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Article ; Online: Huge pneumoretroperitoneum as the first sign of colorectal cancer.

Mazzetti, Claudia Hannele / Carlier, Patrick / Lebrun, Eric / Hossey, Didier / Ramon, Isolde / Winant, Catherine / Lemaitre, Jean

Journal of gastrointestinal cancer

2014 Volume 45 Suppl 1, Page(s) 245–247

MeSH term(s)	Aged ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/pathology ; Female ; Humans ; Retropneumoperitoneum/diagnosis ; Retropneumoperitoneum/pathology
Language	English
Publishing date	2014-09-05
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2452514-5
ISSN	1941-6636 ; 1559-0739 ; 1941-6628 ; 1537-3649
ISSN (online)	1941-6636 ; 1559-0739
ISSN	1941-6628 ; 1537-3649
DOI	10.1007/s12029-014-9649-0
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Zs.A 2184: Show issues

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Article ; Online: Amoxicillin/clavulanate in combination with rifampicin/clarithromycin is bactericidal against Mycobacterium ulcerans.

Sáez-López, Emma / Millán-Placer, Ana C / Lucía, Ainhoa / Ramón-García, Santiago

PLoS neglected tropical diseases

2024 Volume 18, Issue 4, Page(s) e0011867

Abstract: ... against M. ulcerans clinical isolates by TKA, while comparing four methodologies: CFU enumeration ... in combination were performed against different M. ulcerans clinical isolates. Bacterial loads were quantified ...

Abstract	Background: Buruli ulcer (BU) is a skin neglected tropical disease (NTD) caused by Mycobacterium ulcerans. WHO-recommended treatment requires 8-weeks of daily rifampicin (RIF) and clarithromycin (CLA) with wound care. Treatment compliance may be challenging due to socioeconomic determinants. Previous minimum Inhibitory Concentration and checkerboard assays showed that amoxicillin/clavulanate (AMX/CLV) combined with RIF+CLA were synergistic against M. ulcerans. However, in vitro time kill assays (TKA) are a better approach to understand the antimicrobial activity of a drug over time. Colony forming units (CFU) enumeration is the in vitro reference method to measure bacterial load, although this is a time-consuming method due to the slow growth of M. ulcerans. The aim of this study was to assess the in vitro activity of RIF, CLA and AMX/CLV combinations against M. ulcerans clinical isolates by TKA, while comparing four methodologies: CFU enumeration, luminescence by relative light unit (RLU) and optical density (at 600 nm) measurements, and 16S rRNA/IS2404 genes quantification. Methodology/principal findings: TKA of RIF, CLA and AMX/CLV alone and in combination were performed against different M. ulcerans clinical isolates. Bacterial loads were quantified with different methodologies after 1, 3, 7, 10, 14, 21 and 28 days of treatment. RIF+AMX/CLV and the triple RIF+CLA+AMX/CLV combinations were bactericidal and more effective in vitro than the currently used RIF+CLA combination to treat BU. All methodologies except IS2404 quantitative PCR provided similar results with a good correlation with CFU enumeration. Measuring luminescence (RLU) was the most cost-effective methodology to quantify M. ulcerans bacterial loads in in vitro TKA. Conclusions/significance: Our study suggests that alternative and faster TKA methodologies can be used in BU research instead of the cumbersome CFU quantification method. These results provide an in vitro microbiological support to of the BLMs4BU clinical trial (NCT05169554, PACTR202209521256638) to shorten BU treatment.
MeSH term(s)	Humans ; Clarithromycin/pharmacology ; Clarithromycin/therapeutic use ; Rifampin/pharmacology ; Rifampin/therapeutic use ; Mycobacterium ulcerans/genetics ; RNA, Ribosomal, 16S ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Buruli Ulcer/drug therapy ; Buruli Ulcer/microbiology ; Amoxicillin-Potassium Clavulanate Combination/pharmacology ; Amoxicillin-Potassium Clavulanate Combination/therapeutic use
Chemical Substances	Clarithromycin (H1250JIK0A) ; Rifampin (VJT6J7R4TR) ; RNA, Ribosomal, 16S ; Anti-Bacterial Agents ; Amoxicillin-Potassium Clavulanate Combination (74469-00-4)
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2735
ISSN (online)	1935-2735
ISSN	1935-2735
DOI	10.1371/journal.pntd.0011867
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Article ; Online: O trem e a “senhorita espanhola”: a epidemia de gripe em Diamantina, 1918.

Souza, Ramon Feliphe

Historia, ciencias, saude--Manguinhos

2023 Volume 30, Page(s) e2023024

Abstract: ... which had until then been represented in the discourse of its elites as insalubrious and isolated ...

Title translation	The train and the "Spanish señorita":the flu epidemic in Diamantina, 1918.
Abstract	The article analyzes the influenza epidemic in 1918 in Diamantina, a town in the Brazilian state of Minas Gerais. Bibliographic and documental sources are used to investigate the influence of the Vitória-Minas railroad (Estrada de Ferro Vitória a Minas), opened in 1914, on the arrival of the disease in the town, which had until then been represented in the discourse of its elites as insalubrious and isolated. The interrelations between the spread of transportation systems across Brazil, the environment, scientific knowledge, and health-disease processes are discussed.
MeSH term(s)	Humans ; Influenza, Human/epidemiology ; Epidemics ; Brazil/epidemiology
Language	Portuguese
Publishing date	2023-07-10
Publishing country	Brazil
Document type	English Abstract ; Journal Article
ZDB-ID	2053148-5
ISSN	1678-4758 ; 0104-5970
ISSN (online)	1678-4758
ISSN	0104-5970
DOI	10.1590/S0104-59702023000100024
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Article ; Online: Fibroblast growth factor 23 and its role in phosphate homeostasis.

Ramon, Isolde / Kleynen, Pierre / Body, Jean-Jacques / Karmali, Rafik

European journal of endocrinology

2010 Volume 162, Issue 1, Page(s) 1–10

Abstract: Phosphate homeostasis is complex and incompletely understood. The identification of different factors involved in the regulation of phosphate balance, also called phosphatonins, has largely changed our view on the regulation of phosphate homeostasis. The ...

Abstract	Phosphate homeostasis is complex and incompletely understood. The identification of different factors involved in the regulation of phosphate balance, also called phosphatonins, has largely changed our view on the regulation of phosphate homeostasis. The active role of bone has been demonstrated clearly. Currently, maintaining phosphate homeostasis is considered the result of a complex network of endocrine feedback loops between parathyroid gland, kidney, and bone. This review describes current knowledge on fibroblast growth factor 23, which is one of the best studied phosphatonins.
MeSH term(s)	Animals ; Endocrine Cells/cytology ; Endocrine Cells/metabolism ; Endocrine Cells/secretion ; Fibroblast Growth Factors/genetics ; Fibroblast Growth Factors/physiology ; Fibroblast Growth Factors/secretion ; Homeostasis/genetics ; Homeostasis/physiology ; Humans ; Kidney/metabolism ; Kidney/physiology ; Kidney/secretion ; Osteogenesis/genetics ; Osteogenesis/physiology ; Phosphates/metabolism ; Phosphates/physiology ; Phosphates/urine
Chemical Substances	Phosphates ; fibroblast growth factor 23 ; Fibroblast Growth Factors (62031-54-3)
Language	English
Publishing date	2010-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1183856-5
ISSN	1479-683X ; 0804-4643
ISSN (online)	1479-683X
ISSN	0804-4643
DOI	10.1530/EJE-09-0597
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Article ; Online: O trem e a “senhorita espanhola”

Ramon Feliphe Souza

História, Ciências, Saúde: Manguinhos, Vol

a epidemia de gripe em Diamantina, 1918

2023 Volume 30

Abstract: ... que, até então, era representada no discurso de suas elites como isolada e salubre. Aborda as imbricadas relações entre a expansão ...

Abstract	Resumo O artigo analisa a epidemia de gripe de 1918 em Diamantina, no interior de Minas Gerais. A partir de fontes bibliográficas e documentais, discute como o ramal ferroviário da Estrada de Ferro Vitória a Minas, inaugurado em 1914, contribuiu para a chegada da doença à cidade que, até então, era representada no discurso de suas elites como isolada e salubre. Aborda as imbricadas relações entre a expansão dos sistemas de transportes pelo interior do Brasil, o meio ambiente, o conhecimento científico e os processos saúde/doença.
Keywords	história ; gripe espanhola ; epidemia ; Minas Gerais ; ferrovias ; History of medicine. Medical expeditions ; R131-687
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Fundação Oswaldo Cruz, Casa de Oswaldo Cruz
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Genomic Approach of Listeria monocytogenes Strains Isolated from Deli-Meats in Mexico.

Jiménez-Edeza, Maribel / Galván-Gordillo, Santiago Valentin / Pacheco-Arjona, Ramón / Castañeda-Ruelas, Gloria Marisol

Current microbiology

2024 Volume 81, Issue 6, Page(s) 145

Abstract: ... genes is lacking. Here, we present four high-quality genome drafts of L. monocytogenes strains isolated ...

Abstract	Listeria monocytogenes is a foodborne pathogen that causes listeriosis worldwide. In México, L. monocytogenes has been identified as a hazard of deli-meats. However, the genomic analysis that supports the transmission of L. monocytogenes strains via deli-meats and its role as a source for virulence and resistance genes is lacking. Here, we present four high-quality genome drafts of L. monocytogenes strains isolated from deli-meats in Mexico. In silico typing was used to determine the serotype, lineage, clonal complexes (CC), and multilocus sequence (ST). Also, comparative genomics were performed to explore the diversity, virulence, mobile elements, antimicrobial resistant and stress survival traits. The genome sequence size of these strains measured 3.05 ± 0.07 Mb with a mean value of 37.9%
MeSH term(s)	Humans ; Listeria monocytogenes/genetics ; Mexico ; Listeriosis ; Genomics ; Meat ; Food Microbiology
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	134238-1
ISSN	1432-0991 ; 0343-8651
ISSN (online)	1432-0991
ISSN	0343-8651
DOI	10.1007/s00284-024-03680-2
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Zs.A 1446: Show issues

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Article ; Online: Antioxidant and Antidiabetic Properties of Phlorotannins from Ascophyllum nodosum Seaweed Extracts

Mauro Gisbert / Daniel Franco / Jorge Sineiro / Ramón Moreira

Molecules, Vol 28, Iss 4937, p

2023 Volume 4937

Abstract: ... for their effectiveness in isolating phlorotannins. The chemical structure and isolation of phlorotannins are discussed ...

Abstract	Seaweeds have gained considerable attention in recent years due to their potential health benefits and high contents of bioactive compounds. This review focuses on the exploration of seaweed’s health-promoting properties, with particular emphasis on phlorotannins, a class of bioactive compounds known for their antioxidant and antidiabetic properties. Various novel and ecofriendly extraction methods, including solid–liquid extraction, ultrasound-assisted extraction, and microwave-assisted extraction are examined for their effectiveness in isolating phlorotannins. The chemical structure and isolation of phlorotannins are discussed, along with methods for their characterization, such as spectrophotometry, nuclear magnetic resonance, Fourier transform infrared spectroscopy, and chromatography. Special attention is given to the antioxidant activity of phlorotannins. The inhibitory capacities of polyphenols, specifically phlorotannins from Ascophyllum nodosum against digestive enzymes, such as α-amylase and α-glucosidase, are explored. The results suggest that polyphenols from Ascophyllum nodosum seaweed hold significant potential as enzyme inhibitors, although the inhibitory activity may vary depending on the extraction conditions and the specific enzyme involved. In conclusion, seaweed exhibits great potential as a functional food ingredient for promoting health and preventing chronic diseases. Overall, this review aims to condense a comprehensive collection of high-yield, low-cost, and ecofriendly extraction methods for obtaining phlorotannins with remarkable antioxidant and antidiabetic capacities.
Keywords	ultrasound-assisted extraction ; phlorotannins ; solid–liquid extraction ; antioxidant activity ; functional food ; α-amylase ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Hypophosphatemia related to paraneoplastic Cushing syndrome in prostate cancer: cure after bilateral adrenalectomy.

Ramon, Isolde / Kleynen, Pierre / Valsamis, Joseph / Body, Jean-Jacques / Karmali, Rafik

Calcified tissue international

2011 Volume 89, Issue 6, Page(s) 442–445

Abstract: We report the case of a 71-year-old man with progressive metastatic prostate cancer in whom simultaneous occurrence of paraneoplastic Cushing syndrome (CS) and tumor-induced osteomalacia (TIO) initially was suspected. However, the evolution of ... ...

Abstract	We report the case of a 71-year-old man with progressive metastatic prostate cancer in whom simultaneous occurrence of paraneoplastic Cushing syndrome (CS) and tumor-induced osteomalacia (TIO) initially was suspected. However, the evolution of biochemical markers of phosphate metabolism during disease course and after bilateral adrenalectomy argued against the diagnosis of TIO. Despite the persistence of progressive prostate cancer, CS and hypophosphatemia resolved in parallel after bilateral adrenalectomy. Thus, these data suggest that paraneoplastic CS per se was involved in the pathogenesis of hypophosphatemia. Calcitriol and intact fibroblast growth factor 23 (FGF23) levels were within the reference range at onset, which is inappropriate in the setting of severe hypophosphatemia. All parameters of phosphate metabolism normalized after resolution of hypercortisolism. Based on the known suppressive effect of glucocorticoids (GCs) on bone remodeling and the inverse relationship between bone turnover rate and circulating FGF23 levels, we postulate that GCs interfere indirectly with phosphate homeostasis by inducing inappropriate FGF23 production and release. This mechanism could further aggravate the hypophosphatemia resulting from GC-induced inhibition of intestinal phosphate absorption. Studies directed at the identification of the molecular pathways in bone mediating the interference of GCs with phosphate metabolism are warranted.
MeSH term(s)	Adrenalectomy ; Aged ; Calcitriol/metabolism ; Cushing Syndrome/complications ; Fibroblast Growth Factors/metabolism ; Humans ; Hypophosphatemia/etiology ; Hypophosphatemia/therapy ; Male ; Paraneoplastic Syndromes/complications ; Prostatic Neoplasms/complications ; Prostatic Neoplasms/pathology
Chemical Substances	fibroblast growth factor 23 ; Fibroblast Growth Factors (62031-54-3) ; Calcitriol (FXC9231JVH)
Language	English
Publishing date	2011-12
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	304266-2
ISSN	1432-0827 ; 0944-0747 ; 0008-0594 ; 0171-967X
ISSN (online)	1432-0827
ISSN	0944-0747 ; 0008-0594 ; 0171-967X
DOI	10.1007/s00223-011-9527-8
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Zs.A 317: Show issues

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Article ; Online: A workflow for the relative quantification of multiple fish species from oceanic water samples using environmental DNA (eDNA) to support large-scale fishery surveys.

Ramón-Laca, Ana / Wells, Abigail / Park, Linda

PloS one

2021 Volume 16, Issue 9, Page(s) e0257773

Abstract: While the number of published marine studies using environmental DNA (eDNA) has increased substantially in recent years, marine fish surveys are still scarce. To examine the potential for eDNA to support marine fisheries monitoring surveys, we optimized ... ...

Abstract	While the number of published marine studies using environmental DNA (eDNA) has increased substantially in recent years, marine fish surveys are still scarce. To examine the potential for eDNA to support marine fisheries monitoring surveys, we optimized an eDNA isolation method, developed a multispecies assay and tested it on eDNA samples collected along the Pacific coast of the United States. Four commercial DNA extraction kits that exploit the capability of the nucleic acids binding a solid phase (two using a silica matrix and two magnetic beads) as well an organic separation method were tested. A species-specific multiplex qPCR assay was developed and tested to simultaneously target Pacific hake (Merluccius productus), Pacific lamprey (Entosphenus tridentatus) and eulachon (Thaleichthys pacificus). The specificity of the assay was tested in silico, in vitro and in natura. Environmental DNA isolation using phenol:chloroform:isoamyl purification with a phase lock was optimized and yielded the highest amount of total and target DNA and was used to extract 46 marine water samples for the detection of the three species of interest. The multiplex qPCR assay used in the quantification process was also optimized to provide convenience and accuracy. Pacific hake was present in 44% of the eDNA samples while the other two species were absent. Here, we present a complete workflow for the simultaneous detection and quantification of multiple marine fish species using eDNA. This workflow supports large-scale at-sea sampling efforts with preservation at ambient temperatures and has demonstrated DNA extraction efficiency and reliability. The multiplex qPCR assay is shown to be sensitive and specific for the purposes of simultaneously monitoring the relative abundance of multiple targeted fish species.
MeSH term(s)	Animals ; DNA, Environmental/analysis ; DNA, Environmental/isolation & purification ; Environmental Monitoring/methods ; Fisheries ; Fishes/genetics ; Oceans and Seas ; Population ; Real-Time Polymerase Chain Reaction/methods ; Reproducibility of Results ; Sensitivity and Specificity ; Workflow
Chemical Substances	DNA, Environmental
Language	English
Publishing date	2021-09-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Validation Study
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0257773
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Article ; Online: A Tailored Strategy to Crosslink the Aspartate Transcarbamoylase Domain of the Multienzymatic Protein CAD.

Del Caño-Ochoa, Francisco / Rubio-Del-Campo, Antonio / Ramón-Maiques, Santiago

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 2

Abstract: ... by its large size and sensitivity to proteolytic cleavage. Recently, we succeeded in isolating intact CAD-like ...

Abstract	CAD is a 1.5 MDa hexameric protein with four enzymatic domains responsible for initiating de novo biosynthesis of pyrimidines nucleotides: glutaminase, carbamoyl phosphate synthetase, aspartate transcarbamoylase (ATC), and dihydroorotase. Despite its central metabolic role and implication in cancer and other diseases, our understanding of CAD is poor, and structural characterization has been frustrated by its large size and sensitivity to proteolytic cleavage. Recently, we succeeded in isolating intact CAD-like particles from the fungus
MeSH term(s)	Aspartic Acid ; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)/chemistry ; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)/metabolism ; Cryoelectron Microscopy ; Proteins ; Dihydroorotase/chemistry ; Aspartate Carbamoyltransferase/genetics ; Aspartate Carbamoyltransferase/chemistry ; Aspartate Carbamoyltransferase/metabolism
Chemical Substances	Aspartic Acid (30KYC7MIAI) ; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) (EC 6.3.5.5) ; Proteins ; Dihydroorotase (EC 3.5.2.3) ; Aspartate Carbamoyltransferase (EC 2.1.3.2)
Language	English
Publishing date	2023-01-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28020660
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