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  1. Article ; Online: Integrating safety and health practices in therapeutic communities: Insights from Taiwan's Chieh-Lo-Shan Villa.

    Lee, Jen-Chin / Wei, Lien-Chung

    Research in nursing & health

    2024  

    Language English
    Publishing date 2024-05-05
    Publishing country United States
    Document type Letter
    ZDB-ID 424453-9
    ISSN 1098-240X ; 0160-6891
    ISSN (online) 1098-240X
    ISSN 0160-6891
    DOI 10.1002/nur.22390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Assembly and comparative analysis of the first complete mitochondrial genome of a traditional Chinese medicine Angelica biserrata (Shan et Yuan) Yuan et Shan.

    Wang, Le / Liu, Xue / Xu, Yuanjiang / Zhang, Zhiwei / Wei, Yongsheng / Hu, Ying / Zheng, Changbing / Qu, Xianyou

    International journal of biological macromolecules

    2023  Volume 257, Issue Pt 1, Page(s) 128571

    Abstract: Duhuo, a member of the Angelica family, is widely used to treat ailments such as rheumatic pain. It possesses a diverse array of bioactivities, including anti-tumor, anti-inflammatory, and analgesic properties, as recent pharmacological research has ... ...

    Abstract Duhuo, a member of the Angelica family, is widely used to treat ailments such as rheumatic pain. It possesses a diverse array of bioactivities, including anti-tumor, anti-inflammatory, and analgesic properties, as recent pharmacological research has revealed. Nevertheless, the mtDNA of Angelica species remains relatively unexplored. To address this gap, we sequenced and assembled the mtDNA of A. biserrata to shed light on its genetic mechanisms and evolutionary pathways. Our investigation indicated a distinctive multi-branched conformation in the A. biserrata mtDNA. A comprehensive analysis of protein-coding sequences (PCGs) across six closely related species revealed the presence of 11 shared genes in their mitochondrial genomes. Intriguingly, positive selection emerged as a significant factor in the evolution of the atp4, matR, nad3, and nad7 genes. In addition, our data highlighted a recurring trend of homologous fragment migration between chloroplast and mitochondrial organelles. We identified 13 homologous fragments spanning both chloroplast and mitochondrial genomes. The phylogenetic tree established a close relationship between A. biserrata and Saposhnikovia divaricata. To sum up, our research would contribute to the application of population genetics and evolutionary studies in the genus Acanthopanax and other genera in the Araliaceae family.
    MeSH term(s) Medicine, Chinese Traditional ; Angelica/genetics ; Phylogeny ; Genome, Mitochondrial/genetics ; DNA, Mitochondrial
    Chemical Substances DNA, Mitochondrial
    Language English
    Publishing date 2023-12-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.128571
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Effect of Shan Zha (Hawthorn or Crataegus) on gastrointestinal cancer: A network pharmacology and molecular docking study.

    Yang, Jing / Gu, Jialin / Shen, Ying / Cao, Ling / Zhou, Hong / Zhu, Wei

    Cancer pathogenesis and therapy

    2023  Volume 1, Issue 4, Page(s) 229–237

    Abstract: Background: Shan Zha (Hawthorn or Crataegus) is a traditional Chinese medicine (TCM) most commonly ... with blood lipid levels. This study illustrates the potential anticancer effects of Shan Zha ... main bioactive components were identified in Shan Zha. A total of 271 potential drug targets were ...

    Abstract Background: Shan Zha (Hawthorn or Crataegus) is a traditional Chinese medicine (TCM) most commonly used for the treatment of hyperlipidemia. Gastrointestinal cancer is closely correlated with blood lipid levels. This study illustrates the potential anticancer effects of Shan Zha on gastrointestinal tumors based on network pharmacology and molecular docking.
    Methods: Hawthorn's bioactive ingredients and drug targets were obtained from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), Integrative Pharmacology-based Research Platform of Traditional Chinese Medicine version 2.0 (TCMIP v2.0), and Herbal Ingredients' Targets Platform (HIT 2.0) databases. Validated disease targets of gastrointestinal cancer were obtained from the Therapeutic Targets Database (TTD) and HIT 2.0 databases. Protein-protein interaction analysis of intersecting genes was performed using the Search Tool for the Retrieval of Interacting Genes (STRING) database. The functions of these genes were further analyzed by performing gene ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. Molecular docking verification was performed using Molecular Operating Environment (MOE) software.
    Results: Four main bioactive components were identified in Shan Zha. A total of 271 potential drug targets were identified, and 393 gastrointestinal-tumor targets were obtained. Through protein interaction analysis of intersecting targets, the main components of Shan Zha were found to interact more closely with proteins such as tumor protein p53 (TP53), AKT serine/threonine kinase 1 (AKT1),
    Conclusion: These findings suggest that Shan Zha exerts its effects on gastrointestinal cancers through a multitarget, multi-component, and a multi-pathway mechanism.
    Language English
    Publishing date 2023-02-07
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2949-7132
    ISSN (online) 2949-7132
    DOI 10.1016/j.cpt.2023.02.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Evidence of elevation-dependent warming from the Chinese Tian Shan

    L. Gao / H. Deng / X. Lei / J. Wei / Y. Chen / Z. Li / M. Ma / X. Chen / M. Liu / J. Gao

    The Cryosphere, Vol 15, Pp 5765-

    2021  Volume 5783

    Abstract: ... amplification and altitude warming amplification) in the Chinese Tian Shan (CTM) were detected using a unique ...

    Abstract The phenomenon in which the warming rate of air temperature is amplified with elevation is termed elevation-dependent warming (EDW). It has been clarified that EDW can accelerate the retreat of glaciers and melting of snow, which can have significant impacts on the regional ecological environment. Owing to the lack of high-density ground observations in high mountains, there is widespread controversy regarding the existence of EDW. Current evidence is mainly derived from typical high-mountain regions such as the Swiss Alps, the Colorado Rocky Mountains, the tropical Andes and the Tibetan Plateau–Himalayas. Rare evidence in other mountain ranges has been reported, especially in arid regions. In this study, EDW features (regional warming amplification and altitude warming amplification) in the Chinese Tian Shan (CTM) were detected using a unique high-resolution (1 km , 6-hourly) air temperature dataset (CTMD) from 1979 to 2016. The results showed that there were significant EDW signals at different altitudes on different timescales. The CTM showed significant regional warming amplification in spring, especially in March, and the warming trends were greater than those of continental China with respect to three temperatures (minimum temperature, mean temperature and maximum temperature). The significance values of EDW above different altitude thresholds are distinct for three temperatures in 12 months. The warming rate of the minimum temperature in winter showed a significant elevation dependence ( p <0.01 ), especially above 3000 m . The greatest altitudinal gradient in the warming rate of the maximum temperature was found above 4000 m in April. For the mean temperature, the warming rates in June and August showed prominent altitude warming amplification but with different significance above 4500 m . Within the CTM, the Tolm Mountains, the eastern part of the Borokoonu Mountains, the Bogda Mountains and the Balikun Mountains are representative regions that showed significant altitude warming amplification on ...
    Keywords Environmental sciences ; GE1-350 ; Geology ; QE1-996.5
    Subject code 550
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher Copernicus Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: The Shan people's health beliefs, knowledge and perceptions of dengue in Eastern Shan Special Region IV, Myanmar.

    Xu, Jian-Wei / Liu, Hui / Ai, Didan / Yu, Yan / Yu, Bian

    PLoS neglected tropical diseases

    2019  Volume 13, Issue 6, Page(s) e0007498

    Abstract: ... knowledge and perceptions of dengue among the Shan people in Eastern Shan Special Region IV (ESSR4), Myanmar ... that the health beliefs of the Shan people were closely associated with their lifestyles, social and ... natural environments. To stay healthy, the Shan people clean their houses and surroundings regularly ...

    Abstract Sustainable dengue intervention requires the participation of communities. Therefore, understanding the health beliefs, knowledge and perceptions of dengue among the local people can help to design locally appropriate strategies for effective interventions. A combination of qualitative semi-structured in-depth interviews (SDIs) and quantitative household questionnaire surveys (HHSs) was used to investigate the beliefs, knowledge and perceptions of dengue among the Shan people in Eastern Shan Special Region IV (ESSR4), Myanmar. The SDI was administered to 18 key informants, and the HHS was administered to 259 respondents. Only 14.7% (95% CI: 10.6-19.6%) of the HHS respondents could confirm that mosquitoes transmit dengue; 14.3% (95% CI: 10.3-19.1%) knew that piebald or Aedes mosquitoes transmit dengue; and 24.3% (95% CI: 19.2-30.0%) believed that dengue-transmitting mosquitoes mainly lived in small ponds. Merely ten (0.4%) of the 259 respondents of the HHS thought that dengue-transmitting mosquitoes bite in the day time. The people in the villages where there were outbreaks of dengue had more knowledge about dengue. This study demonstrates that the health beliefs of the Shan people were closely associated with their lifestyles, social and natural environments. To stay healthy, the Shan people clean their houses and surroundings regularly. However, their knowledge about dengue was not adequate for effective dengue control because it was mostly learned from previous dengue experiences and in a context that lacks systematic health education. Thus, in this setting, with a weak public health structure, more international support should be provided to promote the knowledge of the Shan people about dengue and to increase their sensitive awareness to dengue, which might be beneficial for social mobilization and community participation during future dengue prevention.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Animals ; Cross-Sectional Studies ; Dengue/epidemiology ; Dengue/prevention & control ; Disease Transmission, Infectious/prevention & control ; Ethnic Groups ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Male ; Middle Aged ; Myanmar/epidemiology ; Surveys and Questionnaires ; Young Adult
    Language English
    Publishing date 2019-06-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2727
    ISSN (online) 1935-2735
    ISSN 1935-2727
    DOI 10.1371/journal.pntd.0007498
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Treatment seeking behavior and associated factors of suspected dengue fever among Shan people in eastern Shan special region IV, Myanmar: a cross-sectional study.

    Liu, Hui / Xu, Jian-Wei / Ai, Zadan / Yu, Yan / Yu, Bian

    BMC health services research

    2020  Volume 20, Issue 1, Page(s) 318

    Abstract: ... of suspected DF patients in the Eastern Shan Special Region IV (ESSR4), Myanmar.: Results: The key ... appropriate healthcare-seeking behavior among Shan People. ...

    Abstract Background: Dengue fever (DF) is a rapidly spreading mosquito-borne disease along the China-Myanmar border. Understanding treatment-seeking behaviors (TSBs) and associated factors of suspected DF patients in local communities helps to improve health services via promoting prompt treatment, improving patients' prognosis, finding DF information and timely response to DF foci.
    Methods: A combination of qualitative semi-structured in-depth interview (SDIs) included 18 key-informants, and quantitative household questionnaire survey (HHSs) involved 259 households was carried out to investigate TSBs and associated factors of suspected DF patients in the Eastern Shan Special Region IV (ESSR4), Myanmar.
    Results: The key informants mentioned that most of their fellow villagers did not seek treatment in public health facilities first. The HHS questionnaires were distributed to household heads, and 241 of the 259 HHS respondents were valid after data auditing. Only 102 (43.2%) household heads reported that their family sought treatment for suspected DF at a public health facility immediately; 111 (46.1%) respondents said that they chose self-medication first. The adjusted odds ratio of multivariate logistic analysis (MLA) predicting household heads' first seeking healthcare at a public hospital were 1.91 (95%CI: 1.03-3.53) for those who knew DF and 5.11 (95%CI: 2.08-12.58) for those who regarded DF as a deadly disease, indicating that families who knew DF and regarded DF as a deadly disease were more likely to seek treatment for suspected DF at a public health facility immediately.
    Conclusion: The inappropriateness of treatment-seeking behaviors for suspected DF hinders the improvement of the patient prognosis and dengue control in ESSR4, Myanmar. People's awareness of the potential seriousness of DF is a factor influencing appropriate healthcare-seeking behavior among Shan People.
    MeSH term(s) Adolescent ; Adult ; Animals ; Cross-Sectional Studies ; Dengue/therapy ; Female ; Health Knowledge, Attitudes, Practice/ethnology ; Herbal Medicine ; Humans ; Male ; Medicine, Traditional ; Middle Aged ; Myanmar ; Odds Ratio ; Patient Acceptance of Health Care/ethnology ; Self Medication ; Surveys and Questionnaires ; Young Adult
    Language English
    Publishing date 2020-04-16
    Publishing country England
    Document type Journal Article
    ISSN 1472-6963
    ISSN (online) 1472-6963
    DOI 10.1186/s12913-020-05163-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: U-Pb ages of Gongga Shan granite, western Sichuan and its implication to the tectonic evolutions of eastern Tibet

    Yuan-Hsi Lee / Kristen L. Cook / Xi-Bin Tan / Mei-Fei Chu / Han-Yi Chiu / Qui-Li Li / J. Gregory Shellnutt / Xi-Wei Xu

    Frontiers in Earth Science, Vol

    2023  Volume 11

    Abstract: ... but data on crustal evolution through time are lacking. Here, we turn to the Gongga Shan granite ... conditions. We present 124 U-Pb samples from the Gongga Shan granite (GSG) that prove that the crust has been ...

    Abstract The eastern margin of the Tibetan Plateau has given rise to much debate about mechanisms of plateau uplift and evolution and, in particular, the role of the lower crust in crustal thickening. Knowledge of the middle to lower crust conditions is critical for evaluating various models of crustal deformation, but data on crustal evolution through time are lacking. Here, we turn to the Gongga Shan granite, an intrusion along the Xianshuihe fault in easternmost Tibet that directly records local Cenozoic crustal conditions. We present 124 U-Pb samples from the Gongga Shan granite (GSG) that prove that the crust has been stepwise producing partial melt from 56 Ma to 4 Ma. According to the age distribution, the GSG can be separated into four major groups with ages of 4–10 Ma, 12–20 Ma, 25–40 Ma, and 43–56 Ma. Combining the timing information with geophysics and low-temperature thermochronology data, we suggest that events younger than 10 Ma may indicate the onset of recent crustal channel flow in the middle to lower crust. In contrast, the youngest 4 Ma ages indicate the ongoing partial melting of the middle crust. The 12–20 Ma events could be related to an earlier stage of crustal channel flow, consistent with the regional large-scale crustal channel flow in central Tibet.
    Keywords Gongga Shan granite ; eastern Tibet ; magmatism ; U-Pb dating ; crustal channel flow ; Science ; Q
    Subject code 550
    Language English
    Publishing date 2023-08-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Geological characteristics and exploration potential of the coal measure gas from Shan 2 of the Shanxi formation in the eastern Ordos Basin

    Wei-Bo Zhao / Hui Zhang / Yun-He Shi / Xun-Xun Fu / Jie Hui / Xue-Yuan Jing

    Frontiers in Earth Science, Vol

    2023  Volume 11

    Abstract: ... configurations of vertically multiple-stacked gas-bearing reservoirs. Coal measure gas from Shan 2 can be divided ...

    Abstract “Coal measure gas,” excluding tight (low-permeability) sandstone gas, refers in this study to the self-sourcing unconventional natural gas stored in coal, shale, and fine siltstone. It is characterized by various types of occurrences and reservoirs, a distinct cyclic succession of coal measure strata, widely distributed mosaic hydrocarbon accumulations, three types of coal measure gas accumulations, and configurations of vertically multiple-stacked gas-bearing reservoirs. Coal measure gas from Shan 2 can be divided—according to the grain size of sandstone, configurations of sandstone–coal–mudstone association, thickness, and layers—into four types: thick massive sandstone–coal–mudstone (type I), fine siltstone–coal–mudstone (type II), thin sandstone–mudstone–sandstone (type III), and coal–mudstone (type IV). Comprehensive evaluation suggests that the coal measure gas in the Suide-Mizhi area of the southern Ordos Basin presents an important and favorable accumulation option, characterized by coalbed methane, shale gas, and tight gas stored in sandstone–mudstone–coal strata. Therefore, it is essential to conduct full future assessments for the coal beds, shale, and tight gas controlling exploration for the “vertical gas-bearing zone” by three-dimensional exploration.
    Keywords Ordos Basin ; Upper Paleozoic ; Shan 2 ; coal measure gas ; exploration potential ; Science ; Q
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: A systems-based analysis to explore the multiple mechanisms of Shan Zha for treating human diseases.

    Zhang, Jingxiao / Chen, Ziyi / Zhang, Lilei / Zhao, Xiaoxiao / Liu, Zhigang / Zhou, Wei

    Food & function

    2021  Volume 12, Issue 3, Page(s) 1176–1191

    Abstract: Shan Zha has garnered increasing attention in the field of functional foods and medicines due ... to its widely reported healing effects. However, the potential mechanisms of Shan Zha for human health benefits ... pathway analysis is proposed to clarify the underlying pharmacological mechanisms of Shan Zha. As a result ...

    Abstract Shan Zha has garnered increasing attention in the field of functional foods and medicines due to its widely reported healing effects. However, the potential mechanisms of Shan Zha for human health benefits have not been fully interpreted. Therefore, in the current study, a systems-based method that integrates ADME evaluation, target fishing, gene ontology enrichment analysis, network pharmacology, and pathway analysis is proposed to clarify the underlying pharmacological mechanisms of Shan Zha. As a result, 45 active components of Shan Zha that interacted with 161 protein targets were screened and identified. Moreover, gene ontology enrichment, network and pathway analysis indicated that Shan Zha is beneficial for the treatment of cardiovascular system diseases, digestive system diseases, immune system diseases, inflammatory diseases, cancer, and other diseases through multiple mechanisms. Our study not only proposed an integrated method to comprehensively elucidate the complicated mechanisms of Shan Zha for the treatment of various disorders at the system level, but also provided a reference approach for the mechanistic research of other functional foods.
    MeSH term(s) Crataegus/chemistry ; Databases, Chemical ; Fruit/chemistry ; Functional Food ; Humans ; Molecular Structure ; Phytochemicals/chemistry ; Phytochemicals/pharmacology ; Phytotherapy ; Structure-Activity Relationship
    Chemical Substances Phytochemicals
    Language English
    Publishing date 2021-01-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d0fo02433c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Numerical Simulation Study on the Influence of Branching Structure of Longmen Shan Thrust Belt on the Nucleation of Mw7.9 Wenchuan Earthquake

    Chong Yue / Chunyan Qu / Xinjian Shan / Wei Yan / Jing Zhao / Huaizhong Yu / Weiyu Ma / Qi Yao

    Remote Sensing, Vol 12, Iss 4031, p

    2020  Volume 4031

    Abstract: On the Longmen Shan thrust belt (LMS) on the eastern margin of Tibet Plateau, the Mw7.9 Wenchuan ...

    Abstract On the Longmen Shan thrust belt (LMS) on the eastern margin of Tibet Plateau, the Mw7.9 Wenchuan earthquake occurred in 2008. As for the dynamic cause of the Wenchuan earthquake, many scholars have studied the rheological difference and terrain elevation difference on both sides of the fault. However, previous studies have simplified the LMS as a single listric-reverse fault. In fact, the LMS is composed of four faults with different dip angles in the shallow part, and the faults are Wenchuan-Maoxian fault (WMF), Yingxiu-Beichuan fault (YBF), Guanxian-Jiangyou fault (GJF) and Range Front Thrust (RFT) from west to east. However, the control of the branching structure of these faults on the distribution and accumulation of stress and strain during the seismogenic of the Wenchuan earthquake has not been discussed. In this paper, four viscoelastic finite element models with different fault numbers and combination structures are built to analyze the effect of fault branching structures on the stress distribution and accumulation during the seismogenic of Wenchuan earthquake, and we use geodetic data such as GPS and precise leveling data to constrain our models. At the same time, we also study the influence of the existence of the detachment layer, which is formed by the low-resistivity and low-velocity layer, between the upper and lower crust of the Bayan Har block and the change of its frontal edge position on the stress accumulation and distribution. The results show that the combinations of YBF and GJF is most conducive to the concentration of equivalent stress below the intersection of the two faults, and the accumulated stress on GJF is shallower than that on YBF, which means that more stress is transferred to the surface along GJF; and the existence of a detachment layer can effectively promote the accumulation of stress at the bottom of YBF and GJF, and the closer the frontal edge position of the detachment layer is to the LMS fault, the more favorable the stress accumulation is. Based on the magnitude of ...
    Keywords listric-reverse fault structure ; detachment layer ; viscoelastic finite element method ; equivalent stress ; Wenchuan earthquake ; Science ; Q
    Subject code 550
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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