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  1. Article: Outcome of patients ≥ 60 years of age after alcohol septal ablation for hypertrophic obstructive cardiomyopathy.

    Jahnlová, Denisa / Tomašov, Pavol / Adlová, Radka / Januška, Jaroslav / Krejčí, Jan / Dabrowski, Maciej / Veselka, Josef

    Archives of medical science : AMS

    2019  Volume 15, Issue 3, Page(s) 650–655

    Abstract: Introduction: The outcome of patients ≥ 60 years of age after alcohol septal ablation (ASA) for obstructive hypertrophic cardiomyopathy (HCM) remains unresolved. We sought to determine the long-term survival and the causes of death in this population.!## ...

    Abstract Introduction: The outcome of patients ≥ 60 years of age after alcohol septal ablation (ASA) for obstructive hypertrophic cardiomyopathy (HCM) remains unresolved. We sought to determine the long-term survival and the causes of death in this population.
    Material and methods: We enrolled 156 consecutive patients (69 ±6 years, 69% women, follow-up: 4.8 ±3.5 years) who underwent ASA at ≥ 60 years of age.
    Results: The 30-day mortality rate was 1.3%. At the last check-up, 81% of patients were in New York Heart Association class ≤ 2 and 76% had a left ventricular outflow tract gradient (LVOG) ≤ 30 mm Hg. A total of 39 patients died (51% of cardiovascular causes, 44% of non-cardiovascular causes, 5% of unknown causes) during the 734 patient-years. The annual sudden mortality, the sudden mortality and the all-cause mortality rates were 0.5%, 1.1%, and 4.8%, respectively. The all-cause mortality was higher compared to the age- and sex-matched general population (
    Conclusions: Alcohol septal ablation was safe and effective in the long-term follow-up. We observed a reduced life expectancy compared to the age- and sex-matched general population. Mortality was almost equally due to cardiovascular and non-cardiovascular causes of death.
    Language English
    Publishing date 2019-04-30
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2203781-0
    ISSN 1734-1922
    ISSN 1734-1922
    DOI 10.5114/aoms.2019.84735
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Transatlantic differences in assessment of risk of sudden cardiac death in patients with hypertrophic cardiomyopathy.

    Jahnlová, Denisa / Tomašov, Pavol / Zemánek, David / Veselka, Josef

    International journal of cardiology

    2015  Volume 186, Page(s) 3–4

    MeSH term(s) Cardiomyopathy, Hypertrophic/complications ; Cardiomyopathy, Hypertrophic/therapy ; Death, Sudden, Cardiac/epidemiology ; Death, Sudden, Cardiac/etiology ; Death, Sudden, Cardiac/prevention & control ; Defibrillators, Implantable ; Female ; Global Health ; Humans ; Incidence ; Male ; Middle Aged ; Retrospective Studies
    Language English
    Publishing date 2015
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2015.03.207
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Outcome of patients ≥ 60 years of age after alcohol septal ablation for hypertrophic obstructive cardiomyopathy

    Denisa Jahnlová / Pavol Tomašov / Radka Adlová / Jaroslav Januška / Jan Krejčí / Maciej Dabrowski / Josef Veselka

    Archives of Medical Science, Vol 15, Iss 3, Pp 650-

    2019  Volume 655

    Keywords hypertrophic cardiomyopathy ; sudden cardiac death ; survival ; Medicine ; R
    Language English
    Publishing date 2019-04-01T00:00:00Z
    Publisher Termedia Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Myectomy-Like Extended Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy.

    Jahnlová, Denisa / Tomašov, Pavol / Veselka, Josef

    The International journal of angiology : official publication of the International College of Angiology, Inc

    2015  Volume 25, Issue 5, Page(s) e153–e155

    Abstract: Currently, two therapeutic options are available for patients with drug-resistant obstructive hypertrophic cardiomyopathy. While there is a tendency in extended myectomy to perform a larger septal reduction to eliminate left ventricular outflow tract ... ...

    Abstract Currently, two therapeutic options are available for patients with drug-resistant obstructive hypertrophic cardiomyopathy. While there is a tendency in extended myectomy to perform a larger septal reduction to eliminate left ventricular outflow tract gradient more effectively, there has been a trend in recent years toward using lower dosages of alcohol during alcohol septal ablation (ASA) to reduce the risk of arrhythmic complications. We report a case of a symptomatic patient with severe septal hypertrophy who underwent an extended ASA of three septal branches. This led to a result similar to an extended myectomy with a favorable short-term follow-up.
    Language English
    Publishing date 2015-09-30
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1144390-x
    ISSN 1061-1711
    ISSN 1061-1711
    DOI 10.1055/s-0035-1564660
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Fibromuscular Dysplasia of Renal and Carotid Arteries.

    Jahnlova, Denisa / Veselka, Josef

    The International journal of angiology : official publication of the International College of Angiology, Inc

    2015  Volume 24, Issue 3, Page(s) 241–243

    Abstract: We report here two cases of fibromuscular dysplasia (FMD). The first case describes an asymptomatic 75-year-old man with FMD of the right internal carotid artery. The second case reports a 17-year-old man who presented with arterial hypertension caused ... ...

    Abstract We report here two cases of fibromuscular dysplasia (FMD). The first case describes an asymptomatic 75-year-old man with FMD of the right internal carotid artery. The second case reports a 17-year-old man who presented with arterial hypertension caused by FMD of the left renal artery and was subsequently successfully treated by angioplasty. FMD is a rare nonatherosclerotic, noninflammatory angiopathy, which can involve almost every arterial vascular bed. It is a less common cause of stenosis of renal and carotid arteries. FMD can present with arterial hypertension when it involves renal arteries or with ischemic stroke or transient ischemic attack when the disease affects the carotid or vertebral arteries. Many cases are asymptomatic and may be discovered incidentally. Percutaneous transluminal angioplasty should be used in patients with a stenosis of the renal artery causing arterial hypertension. On the contrary, conservative therapy should be chosen in patients with asymptomatic and extensive lesions of the carotid arteries.
    Language English
    Publishing date 2015-04-24
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1144390-x
    ISSN 1061-1711
    ISSN 1061-1711
    DOI 10.1055/s-0034-1396931
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Myectomy-Like Extended Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy

    Jahnlová, Denisa / Tomašov, Pavol / Veselka, Josef

    International Journal of Angiology

    2015  Volume 25, Issue 05, Page(s) e153–e155

    Abstract: Currently, two therapeutic options are available for patients with drug-resistant obstructive hypertrophic cardiomyopathy. While there is a tendency in extended myectomy to perform a larger septal reduction to eliminate left ventricular outflow tract ... ...

    Abstract Currently, two therapeutic options are available for patients with drug-resistant obstructive hypertrophic cardiomyopathy. While there is a tendency in extended myectomy to perform a larger septal reduction to eliminate left ventricular outflow tract gradient more effectively, there has been a trend in recent years toward using lower dosages of alcohol during alcohol septal ablation (ASA) to reduce the risk of arrhythmic complications. We report a case of a symptomatic patient with severe septal hypertrophy who underwent an extended ASA of three septal branches. This led to a result similar to an extended myectomy with a favorable short-term follow-up.
    Keywords hypertrophic cardiomyopathy ; coronary artery ; symptomatic
    Language English
    Publishing date 2015-09-30
    Publisher Thieme Medical Publishers
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 1144390-x
    ISSN 1615-5939 ; 1061-1711
    ISSN (online) 1615-5939
    ISSN 1061-1711
    DOI 10.1055/s-0035-1564660
    Database Thieme publisher's database

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  7. Article: Fibromuscular Dysplasia of Renal and Carotid Arteries

    Jahnlova, Denisa / Veselka, Josef

    International Journal of Angiology

    2015  Volume 24, Issue 03, Page(s) 241–243

    Abstract: We report here two cases of fibromuscular dysplasia (FMD). The first case describes an asymptomatic 75-year-old man with FMD of the right internal carotid artery. The second case reports a 17-year-old man who presented with arterial hypertension caused ... ...

    Abstract We report here two cases of fibromuscular dysplasia (FMD). The first case describes an asymptomatic 75-year-old man with FMD of the right internal carotid artery. The second case reports a 17-year-old man who presented with arterial hypertension caused by FMD of the left renal artery and was subsequently successfully treated by angioplasty. FMD is a rare nonatherosclerotic, noninflammatory angiopathy, which can involve almost every arterial vascular bed. It is a less common cause of stenosis of renal and carotid arteries. FMD can present with arterial hypertension when it involves renal arteries or with ischemic stroke or transient ischemic attack when the disease affects the carotid or vertebral arteries. Many cases are asymptomatic and may be discovered incidentally. Percutaneous transluminal angioplasty should be used in patients with a stenosis of the renal artery causing arterial hypertension. On the contrary, conservative therapy should be chosen in patients with asymptomatic and extensive lesions of the carotid arteries.
    Keywords fibromuscular dysplasia ; “string-of-beads” sign ; stenosis ; percutaneous transluminal angioplasty ; arterial hypertension
    Language English
    Publishing date 2015-04-24
    Publisher Thieme Medical Publishers
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 1144390-x
    ISSN 1615-5939 ; 1061-1711
    ISSN (online) 1615-5939
    ISSN 1061-1711
    DOI 10.1055/s-0034-1396931
    Database Thieme publisher's database

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  8. Article ; Online: Risk and Causes of Death in Patients After Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy.

    Veselka, Josef / Zemánek, David / Jahnlová, Denisa / Krejčí, Jan / Januška, Jaroslav / Dabrowski, Maciej / Bartel, Thomas / Tomašov, Pavol

    The Canadian journal of cardiology

    2015  Volume 31, Issue 10, Page(s) 1245–1251

    Abstract: Background: Because the final myocardial scar might be theoretically associated with an increased risk of sudden cardiac death, the long-term clinical course of patients who undergo alcohol septal ablation (ASA) is still a matter of debate. In this ... ...

    Abstract Background: Because the final myocardial scar might be theoretically associated with an increased risk of sudden cardiac death, the long-term clinical course of patients who undergo alcohol septal ablation (ASA) is still a matter of debate. In this retrospective multicentre study, we report outcomes after ASA, including survival, analysis of causes of deaths, and association between time and cause of death.
    Methods: We enrolled 366 consecutive patients (58 ± 12 years, 54% women) who were treated using ASA and followed-up for 5.1 ± 4.5 years.
    Results: The in-hospital and 30-day mortality were 0.5% and 0.8%, respectively; the ASA-related morbidity was < 20%. Overall, 52 patients died during 1867 patient-years, which means the all-cause mortality rate was 2.8% per year. The mortality rates of sudden death and sudden death with an appropriate implantable cardioverter-defibrillator (ICD) discharge were 0.4% and 1% per year, respectively. Patients with sudden death or appropriate ICD discharge experienced these mortality events at younger age than patients who died of other hypertrophic obstructive cardiomyopathy-related causes (60.8 years [range, 52-71.5 years] vs 72.4 years [range, 64.2-75.2 years]; P = 0.048). A total of 292 patients (80%) had an outflow gradient ≤ 30 mm Hg, and 327 patients (89%) were in New York Heart Association class ≤ II at the last clinical check-up.
    Conclusions: ASA had low procedure-related mortality, with subsequent 1% occurrence of sudden mortality events per year and 2.8% mortality rate per year in the long-term follow-up. Patients with sudden death or ICD discharge experienced the mortality events approximately 1 decade earlier than patients who died from other causes not related to hypertrophic cardiomyopathy.
    MeSH term(s) Aged ; Alcohols/therapeutic use ; Austria/epidemiology ; Cardiomyopathy, Hypertrophic/diagnosis ; Cardiomyopathy, Hypertrophic/mortality ; Cardiomyopathy, Hypertrophic/surgery ; Catheter Ablation/adverse effects ; Catheter Ablation/methods ; Catheter Ablation/mortality ; Cause of Death ; Cicatrix/etiology ; Cicatrix/mortality ; Cicatrix/pathology ; Czech Republic/epidemiology ; Death, Sudden, Cardiac/etiology ; Death, Sudden, Cardiac/prevention & control ; Defibrillators, Implantable ; Electric Countershock/methods ; Electric Countershock/mortality ; Female ; Follow-Up Studies ; Hospital Mortality ; Humans ; Male ; Middle Aged ; Myocardium/pathology ; Poland/epidemiology ; Sclerosing Solutions/therapeutic use ; Survival Analysis ; Time Factors
    Chemical Substances Alcohols ; Sclerosing Solutions
    Language English
    Publishing date 2015-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2015.02.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Survival of patients ≤ 50 years of age after alcohol septal ablation for hypertrophic obstructive cardiomyopathy.

    Veselka, Josef / Krejčí, Jan / Tomašov, Pavol / Jahnlová, Denisa / Honěk, Tomáš / Januška, Jaroslav / Branny, Marian / Zemánek, David

    The Canadian journal of cardiology

    2014  Volume 30, Issue 6, Page(s) 634–638

    Abstract: Background: The long-term efficacy and safety of alcohol septal ablation (ASA) has recently been demonstrated. However, there is still debate about the outcome of younger patients who should be treated using myectomy, according to American College of ... ...

    Abstract Background: The long-term efficacy and safety of alcohol septal ablation (ASA) has recently been demonstrated. However, there is still debate about the outcome of younger patients who should be treated using myectomy, according to American College of Cardiology Foundation/American Heart Association guidelines. The aim of this study was to evaluate the long-term outcome of patients ≤ 50 years of age after ASA for hypertrophic obstructive cardiomyopathy (HOCM).
    Methods: We retrospectively evaluated consecutive, highly symptomatic patients aged ≤ 50 years with HOCM who underwent ASA.
    Results: Institutional databases of 3 cardiovascular centres identified 290 patients with HOCM who underwent ASA; 75 (26%) of them were aged ≤ 50 years at the time of their first ASA. Median duration of follow-up was 5.1 years (range, 0.1-15.4 years). Four patients (5%) died during the study period (438 patient-years; the annual mortality rate was 0.91%; 95% confidence interval [CI], 0.25-2.34%; the annual mortality rate combined with the first appropriate implantable cardioverter-defibrillator discharge was 1.43%; 95% CI, 0.52-3.10%). Survival free of all-cause mortality at 1, 5, and 10 years was 97% (95% CI, 89-99%), 94% (95% CI, 84-98%), and 94% (95% CI, 84-98%), respectively.
    Conclusions: Results of this first study focused on HOCM patients aged ≤ 50 years who underwent ASA suggest a low risk of all-cause death or appropriate implantable cardioverter-defibrillator discharge in the long-term follow-up.
    MeSH term(s) Ablation Techniques ; Adult ; Cardiomyopathy, Hypertrophic/mortality ; Cardiomyopathy, Hypertrophic/surgery ; Czech Republic/epidemiology ; Death, Sudden/epidemiology ; Defibrillators, Implantable ; Ethanol/administration & dosage ; Follow-Up Studies ; Humans ; Kaplan-Meier Estimate ; Middle Aged ; Multivariate Analysis ; Pacemaker, Artificial ; Retrospective Studies ; Solvents/administration & dosage ; Stroke/mortality ; Ventricular Septum/surgery
    Chemical Substances Solvents ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2014-06
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2014.03.041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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