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  1. Article ; Online: The yield of tuberculosis contact investigation on relapsed TB patients and analysis of associated risk factors: Singapore's experience.

    Kyaw, Win M / Lim, Leo K-Y / Tay, Jun Y / Cutter, Jeffery L / Ng, Deborah H L

    Epidemiology and infection

    2024  Volume 152, Page(s) e26

    Abstract: The yield of contact investigation on relapsed tuberculosis (TB) cases can guide strategies and resource allocation in the TB control programme. We conducted a retrospective cohort study to review the yield of contact investigation in relapsed TB cases ... ...

    Abstract The yield of contact investigation on relapsed tuberculosis (TB) cases can guide strategies and resource allocation in the TB control programme. We conducted a retrospective cohort study to review the yield of contact investigation in relapsed TB cases and identify factors associated with TB infection (TBI) among close contacts of relapsed TB cases notified between 2018 and 2022 in Singapore. TB infection positivity was higher among contacts of relapsed cases which were culture-positive
    MeSH term(s) Humans ; Contact Tracing ; Retrospective Studies ; Singapore/epidemiology ; Tuberculosis/epidemiology ; Tuberculosis/diagnosis ; Mycobacterium tuberculosis ; Latent Tuberculosis/epidemiology
    Language English
    Publishing date 2024-01-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 632982-2
    ISSN 1469-4409 ; 0950-2688
    ISSN (online) 1469-4409
    ISSN 0950-2688
    DOI 10.1017/S0950268824000104
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  2. Article ; Online: Implementation of national whole-genome sequencing of

    Lim, Ansel Yi Herh / Ang, Michelle L T / Cho, Sharol S L / Ng, Deborah H L / Cutter, Jeffery / Lin, Raymond T P

    Microbial genomics

    2023  Volume 9, Issue 11

    Abstract: The National Tuberculosis Programme (NTBP) monitors the occurrence and spread of tuberculosis (TB) and multidrug-resistant TB (MDR-TB) in Singapore. Since 2020, whole-genome sequencing (WGS) ... ...

    Abstract The National Tuberculosis Programme (NTBP) monitors the occurrence and spread of tuberculosis (TB) and multidrug-resistant TB (MDR-TB) in Singapore. Since 2020, whole-genome sequencing (WGS) of
    MeSH term(s) Animals ; Horses ; Mycobacterium tuberculosis ; Antitubercular Agents/pharmacology ; Microbial Sensitivity Tests ; Public Health ; Singapore/epidemiology ; Drug Resistance, Multiple, Bacterial/genetics ; Tuberculosis, Multidrug-Resistant/epidemiology ; Tuberculosis, Multidrug-Resistant/microbiology ; Tuberculosis/epidemiology
    Chemical Substances Antitubercular Agents
    Language English
    Publishing date 2023-11-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835258-0
    ISSN 2057-5858 ; 2057-5858
    ISSN (online) 2057-5858
    ISSN 2057-5858
    DOI 10.1099/mgen.0.001139
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  3. Article: Into the shadow: a reflection on the stigma of human immunodeficiency virus (HIV) in Singapore.

    Ng, Deborah H L

    Annals of the Academy of Medicine, Singapore

    2012  Volume 41, Issue 12, Page(s) 625–627

    MeSH term(s) HIV Infections/economics ; HIV Infections/psychology ; HIV Infections/transmission ; Humans ; Refusal to Treat ; Singapore ; Social Stigma
    Language English
    Publishing date 2012-12-04
    Publishing country Singapore
    Document type Letter
    ZDB-ID 604527-3
    ISSN 0304-4602
    ISSN 0304-4602
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    Zs.B 2420: Show issues Location:
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  4. Article: Examining a Continuous Glucose Monitoring Plus Online Peer Support Community Intervention to Support Hispanic Adults With Type 2 Diabetes: Protocol for a Mixed Methods Feasibility Study.

    Ng, Ashley H / Greenwood, Deborah A / Iacob, Eli / Allen, Nancy A / Ferrer, Mila / Rodriguez, Bruno / Litchman, Michelle L

    JMIR research protocols

    2022  Volume 11, Issue 2, Page(s) e31595

    Abstract: Background: Type 2 diabetes is twice as likely to affect Hispanic people than their White counterparts. Technology and social support may be an important part of behavior change. In this study, we address gaps in diabetes care for Hispanic Spanish- ... ...

    Abstract Background: Type 2 diabetes is twice as likely to affect Hispanic people than their White counterparts. Technology and social support may be an important part of behavior change. In this study, we address gaps in diabetes care for Hispanic Spanish-speaking people with diabetes through an online peer support community (OPSC) pilot intervention using Hispanic Spanish-speaking peer facilitators with diabetes to enhance the use of continuous glucose monitoring (CGM) for diabetes management.
    Objective: This study aims to address gaps in diabetes care for Hispanic Spanish-speaking people with diabetes through an OPSC pilot intervention using Hispanic Spanish-speaking peer facilitators with diabetes to enhance the use of CGM for diabetes management.
    Methods: A mixed-methods, pre-post test design will be used in this feasibility study. A total of 50 Hispanic participants with type 2 diabetes willing to wear a continuous glucose monitor for 13 weeks will be recruited. Hispanic Spanish-speaking peer facilitators with diabetes and experience wearing a continuous glucose monitor will be employed and undergo training. Peer facilitators will help participants learn how CGM data can inform behavior changes via an OPSC. Participants will interact with the private OPSC at least three times a week. Weekly questions and prompts derived from the Association of Diabetes Care and Education Specialists, previously American Association of Diabetes Educators, and seven self-care behaviors will be delivered by peer facilitators to engage participants. Measures of feasibility and acceptability will be determined by the percentage of participants who enroll, complete the study, and use CGM (number of scans) and objective metrics from the OPSC. Efficacy potential outcomes include change in time in range of 70 to 180 mg/dL from baseline to 12 weeks, A
    Results: Funding for this project was secured in November 2018 and approved by the institutional review board in April 2019. Peer facilitator recruitment and training were undertaken in the second half of 2019, with participant recruitment and data collection conducted in January and April 2020. The study has now concluded.
    Conclusions: This study will generate new evidence about the use of an OPSC for Hispanic Spanish-speaking patients with diabetes to make behavior changes incorporating feedback from CGM.
    Trial registration: ClinicalTrials.gov NCT03799796; https://clinicaltrials.gov/ct2/show/NCT03799796.
    International registered report identifier (irrid): RR1-10.2196/31595.
    Language English
    Publishing date 2022-02-24
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2719222-2
    ISSN 1929-0748
    ISSN 1929-0748
    DOI 10.2196/31595
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  5. Article ; Online: "Locked in a cage"-A case of dengue virus 4 encephalitis.

    Deborah H L Ng / Sapna P Sadarangani

    PLoS Neglected Tropical Diseases, Vol 11, Iss 5, p e

    2017  Volume 0005369

    Keywords Arctic medicine. Tropical medicine ; RC955-962 ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2017-05-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: "Locked in a cage"-A case of dengue virus 4 encephalitis.

    Ng, Deborah H L / Sadarangani, Sapna P

    PLoS neglected tropical diseases

    2017  Volume 11, Issue 5, Page(s) e0005369

    MeSH term(s) Acyclovir/therapeutic use ; Antiviral Agents/therapeutic use ; Dengue/drug therapy ; Dengue/pathology ; Dengue/virology ; Encephalitis, Viral/drug therapy ; Encephalitis, Viral/pathology ; Encephalitis, Viral/virology ; Endemic Diseases ; Female ; Humans ; Middle Aged
    Chemical Substances Antiviral Agents ; Acyclovir (X4HES1O11F)
    Language English
    Publishing date 2017-05-04
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2727
    ISSN (online) 1935-2735
    ISSN 1935-2727
    DOI 10.1371/journal.pntd.0005369
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  7. Article ; Online: Functional analysis of germline VANGL2 variants using rescue assays of vangl2 knockout zebrafish.

    Derrick, Christopher J / Szenker-Ravi, Emmanuelle / Santos-Ledo, Adrian / Alqahtani, Ahlam / Yusof, Amirah / Eley, Lorraine / Coleman, Alistair H L / Tohari, Sumanty / Ng, Alvin Yu-Jin / Venkatesh, Byrappa / Alharby, Essa / Mansard, Luke / Bonnet-Dupeyron, Marie-Noelle / Roux, Anne-Francoise / Vaché, Christel / Roume, Joëlle / Bouvagnet, Patrice / Almontashiri, Naif A M / Henderson, Deborah J /
    Reversade, Bruno / Chaudhry, Bill

    Human molecular genetics

    2023  Volume 33, Issue 2, Page(s) 150–169

    Abstract: Developmental studies have shown that the evolutionarily conserved Wnt Planar Cell Polarity (PCP) pathway is essential for the development of a diverse range of tissues and organs including the brain, spinal cord, heart and sensory organs, as well as ... ...

    Abstract Developmental studies have shown that the evolutionarily conserved Wnt Planar Cell Polarity (PCP) pathway is essential for the development of a diverse range of tissues and organs including the brain, spinal cord, heart and sensory organs, as well as establishment of the left-right body axis. Germline mutations in the highly conserved PCP gene VANGL2 in humans have only been associated with central nervous system malformations, and functional testing to understand variant impact has not been performed. Here we report three new families with missense variants in VANGL2 associated with heterotaxy and congenital heart disease p.(Arg169His), non-syndromic hearing loss p.(Glu465Ala) and congenital heart disease with brain defects p.(Arg135Trp). To test the in vivo impact of these and previously described variants, we have established clinically-relevant assays using mRNA rescue of the vangl2 mutant zebrafish. We show that all variants disrupt Vangl2 function, although to different extents and depending on the developmental process. We also begin to identify that different VANGL2 missense variants may be haploinsufficient and discuss evidence in support of pathogenicity. Together, this study demonstrates that zebrafish present a suitable pipeline to investigate variants of unknown significance and suggests new avenues for investigation of the different developmental contexts of VANGL2 function that are clinically meaningful.
    MeSH term(s) Animals ; Humans ; Cell Polarity/genetics ; Germ Cells/metabolism ; Germ-Line Mutation/genetics ; Heart Defects, Congenital/genetics ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Zebrafish/genetics ; Zebrafish/metabolism ; Zebrafish Proteins/genetics
    Chemical Substances Membrane Proteins ; VANGL1 protein, zebrafish ; vangl2 protein, zebrafish ; Zebrafish Proteins
    Language English
    Publishing date 2023-10-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1108742-0
    ISSN 1460-2083 ; 0964-6906
    ISSN (online) 1460-2083
    ISSN 0964-6906
    DOI 10.1093/hmg/ddad171
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    Zs.A 3469: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article: Fever Patterns, Cytokine Profiles, and Outcomes in COVID-19.

    Ng, Deborah H L / Choy, Chiaw Yee / Chan, Yi-Hao / Young, Barnaby E / Fong, Siew-Wai / Ng, Lisa F P / Renia, Laurent / Lye, David C / Chia, Po Ying

    Open forum infectious diseases

    2020  Volume 7, Issue 9, Page(s) ofaa375

    Abstract: Background: Prolonged fever is associated with adverse outcomes in dengue viral infection. Similar fever patterns are observed in COVID-19 with unclear significance.: Methods: We conducted a hospital-based case-control study of patients admitted for ... ...

    Abstract Background: Prolonged fever is associated with adverse outcomes in dengue viral infection. Similar fever patterns are observed in COVID-19 with unclear significance.
    Methods: We conducted a hospital-based case-control study of patients admitted for COVID-19 with prolonged fever (fever >7 days) and saddleback fever (recurrence of fever, lasting <24 hours, after defervescence beyond day 7 of illness). Fever was defined as a temperature of ≥38.0°C. Cytokines were determined with multiplex microbead-based immunoassay for a subgroup of patients. Adverse outcomes were hypoxia, intensive care unit (ICU) admission, mechanical ventilation, and mortality.
    Results: A total of 142 patients were included in the study; 12.7% (18/142) of cases had prolonged fever, and 9.9% (14/142) had saddleback fever. Those with prolonged fever had a median duration of fever (interquartile range [IQR]) of 10 (9-11) days for prolonged fever cases, while fever recurred at a median (IQR) of 10 (8-12) days for those with saddleback fever. Both prolonged (27.8% vs 0.9%;
    Conclusions: Prolonged fever beyond 7 days from onset of illness can identify patients who may be at risk of adverse outcomes from COVID-19. Patients with saddleback fever appeared to have good outcomes regardless of the fever.
    Keywords covid19
    Language English
    Publishing date 2020-08-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofaa375
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  9. Article: Fever Patterns, Cytokine Profiles and Outcomes in Covid-19

    Ng, Deborah H. L. / Choy, Chiaw Yee / Chan, Yi-Hao / Young, Barnaby E. / Fong, Siew-Wai / Ng, Lisa F. P. / Renia, Laurent / Lye, David C. / Chia, Po Ying

    Open Forum Infectious Diseases

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #729189
    Database COVID19

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  10. Article ; Online: Environmental colonization and onward clonal transmission of carbapenem-resistant

    Ng, Deborah H L / Marimuthu, Kalisvar / Lee, Jia Jun / Khong, Wei Xin / Ng, Oon Tek / Zhang, Wei / Poh, Bee Fong / Rao, Pooja / Raj, Maya Devi Rajinder / Ang, Brenda / De, Partha Pratim

    Antimicrobial resistance and infection control

    2018  Volume 7, Page(s) 51

    Abstract: Background: In May 2015, we noticed an increase in carbapenem-resistant : Methods: We conducted a one-day point prevalence screening (PPS) of the patients and environment in the MICU. We screened patients using endotracheal tube aspirates and swabs ... ...

    Abstract Background: In May 2015, we noticed an increase in carbapenem-resistant
    Methods: We conducted a one-day point prevalence screening (PPS) of the patients and environment in the MICU. We screened patients using endotracheal tube aspirates and swabs from nares, axillae, groin, rectum, wounds, and exit sites of drains. We collected environmental samples from patients' rooms and environment outside the patients' rooms. CRAB isolates from the PPS and clinical samples over the subsequent one month were studied for genetic relatedness by whole genome sequencing (WGS).
    Results: We collected 34 samples from seven patients and 244 samples from the environment. On the day of PPS, we identified 8 CRAB carriers: 3 who screened positive and 5 previously known clinical infections. We detected environmental contamination in nearly two-thirds of the rooms housing patients with CRAB. WGS demonstrated genetic clustering of isolates within rooms but not across rooms. We analysed 4 CRAB isolates from clinical samples following the PPS. One genetically-related CRAB was identified in the respiratory sample of a patient with nosocomial pneumonia, who was admitted to the MICU five days after the PPS.
    Conclusion: The extensive environmental colonization of CRAB by patients highlights the importance of environmental hygiene. The transmission dynamics of CRAB needs further investigation.
    MeSH term(s) Acinetobacter Infections/epidemiology ; Acinetobacter Infections/microbiology ; Acinetobacter Infections/transmission ; Acinetobacter baumannii/classification ; Acinetobacter baumannii/drug effects ; Acinetobacter baumannii/isolation & purification ; Anti-Bacterial Agents/pharmacology ; Carbapenems/pharmacology ; Cross Infection/epidemiology ; Drug Resistance, Multiple, Bacterial/physiology ; Female ; Humans ; Hygiene ; Intensive Care Units/statistics & numerical data ; Intubation/adverse effects ; Male ; Mass Screening ; Microbial Sensitivity Tests
    Chemical Substances Anti-Bacterial Agents ; Carbapenems
    Language English
    Publishing date 2018-04-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2666706-X
    ISSN 2047-2994 ; 2047-2994
    ISSN (online) 2047-2994
    ISSN 2047-2994
    DOI 10.1186/s13756-018-0343-z
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