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  1. Article ; Online: Validation of tag SNPs for multiple sclerosis HLA risk alleles across the 1000 genomes panel.

    Boullerne, Anne I / Goudey, Benjamin / Paganini, Julien / Erlichster, Michael / Gaitonde, Sujata / Feinstein, Douglas L

    Human immunology

    2024  , Page(s) 110790

    Abstract: Currently, the genetic variants strongly associated with risk for Multiple Sclerosis (MS) are located in the Major Histocompatibility Complex. This includes DRB1*15:01 and DRB1*15:03 alleles at the HLA-DRB1 locus, the latter restricted to African ... ...

    Abstract Currently, the genetic variants strongly associated with risk for Multiple Sclerosis (MS) are located in the Major Histocompatibility Complex. This includes DRB1*15:01 and DRB1*15:03 alleles at the HLA-DRB1 locus, the latter restricted to African populations; the DQB1*06:02 allele at the HLA-DQB1 locus which is in high linkage disequilibrium (LD) with DRB1*15:01; and protective allele A*02:01 at the HLA-A locus. HLA allele identification is facilitated by co-inherited ('tag') single nucleotide polymorphisms (SNPs); however, SNP validation is not typically done outside of the discovery population. We examined 19 SNPs reported to be in high LD with these alleles in 2,502 healthy subjects included in the 1000 Genomes panel having typed HLA data. Examination of 3 indices (LD R
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 801524-7
    ISSN 1879-1166 ; 0198-8859
    ISSN (online) 1879-1166
    ISSN 0198-8859
    DOI 10.1016/j.humimm.2024.110790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Assessing widening disparities in HbA1c and systolic blood pressure retesting during the COVID-19 pandemic in an LGBTQ+-focused federally qualified health center in Chicago: a retrospective cohort study using electronic health records.

    Rivera, Adovich S / Plank, Megan / Davis, Ash / Feinstein, Matthew J / Rusie, Laura K / Beach, Lauren B

    BMJ open diabetes research & care

    2023  Volume 10, Issue 6

    Abstract: Introduction: To assess disparities in retesting for glycated hemoglobin (HbA1c) and systolic blood pressure (SBP) among people with diabetes mellitus (DM) and hypertension (HTN), respectively, we analyzed medical records from a lesbian, gay, bisexual, ... ...

    Abstract Introduction: To assess disparities in retesting for glycated hemoglobin (HbA1c) and systolic blood pressure (SBP) among people with diabetes mellitus (DM) and hypertension (HTN), respectively, we analyzed medical records from a lesbian, gay, bisexual, transgender, queer-specialized federally qualified health center with multiple sites in Chicago.
    Research design and methods: We identified people with DM seen in 2018 and 2019 then assessed if individuals had HbA1c retested the following year (2019 and 2020). We repeated this using SBP for people with HTN. Rates of retesting were compared across gender, sexual orientation, and race and ethnicity and across the 2 years for each categorization with adjustment for socioeconomic indicators.
    Results: Retesting rates declined from 2019 to 2020 for both HbA1c and SBP overall and across all groups. Cisgender women and transgender men with DM (vs cisgender men) and straight people (vs gay men) had significantly lower odds of HbA1c retesting for both years. There was evidence of widening of HbA1c retesting disparities in 2020 between gay men and other orientations. Cisgender women, straight people, and black people (vs white) with HTN had significantly lower odds of SBP retesting for both years. There was evidence of narrowing in the retesting gap between black and white people with HTN, but this was due to disproportionate increase in no retesting in white people rather than a decline in no retesting among black people with HTN.
    Conclusions: Disparities in DM and HTN care according to gender, race, ethnicity, and sexual orientation persisted during the pandemic with significant widening according to sexual orientation.
    MeSH term(s) Humans ; Male ; Female ; Glycated Hemoglobin ; Pandemics ; Electronic Health Records ; Retrospective Studies ; Blood Pressure ; Chicago/epidemiology ; Healthcare Disparities ; COVID-19/diagnosis ; COVID-19/epidemiology ; Sexual and Gender Minorities
    Chemical Substances Glycated Hemoglobin
    Language English
    Publishing date 2023-01-30
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2732918-5
    ISSN 2052-4897 ; 2052-4897
    ISSN (online) 2052-4897
    ISSN 2052-4897
    DOI 10.1136/bmjdrc-2022-002990
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  3. Article ; Online: Correction: Soluble urokinase plasminogen activator receptor and cardiotoxicity in doxorubicin‑treated breast cancer patients: a prospective exploratory study.

    Chu, Jian / Tung, Lillian / Atallah, Issam / Wei, Changli / Cobleigh, Melody / Rao, Ruta / Feinstein, Steven B / Usha, Lydia / Banach, Kathrin / Reiser, Jochen / Okwuosa, Tochukwu M

    Cardio-oncology (London, England)

    2024  Volume 10, Issue 1, Page(s) 5

    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Published Erratum
    ISSN 2057-3804
    ISSN (online) 2057-3804
    DOI 10.1186/s40959-024-00205-5
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  4. Article ; Online: Soluble urokinase plasminogen activator receptor and cardiotoxicity in doxorubicin-treated breast cancer patients: a prospective exploratory study.

    Chu, Jian / Tung, Lillian / Atallah, Issam / Wei, Changli / Cobleigh, Melody / Rao, Ruta / Feinstein, Steven B / Usha, Lydia / Banach, Kathrin / Reiser, Jochen / Okwuosa, Tochukwu M

    Cardio-oncology (London, England)

    2024  Volume 10, Issue 1, Page(s) 3

    Abstract: ... standard-dose doxorubicin (240 mg/m: Results: Our study included 37 women (mean age 47.0 ± 9.3 years, 60 ...

    Abstract Background: Soluble urokinase plasminogen activator receptor is an inflammatory biomarker that may prognosticate cardiovascular outcomes. We sought to determine the associations between soluble urokinase plasminogen activator receptor and established markers of cardiotoxicity in breast cancer patients receiving doxorubicin.
    Methods: We conducted a prospective cohort study of women with newly diagnosed breast cancer receiving standard-dose doxorubicin (240 mg/m
    Results: Our study included 37 women (mean age 47.0 ± 9.3 years, 60% white) with a median baseline soluble urokinase plasminogen activator receptor level of 2.83 ng/dL. No participant developed cardiomyopathy based on serial echocardiography by one-year follow-up. The median percent change in left ventricular strain was -4.3% at 6-month follow-up and absolute changes in cardiac biomarkers were clinically insignificant. There were no significant associations between soluble urokinase plasminogen activator receptor and these markers of cardiotoxicity (all p > 0.05).
    Conclusions: In this breast cancer cohort, doxorubicin treatment was associated with a very low risk for cardiotoxicity. Across this narrow range of clinical endpoints, soluble urokinase plasminogen activator receptor was not associated with markers of subclinical cardiotoxicity. Further studies are needed to clarify the prognostic utility of soluble urokinase plasminogen activator receptor in doxorubicin-associated cardiomyopathy and should include a larger cohort of leukemia and lymphoma patients who receive higher doses of doxorubicin.
    Language English
    Publishing date 2024-01-15
    Publishing country England
    Document type Journal Article
    ISSN 2057-3804
    ISSN (online) 2057-3804
    DOI 10.1186/s40959-023-00191-0
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  5. Article: A randomized controlled safety and feasibility trial of floatation-REST in anxious and depressed individuals.

    Garland, McKenna M / Wilson, Raminta / Thompson, Wesley K / Stein, Murray B / Paulus, Martin P / Feinstein, Justin S / Khalsa, Sahib S

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: Background: Reduced Environmental Stimulation Therapy via floatation (floatation-REST) is a behavioral intervention designed to attenuate exteroceptive sensory input to the nervous system. Pilot studies in anxious and depressed individuals demonstrated ... ...

    Abstract Background: Reduced Environmental Stimulation Therapy via floatation (floatation-REST) is a behavioral intervention designed to attenuate exteroceptive sensory input to the nervous system. Pilot studies in anxious and depressed individuals demonstrated that single sessions of floatation-REST are safe, well-tolerated, and associated with acute anxiolysis. However, there is not sufficient evidence of the feasibility of floatation-REST as a repeated intervention.
    Methods: We randomized 75 individuals with anxiety and depression to six sessions of floatation-REST in different formats (pool-REST or pool-REST preferred) or an active comparator (chair-REST). Feasibility was assessed via adherence rate to the assigned intervention, tolerability via duration of REST utilization and overall study dropout rate, and safety via incidence of serious or non-serious adverse events.
    Results: Six-session adherence was 85% for pool-REST, 89% for pool-REST preferred, and 74% for chair-REST. Dropout rates did not differ significantly between the treatment conditions. Mean session durations were consistently above 50 minutes, and when allowed to choose the duration and frequency, participants opted to float for an average of 75 minutes. There were no serious adverse events associated with any intervention. Positive experiences were endorsed more commonly than negative ones and were also rated at higher levels of intensity.
    Conclusions: Taken together, six sessions of floatation-REST appear feasible, well-tolerated, and safe in anxious and depressed individuals. Floatation-REST induces positively-valenced experiences with few negative effects. Larger randomized controlled trials evaluating markers of clinical efficacy are warranted.
    Language English
    Publishing date 2023-06-08
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.05.27.23290633
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  6. Article ; Online: Intersectionality-informed analysis of durable viral suppression disparities in people with HIV.

    Rivera, Adovich S / Rusie, Laura K / Feinstein, Matthew J / Siddique, Juned / Lloyd-Jones, Donald M / Beach, Lauren B

    AIDS (London, England)

    2023  Volume 37, Issue 8, Page(s) 1285–1296

    Abstract: Objective: The aim of this study was to examine drivers of durable viral suppression (DVS) disparities among people with HIV (PWH) using quantitative intersectional approaches.: Design: A retrospective cohort analysis from electronic health records ... ...

    Abstract Objective: The aim of this study was to examine drivers of durable viral suppression (DVS) disparities among people with HIV (PWH) using quantitative intersectional approaches.
    Design: A retrospective cohort analysis from electronic health records informed by intersectionality to better capture the concept of interlocking and interacting systems of oppression.
    Methods: We analyzed data of PWH seen at a LGBTQ federally qualified health center in Chicago (2012-2019) with at least three viral loads. We identified PWH who achieved DVS using latent trajectory analysis and examined disparities using three intersectional approaches: Adding interactions, latent class analysis (LCA), and qualitative comparative analysis (QCA). Findings were compared with main effects only regression.
    Results: Among 5967 PWH, 90% showed viral trajectories consistent with DVS. Main effects regression showed that substance use [odds ratio (OR) 0.56, 0.46-0.68] and socioeconomic status like being unhoused (OR: 0.39, 0.29-0.53), but not sexual orientation or gender identity (SOGI) were associated with DVS. Adding interactions, we found that race and ethnicity modified the association between insurance and DVS ( P for interaction <0.05). With LCA, we uncovered four social position categories influenced by SOGI with varying rates of DVS. For example, the transgender women-majority class had worse DVS rates versus the class of mostly nonpoor white cisgender gay men (82 vs. 95%). QCA showed that combinations, rather than single factors alone, were important for achieving DVS. Combinations vary with marginalized populations (e.g. black gay/lesbian transgender women) having distinct sufficient combinations compared with historically privileged groups (e.g. white cisgender gay men).
    Conclusion: Social factors likely interact to produce DVS disparities. Intersectionality-informed analysis uncover nuance that can inform solutions.
    MeSH term(s) Humans ; Male ; Female ; Gender Identity ; Retrospective Studies ; Intersectional Framework ; HIV Infections ; Sexual Behavior
    Language English
    Publishing date 2023-04-05
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 639076-6
    ISSN 1473-5571 ; 0269-9370 ; 1350-2840
    ISSN (online) 1473-5571
    ISSN 0269-9370 ; 1350-2840
    DOI 10.1097/QAD.0000000000003565
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    Zs.A 2228: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Contrast-enhanced ultrasound in pediatric echocardiography.

    Kutty, Shelby / Biko, David M / Goldberg, Alan B / Quartermain, Michael D / Feinstein, Steven B

    Pediatric radiology

    2021  Volume 51, Issue 12, Page(s) 2408–2417

    Abstract: The safety and benefits of cardiac contrast-enhanced ultrasound (CEUS) have been demonstrated in children and adolescents for a variety of clinical indications, including congenital heart disease. Cardiac CEUS is performed with US and the intravenous ... ...

    Abstract The safety and benefits of cardiac contrast-enhanced ultrasound (CEUS) have been demonstrated in children and adolescents for a variety of clinical indications, including congenital heart disease. Cardiac CEUS is performed with US and the intravenous administration of ultrasound contrast agents (UCAs). It improves transthoracic echocardiography, which can be challenging in children and adults with acoustic window limitations (e.g., from obesity) and alterations in chest wall and cardiac geometry (e.g., from prior surgical procedures). Cardiac CEUS is also used to evaluate ischemia in the follow-up of congenital and acquired heart disease. In 2019, the United States Food and Drug Administration (FDA) approved a UCA for pediatric echocardiography. This article focuses on the clinical applications of UCAs in pediatric and adult echocardiography, outlining its diagnostic value, safety and potential for future applications.
    MeSH term(s) Adolescent ; Adult ; Child ; Contrast Media ; Echocardiography ; Forecasting ; Heart Diseases/diagnostic imaging ; Humans ; Ultrasonography
    Chemical Substances Contrast Media
    Language English
    Publishing date 2021-07-09
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 124459-0
    ISSN 1432-1998 ; 0301-0449
    ISSN (online) 1432-1998
    ISSN 0301-0449
    DOI 10.1007/s00247-021-05119-3
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    Zs.A 927: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: Development of Fluoroquinolone Resistance through Antibiotic Tolerance in Campylobacter jejuni.

    Park, Myungseo / Kim, Jinshil / Feinstein, Jill / Lang, Kevin S / Ryu, Sangryeol / Jeon, Byeonghwa

    Microbiology spectrum

    2022  Volume 10, Issue 5, Page(s) e0166722

    Abstract: Antibiotic tolerance not only enables bacteria to survive acute antibiotic exposures but also provides bacteria with a window of time in which to develop antibiotic resistance. The increasing prevalence of Campylobacter jejuni isolates resistant to ... ...

    Abstract Antibiotic tolerance not only enables bacteria to survive acute antibiotic exposures but also provides bacteria with a window of time in which to develop antibiotic resistance. The increasing prevalence of Campylobacter jejuni isolates resistant to clinically important antibiotics, particularly fluoroquinolones (FQs), is a global public health concern. Currently, little is known about antibiotic tolerance and its effects on resistance development in C. jejuni. Here, we show that exposure to ciprofloxacin or tetracycline at concentrations 10 and 100 times higher than the MIC induces antibiotic tolerance in C. jejuni, whereas gentamicin or erythromycin treatment causes cell death. Interestingly, FQ resistance rapidly develops in C. jejuni after tolerance induction by ciprofloxacin and tetracycline. Furthermore, after tolerance is induced, alkyl hydroperoxide reductase (AhpC) plays a critical role in reducing FQ resistance development by alleviating oxidative stress. Together, these results demonstrate that exposure of C. jejuni to antibiotics can induce antibiotic tolerance and that FQ-resistant (FQ
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacteria ; Campylobacter jejuni/drug effects ; Campylobacter jejuni/genetics ; Ciprofloxacin/pharmacology ; Drug Resistance, Bacterial/genetics ; Erythromycin/pharmacology ; Fluoroquinolones/pharmacology ; Gentamicins/pharmacology ; Microbial Sensitivity Tests ; Peroxiredoxins/pharmacology ; Tetracycline/pharmacology
    Chemical Substances Anti-Bacterial Agents ; Ciprofloxacin (5E8K9I0O4U) ; Erythromycin (63937KV33D) ; Fluoroquinolones ; Gentamicins ; Peroxiredoxins (EC 1.11.1.15) ; Tetracycline (F8VB5M810T)
    Language English
    Publishing date 2022-09-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01667-22
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  9. Article: The psychological wellbeing of Iranian journalists: a descriptive study.

    Feinstein, Anthony / Feinstein, Saul / Behari, Maziar / Pavisian, Bennis

    JRSM open

    2016  Volume 7, Issue 12, Page(s) 2054270416675560

    Abstract: Objective: Iran ranks 173 out of 180 countries on an index of press freedom. The purpose of the study was to assess the psychological wellbeing of Iranian journalists and document the stressors encountered in their work.: Design: A secure website was ...

    Abstract Objective: Iran ranks 173 out of 180 countries on an index of press freedom. The purpose of the study was to assess the psychological wellbeing of Iranian journalists and document the stressors encountered in their work.
    Design: A secure website was established and participants were given their unique identifying number and password to access the site.
    Setting: Newsrooms in Iran and the diaspora.
    Participants: Responses were received from 114 journalists (76%) of whom 65.8% were living in the diaspora. The mean age was 37.8 years (SD = 7.30) and 57% male.
    Main outcomes measures: Type of stressor and behavioural data: Impact of Event Scale-revised for posttraumatic stress disorder, Beck Depression Inventory-II for depression.
    Results: Stressors include arrest (41.2%), torture (19.3%), assault (10.5%), intimidation (51.4%) and family threatened (43.1%). Eighty nine (78.1%) journalists had stopped working on a story because of intimidation. Arrest, torture, intimidation and family threatened were associated with more intrusive and arousal PTSD symptoms (p < .01 to .001) and assault and intimidation with more depressive symptoms (p < .05). Almost a third of Iranian journalists regularly used barbiturates, with use correlating with symptoms of intrusion (p < .0001), avoidance (p < .01), arousal (p < .0001) and depression (p < .0001). 46.5% of Iranian journalists were not receiving therapy for their distress.
    Conclusions: The findings, the first of their kind, provide data highlighting the extraordinary degree of danger confronted by Iranian journalists, their emotional distress in response to this and their proclivity to self-medicate with barbiturates.
    Language English
    Publishing date 2016-12-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2762955-7
    ISSN 2054-2704
    ISSN 2054-2704
    DOI 10.1177/2054270416675560
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  10. Article ; Online: Association of Cumulative Viral Load With the Incidence of Hypertension and Diabetes in People With HIV.

    Rivera, Adovich S / Rusie, Laura / Plank, Megan / Siddique, Juned / Beach, Lauren B / Lloyd-Jones, Donald M / Feinstein, Matthew J

    Hypertension (Dallas, Tex. : 1979)

    2022  Volume 79, Issue 11, Page(s) e135–e142

    Abstract: Background: HIV induces several metabolic derangements that contribute to cardiovascular disease, but it is unclear if HIV increases diabetes or hypertension risk. Refining longitudinal relationships between HIV-specific factors and cardiovascular ... ...

    Abstract Background: HIV induces several metabolic derangements that contribute to cardiovascular disease, but it is unclear if HIV increases diabetes or hypertension risk. Refining longitudinal relationships between HIV-specific factors and cardiovascular disease risk factors across different care settings may help inform cardiovascular disease prevention among people with HIV (PWH).
    Methods: We tested the hypothesis that long-term higher cumulative viral load (viremia-copy-year) is associated with higher risk of diabetes and hypertension by analyzing electronic records of PWH from 2 distinct health systems in Chicago (Northwestern Medicine and Howard Brown Health Care) receiving care in 2004 to 2019. We used joint longitudinal-survival models to assess multivariable-adjusted associations. Subgroup analyses per site were also conducted.
    Results: We observed 230 (3.0%) incident diabetes cases in 7628 PWH without baseline diabetes and 496 (6.7%) hypertension cases in 7450 PWH without baseline hypertension. Pooled analysis showed a direct association of viremia-copy-year with incident hypertension (hazards ratio, 1.20 [95% CI, 1.14-1.26]) but not with diabetes (hazards ratio, 1.03 [95% CI, 0.96-1.10]). However, site-specific differences existed whereby the Northwestern-only analysis demonstrated a significant association of viremia-copy-year with hypertension (hazards ratio, 1.29 [95% CI, 1.08-1.32]). Additionally, higher social deprivation index (both sites) and diagnosis of mental health disorder (Howard Brown Health only) was associated with higher diabetes and hypertension risk.
    Conclusions: Cumulative viral load may be associated with incident hypertension among PWH. Associations of HIV control with cardiovascular disease risk factors among PWH may differ by health care system context.
    MeSH term(s) Humans ; Viral Load ; Viremia/complications ; Viremia/epidemiology ; Incidence ; Cardiovascular Diseases/complications ; HIV Infections/epidemiology ; HIV Infections/complications ; Hypertension/epidemiology ; Hypertension/complications ; Diabetes Mellitus/epidemiology
    Language English
    Publishing date 2022-08-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.122.19302
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    Zs.A 1488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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