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  1. Article ; Online: Fighting Fire with Fire: Immunogenicity of Viral Vectored Vaccines against COVID-19.

    Chang, Aiquan / Yu, Jingyou

    Viruses

    2022  Volume 14, Issue 2

    Abstract: The persistent expansion of the coronavirus disease 2019 (COVID-19) global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires the rapid development of safe and effective countermeasures to reduce transmission, ... ...

    Abstract The persistent expansion of the coronavirus disease 2019 (COVID-19) global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires the rapid development of safe and effective countermeasures to reduce transmission, morbidity, and mortality. Several highly efficacious vaccines are actively being deployed around the globe to expedite mass vaccination and control of COVID-19. Notably, viral vectored vaccines (VVVs) are among the first to be approved for global distribution and use. In this review, we examine the humoral, cellular, and innate immune responses elicited by viral vectors, and the immune correlates of protection against COVID-19 in preclinical and clinical studies. We also discuss the durability and breadth of immune response induced by VVVs and boosters. Finally, we present challenges associated with VVVs and offer solutions for overcoming certain limitations of current vaccine regimens. Collectively, this review provides the rationale for expanding the portfolio of VVVs against SARS-CoV-2.
    MeSH term(s) Animals ; Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19 Vaccines/genetics ; COVID-19 Vaccines/immunology ; Clinical Trials as Topic ; Disease Models, Animal ; Genetic Vectors/immunology ; Immunity, Cellular ; Immunity, Humoral ; Immunity, Innate ; Immunization, Secondary ; Immunogenicity, Vaccine ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/genetics ; Vaccination ; Viral Vaccines/classification ; Viral Vaccines/genetics ; Viral Vaccines/immunology
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; Spike Glycoprotein, Coronavirus ; Viral Vaccines
    Language English
    Publishing date 2022-02-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14020380
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Fighting Fire with Fire: Immunogenicity of Viral Vectored Vaccines against COVID-19

    Chang, Aiquan / Yu, Jingyou

    Viruses. 2022 Feb. 12, v. 14, no. 2

    2022  

    Abstract: The persistent expansion of the coronavirus disease 2019 (COVID-19) global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires the rapid development of safe and effective countermeasures to reduce transmission, ... ...

    Abstract The persistent expansion of the coronavirus disease 2019 (COVID-19) global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires the rapid development of safe and effective countermeasures to reduce transmission, morbidity, and mortality. Several highly efficacious vaccines are actively being deployed around the globe to expedite mass vaccination and control of COVID-19. Notably, viral vectored vaccines (VVVs) are among the first to be approved for global distribution and use. In this review, we examine the humoral, cellular, and innate immune responses elicited by viral vectors, and the immune correlates of protection against COVID-19 in preclinical and clinical studies. We also discuss the durability and breadth of immune response induced by VVVs and boosters. Finally, we present challenges associated with VVVs and offer solutions for overcoming certain limitations of current vaccine regimens. Collectively, this review provides the rationale for expanding the portfolio of VVVs against SARS-CoV-2.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; durability ; geographical distribution ; immune response ; immunogenicity ; morbidity ; mortality ; pandemic ; vaccination ; vaccines
    Language English
    Dates of publication 2022-0212
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14020380
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping.

    Zhang, Zhiqian / Sie, Brandon / Chang, Aiquan / Leng, Yumei / Nardone, Christopher / Timms, Richard T / Elledge, Stephen J

    Molecular cell

    2023  Volume 83, Issue 22, Page(s) 4191–4192

    Language English
    Publishing date 2023-11-16
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2023.10.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5055: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping.

    Zhang, Zhiqian / Sie, Brandon / Chang, Aiquan / Leng, Yumei / Nardone, Christopher / Timms, Richard T / Elledge, Stephen J

    Molecular cell

    2023  Volume 83, Issue 18, Page(s) 3377–3392.e6

    Abstract: The ubiquitin-proteasome system plays a critical role in biology by regulating protein degradation. Despite their importance, precise recognition specificity is known for a few of the 600 E3s. Here, we establish a two-pronged strategy for identifying and ...

    Abstract The ubiquitin-proteasome system plays a critical role in biology by regulating protein degradation. Despite their importance, precise recognition specificity is known for a few of the 600 E3s. Here, we establish a two-pronged strategy for identifying and mapping critical residues of internal degrons on a proteome-scale in HEK-293T cells. We employ global protein stability profiling combined with machine learning to identify 15,800 peptides likely to contain sequence-dependent degrons. We combine this with scanning mutagenesis to define critical residues for over 5,000 predicted degrons. Focusing on Cullin-RING ligase degrons, we generated mutational fingerprints for 219 degrons and developed DegronID, a computational algorithm enabling the clustering of degron peptides with similar motifs. CRISPR analysis enabled the discovery of E3-degron pairs, of which we uncovered 16 pairs that revealed extensive degron variability and structural determinants. We provide the visualization of these data on the public DegronID data browser as a resource for future exploration.
    MeSH term(s) Proteome/genetics ; Algorithms ; Cell Nucleus ; Cluster Analysis ; Ubiquitin-Protein Ligases/genetics
    Chemical Substances Proteome ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2023.08.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5055: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: TScan-II: A genome-scale platform for the de novo identification of CD4

    Dezfulian, Mohammad H / Kula, Tomasz / Pranzatelli, Thomas / Kamitaki, Nolan / Meng, Qingda / Khatri, Bhuwan / Perez, Paola / Xu, Qikai / Chang, Aiquan / Kohlgruber, Ayano C / Leng, Yumei / Jupudi, Ananth Aditya / Joachims, Michelle L / Chiorini, John A / Lessard, Christopher J / Darise Farris, A / Muthuswamy, Senthil K / Warner, Blake M / Elledge, Stephen J

    Cell

    2023  Volume 186, Issue 25, Page(s) 5569–5586.e21

    Abstract: ... ...

    Abstract CD4
    MeSH term(s) Humans ; Antigen-Presenting Cells ; CD4 Antigens/metabolism ; CD4-Positive T-Lymphocytes ; Epitopes, T-Lymphocyte ; HLA Antigens/metabolism ; Receptors, Antigen, T-Cell/metabolism ; Cell Line ; Genome, Human
    Chemical Substances CD4 Antigens ; Epitopes, T-Lymphocyte ; HLA Antigens ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2023.10.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1167: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 58: Show issues

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  6. Article ; Online: Publisher Correction: Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice.

    Nanishi, Etsuro / Borriello, Francesco / Seo, Hyuk-Soo / O'Meara, Timothy R / McGrath, Marisa E / Saito, Yoshine / Chen, Jing / Diray-Arce, Joann / Song, Kijun / Xu, Andrew Z / Barman, Soumik / Menon, Manisha / Dong, Danica / Caradonna, Timothy M / Feldman, Jared / Hauser, Blake M / Schmidt, Aaron G / Baden, Lindsey R / Ernst, Robert K /
    Dillen, Carly / Yu, Jingyou / Chang, Aiquan / Hilgers, Luuk / Platenburg, Peter Paul / Dhe-Paganon, Sirano / Barouch, Dan H / Ozonoff, Al / Zanoni, Ivan / Frieman, Matthew B / Dowling, David J / Levy, Ofer

    NPJ vaccines

    2023  Volume 8, Issue 1, Page(s) 30

    Language English
    Publishing date 2023-03-03
    Publishing country England
    Document type Published Erratum
    ISSN 2059-0105
    ISSN (online) 2059-0105
    DOI 10.1038/s41541-023-00634-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Durable Humoral and Cellular Immune Responses Following Ad26.COV2.S Vaccination for COVID-19.

    Barouch, Dan H / Stephenson, Kathryn E / Sadoff, Jerald / Yu, Jingyou / Chang, Aiquan / Gebre, Makda / McMahan, Katherine / Liu, Jinyan / Chandrashekar, Abishek / Patel, Shivani / Le Gars, Mathieu / de Groot, Anne Marit / Heerwegh, Dirk / Struyf, Frank / Douoguih, Macaya / van Hoof, Johan / Schuitemaker, Hanneke

    medRxiv : the preprint server for health sciences

    2021  

    Abstract: Interim immunogenicity and efficacy data for the Ad26.COV2.S vaccine for COVID-19 have recently been ... ...

    Abstract Interim immunogenicity and efficacy data for the Ad26.COV2.S vaccine for COVID-19 have recently been reported
    Language English
    Publishing date 2021-07-07
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2021.07.05.21259918
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A bivalent SARS-CoV-2 monoclonal antibody combination does not affect the immunogenicity of a vector-based COVID-19 vaccine in macaques.

    Nkolola, Joseph P / Yu, Jingyou / Wan, Huahua / Chang, Aiquan / McMahan, Katherine / Anioke, Tochi / Jacob-Dolan, Catherine / Powers, Olivia / Ye, Tianyi / Chandrashekar, Abishek / Sellers, Daniel / Barrett, Julia / Loo, Yueh-Ming / Esser, Mark T / Carnahan, Robert H / Crowe, James E / Barouch, Dan H

    Science translational medicine

    2022  Volume 14, Issue 665, Page(s) eabo6160

    Abstract: Human monoclonal antibodies (mAbs) that target the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) offer a promising approach for the prevention and treatment of coronavirus disease 2019 (COVID-19). Given suboptimal ... ...

    Abstract Human monoclonal antibodies (mAbs) that target the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) offer a promising approach for the prevention and treatment of coronavirus disease 2019 (COVID-19). Given suboptimal global vaccination rates, waning immunity in vaccinated individuals, and the emergence of SARS-CoV-2 variants of concern, the use of mAbs for COVID-19 prevention may increase and may need to be administered together with vaccines in certain settings. However, it is unknown whether administration of mAbs will affect the immunogenicity of SARS-CoV-2 vaccines. Using an adenovirus vector-based SARS-CoV-2 vaccine, we show that simultaneous administration of the vaccine with SARS-CoV-2 mAbs does not diminish vaccine-induced humoral or cellular immunity in cynomolgus macaques. These results suggest that SARS-CoV-2 mAbs and viral vector-based SARS-CoV-2 vaccines can be administered together without loss of potency of either product. Additional studies will be required to evaluate coadministration of mAbs with other vaccine platforms.
    MeSH term(s) Animals ; Antibodies, Monoclonal ; Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; Macaca ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Vaccination ; Viral Vaccines
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; Spike Glycoprotein, Coronavirus ; Viral Vaccines ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2022-10-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.abo6160
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6941: Show issues Location:
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  9. Article ; Online: Durable Humoral and Cellular Immune Responses 8 Months after Ad26.COV2.S Vaccination.

    Barouch, Dan H / Stephenson, Kathryn E / Sadoff, Jerald / Yu, Jingyou / Chang, Aiquan / Gebre, Makda / McMahan, Katherine / Liu, Jinyan / Chandrashekar, Abishek / Patel, Shivani / Le Gars, Mathieu / de Groot, Anne M / Heerwegh, Dirk / Struyf, Frank / Douoguih, Macaya / van Hoof, Johan / Schuitemaker, Hanneke

    The New England journal of medicine

    2021  Volume 385, Issue 10, Page(s) 951–953

    MeSH term(s) Ad26COVS1 ; Antibodies, Neutralizing/blood ; Antibodies, Viral/blood ; COVID-19 Vaccines/immunology ; Follow-Up Studies ; Humans ; Immunity, Cellular ; Immunity, Humoral ; Immunogenicity, Vaccine ; SARS-CoV-2 ; T-Lymphocytes/physiology ; Vaccination
    Chemical Substances Ad26COVS1 (JT2NS6183B) ; Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines
    Language English
    Publishing date 2021-07-14
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2108829
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.34: Show issues Location:
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  10. Article ; Online: Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice.

    Nanishi, Etsuro / Borriello, Francesco / Seo, Hyuk-Soo / O'Meara, Timothy R / McGrath, Marisa E / Saito, Yoshine / Chen, Jing / Diray-Arce, Joann / Song, Kijun / Xu, Andrew Z / Barman, Soumik / Menon, Manisha / Dong, Danica / Caradonna, Timothy M / Feldman, Jared / Hauser, Blake M / Schmidt, Aaron G / Baden, Lindsey R / Ernst, Robert K /
    Dillen, Carly / Yu, Jingyou / Chang, Aiquan / Hilgers, Luuk / Platenburg, Peter Paul / Dhe-Paganon, Sirano / Barouch, Dan H / Ozonoff, Al / Zanoni, Ivan / Frieman, Matthew B / Dowling, David J / Levy, Ofer

    NPJ vaccines

    2023  Volume 8, Issue 1, Page(s) 18

    Abstract: Development of SARS-CoV-2 vaccines that protect vulnerable populations is a public health priority. Here, we took a systematic and iterative approach by testing several adjuvants and SARS-CoV-2 antigens to identify a combination that elicits antibodies ... ...

    Abstract Development of SARS-CoV-2 vaccines that protect vulnerable populations is a public health priority. Here, we took a systematic and iterative approach by testing several adjuvants and SARS-CoV-2 antigens to identify a combination that elicits antibodies and protection in young and aged mice. While demonstrating superior immunogenicity to soluble receptor-binding domain (RBD), RBD displayed as a protein nanoparticle (RBD-NP) generated limited antibody responses. Comparison of multiple adjuvants including AddaVax, AddaS03, and AS01B in young and aged mice demonstrated that an oil-in-water emulsion containing carbohydrate fatty acid monosulphate derivative (CMS:O/W) most effectively enhanced RBD-NP-induced cross-neutralizing antibodies and protection across age groups. CMS:O/W enhanced antigen retention in the draining lymph node, induced injection site, and lymph node cytokines, with CMS inducing MyD88-dependent Th1 cytokine polarization. Furthermore, CMS and O/W synergistically induced chemokine production from human PBMCs. Overall, CMS:O/W adjuvant may enhance immunogenicity and protection of vulnerable populations against SARS-CoV-2 and other infectious pathogens.
    Language English
    Publishing date 2023-02-14
    Publishing country England
    Document type Journal Article
    ISSN 2059-0105
    ISSN (online) 2059-0105
    DOI 10.1038/s41541-023-00610-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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