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  1. Article: Fibrosis in diabetes complications: pathogenic mechanisms and circulating and urinary markers.

    Ban, Camelia R / Twigg, Stephen M

    Vascular health and risk management

    2008  Volume 4, Issue 3, Page(s) 575–596

    Abstract: Diabetes mellitus is characterized by a lack of insulin causing elevated blood glucose, often with associated insulin resistance. Over time, especially in genetically susceptible individuals, such chronic hyperglycemia can cause tissue injury. One ... ...

    Abstract Diabetes mellitus is characterized by a lack of insulin causing elevated blood glucose, often with associated insulin resistance. Over time, especially in genetically susceptible individuals, such chronic hyperglycemia can cause tissue injury. One pathological response to tissue injury is the development of fibrosis, which involves predominant extracellular matrix (ECM) accumulation. The main factors that regulate ECM in diabetes are thought to be pro-sclerotic cytokines and protease/anti-protease systems. This review will examine the key markers and regulators of tissue fibrosis in diabetes and whether their levels in biological fluids may have clinical utility.
    MeSH term(s) Animals ; Basement Membrane/pathology ; Biomarkers/blood ; Biomarkers/metabolism ; Biomarkers/urine ; Cardiomyopathies/metabolism ; Cardiomyopathies/pathology ; Connective Tissue Growth Factor ; Diabetes Complications/blood ; Diabetes Complications/metabolism ; Diabetes Complications/pathology ; Diabetes Complications/urine ; Diabetic Angiopathies/metabolism ; Diabetic Angiopathies/pathology ; Diabetic Nephropathies/metabolism ; Diabetic Nephropathies/pathology ; Diabetic Retinopathy/metabolism ; Diabetic Retinopathy/pathology ; Endothelium, Vascular/pathology ; Extracellular Matrix/metabolism ; Extracellular Matrix/pathology ; Fatty Liver/pathology ; Fibrosis ; Glycation End Products, Advanced/metabolism ; Heart Diseases/metabolism ; Heart Diseases/pathology ; Heart Failure/metabolism ; Heart Failure/pathology ; Humans ; Hyperglycemia/metabolism ; Hyperglycemia/pathology ; Immediate-Early Proteins/metabolism ; Insulin Resistance ; Intercellular Signaling Peptides and Proteins/metabolism ; Liver Cirrhosis/metabolism ; Metalloproteases/metabolism ; Peptide Fragments/blood ; Procollagen/blood ; Renin-Angiotensin System/physiology ; Transforming Growth Factor beta/metabolism ; Tunica Intima/pathology ; Up-Regulation/physiology
    Chemical Substances Biomarkers ; CCN2 protein, human ; Glycation End Products, Advanced ; Immediate-Early Proteins ; Intercellular Signaling Peptides and Proteins ; Peptide Fragments ; Procollagen ; Transforming Growth Factor beta ; procollagen Type III-N-terminal peptide ; Connective Tissue Growth Factor (139568-91-5) ; Metalloproteases (EC 3.4.-)
    Language English
    Publishing date 2008-10-21
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2186568-1
    ISSN 1178-2048 ; 1176-6344
    ISSN (online) 1178-2048
    ISSN 1176-6344
    DOI 10.2147/vhrm.s1991
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6066: Show issues Location:
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  2. Article ; Online: Fibrosis in diabetes complications

    Camelia R Ban / Stephen M Twigg

    Vascular Health and Risk Management, Vol 2008, Iss Issue 3, Pp 575-

    Pathogenic mechanisms and circulating and urinary markers

    2008  Volume 596

    Abstract: Camelia R Ban, Stephen M TwiggDiscipline of Medicine and Department of Endocrinology ...

    Abstract Camelia R Ban, Stephen M TwiggDiscipline of Medicine and Department of Endocrinology, The University of Sydney and Royal Prince Alfred Hospital, Sydney, New South Wales, 2006, AustraliaAbstract: Diabetes mellitus is characterized by a lack of insulin causing elevated blood glucose, often with associated insulin resistance. Over time, especially in genetically susceptible individuals, such chronic hyperglycemia can cause tissue injury. One pathological response to tissue injury is the development of fibrosis, which involves predominant extracellular matrix (ECM) accumulation. The main factors that regulate ECM in diabetes are thought to be pro-sclerotic cytokines and protease/anti-protease systems. This review will examine the key markers and regulators of tissue fibrosis in diabetes and whether their levels in biological fluids may have clinical utility.Keywords: diabetic complications, extracellular matrix, markers
    Keywords Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Cardiovascular ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 571
    Language English
    Publishing date 2008-06-01T00:00:00Z
    Publisher Dove Medical Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Tumor necrosis factor-alpha neutralization reduced cerebral edema through inhibition of matrix metalloproteinase production after transient focal cerebral ischemia.

    Hosomi, Naohisa / Ban, Camelia R / Naya, Takayuki / Takahashi, Tsutomu / Guo, Peng / Song, Xiao-yu R / Kohno, Masakazu

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    2005  Volume 25, Issue 8, Page(s) 959–967

    Abstract: After focal cerebral ischemia, tumor necrosis factor-alpha deteriorates cerebral edema and survival rate. Therefore, tumor necrosis factor-alpha neutralization could reduce cerebral microvascular permeability in acute cerebral ischemia. Left middle ... ...

    Abstract After focal cerebral ischemia, tumor necrosis factor-alpha deteriorates cerebral edema and survival rate. Therefore, tumor necrosis factor-alpha neutralization could reduce cerebral microvascular permeability in acute cerebral ischemia. Left middle cerebral artery occlusion for 120 mins followed by reperfusion was performed with the thread method under halothane anesthesia in Sprague-Dawley rats. Antirat tumor necrosis factor-alpha neutralizing monoclonal antibody with a rat IgG Fc portion (15 mg/kg) was infused intravenously right after reperfusion. Stroke index score, infarct volume, cerebral specific gravity, and the endogenous expression of tumor necrosis factor-alpha, matrix metalloproteinase (MMP)-2, MMP-9, and membrane type 1-MMP in the brain tissue were quantified in the ischemic and matched contralateral nonischemic hemisphere. In the antitumor necrosis factor-alpha neutralizing antibody-treated rats, infarct volume was significantly reduced (P=0.014, n=7; respectively), and cerebral specific gravity was dramatically increased in the cortex and caudate putamen (P<0.001, n=7; respectively) in association with a reduction in MMP-9 and membrane type 1-MMP upregulation. Tumor necrosis factor-alpha in the brain tissue was significantly elevated in the ischemic hemisphere 6 h after reperfusion in the nonspecific IgG-treated rats (P=0.021, n=7) and was decreased in the antitumor necrosis factor-alpha neutralizing antibody-treated rats (P=0.001, n=7). Postreperfusion treatment with antirat tumor necrosis factor-alpha neutralizing antibody reduced brain infarct volume and cerebral edema, which is likely mediated by a reduction in MMP upregulation.
    MeSH term(s) Animals ; Antibodies, Blocking/pharmacology ; Antibodies, Monoclonal/pharmacology ; Blood Pressure/drug effects ; Brain Chemistry ; Brain Edema/drug therapy ; Brain Edema/enzymology ; Brain Edema/pathology ; Brain Ischemia/enzymology ; Cerebral Infarction/enzymology ; Cerebral Infarction/pathology ; Male ; Matrix Metalloproteinase 1/metabolism ; Matrix Metalloproteinase 2/metabolism ; Matrix Metalloproteinase 9/metabolism ; Matrix Metalloproteinases/biosynthesis ; Rats ; Rats, Sprague-Dawley ; Specific Gravity ; Stroke/enzymology ; Stroke/pathology ; Tumor Necrosis Factor-alpha/antagonists & inhibitors
    Chemical Substances Antibodies, Blocking ; Antibodies, Monoclonal ; Tumor Necrosis Factor-alpha ; Matrix Metalloproteinases (EC 3.4.24.-) ; Matrix Metalloproteinase 2 (EC 3.4.24.24) ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; Matrix Metalloproteinase 1 (EC 3.4.24.7)
    Language English
    Publishing date 2005-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604628-9
    ISSN 1559-7016 ; 0271-678X
    ISSN (online) 1559-7016
    ISSN 0271-678X
    DOI 10.1038/sj.jcbfm.9600086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1663: Show issues Location:
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  4. Article: Plasma adrenomedullin and carotid atherosclerosis in atherothrombotic ischemic stroke.

    Hosomi, Naohisa / Ohyama, Hideo / Takahashi, Tsutomu / Shinomiya, Kaori / Naya, Takayuki / Ban, Camelia R / Osaka, Kunihiko / Kohno, Masakazu / Koziol, James A

    Journal of hypertension

    2004  Volume 22, Issue 10, Page(s) 1945–1951

    Abstract: ... elastic modulus (R = 0.79; F5,105 = 85.39, P < 0.0001).: Conclusion: Plasma mature-adrenomedullin showed ...

    Abstract Objective: Adrenomedullin is known to exert anti-atherosclerotic actions by inhibiting proliferation and migration of smooth muscle cells in vitro. Here we examine the relationship between the plasma concentration of adrenomedullin and ultrasonographic characteristics of carotid arteries both in ischemic stroke and in the absence of cerebrovascular disease.
    Methods: We studied 61 patients with atherothrombotic ischemic stroke in the chronic phase and 50 patients without any cerebrovascular disease. Intima-media thickness and vascular lumen diameters were evaluated by carotid ultrasonography. Plasma mature-adrenomedullin was determined by radioimmunoassay.
    Results: Plasma mature-adrenomedullin in the patients with atherothrombotic ischemic stroke in the chronic phase (2.01 +/- 0.58 fmol/ml) was significantly higher than that in the patients without any cerebrovascular disease (1.24 +/- 0.18 fmol/ml, P < 0.001). With multiple regression analysis, plasma mature-adrenomedullin was found to be predicted by: stroke status (atherothrombotic ischemic stroke versus no cerebrovascular disease), diabetes status (yes/no), left ventricular ejection fraction, internal carotid artery intima-media thickness, and common carotid artery pressure strain elastic modulus (R = 0.79; F5,105 = 85.39, P < 0.0001).
    Conclusion: Plasma mature-adrenomedullin showed significantly positive associations with carotid atherosclerosis and atherothrombotic ischemic stroke, independent of systolic blood pressure.
    MeSH term(s) Adrenomedullin ; Aged ; Blood Pressure ; Brain Ischemia/complications ; Carotid Arteries/diagnostic imaging ; Carotid Artery Diseases/complications ; Carotid Artery Thrombosis/complications ; Carotid Artery, Common/physiopathology ; Carotid Artery, Internal/diagnostic imaging ; Case-Control Studies ; Chronic Disease ; Diabetic Angiopathies/complications ; Elasticity ; Female ; Humans ; Intracranial Arteriosclerosis/complications ; Male ; Middle Aged ; Peptides/blood ; Stress, Mechanical ; Stroke/blood ; Stroke/diagnostic imaging ; Stroke/etiology ; Stroke Volume ; Tunica Intima/diagnostic imaging ; Tunica Media/diagnostic imaging ; Ultrasonography
    Chemical Substances Peptides ; Adrenomedullin (148498-78-6)
    Language English
    Publishing date 2004-07-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/00004872-200410000-00017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1885: Show issues Location:
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    Zs.MO 614: Show issues

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  5. Article: Smoking, fasting serum insulin, and obesity are the predictors of carotid atherosclerosis in relatively young subjects.

    Naya, Takayuki / Hosomi, Naohisa / Ohyama, Hideo / Ichihara, Shin-Ichiro / Ban, Camelia R / Takahashi, Tsutomu / Taminato, Tomohiko / Feng, Anne / Kohno, Masakazu / Koziol, James A

    Angiology

    2007  Volume 58, Issue 6, Page(s) 677–684

    Abstract: The purpose of this study was to identify predictors of atherosclerosis in a healthy young cohort comprised of 241 subjects who underwent a regular employee medical check-up at Ohshima National Sanatorium over a 9-month period. All subjects underwent ... ...

    Abstract The purpose of this study was to identify predictors of atherosclerosis in a healthy young cohort comprised of 241 subjects who underwent a regular employee medical check-up at Ohshima National Sanatorium over a 9-month period. All subjects underwent carotid ultrasound examinations to determine maximal common carotid artery intima media thickness. In addition, serum total cholesterol, triglycerides, high-density lipoprotein cholesterol, blood urea nitrogen, creatinine, glucose, and insulin were evaluated. The subjects were relatively young (mean age, 44 years; range, 18 to 62 years), with 130 females (54%) and 111 males (46%). Maximal common carotid artery intima media thickness was predicted by smoking habit, body mass index, fasting blood sugar, fasting serum insulin, and systolic blood pressure (F(5,235) = 52.8, P < 10(-5)). There was clear separation in common carotid artery intima media thickness values based on body mass index, smoking, and fasting serum insulin, and somewhat more overlap with systolic blood pressure and fasting blood sugar. These findings suggest that smoking and high values of body mass index, fasting serum insulin, systolic blood pressure, and fasting blood sugar are warning factors for early atherosclerosis development, and could conceivably serve as the basis of diagnostic screening. Smoking is particularly deleterious, as smokers with high body mass index, high fasting serum insulin, or high systolic blood pressure tend to have larger common carotid artery intima media thickness values than would have been predicted by consideration solely of the individual risk factors.
    MeSH term(s) Adult ; Age Factors ; Aging ; Blood Glucose/analysis ; Blood Pressure ; Blood Urea Nitrogen ; Body Mass Index ; Carotid Artery Diseases/blood ; Carotid Artery Diseases/diagnostic imaging ; Carotid Artery Diseases/etiology ; Carotid Artery Diseases/physiopathology ; Carotid Artery, Common/diagnostic imaging ; Cohort Studies ; Creatinine/blood ; Fasting/blood ; Female ; Humans ; Hyperinsulinism/blood ; Hyperinsulinism/complications ; Hypertension/complications ; Hypertension/physiopathology ; Insulin/blood ; Least-Squares Analysis ; Linear Models ; Lipids/blood ; Male ; Middle Aged ; Obesity/complications ; Obesity/physiopathology ; Population Surveillance ; Risk Assessment ; Risk Factors ; Smoking/adverse effects ; Tunica Intima/diagnostic imaging ; Tunica Media/diagnostic imaging ; Ultrasonography
    Chemical Substances Blood Glucose ; Insulin ; Lipids ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2007-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80040-5
    ISSN 0003-3197
    ISSN 0003-3197
    DOI 10.1177/0003319707303589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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