISSN	0390-6663
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Intravenous intralipid therapy is not beneficial in having a live delivery in women aged 40-42 years with a previous history of miscarriage or failure to conceive despite embryo transfer undergoing in vitro fertilization-embryo transfer.

Check, J H / Check, D L

Clinical and experimental obstetrics & gynecology

2016 Volume 43, Issue 1, Page(s) 14–15

Abstract: Purpose: To evaluate the efficacy of intralipid intravenous infusion in achieving a live pregnancy following IVF--embryo transfer in women of advanced reproductive age (40-42 years).: Materials and methods: A matched control was performed. Women aged ...

Abstract	Purpose: To evaluate the efficacy of intralipid intravenous infusion in achieving a live pregnancy following IVF--embryo transfer in women of advanced reproductive age (40-42 years). Materials and methods: A matched control was performed. Women aged 40-42 with a previous history of miscarriage or who failed to conceive despite previous embryo transfer who entered an IVF program were offered intravenous intralipid therapy (four ml of 20% liposyn II in 100 ml normal saline over one hour) during the mid-follicular phase. Clinical pregnancy rates (eight weeks with viable gestation) and live delivered pregnancy rates were then determined and compared. Results: The results were evaluated after ten matched cycles. There were no clinical pregnancies in those receiving intralipid vs. a 40% clinical and a 30% live delivered pregnancy rate in the untreated controls (p = 0.087, Fisher's exact test). The study was terminated because of these preliminary data. Conclusions: In the test tube, adding intralipid to natural killer cells can inhibit their cytolytic action. However, the use of intravenous intralipid to suppress natural killer cell activity does not seem to improve the chance of a live delivery in women aged 40-42 years with a previous history of miscarriage. In fact this therapy may actually be detrimental in this age group. Since efficacy of this therapy was not found in a group of advanced reproductive age, it is not clear why this should be effective for a younger population. A controlled study for the younger group is needed. Perhaps such a study could be limited to only those with miscarriage rather than also concluding failure to conceive despite embryo transfer. Intralipid failed to improve live delivered pregnancy rates in women with prior miscarriage or previous failure with embryo transfer.
MeSH term(s)	Abortion, Spontaneous ; Adult ; Delivery, Obstetric/methods ; Embryo Transfer/methods ; Emulsions/administration & dosage ; Fat Emulsions, Intravenous/administration & dosage ; Female ; Fertilization in Vitro/methods ; Humans ; Infusions, Intravenous ; Phospholipids/administration & dosage ; Pregnancy ; Pregnancy Rate ; Soybean Oil/administration & dosage
Chemical Substances	Emulsions ; Fat Emulsions, Intravenous ; Phospholipids ; soybean oil, phospholipid emulsion ; Soybean Oil (8001-22-7)
Language	English
Publishing date	2016-02-24
Publishing country	China
Document type	Journal Article
ZDB-ID	754459-5
ISSN	0390-6663
ISSN	0390-6663
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Influence of the conclusion of a recent large cooperative study in changing standard protocol of inducing menses in anovulatory women with oligomenorrhea prior to initiating ovulation induction with anti-estrogens and outcome.

Check, J H / Liss, J R / Check, D

Clinical and experimental obstetrics & gynecology

2018 Volume 44, Issue 2, Page(s) 180–182

Abstract: Purpose: To compare pregnancy rates following ovulation induction in anovulatory women with clomiphene citrate vs. letrozole and to determine the relative confounding effect of inducing menses or not. The study also evaluated whether starting these anti- ...

Abstract	Purpose: To compare pregnancy rates following ovulation induction in anovulatory women with clomiphene citrate vs. letrozole and to determine the relative confounding effect of inducing menses or not. The study also evaluated whether starting these anti-estrogen drugs later in the menstrual cycle has-less adverse effect on endometrial thickness. Materials and methods: Prospective series with choice by physician of inducing menses or not or choosing clomiphene citrate or letrozole for ovulation induction. Peak endometrial thickness was compared between drugs and between those conceiving or not. Results: There were 21 first cycles using letrozole and 42 using clomiphene. Menses were not induced in 18/21 (86%) letrozole cycles and 24/42 (57%) clomiphene cycles. Clinical pregnancies occurred in four (22.2%) letrozole cycles without induced menses with one miscarriage vs. 4/24 (16.6%) clomiphene cycles, no mis- carriage. One of three (33.3%) letrozole cycles with menses induced achieved a clinical pregnancy vs. only 1/18 (5.5%) of clomiphene cycles. There were no miscarriages. Conclusions: Though the endometrial thickness was higher with clomiphene without induced menses vs. menses induced (11 mm vs. 9.5 mm), one cannot explain the trend for lower pregnancy rates in women with induced menses because of thinner endometria since the thickness was 10.3 mm for clomiphene and 10.0 with letrozole.
MeSH term(s)	Adult ; Anovulation/drug therapy ; Clomiphene/therapeutic use ; Endometrium/drug effects ; Endometrium/pathology ; Estrogen Antagonists/therapeutic use ; Estrogens/pharmacology ; Female ; Fertility Agents, Female/therapeutic use ; Humans ; Letrozole ; Nitriles/therapeutic use ; Oligomenorrhea/drug therapy ; Ovulation Induction/methods ; Polycystic Ovary Syndrome/drug therapy ; Pregnancy ; Pregnancy Rate ; Triazoles/therapeutic use
Chemical Substances	Estrogen Antagonists ; Estrogens ; Fertility Agents, Female ; Nitriles ; Triazoles ; Clomiphene (1HRS458QU2) ; Letrozole (7LKK855W8I)
Language	English
Publishing date	2018-07-03
Publishing country	China
Document type	Journal Article
ZDB-ID	754459-5
ISSN	0390-6663
ISSN	0390-6663
Database	MEDical Literature Analysis and Retrieval System OnLINE

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