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  1. Book ; Online ; E-Book: Fibroblast growth factors

    Li, Xiaokun

    2024  

    Abstract: Fibroblast Growth Factors, Second Edition systematically introduces readers to FGF in the fields of injury repair and regeneration, endocrinology and metabolism, structure and modification, pharmaceutics, pharmacology, FGF/FGFR inhibitor, engineering and ...

    Author's details Xiaokun Li
    Abstract Fibroblast Growth Factors, Second Edition systematically introduces readers to FGF in the fields of injury repair and regeneration, endocrinology and metabolism, structure and modification, pharmaceutics, pharmacology, FGF/FGFR inhibitor, engineering and new drug development. Fibroblast growth factors (FGFs) are secreted protein ligands that act in a paracrine or endocrine fashion to carry out their pleiotropic functions in development, tissue homeostasis and metabolism. This book covers the work from Li's team from 2013 to 2018 and will be a primer for scientists, particularly young students entering the FGFs field with an eye on basic research and application.
    MeSH term(s) Fibroblast Growth Factors
    Keywords Fibroblast growth factors
    Subject code 910.5
    Language English
    Size 1 online resource (1034 pages)
    Edition Second edition.
    Publisher Academic Press
    Publishing place London
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-443-15794-4 ; 9780443157936 ; 978-0-443-15794-3 ; 0443157936
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: The Fibroblast Growth Factor Signaling Pathway in Metabolic Regulation, Development, Disease and Repair After Injury

    Wang, Zhouguang / Li, Xiaokun / Lin, Li / Bellusci, Saverio / Zhang, Jin-San

    2020  

    Keywords Science: general issues ; Pharmacology ; FGF (fibroblast growth factor) ; regeneration ; development ; metabolic regulation ; ischema-reperfusion injury
    Size 1 electronic resource (203 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230888
    ISBN 9782889661282 ; 2889661288
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Ischemic and Hemorrhagic Lesions Associated with Heatstroke.

    Hao, Xinlei / Yang, Ting / Li, Jun / Li, Xiaokun

    Neurology India

    2023  Volume 71, Issue 4, Page(s) 849–850

    MeSH term(s) Humans ; Heat Stroke/complications ; Ischemia
    Language English
    Publishing date 2023-08-28
    Publishing country India
    Document type Journal Article
    ZDB-ID 415522-1
    ISSN 1998-4022 ; 0028-3886
    ISSN (online) 1998-4022
    ISSN 0028-3886
    DOI 10.4103/0028-3886.383819
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 698: Show issues Location:
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  4. Article ; Online: Greater occipital nerve acupotomy combined with ultrasound-guided stellate ganglion block in the treatment of a case of cervicogenic headache.

    Yu, Qian / Zheng, Enrui / Li, Xiaokun / Ding, Xiuju

    Minerva medica

    2023  

    Language English
    Publishing date 2023-07-04
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 123586-2
    ISSN 1827-1669 ; 0026-4806
    ISSN (online) 1827-1669
    ISSN 0026-4806
    DOI 10.23736/S0026-4806.23.08740-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Risk factors and mortality of carbapenem-resistant Pseudomonas aeruginosa bloodstream infection in haematology department: A 10-year retrospective study.

    Yuan, Fangfang / Li, Minghui / Wang, Xiaokun / Fu, Yuewen

    Journal of global antimicrobial resistance

    2024  Volume 37, Page(s) 150–156

    Abstract: Objectives: This study aims to investigate the risk factors for carbapenem-resistant Pseudomonas aeruginosa bloodstream infection (CRPA-BSI) and identify predictors of outcomes among patients with P. aeruginosa bloodstream infection (PA-BSI).: Methods! ...

    Abstract Objectives: This study aims to investigate the risk factors for carbapenem-resistant Pseudomonas aeruginosa bloodstream infection (CRPA-BSI) and identify predictors of outcomes among patients with P. aeruginosa bloodstream infection (PA-BSI).
    Methods: A retrospective cohort study was conducted on patients with PA-BSI at Henan Cancer Hospital from 2013 to 2022.
    Results: Among the 503 incidences analysed, 15.1% of them were CRPA strains. Age, ANC < 100/mmc, receiving antifungal prophylaxis, exposure to carbapenems within the previous 90 days to onset of BSI, and allogeneic HSCT (allo-HSCT) were associated with the development of CRPA-BSI. CRPA-BSI patients experienced significantly higher 28-day mortality rates compared to those with carbapenem-susceptible P. aeruginosa bloodstream infection. Multivariate logistic regression analysis identified age at BSI, active stage of haematological disease, procalcitonin levels, prior corticosteroid treatment, isolation of CRPA, and septic shock as independent predictors of 28-day mortality.
    Conclusions: Risk factors for CRPA-BSI include age, ANC < 100/mmc, antifungal prophylaxis, exposure to carbapenems, and allo-HSCT. Additionally, age at BSI, active haematological disease, procalcitonin levels, prior corticosteroid treatment, CRPA isolation, and septic shock contribute to increased mortality rates among patients with PA-BSI.
    Language English
    Publishing date 2024-04-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2710046-7
    ISSN 2213-7173 ; 2213-7173
    ISSN (online) 2213-7173
    ISSN 2213-7173
    DOI 10.1016/j.jgar.2024.03.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Targeting the FGF19-FGFR4 pathway for cholestatic, metabolic, and cancerous diseases.

    Li, Xiaokun / Lu, Weiqin / Kharitonenkov, Alexei / Luo, Yongde

    Journal of internal medicine

    2024  Volume 295, Issue 3, Page(s) 292–312

    Abstract: Human fibroblast growth factor 19 (FGF19, or FGF15 in rodents) plays a central role in controlling bile acid (BA) synthesis through a negative feedback mechanism. This process involves a postprandial crosstalk between the BA-activated ileal farnesoid X ... ...

    Abstract Human fibroblast growth factor 19 (FGF19, or FGF15 in rodents) plays a central role in controlling bile acid (BA) synthesis through a negative feedback mechanism. This process involves a postprandial crosstalk between the BA-activated ileal farnesoid X receptor and the hepatic Klotho beta (KLB) coreceptor complexed with fibrobalst growth factor receptor 4 (FGFR4) kinase. Additionally, FGF19 regulates glucose, lipid, and energy metabolism by coordinating responses from functional KLB and FGFR1-3 receptor complexes on the periphery. Pharmacologically, native FGF19 or its analogs decrease elevated BA levels, fat content, and collateral tissue damage. This makes them effective in treating both cholestatic diseases such as primary biliary or sclerosing cholangitis (PBC or PSC) and metabolic abnormalities such as nonalcoholic steatohepatitis (NASH). However, chronic administration of FGF19 drives oncogenesis in mice by activating the FGFR4-dependent mitogenic or hepatic regenerative pathway, which could be a concern in humans. Agents that block FGF19 or FGFR4 signaling have shown great potency in preventing FGF19-responsive hepatocellular carcinoma (HCC) development in animal models. Recent phase 1/2 clinical trials have demonstrated promising results for several FGF19-based agents in selectively treating patients with PBC, PSC, NASH, or HCC. This review aims to provide an update on the clinical development of both analogs and antagonists targeting the FGF19-FGFR4 signaling pathway for patients with cholestatic, metabolic, and cancer diseases. We will also analyze potential safety and mechanistic concerns that should guide future research and advanced trials.
    MeSH term(s) Humans ; Mice ; Animals ; Carcinoma, Hepatocellular/drug therapy ; Liver Neoplasms/drug therapy ; Non-alcoholic Fatty Liver Disease ; Fibroblast Growth Factors/metabolism ; Signal Transduction ; Carcinogenesis/metabolism ; Receptor, Fibroblast Growth Factor, Type 4/metabolism
    Chemical Substances Fibroblast Growth Factors (62031-54-3) ; FGF19 protein, human ; FGFR4 protein, human (EC 2.7.10.1) ; Receptor, Fibroblast Growth Factor, Type 4 (EC 2.7.10.1)
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 96274-0
    ISSN 1365-2796 ; 0954-6820
    ISSN (online) 1365-2796
    ISSN 0954-6820
    DOI 10.1111/joim.13767
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.44: Show issues Location:
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  7. Article: Pulmonary embolism caused by hepatocellular carcinoma with tumor thrombus extending from hepatic veins into inferior vena cava and right atrium.

    Li, Xiaokun / Wang, Lihua / Li, Jun

    Revista espanola de enfermedades digestivas

    2023  

    Abstract: A 63-year-old man presented to emergency department with a 2-hour history of chest tightness and suffocation. The oxygen saturation was 50% while he was breathing ambient air. Laboratory evaluation revealed D2 polymer level, 0.69 mg/L (reference range, 0 ...

    Abstract A 63-year-old man presented to emergency department with a 2-hour history of chest tightness and suffocation. The oxygen saturation was 50% while he was breathing ambient air. Laboratory evaluation revealed D2 polymer level, 0.69 mg/L (reference range, 0 to 0.50), activated partial thromboplastin time, 75.0 s (reference range, 28.0 to 43.5). Computed tomography angiography of the chest showed thrombus in the right pulmonary artery, inferior vena cava and right atrium. Coronal view also demonstrated a hepatic mass with a massive neovascularization, extending from hepatic veins into the inferior vena cava.
    Language English
    Publishing date 2023-11-30
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2023.10113/2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 199: Show issues Location:
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  8. Article ; Online: The FGF metabolic axis.

    Li, Xiaokun

    Frontiers of medicine

    2019  Volume 13, Issue 5, Page(s) 511–530

    Abstract: Members of the fibroblast growth factor (FGF) family play pleiotropic roles in cellular and metabolic homeostasis. During evolution, the ancestor FGF expands into multiple members by acquiring divergent structural elements that enable functional ... ...

    Abstract Members of the fibroblast growth factor (FGF) family play pleiotropic roles in cellular and metabolic homeostasis. During evolution, the ancestor FGF expands into multiple members by acquiring divergent structural elements that enable functional divergence and specification. Heparan sulfate-binding FGFs, which play critical roles in embryonic development and adult tissue remodeling homeostasis, adapt to an autocrine/paracrine mode of action to promote cell proliferation and population growth. By contrast, FGF19, 21, and 23 coevolve through losing binding affinity for extracellular matrix heparan sulfate while acquiring affinity for transmembrane α-Klotho (KL) or β-KL as a coreceptor, thereby adapting to an endocrine mode of action to drive interorgan crosstalk that regulates a broad spectrum of metabolic homeostasis. FGF19 metabolic axis from the ileum to liver negatively controls diurnal bile acid biosynthesis. FGF21 metabolic axes play multifaceted roles in controlling the homeostasis of lipid, glucose, and energy metabolism. FGF23 axes from the bone to kidney and parathyroid regulate metabolic homeostasis of phosphate, calcium, vitamin D, and parathyroid hormone that are important for bone health and systemic mineral balance. The significant divergence in structural elements and multiple functional specifications of FGF19, 21, and 23 in cellular and organismal metabolism instead of cell proliferation and growth sufficiently necessitate a new unified and specific term for these three endocrine FGFs. Thus, the term "FGF Metabolic Axis," which distinguishes the unique pathways and functions of endocrine FGFs from other autocrine/paracrine mitogenic FGFs, is coined.
    MeSH term(s) Animals ; Calcium/metabolism ; Cell Proliferation ; Endocrine System/metabolism ; Fibroblast Growth Factors/classification ; Fibroblast Growth Factors/metabolism ; Homeostasis ; Humans ; Liver/metabolism ; Metabolic Diseases/metabolism ; Neoplasms/metabolism ; Phosphates/metabolism ; Signal Transduction ; Vitamin D/metabolism
    Chemical Substances Phosphates ; Vitamin D (1406-16-2) ; Fibroblast Growth Factors (62031-54-3) ; Calcium (SY7Q814VUP)
    Keywords covid19
    Language English
    Publishing date 2019-09-07
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2617113-2
    ISSN 2095-0225 ; 2095-0217
    ISSN (online) 2095-0225
    ISSN 2095-0217
    DOI 10.1007/s11684-019-0711-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Cross-Cultural Communication on Social Media: Review From the Perspective of Cultural Psychology and Neuroscience.

    Yuna, Di / Xiaokun, Liu / Jianing, Li / Lu, Han

    Frontiers in psychology

    2022  Volume 13, Page(s) 858900

    Abstract: Introduction: In recent years, with the popularity of many social media platforms worldwide, the role of "virtual social network platforms" in the field of cross-cultural communication has become increasingly important. Scholars in psychology and ... ...

    Abstract Introduction: In recent years, with the popularity of many social media platforms worldwide, the role of "virtual social network platforms" in the field of cross-cultural communication has become increasingly important. Scholars in psychology and neuroscience, and cross-disciplines, are attracted to research on the motivation, mechanisms, and effects of communication on social media across cultures.
    Methods and analysis: This paper collects the co-citation of keywords in "cultural psychology," "cross-culture communication," "neuroscience," and "social media" from the database of web of science and analyzes the hotspots of the literature in word cloud.
    Results: Based on our inclusion criteria, 85 relevant studies were extracted from a database of 842 papers. There were 44 articles on cultural communication on social media, of which 26 were from the perspective of psychology and five from the perspective of neuroscience. There are 27 articles that focus on the integration of psychology and neuroscience, but only a few are related to cross-cultural communication on social media.
    Conclusion: Scholars have mainly studied the reasons and implications of cultural communication on social media from the perspectives of cultural psychology and neuroscience separately. Keywords "culture" and "social media" generate more links in the hot map, and a large number of keywords of cultural psychology and neuroscience also gather in the hot map, which reflects the trend of integration in academic research. While cultural characteristics have changed with the development of new media and virtual communities, more research is needed to integrate the disciplines of culture, psychology, and neuroscience.
    Language English
    Publishing date 2022-03-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.858900
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: An update on the mechanism of neural stem cell transplantation in the treatment of Alzheimer’s disease

    CHEN Xiaokun, BAO Xinjie, GAO Jun, LI Yongning

    Jichu yixue yu linchuang, Vol 43, Iss 7, Pp 1148-

    2023  Volume 1151

    Abstract: At present, no effective strategy exists to slow down the progression of Alzheimer’s disease (AD). A deeper understanding of the pathogenesis of AD and the development of new therapeutic approaches are essential. Stem cell transplantation for the ... ...

    Abstract At present, no effective strategy exists to slow down the progression of Alzheimer’s disease (AD). A deeper understanding of the pathogenesis of AD and the development of new therapeutic approaches are essential. Stem cell transplantation for the treatment of neurodegenerative diseases is currently a research hotspot. Numerous studies have suggested that neural stem cells (NSCs) can differentiate into functional neurons, replace dead neurons, and form synaptic connections with adjacent surviving neurons, thereby achieving a therapeutic effect. In theory, the use of NSCs to replace and restore damaged cholinergic neurons and synapses may provide a new therapeutic option for AD. This review summarizes the recent preclinical research progress of NSC transplantation for the treatment of AD.
    Keywords alzheimer’s disease|cell transplantation|neural stem cells ; Medicine ; R
    Language Chinese
    Publishing date 2023-07-01T00:00:00Z
    Publisher Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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