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  1. Book ; Online: R S Thomas

    Thomas, M Wynn

    Serial Obsessive

    2013  

    Abstract: The study places the work of a major religious poet of the late twentieth century in a number of striking new perspectives that allow him to be viewed for the first time as an 'alternative' war poet, a conscience-stricken pacifist, a jealously ... ...

    Abstract The study places the work of a major religious poet of the late twentieth century in a number of striking new perspectives that allow him to be viewed for the first time as an 'alternative' war poet, a conscience-stricken pacifist, a jealously opportunistic student of art, and an experimental biographer of the modern soul
    Language English
    Size Online-Ressource (352 p)
    Publisher University of Wales Press
    Publishing place Cardiff
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9780708325704 ; 070832570X
    Database Former special subject collection: coastal and deep sea fishing

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  2. Book ; Online: R S Thomas

    Thomas, M Wynn

    Serial Obsessive

    2013  

    Abstract: Published to mark the centenary of the sometime 'ogre of Wales', this volume (by the executor of his unpublished literary estate) deals with the idées fixes that serially possessed his fiercely intense imagination: Iago Prytherch, Wales, his family, and ... ...

    Abstract Published to mark the centenary of the sometime 'ogre of Wales', this volume (by the executor of his unpublished literary estate) deals with the idées fixes that serially possessed his fiercely intense imagination: Iago Prytherch, Wales, his family, and of course a vexingly elusive Deity. Here, these familiar obsessions are set in several unusual contexts that bring his poetry into startling new relief: his war poetry is considered alongside his early poetry's relationship to English topographical tradition; comparisons with Borges and Levertov underline the international dimensions of his con
    Language English
    Size Online-Ressource (352 p)
    Publisher University of Wales Press
    Publishing place London
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9780708325704 ; 070832570X
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  3. Article ; Online: Two types of fibroblast drive arthritis.

    Wynn, Thomas A

    Nature

    2019  Volume 570, Issue 7760, Page(s) 169–170

    MeSH term(s) Arthritis ; Arthritis, Rheumatoid ; Fibroblasts ; Humans ; Inflammation
    Language English
    Publishing date 2019-06-10
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-019-01594-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Opinion on Immune Tolerance Therapeutic Development.

    Radi, Zaher A / Wynn, Thomas A

    Toxicologic pathology

    2020  Volume 48, Issue 6, Page(s) 712–717

    Abstract: Immune tolerance is defined by an active state of immune system unresponsiveness to foreign and self-antigens. Loss of immune tolerance to self-antigens and the resulting overexpression of autoantibodies can lead to tissue injury and development of ... ...

    Abstract Immune tolerance is defined by an active state of immune system unresponsiveness to foreign and self-antigens. Loss of immune tolerance to self-antigens and the resulting overexpression of autoantibodies can lead to tissue injury and development of various autoimmune diseases. In drug development, the goal of newly emerging immune tolerance therapies is to treat autoimmune disorders by restoring the immunoregulatory capacity of the immune system. Development of immune tolerance targets is initiated with the establishment of pharmacological efficacy in relevant disease animal models, followed by their stepwise translation to humans. This review discusses the major challenges to developing tolerance inducing pharmaceutical drugs, including the selection of appropriate disease models to establish efficacy, adequate, and acceptable in vitro and in vivo safety assessments, relevant biomarkers of human safety and efficacy, and finally, some regulatory guidelines to successfully develop immune tolerance therapeutics. [Box: see text].
    MeSH term(s) Animals ; Autoantibodies ; Autoimmune Diseases/drug therapy ; Humans ; Immune Tolerance
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2020-08-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 841009-4
    ISSN 1533-1601 ; 0192-6233
    ISSN (online) 1533-1601
    ISSN 0192-6233
    DOI 10.1177/0192623320948805
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online: Learning Human-like Representations to Enable Learning Human Values

    Wynn, Andrea / Sucholutsky, Ilia / Griffiths, Thomas L.

    2023  

    Abstract: How can we build AI systems that are aligned with human values and objectives in order to avoid causing harm or violating societal standards for acceptable behavior? Making AI systems learn human-like representations of the world has many known benefits, ...

    Abstract How can we build AI systems that are aligned with human values and objectives in order to avoid causing harm or violating societal standards for acceptable behavior? Making AI systems learn human-like representations of the world has many known benefits, including improving generalization, robustness to domain shifts, and few-shot learning performance, among others. We propose that this kind of representational alignment between machine learning (ML) models and humans is also a necessary condition for value alignment, where ML systems conform to human values and societal norms. We focus on ethics as one aspect of value alignment and train multiple ML agents (support vector regression and kernel regression) in a multi-armed bandit setting, where rewards are sampled from a distribution that reflects the morality of the chosen action. We then study the relationship between each agent's degree of representational alignment with humans and their performance when learning to take the most ethical actions.

    Comment: Paper accepted in Human-Centric Representation Learning workshop at AAAI 2024 (https://hcrl-workshop.github.io/2024/)
    Keywords Computer Science - Artificial Intelligence ; Computer Science - Machine Learning
    Subject code 006
    Publishing date 2023-12-21
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article ; Online: Type 2 cytokines: mechanisms and therapeutic strategies.

    Wynn, Thomas A

    Nature reviews. Immunology

    2015  Volume 15, Issue 5, Page(s) 271–282

    Abstract: Type 2 immune responses are defined by the cytokines interleukin-4 (IL-4), IL-5, IL-9 and IL-13, which can either be host protective or have pathogenic activity. Type 2 immunity promotes antihelminth immunity, suppresses type 1-driven autoimmune disease, ...

    Abstract Type 2 immune responses are defined by the cytokines interleukin-4 (IL-4), IL-5, IL-9 and IL-13, which can either be host protective or have pathogenic activity. Type 2 immunity promotes antihelminth immunity, suppresses type 1-driven autoimmune disease, neutralizes toxins, maintains metabolic homeostasis, and regulates wound repair and tissue regeneration pathways following infection or injury. Nevertheless, when type 2 responses are dysregulated, they can become important drivers of disease. Type 2 immunity induces a complex inflammatory response characterized by eosinophils, mast cells, basophils, type 2 innate lymphoid cells, IL-4-and/or IL-13-conditioned macrophages and T helper 2 (TH2) cells, which are crucial to the pathogenesis of many allergic and fibrotic disorders. As chronic type 2 immune responses promote disease, the mechanisms that regulate their maintenance are thought to function as crucial disease modifiers. This Review discusses the many endogenous negative regulatory mechanisms that antagonize type 2 immunity and highlights how therapies that target some of these pathways are being developed to treat type 2-mediated disease.
    MeSH term(s) Adaptive Immunity/immunology ; Basophils/immunology ; Cytokines/immunology ; Eosinophils/immunology ; Humans ; Immunity, Innate/immunology ; Interleukin-13/immunology ; Interleukin-17/immunology ; Interleukin-4/immunology ; Interleukin-5/immunology ; Interleukin-9/immunology ; Mast Cells/immunology ; Th2 Cells/immunology
    Chemical Substances Cytokines ; Interleukin-13 ; Interleukin-17 ; Interleukin-5 ; Interleukin-9 ; thymic stromal lymphopoietin ; Interleukin-4 (207137-56-2)
    Language English
    Publishing date 2015-05
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/nri3831
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Lost in translation: Misguided application of a laudable and well-intentioned policy.

    Thomas, Christie P / Wynn, James J / Stratta, Robert J

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2023  Volume 23, Issue 8, Page(s) 1274–1275

    MeSH term(s) Humans ; Tissue Donors ; Tissue and Organ Procurement ; Policy ; Glomerular Filtration Rate ; Waiting Lists
    Language English
    Publishing date 2023-04-21
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1016/j.ajt.2023.04.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5542: Show issues Location:
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  8. Article ; Online: Fibrosis: from mechanisms to medicines.

    Henderson, Neil C / Rieder, Florian / Wynn, Thomas A

    Nature

    2020  Volume 587, Issue 7835, Page(s) 555–566

    Abstract: Fibrosis can affect any organ and is responsible for up to 45% of all deaths in the industrialized world. It has long been thought to be relentlessly progressive and irreversible, but both preclinical models and clinical trials in various organ systems ... ...

    Abstract Fibrosis can affect any organ and is responsible for up to 45% of all deaths in the industrialized world. It has long been thought to be relentlessly progressive and irreversible, but both preclinical models and clinical trials in various organ systems have shown that fibrosis is a highly dynamic process. This has clear implications for therapeutic interventions that are designed to capitalize on this inherent plasticity. However, despite substantial progress in our understanding of the pathobiology of fibrosis, a translational gap remains between the identification of putative antifibrotic targets and conversion of this knowledge into effective treatments in humans. Here we discuss the transformative experimental strategies that are being leveraged to dissect the key cellular and molecular mechanisms that regulate fibrosis, and the translational approaches that are enabling the emergence of precision medicine-based therapies for patients with fibrosis.
    MeSH term(s) Cytokines ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Fibrosis/drug therapy ; Fibrosis/genetics ; Fibrosis/metabolism ; Fibrosis/pathology ; Gastrointestinal Microbiome ; Genome, Human/genetics ; Humans ; Integrins ; Macrophages ; Mesoderm/metabolism ; Mesoderm/pathology ; Precision Medicine ; Single-Cell Analysis ; Transforming Growth Factor beta ; Translational Medical Research
    Chemical Substances Cytokines ; Integrins ; Transforming Growth Factor beta
    Language English
    Publishing date 2020-11-25
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-020-2938-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Myeloid-cell differentiation redefined in cancer.

    Wynn, Thomas A

    Nature immunology

    2013  Volume 14, Issue 3, Page(s) 197–199

    MeSH term(s) Animals ; Gene Silencing ; Genes, Retinoblastoma ; Myeloid Cells/pathology ; Neoplasms/genetics
    Language English
    Publishing date 2013-02-17
    Publishing country United States
    Document type News ; Comment
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/ni.2539
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: The rise of homo sapiens

    Coolidge, Frederick L. / Wynn, Thomas Grant

    the evolution of modern thinking

    2009  

    Author's details Frederick L. Coolidge ; Thomas Wynn
    Keywords Brain/Evolution ; Human evolution ; Cognition and culture
    Subject code 612.82
    Language English
    Size VII, 308 S. : Ill., graph. Darst., 23cm
    Publisher Wiley-Blackwell
    Publishing place Malden, MA u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT015943134
    ISBN 1-4051-5253-2 ; 1-4051-5254-0 ; 978-1-4051-5253-2 ; 978-1-4051-5254-9
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2009 A 2229 order for loan Magazin

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