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Article: Zwillingschwangerschaft bei M. Glanzmann.

Riedel, H / Barthels, M / Lingelbach, E / Weitzel, H

1978 Volume 38, Issue 4, Page(s) 285–288

Abstract: Report on a 30-year old primigravida with a family history of bleeding and a personal history of nasopharyngeal bleeding since age four. Severe menorrhagia since her menarche. First seen at 20 weeks gestation with naso-pharyngeal bleeding and a twin ... ...

Title translation	Twin pregnancy in a patient with Glanzmann disease (congenital thrombasthenia) (author's transl).
Abstract	Report on a 30-year old primigravida with a family history of bleeding and a personal history of nasopharyngeal bleeding since age four. Severe menorrhagia since her menarche. First seen at 20 weeks gestation with naso-pharyngeal bleeding and a twin pregnancy. The patient was found to have Glanzmann's disease (congenital thrombasthenia) with an excessive lack of factor XIII. Ambulatory treatment with packed cell transfusions until 35 weeks gestation. The thrombelastogram did not improve with transfusions of platelet concentrates. In-patient treatment from 35 to 37 weeks gestation, no vaginal bleeding throughout the pregnancy. Elective Caesarean hysterectomy at 37 weeks gestation with lo units fresh blood, 3 units platelet concentrate and 10 ampules factor XIII concentrate in readiness. Delivery of twin girls 3180 and 3050 g without signs of Glanzmann's disease. Treatment of the maternal bleeding by replacement. Factor XIII 80% of normal 8 weeks postpartum. This appears to be the first case of twin pregnancy in the presence of Glanzmann's disease and the fourth case in the world literature.
MeSH term(s)	Adult ; Blood Transfusion ; Cesarean Section ; Erythrocyte Transfusion ; Factor XIII Deficiency/diagnosis ; Female ; Humans ; Infant, Newborn ; Pregnancy ; Pregnancy Complications, Hematologic/diagnosis ; Purpura, Thrombocytopenic/genetics ; Syndrome ; Time Factors
Language	German
Publishing date	1978-04
Publishing country	Germany
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	80111-2
ISSN	1438-8804 ; 0016-5751 ; 1615-3359
ISSN (online)	1438-8804
ISSN	0016-5751 ; 1615-3359
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Article: The various facets of orthorexic eating behavior: five case reports of individuals with supposed orthorexia nervosa.

Barthels, Friederike / Fischer, Maren / Keskini, Raphaela / Schöl, Amelie Marie / Pietrowsky, Reinhard

Journal of eating disorders

2024 Volume 12, Issue 1, Page(s) 31

Abstract: Background: Orthorexia nervosa, defined as a fixation on eating healthy according to subjective criteria, is recently being discussed as another variant of disordered eating behavior. Further characteristics are rigid adherence to nutritional rules, ... ...

Abstract	Background: Orthorexia nervosa, defined as a fixation on eating healthy according to subjective criteria, is recently being discussed as another variant of disordered eating behavior. Further characteristics are rigid adherence to nutritional rules, anxieties and avoidance behavior in the context of eating as well as a focus on health, not on body shape or weight loss, which is supposed to differentiate orthorexic from other disordered eating behavior. Although diagnostic criteria have been suggested, they have rarely been used in case reports published to date. Hence, the aim of this study was to present five individuals with supposed orthorexia nervosa, using preliminary diagnostic criteria to assess their eating behavior. Case presentation: The five cases (three females, two males) reveal the great variety of disordered eating behavior. Fear of unhealthy overweight (case A), supposed orthorexic eating behavior as a coping strategy for anorexia nervosa (case B), the exclusive consumption of animal products with a total exclusion of fruits and vegetables (case C), the fixation on exercise and athletic goals (case D) as well as a focus on a vegan diet and unprocessed foods (case E) are facets of orthorexia nervosa with varying degrees of impairment. Conclusions: It is concluded that orthorexia nervosa manifests itself in very different ways and that more research is needed in order to determine whether it could be a useful additional category of disordered eating behavior.
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2699357-0
ISSN	2050-2974
ISSN	2050-2974
DOI	10.1186/s40337-024-00988-z
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Article: A Low Rate of Periprosthetic Infections after Aseptic Knee Prosthesis Revision Using Dual-Antibiotic-Impregnated Bone Cement.

Blersch, Benedikt Paul / Barthels, Michael / Schuster, Philipp / Fink, Bernd

Antibiotics (Basel, Switzerland)

2023 Volume 12, Issue 9

Abstract: Aim: The incidence of periprosthetic joint infections (PJI) following aseptic knee revision arthroplasty lies between 3% and 7.5%. The aim of this study was to verify the hypothesis that the use of dual-antibiotic-impregnated cement in knee revision ... ...

Abstract	Aim: The incidence of periprosthetic joint infections (PJI) following aseptic knee revision arthroplasty lies between 3% and 7.5%. The aim of this study was to verify the hypothesis that the use of dual-antibiotic-impregnated cement in knee revision arthroplasty leads to a lower rate of periprosthetic joint infections. Methods: We retrospectively reviewed 403 aseptic revision knee arthroplasties performed between January 2013 and March 2021 (148 revisions of a unicompartmental prosthesis, 188 revisions of a bicondylar total knee arthroplasty (TKA), 41 revisions of an axis-guided prosthesis, and 26 revisions of only one component of a surface replacement prosthesis). The bone cement Copal G+C (Heraeus Medical, Wertheim, Germany) with two antibiotics-gentamycin and clindamycin-was used for the fixation of the new implant. The follow-up period was 53.4 ± 27.9 (4.0-115.0) months. Results: Five patients suffered from PJI within follow-up (1.2%). The revision rate for any reason was 8.7%. Survival for any reason was significantly different between the types of revision ( Conclusion: The use of the dual-antibiotic-impregnated bone cement Copal G+C results in a lower rate of periprosthetic infections after aseptic knee prosthesis replacement than that reported in published prosthesis revisions using only one antibiotic in the bone cement.
Language	English
Publishing date	2023-08-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics12091368
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Article: Non-covalent dyes in microscale thermophoresis for studying RNA ligand interactions and modifications.

Kallert, Elisabeth / Behrendt, Malte / Frey, Ariane / Kersten, Christian / Barthels, Fabian

Chemical science

2023 Volume 14, Issue 36, Page(s) 9827–9837

Abstract: Microscale Thermophoresis (MST) is a powerful biophysical technique that measures the mobility of biomolecules in response to a temperature gradient, making it useful for investigating the interactions between biological molecules. This study presents a ... ...

Abstract	Microscale Thermophoresis (MST) is a powerful biophysical technique that measures the mobility of biomolecules in response to a temperature gradient, making it useful for investigating the interactions between biological molecules. This study presents a novel methodology for studying RNA-containing samples using non-covalent nucleic acid-sensitive dyes in MST. This "mix-and-measure" protocol uses non-covalent dyes, such as those from the Syto or Sybr series, which lead to the statistical binding of one fluorophore per RNA oligo showing key advantages over traditional covalent labelling approaches. This new approach has been successfully used to study the binding of ligands to RNA molecules (
Language	English
Publishing date	2023-08-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d3sc02993j
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Article ; Online: KLF2 Regulates Neural Differentiation of Dental Pulp-derived Stem Cells by Modulating Autophagy and Mitophagy.

Prateeksha, Prateeksha / Naidu, Prathyusha / Das, Manjusri / Barthels, Derek / Das, Hiranmoy

Stem cell reviews and reports

2023 Volume 19, Issue 8, Page(s) 2886–2900

Abstract: Background: Transplantation of stem cells for treating neurodegenerative disorders is a promising future therapeutic approach. However, the molecular mechanism underlying the neuronal differentiation of dental pulp-derived stem cells (DPSC) remains ... ...

Abstract	Background: Transplantation of stem cells for treating neurodegenerative disorders is a promising future therapeutic approach. However, the molecular mechanism underlying the neuronal differentiation of dental pulp-derived stem cells (DPSC) remains inadequately explored. The current study aims to define the regulatory role of KLF2 (Kruppel-like factor 2) during the neural differentiation (ND) of DPSC. Methods: We first investigated the transcriptional and translational expression of KLF2, autophagy, and mitophagy-associated markers during the ND of DPSC by using quantitative RT-PCR and western blot methods. After that, we applied the chemical-mediated loss- and gain-of-function approaches using KLF2 inhibitor, GGPP (geranylgeranyl pyrophosphate), and KLF2 activator, GGTI-298 (geranylgeranyl transferase inhibitor-298) to delineate the role of KLF2 during ND of DPSC. The western blot, qRT-PCR, and immunocytochemistry were performed to determine the molecular changes during ND after KLF2 deficiency and KLF2 sufficiency. We also analyzed the oxygen consumption rate (OCR) and the extracellular acidification rate (ECAR) using the Seahorse XFe24 analyzer. Results: Our study demonstrated that the expression level of KLF2, autophagy, and mitophagy-associated markers were significantly elevated during the ND of DPSC. Next, we found that the KLF2 inhibitor, GGPP significantly reduced the ND of DPSC. Inversely, KLF2 overexpression accelerated the molecular phenomenon of DPSC's commitment towards ND, indicating the crucial role of KLF2 in neurogenesis. Moreover, we found that the KLF2 positively regulated autophagy, mitophagy, and the Wnt5a signaling pathway during neurogenesis. Seahorse XFe24 analysis revealed that the ECAR and OCR parameters were significantly increased during ND, and inhibition of KLF2 marginally reversed them towards DPSC's cellular bioenergetics. However, KLF2 overexpression shifted the cellular energy metabolism toward the quiescent stage. Conclusion: Collectively, our findings provide the first evidence that the KLF2 critically regulates the neurogenesis of DPSC by inducing autophagy and mitophagy.
MeSH term(s)	Autophagy ; Cell Differentiation ; Dental Pulp ; Mitophagy ; Stem Cells ; Transcription Factors/metabolism ; Humans
Chemical Substances	Transcription Factors ; KLF2 protein, human
Language	English
Publishing date	2023-08-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2495577-2
ISSN	2629-3277 ; 1558-6804 ; 1550-8943
ISSN (online)	2629-3277 ; 1558-6804
ISSN	1550-8943
DOI	10.1007/s12015-023-10607-0
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Article ; Online: FINDUS: An Open-Source 3D Printable Liquid-Handling Workstation for Laboratory Automation in Life Sciences.

Barthels, Fabian / Barthels, Ulrich / Schwickert, Marvin / Schirmeister, Tanja

SLAS technology

2019 Volume 25, Issue 2, Page(s) 190–199

Abstract: 3D-printed laboratory devices can enable ambitious research purposes even at a low-budget level. To follow this trend, here we describe the construction, calibration, and usage of the FINDUS (Fully Integrable Noncommercial Dispensing Utility System). We ... ...

Abstract	3D-printed laboratory devices can enable ambitious research purposes even at a low-budget level. To follow this trend, here we describe the construction, calibration, and usage of the FINDUS (Fully Integrable Noncommercial Dispensing Utility System). We report the successful 3D printing and assembly of a liquid-handling workstation for less than $400. Using this setup, we achieve reliable and flexible liquid-dispensing automation with relative pipetting errors of less than 0.3%. We show our system is well suited for several showcase applications from both the biology and chemistry fields. In support of the open-source spirit, we make all 3D models, assembly instructions, and source code available for free download, rebuild, and modification.
MeSH term(s)	Automation, Laboratory ; Biological Science Disciplines ; Calibration ; Cathepsin B/metabolism ; Humans ; Peptides/chemical synthesis ; Printing, Three-Dimensional ; Software ; Solid-Phase Synthesis Techniques
Chemical Substances	Peptides ; Cathepsin B (EC 3.4.22.1)
Language	English
Publishing date	2019-09-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2900310-6
ISSN	2472-6311 ; 2472-6303
ISSN (online)	2472-6311
ISSN	2472-6303
DOI	10.1177/2472630319877374
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Article ; Online: No elevated levels of orthorexic eating behavior in a sample of adults with allergies and food intolerances.

Barthels, Friederike / Bamberg, Leonie / Pietrowsky, Reinhard

Eating and weight disorders : EWD

2022 Volume 27, Issue 8, Page(s) 3781–3785

Abstract: ... age: M = 28.13, SD = 11.96 years) completed an online survey with the Düsseldorf Orthorexia Scale and ...

Abstract	Purpose: To compare orthorexic eating behavior in a sample of adults with and without self-reported allergies and food intolerances. Methods: N = 52 individuals with and n = 102 individuals without self-reported allergies and food intolerances (80% with medical diagnosis; in total 74.6% female, 23.7% male; age: M = 28.13, SD = 11.96 years) completed an online survey with the Düsseldorf Orthorexia Scale and answered several questions regarding their allergies/intolerances. Results: The groups did not differ in their orthorexic eating behavior. In the sample of individuals with allergies/intolerances, orthorexic eating behavior correlated with the perceived severity of the allergic symptoms and the number of consequences that the allergies had for eating behavior. Conclusions: In line with previous findings, orthorexic eating behavior does not seem to be elevated in individuals with allergies/intolerances. However, focusing on a healthy diet despite adverse food reactions and experiencing a number of allergy-related consequences for one's eating behavior might be associated with orthorexic eating behavior. Level of evidence: III, case-control analytic study.
MeSH term(s)	Adult ; Humans ; Male ; Female ; Food Intolerance ; Feeding Behavior ; Hypersensitivity ; Surveys and Questionnaires ; Diet, Healthy ; Feeding and Eating Disorders
Language	English
Publishing date	2022-10-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2038625-4
ISSN	1590-1262 ; 1124-4909
ISSN (online)	1590-1262
ISSN	1124-4909
DOI	10.1007/s40519-022-01498-0
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Article ; Online: Vegan diet and orthorexia.

Barthels, Friederike / Abbate-Daga, Giovanni / Donini, Lorenzo M

Eating and weight disorders : EWD

2021 Volume 26, Issue 8, Page(s) 2809–2810

MeSH term(s)	Diet ; Diet, Vegan ; Diet, Vegetarian ; Humans ; Orthorexia Nervosa ; Vegans ; Vegetarians
Language	English
Publishing date	2021-02-25
Publishing country	Germany
Document type	Letter
ZDB-ID	2038625-4
ISSN	1590-1262 ; 1124-4909
ISSN (online)	1590-1262
ISSN	1124-4909
DOI	10.1007/s40519-021-01135-2
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Article: Validation of the Arabic version of the Dusseldorf Orthorexia Scale (DOS) among Lebanese adolescents.

Rogoza, Radoslaw / Hallit, Souheil / Soufia, Michel / Barthels, Friederike / Obeid, Sahar

Journal of eating disorders

2021 Volume 9, Issue 1, Page(s) 130

Abstract: ... Yet, females as compared to males achieved higher scores (M = 20.07, SD = 6.38 vs M = 18.29, SD = 6.37; p ...

Abstract	Background: Orthorexia Nervosa (ON) is defined as a pathological preoccupation characterized by obsessive beliefs and compulsive behaviors regarding 'pure' eating behaviors. Many scales have been established and display good results regarding reliability and validity measures, including but not limited to ORTO-R (revised version of ORTO-15), Eating Habits Questionnaire, Teruel Orthorexia Scale (TOS) and the Düsseldorf Orthorexia Scale (DOS). Among these, the DOS seems to be a promising measure for multiple reasons. The current paper aims to validate the DOS, a measure of ON, in a non-Western population of Lebanese adolescents. Methods: This was a cross-sectional designed study, conducted between May and June 2020, which enrolled 555 adolescents (15-18 years old; 75.7% females). Due the coronavirus pandemic outbreak, the data were gathered through snowball sampling using an online questionnaire. The DOS, TOS and ORTO-R scales were used in this study to screen for orthorexic tendencies and behaviors. Results: We tested four competing structural models of the DOS assessing its factorial validity. The results of the current investigation revealed that the one-factorial model is the best one to represent the structure of the questionnaire. We provided evidence for validity for the DOS through demonstrating that it correlates significantly with other measures of orthorexic behaviours (Teruel Orthorexia Scale and ORTO-R). Finally, we have gathered evidence that the orthorexic behaviours as measured by DOS are not associated with age (r = -.02; p = .589), household crowding index (r = .02; p = .578), and Body Mass Index (r = .04; p = .297). Yet, females as compared to males achieved higher scores (M = 20.07, SD = 6.38 vs M = 18.29, SD = 6.37; p = .005; d = .28). Conclusion: The Arabic version of the DOS seems to be a structurally valid and internally consistent questionnaire measuring orthorexic eating behavior in a sample of Lebanese adolescents. This tool may be useful for psychologists, psychiatrists, dietitians and other clinicians in the assessment and the treatment of the multidimensional nature of ON.
Language	English
Publishing date	2021-10-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2699357-0
ISSN	2050-2974
ISSN	2050-2974
DOI	10.1186/s40337-021-00488-4
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Article: No elevated levels of orthorexic eating behavior in a sample of adults with allergies and food intolerances

Barthels, Friederike / Bamberg, Leonie / Pietrowsky, Reinhard

Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity

2022 Volume 27, Issue 8, Page(s) 3781–3785

Abstract: ... age: M = 28.13, SD = 11.96 years) completed an online survey with the Düsseldorf Orthorexia Scale and ...

Title translation	Keine erhöhten Werte für orthorexisches Essverhalten in einer Stichprobe von Erwachsenen mit Allergien und Nahrungsmittelunverträglichkeiten
Abstract	Purpose: To compare orthorexic eating behavior in a sample of adults with and without self-reported allergies and food intolerances. Methods: N = 52 individuals with and n = 102 individuals without self-reported allergies and food intolerances (80% with medical diagnosis; in total 74.6% female, 23.7% male; age: M = 28.13, SD = 11.96 years) completed an online survey with the Düsseldorf Orthorexia Scale and answered several questions regarding their allergies/intolerances. Results: The groups did not differ in their orthorexic eating behavior. In the sample of individuals with allergies/intolerances, orthorexic eating behavior correlated with the perceived severity of the allergic symptoms and the number of consequences that the allergies had for eating behavior. Conclusion: In line with previous findings, orthorexic eating behavior does not seem to be elevated in individuals with allergies/intolerances. However, focusing on a healthy diet despite adverse food reactions and experiencing a number of allergy-related consequences for one's eating behavior might be associated with orthorexic eating behavior. Level of evidence: III, case-control analytic study.
Keywords	Diets ; Eating Behavior ; Ernährungsweisen ; Essverhalten ; Food ; Food Allergies ; Nahrungsmittel ; Nahrungsmittelallergien ; Orthorexia ; Orthorexie
Language	English
Document type	Article
DOI	10.1007/s40519-022-01498-0
Database	PSYNDEX

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