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Article ; Online: Fibrodysplasia ossificans progressiva: a case report.

Baidoo, Richard O / Dayie, Makafui S

Ghana medical journal

2017 Volume 50, Issue 4, Page(s) 248–250

Abstract: Fibrodysplasia Ossificans Progressiva is a rare debilitating disorder of the musculoskeletal system affecting one in two million individuals. It is characterized by progressive extraskeletal ossification of soft tissues resulting in the original skeleton ...

Abstract	Fibrodysplasia Ossificans Progressiva is a rare debilitating disorder of the musculoskeletal system affecting one in two million individuals. It is characterized by progressive extraskeletal ossification of soft tissues resulting in the original skeleton being encased in unyielding new bone leading to disability and ultimately death from cardiorespiratory failure. The present case brings to light the delays and potential pitfalls in diagnosis as a result of the rarity of the condition.
MeSH term(s)	Analgesics/therapeutic use ; Back/diagnostic imaging ; Child ; Disease Progression ; Glucocorticoids/therapeutic use ; Hallux Valgus/diagnostic imaging ; Hallux Valgus/etiology ; Humans ; Male ; Myositis Ossificans/complications ; Myositis Ossificans/diagnosis ; Myositis Ossificans/diagnostic imaging ; Myositis Ossificans/drug therapy ; Neck/diagnostic imaging ; Prednisolone/therapeutic use ; Radiography
Chemical Substances	Analgesics ; Glucocorticoids ; Prednisolone (9PHQ9Y1OLM)
Language	English
Publishing date	2017-05-31
Publishing country	Ghana
Document type	Case Reports ; Journal Article
ISSN	2616-163X
ISSN (online)	2616-163X
DOI	10.4314/gmj.v50i4.8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Identifying Key Genetic Regions for Cell Sheet Morphogenesis on Chromosome 2L Using a

Fogerson, Stephanie M / Mortensen, Richard D / Moore, Regan P / Chiou, Hellen Y / Prabhu, Neel K / Wei, Angela H / Tsai, Daniel / Jadi, Othmane / Andoh-Baidoo, Kwabena / Crawford, Janice / Mudziviri, Murotiwamambo / Kiehart, Daniel P

G3 (Bethesda, Md.)

2020 Volume 10, Issue 11, Page(s) 4249–4269

Abstract: Cell sheet morphogenesis is essential for metazoan development and homeostasis of animal form - it contributes to developmental milestones including gastrulation, neural tube closure, heart and palate formation and to tissue maintenance during wound ... ...

Abstract	Cell sheet morphogenesis is essential for metazoan development and homeostasis of animal form - it contributes to developmental milestones including gastrulation, neural tube closure, heart and palate formation and to tissue maintenance during wound healing. Dorsal closure, a well-characterized stage in
MeSH term(s)	Animals ; Chromosomes ; Drosophila/genetics ; Drosophila Proteins/genetics ; Drosophila melanogaster/genetics ; Embryo, Nonmammalian ; Embryonic Development ; Epidermis ; Morphogenesis/genetics
Chemical Substances	Drosophila Proteins
Language	English
Publishing date	2020-11-05
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2629978-1
ISSN	2160-1836 ; 2160-1836
ISSN (online)	2160-1836
ISSN	2160-1836
DOI	10.1534/g3.120.401386
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Article: Use of Chemical Flocculation and Nested PCR for Heterodera glycines Detection in DNA Extracts from Field Soils with Low Population Densities

Baidoo, Richard / Yan Guiping / Nelson Berlin / Skantar Andrea M / Chen Senyu

Plant disease. 2017 July, v. 101, no. 7

2017

Abstract: ... coupled with PCR inhibitor removal by AlNHâ(SOâ)â0.12HâO treatment of soil DNA extracts followed ...

Abstract	The soybean cyst nematode (SCN) Heterodera glycines is a major pathogen of soybean worldwide. Distinction between SCN and other members of the H. schachtii sensu stricto group based on morphology is a tedious task. A molecular assay was developed to detect SCN in field soils with low population densities and to differentiate SCN from other species. Various numbers of SCN eggs or juveniles were inoculated into 10 g of sterilized soil from which soil DNA was extracted using the PowerSoil DNA Isolation Kit. A specific amplicon was amplified using published SCN-specific primers SCNF1/SCNR1. This primer set was evaluated for the first time to detect SCN directly in soil DNA extracts. The specificity of the primers was confirmed by testing 36 isolates of other nematode species. The PCR assay detected one SCN egg or juvenile added to 10 g of soil. The assay was validated using 35 field soil samples. Grinding the field soil coupled with PCR inhibitor removal by AlNHâ(SOâ)â0.12HâO treatment of soil DNA extracts followed by nested PCR enabled SCN detection as low as 12 SCN eggs/200 g soil. The PCR assay not only provides a sensitive method for SCN detection at low densities but also provides a discrimination method for SCN from other closely related nematodes.
Keywords	DNA ; DNA primers ; Heterodera glycines ; eggs ; flocculation ; grinding ; juveniles ; pathogens ; polymerase chain reaction ; population density ; soil ; soil sampling ; soil sterilization ; soybeans ; sulfates
Language	English
Dates of publication	2017-07
Size	p. 1153-1161.
Publishing place	Plant Disease
Document type	Article
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094%2FPDIS-08-16-1163-RE
Database	NAL-Catalogue (AGRICOLA)

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Article: The impact of enhanced and non-enhanced biochars on the catabolism of 14C-phenanthrene in soil

Omoni, Victor T / Baidoo, Paul K / Fagbohungbe, Michael O / Semple, Kirk T

Environmental technology & innovation. 2020 Nov., v. 20

2020

Abstract: ... due to its carbon and nutrient-rich properties. The aim of this study was to investigate the impact ...

Abstract	Biochar is a by-product from the pyrolysis of biomass and has a great potential in soil amendment due to its carbon and nutrient-rich properties. The aim of this study was to investigate the impact of increasing amounts (0, 0.01, 0.1, 0.2, 0.5 and 1.0%) of two types of biochar (so-called enhanced and non-enhanced) to soil on the biodegradation of ¹⁴C-phenanthrene. Enhanced biochar contains inoculants which are designed to potentially stimulate microbial activity and promote biological function in soil. After 100 d of incubation, the addition of 0.5% and 1% enhanced (EbioC) and non-enhanced biochars (NEbioC) led to longer lag phases, reduced rates and extents of ¹⁴C-phenanthrene in amended soil. However, in soils amended with 0.01%, 0.1% and 0.2% amendments, extents of mineralisation of ¹⁴C-phenanthrene increased and were found to be higher in the EBioC — as compared to the NEbioC-amended soils. Increasing soil-phenanthrene contact time also increased ¹⁴C-phenanthrene mineralisation in soil which had received smaller amounts of EBioC. Application of both EbioC and NEbioC also enriched the soil microbial populations during the incubation. However, it was found that phenanthrene-degrading microbial populations declined as soil contact time increased; this was particularly true for soils receiving larger amounts due to reduction in the mobile/bioaccessible fraction of the phenanthrene in soil. The findings revealed the importance of the type and amount of biochar that may be added to soil to stimulate or enhance organic contaminant biodegradation.
Keywords	biochar ; biodegradation ; biomass ; byproducts ; carbon ; catabolism ; environmental technology ; microbial activity ; mineralization ; phenanthrenes ; pyrolysis ; soil ; soil amendments
Language	English
Dates of publication	2020-11
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ISSN	2352-1864
DOI	10.1016/j.eti.2020.101146
Database	NAL-Catalogue (AGRICOLA)

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Article: Influence of hydrocracking and ionic liquid pretreatments on composition and properties of Arabidopsis thaliana wild type and CAD mutant lignins

Jacquet, Nicolas / Baidoo, Edward / Benites, Veronica / Bouxin, Florent / Dutta, Tanmoy / Eudes, Aymerick / Kim, Kwang Ho / Loqué, Dominique / Richel, Aurore / Simmons, Blake / Singh, Seema

Renewable energy. 2020 June, v. 152

2020

Abstract: ... of lignin by about 65% and decrease the content of β-O-4 linkages between lignin monomers. For Arabidopsis ... molecular structure of lignin, which indicates that (8-O-4), (8-5), and (8-8) linkages observed in CAD mutant make ...

Abstract	Lignin is the primary contributor to the high cost of biofuel-production from lignocellulosic biomass. In order to study lignin removal and the release of aromatic monomers, we applied hydrocracking and ionic liquid pretreatments on Arabidopsis thaliana biomass from both wild type (WT) and a mutant (CAD cxd) defective in two cinnamyl alcohol dehydrogenase genes involved in the lignin biosynthetic pathway. For Arabidopsis WT, our results highlight that pretreatments reduce average molecular weight of lignin by about 65% and decrease the content of β-O-4 linkages between lignin monomers. For Arabidopsis CAD mutant, an opposite effect is evidenced. Fewer differences were observed on depolymerization and molecular structure of lignin, which indicates that (8-O-4), (8-5), and (8-8) linkages observed in CAD mutant make lignin more resilient to pretreatment than wild-type lignin. Finally, our study shows the potential of hydrocracking pretreatment technology for extracting valuable aldehyde monomers such as vanillin and syringaldehyde from biomass.
Keywords	Arabidopsis thaliana ; biochemical pathways ; biomass ; chemical structure ; cinnamyl alcohol dehydrogenase ; depolymerization ; fuel production ; genes ; ionic liquids ; lignin ; lignocellulose ; molecular weight ; mutants ; renewable energy sources ; vanillin
Language	English
Dates of publication	2020-06
Size	p. 1241-1249.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2001449-1
ISSN	0960-1481
ISSN	0960-1481
DOI	10.1016/j.renene.2020.01.153
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: SbCOMT (Bmr12) is involved in the biosynthesis of tricin-lignin in sorghum.

Eudes, Aymerick / Dutta, Tanmoy / Deng, Kai / Jacquet, Nicolas / Sinha, Anagh / Benites, Veronica T / Baidoo, Edward E K / Richel, Aurore / Sattler, Scott E / Northen, Trent R / Singh, Seema / Simmons, Blake A / Loqué, Dominique

PloS one

2017 Volume 12, Issue 6, Page(s) e0178160

Abstract: ... selgin. It has recently been demonstrated in rice and maize that caffeate O-methyltransferase (COMT ... in the synthesis of tricin in planta. In this work, we validate in sorghum (Sorghum bicolor L.) that the O ...

Abstract	Lignin in plant biomass represents a target for engineering strategies towards the development of a sustainable bioeconomy. In addition to the conventional lignin monomers, namely p-coumaryl, coniferyl and sinapyl alcohols, tricin has been shown to be part of the native lignin polymer in certain monocot species. Because tricin is considered to initiate the polymerization of lignin chains, elucidating its biosynthesis and mechanism of export to the cell wall constitute novel challenges for the engineering of bioenergy crops. Late steps of tricin biosynthesis require two methylation reactions involving the pathway intermediate selgin. It has recently been demonstrated in rice and maize that caffeate O-methyltransferase (COMT) involved in the synthesis syringyl (S) lignin units derived from sinapyl alcohol also participates in the synthesis of tricin in planta. In this work, we validate in sorghum (Sorghum bicolor L.) that the O-methyltransferase responsible for the production of S lignin units (SbCOMT / Bmr12) is also involved in the synthesis of lignin-linked tricin. In particular, we show that biomass from the sorghum bmr12 mutant contains lower level of tricin incorporated into lignin, and that SbCOMT can methylate the tricin precursors luteolin and selgin. Our genetic and biochemical data point toward a general mechanism whereby COMT is involved in the synthesis of both tricin and S lignin units.
MeSH term(s)	Biomass ; Biosynthetic Pathways ; Cellulose/metabolism ; Chromones/metabolism ; Flavonoids/biosynthesis ; Flavonoids/chemistry ; Lignin/biosynthesis ; Lignin/chemistry ; Luteolin/metabolism ; Methanol/chemistry ; Methylation ; Plant Proteins/metabolism ; Sorghum/metabolism
Chemical Substances	Chromones ; Flavonoids ; Plant Proteins ; tricetin (5627PY99ZO) ; Cellulose (9004-34-6) ; Lignin (9005-53-2) ; tricin (D51JZL38TQ) ; Luteolin (KUX1ZNC9J2) ; Methanol (Y4S76JWI15)
Language	English
Publishing date	2017-06-08
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0178160
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Detection of Plasmodium falciparum histidine-rich protein II in saliva of malaria patients.

Wilson, Nana O / Adjei, Andrew A / Anderson, Winston / Baidoo, Stella / Stiles, Jonathan K

The American journal of tropical medicine and hygiene

2008 Volume 78, Issue 5, Page(s) 733–735

Abstract: ... Plasmodium falciparum histidine-rich protein II (PfHRP II) levels in plasma and saliva were compared in malaria-positive ...

Abstract	Detection of Plasmodium falciparum parasites in patients with malaria necessitates drawing blood, which increases the risk of accidental infections and is poorly accepted in communities with blood taboos. Thus, non-invasive, cost-effective malaria tests that minimize the need for blood collection are needed. Plasmodium falciparum histidine-rich protein II (PfHRP II) levels in plasma and saliva were compared in malaria-positive and -negative patients in Ghana. Plasma and saliva obtained from 30 thick-film positive and 10 negative children were evaluated for PfHRP II by ELISA. Among the 30 children with positive blood smear, 16 (53%) were PfHRP II positive in plasma and 13 (43%) had PfHRP II positive saliva. The sensitivity of PfHRP II detection was 53% for plasma and 43% for saliva. The specificity was 100% with no false positive for both plasma and saliva when compared with blood smear. Thus, rapid detection of PfHRP II antigen in saliva may be a useful non-invasive and cost-effective malaria diagnostic technique.
MeSH term(s)	Adolescent ; Animals ; Antigens, Protozoan/analysis ; Antigens, Protozoan/blood ; Child ; Child, Preschool ; Female ; Humans ; Malaria, Falciparum/diagnosis ; Male ; Protozoan Proteins/analysis ; Protozoan Proteins/blood ; Reference Values ; Saliva/parasitology ; Sensitivity and Specificity ; Specimen Handling/methods
Chemical Substances	Antigens, Protozoan ; HRP-2 antigen, Plasmodium falciparum ; Protozoan Proteins
Language	English
Publishing date	2008-05-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: SbCOMT (Bmr12) is involved in the biosynthesis of tricin-lignin in sorghum.

Aymerick Eudes / Tanmoy Dutta / Kai Deng / Nicolas Jacquet / Anagh Sinha / Veronica T Benites / Edward E K Baidoo / Aurore Richel / Scott E Sattler / Trent R Northen / Seema Singh / Blake A Simmons / Dominique Loqué

PLoS ONE, Vol 12, Iss 6, p e

2017 Volume 0178160

Abstract	Lignin in plant biomass represents a target for engineering strategies towards the development of a sustainable bioeconomy. In addition to the conventional lignin monomers, namely p-coumaryl, coniferyl and sinapyl alcohols, tricin has been shown to be part of the native lignin polymer in certain monocot species. Because tricin is considered to initiate the polymerization of lignin chains, elucidating its biosynthesis and mechanism of export to the cell wall constitute novel challenges for the engineering of bioenergy crops. Late steps of tricin biosynthesis require two methylation reactions involving the pathway intermediate selgin. It has recently been demonstrated in rice and maize that caffeate O-methyltransferase (COMT) involved in the synthesis syringyl (S) lignin units derived from sinapyl alcohol also participates in the synthesis of tricin in planta. In this work, we validate in sorghum (Sorghum bicolor L.) that the O-methyltransferase responsible for the production of S lignin units (SbCOMT / Bmr12) is also involved in the synthesis of lignin-linked tricin. In particular, we show that biomass from the sorghum bmr12 mutant contains lower level of tricin incorporated into lignin, and that SbCOMT can methylate the tricin precursors luteolin and selgin. Our genetic and biochemical data point toward a general mechanism whereby COMT is involved in the synthesis of both tricin and S lignin units.
Keywords	Medicine ; R ; Science ; Q
Subject code	580
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: SbCOMT (Bmr12) is involved in the biosynthesis of tricin-lignin in sorghum

Eudes, Aymerick / Tanmoy Dutta / Kai Deng / Nicolas Jacquet / Anagh Sinha / Veronica T. Benites / Edward E.K. Baidoo / Aurore Richel / Scott E. Sattler / Trent R. Northen / Seema Singh / Blake A. Simmons / Dominique LoquÃ©

Plos One. 2017 June, v. 12, no. 6

2017

Abstract	Lignin in plant biomass represents a target for engineering strategies towards the development of a sustainable bioeconomy. In addition to the conventional lignin monomers, namely p-coumaryl, coniferyl and sinapyl alcohols, tricin has been shown to be part of the native lignin polymer in certain monocot species. Because tricin is considered to initiate the polymerization of lignin chains, elucidating its biosynthesis and mechanism of export to the cell wall constitute novel challenges for the engineering of bioenergy crops. Late steps of tricin biosynthesis require two methylation reactions involving the pathway intermediate selgin. It has recently been demonstrated in rice and maize that caffeate O-methyltransferase (COMT) involved in the synthesis syringyl (S) lignin units derived from sinapyl alcohol also participates in the synthesis of tricin in planta. In this work, we validate in sorghum (Sorghum bicolor L.) that the O-methyltransferase responsible for the production of S lignin units (SbCOMT / Bmr12) is also involved in the synthesis of lignin-linked tricin. In particular, we show that biomass from the sorghum bmr12 mutant contains lower level of tricin incorporated into lignin, and that SbCOMT can methylate the tricin precursors luteolin and selgin. Our genetic and biochemical data point toward a general mechanism whereby COMT is involved in the synthesis of both tricin and S lignin units.
Keywords	Sorghum bicolor ; bioeconomics ; biosynthesis ; caffeate O-methyltransferase ; cell walls ; corn ; energy crops ; lignin ; luteolin ; methylation ; mutants ; phytomass ; polymerization ; rice ; sinapyl alcohol
Language	English
Dates of publication	2017-06
Size	p. 1-11.
Document type	Article
ISSN	1932-6203
DOI	10.1371/journal.pone.0178160
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

Jostins, Luke / Ripke, Stephan / Weersma, Rinse K / Duerr, Richard H / McGovern, Dermot P / Hui, Ken Y / Lee, James C / Schumm, L Philip / Sharma, Yashoda / Anderson, Carl A / Essers, Jonah / Mitrovic, Mitja / Ning, Kaida / Cleynen, Isabelle / Theatre, Emilie / Spain, Sarah L / Raychaudhuri, Soumya / Goyette, Philippe / Wei, Zhi /

Abraham, Clara / Achkar, Jean-Paul / Ahmad, Tariq / Amininejad, Leila / Ananthakrishnan, Ashwin N / Andersen, Vibeke / Andrews, Jane M / Baidoo, Leonard / Balschun, Tobias / Bampton, Peter A / Bitton, Alain / Boucher, Gabrielle / Brand, Stephan / Büning, Carsten / Cohain, Ariella / Cichon, Sven / D'Amato, Mauro / De Jong, Dirk / Devaney, Kathy L / Dubinsky, Marla / Edwards, Cathryn / Ellinghaus, David / Ferguson, Lynnette R / Franchimont, Denis / Fransen, Karin / Gearry, Richard / Georges, Michel / Gieger, Christian / Glas, Jürgen / Haritunians, Talin / Hart, Ailsa / Hawkey, Chris / Hedl, Matija / Hu, Xinli / Karlsen, Tom H / Kupcinskas, Limas / Kugathasan, Subra / Latiano, Anna / Laukens, Debby / Lawrance, Ian C / Lees, Charlie W / Louis, Edouard / Mahy, Gillian / Mansfield, John / Morgan, Angharad R / Mowat, Craig / Newman, William / Palmieri, Orazio / Ponsioen, Cyriel Y / Potocnik, Uros / Prescott, Natalie J / Regueiro, Miguel / Rotter, Jerome I / Russell, Richard K / Sanderson, Jeremy D / Sans, Miquel / Satsangi, Jack / Schreiber, Stefan / Simms, Lisa A / Sventoraityte, Jurgita / Targan, Stephan R / Taylor, Kent D / Tremelling, Mark / Verspaget, Hein W / De Vos, Martine / Wijmenga, Cisca / Wilson, David C / Winkelmann, Juliane / Xavier, Ramnik J / Zeissig, Sebastian / Zhang, Bin / Zhang, Clarence K / Zhao, Hongyu / Silverberg, Mark S / Annese, Vito / Hakonarson, Hakon / Brant, Steven R / Radford-Smith, Graham / Mathew, Christopher G / Rioux, John D / Schadt, Eric E / Daly, Mark J / Franke, Andre / Parkes, Miles / Vermeire, Severine / Barrett, Jeffrey C / Cho, Judy H

Nature

2012 Volume 491, Issue 7422, Page(s) 119–124

Abstract: Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease (IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other populations. Genome-wide association studies and subsequent meta- ... ...

Abstract	Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease (IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other populations. Genome-wide association studies and subsequent meta-analyses of these two diseases as separate phenotypes have implicated previously unsuspected mechanisms, such as autophagy, in their pathogenesis and showed that some IBD loci are shared with other inflammatory diseases. Here we expand on the knowledge of relevant pathways by undertaking a meta-analysis of Crohn's disease and ulcerative colitis genome-wide association scans, followed by extensive validation of significant findings, with a combined total of more than 75,000 cases and controls. We identify 71 new associations, for a total of 163 IBD loci, that meet genome-wide significance thresholds. Most loci contribute to both phenotypes, and both directional (consistently favouring one allele over the course of human history) and balancing (favouring the retention of both alleles within populations) selection effects are evident. Many IBD loci are also implicated in other immune-mediated disorders, most notably with ankylosing spondylitis and psoriasis. We also observe considerable overlap between susceptibility loci for IBD and mycobacterial infection. Gene co-expression network analysis emphasizes this relationship, with pathways shared between host responses to mycobacteria and those predisposing to IBD.
MeSH term(s)	Colitis, Ulcerative/genetics ; Colitis, Ulcerative/immunology ; Colitis, Ulcerative/microbiology ; Colitis, Ulcerative/physiopathology ; Crohn Disease/genetics ; Crohn Disease/immunology ; Crohn Disease/microbiology ; Crohn Disease/physiopathology ; Genetic Predisposition to Disease/genetics ; Genome, Human/genetics ; Genome-Wide Association Study ; Haplotypes/genetics ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Humans ; Inflammatory Bowel Diseases/genetics ; Inflammatory Bowel Diseases/immunology ; Inflammatory Bowel Diseases/microbiology ; Inflammatory Bowel Diseases/physiopathology ; Mycobacterium/immunology ; Mycobacterium/pathogenicity ; Mycobacterium Infections/genetics ; Mycobacterium Infections/microbiology ; Mycobacterium tuberculosis/immunology ; Mycobacterium tuberculosis/pathogenicity ; Phenotype ; Polymorphism, Single Nucleotide/genetics ; Reproducibility of Results
Language	English
Publishing date	2012-11-06
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/nature11582
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