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  1. Article: Fighting the COVID-19 Crisis: Debt Monétisation and EU Recovery Bonds.

    Botta, Alberto / Caverzasi, Eugenio / Russo, Alberto

    Inter economics

    2020  Volume 55, Issue 4, Page(s) 239–244

    Abstract: This paper highlights some peculiar characteristics of the economic crisis induced by the spread of COVID-19. It suggests two intertwined policy measures in order to tackle the emergency phase of the crisis and to support the economy in the subsequent ... ...

    Abstract This paper highlights some peculiar characteristics of the economic crisis induced by the spread of COVID-19. It suggests two intertwined policy measures in order to tackle the emergency phase of the crisis and to support the economy in the subsequent recovery phase. The proposed short-term policy measures offer policy responses in the event of a second wave of coronavirus infections in the coming months. In the aftermath of the emergency phase, the current proposal puts forward the implementation of a massive EU-wide recovery plan addressing the long-lasting technological and environmental challenges of these years, which will be financed by European institutions through the issuance of European Pandemic Recovery Bonds.
    Keywords covid19
    Language English
    Publishing date 2020-07-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2066476-X
    ISSN 1613-964X ; 0020-5346
    ISSN (online) 1613-964X
    ISSN 0020-5346
    DOI 10.1007/s10272-020-0907-z
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  2. Article ; Online: Hydrophobicity-enhanced ferritin nanoparticles for efficient encapsulation and targeted delivery of hydrophobic drugs to tumor cells.

    Incocciati, Alessio / Kubeš, Jan / Piacentini, Roberta / Cappelletti, Chiara / Botta, Sofia / Bertuccini, Lucia / Šimůnek, Tomáš / Boffi, Alberto / Macone, Alberto / Bonamore, Alessandra

    Protein science : a publication of the Protein Society

    2023  Volume 32, Issue 12, Page(s) e4819

    Abstract: Ferritin, a naturally occurring iron storage protein, has gained significant attention as a drug delivery platform due to its inherent biocompatibility and capacity to encapsulate therapeutic agents. In this study, we successfully genetically engineered ... ...

    Abstract Ferritin, a naturally occurring iron storage protein, has gained significant attention as a drug delivery platform due to its inherent biocompatibility and capacity to encapsulate therapeutic agents. In this study, we successfully genetically engineered human H ferritin by incorporating 4 or 6 tryptophan residues per subunit, strategically oriented towards the inner cavity of the nanoparticle. This modification aimed to enhance the encapsulation of hydrophobic drugs into the ferritin cage. Comprehensive characterization of the mutants revealed that only the variant carrying four tryptophan substitutions per subunit retained the ability to disassemble and reassemble properly. As a proof of concept, we evaluated the loading capacity of this mutant with ellipticine, a natural hydrophobic indole alkaloid with multimodal anticancer activity. Our data demonstrated that this specific mutant exhibited significantly higher efficiency in loading ellipticine compared to human H ferritin. Furthermore, to evaluate the versatility of this hydrophobicity-enhanced ferritin nanoparticle as a drug carrier, we conducted a comparative study by also encapsulating doxorubicin, a commonly used anticancer drug. Subsequently, we tested both ellipticine and doxorubicin-loaded nanoparticles on a promyelocytic leukemia cell line, demonstrating efficient uptake by these cells and resulting in the expected cytotoxic effect.
    MeSH term(s) Humans ; Ellipticines ; Ferritins/genetics ; Ferritins/chemistry ; Apoferritins/genetics ; Tryptophan ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Drug Delivery Systems ; Drug Carriers/chemistry ; Doxorubicin/pharmacology ; Doxorubicin/chemistry ; Nanoparticles/chemistry ; Hydrophobic and Hydrophilic Interactions ; Cell Line, Tumor
    Chemical Substances Ellipticines ; Ferritins (9007-73-2) ; Apoferritins (9013-31-4) ; Tryptophan (8DUH1N11BX) ; Antineoplastic Agents ; Drug Carriers ; Doxorubicin (80168379AG)
    Language English
    Publishing date 2023-10-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1106283-6
    ISSN 1469-896X ; 0961-8368
    ISSN (online) 1469-896X
    ISSN 0961-8368
    DOI 10.1002/pro.4819
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3407: Show issues Location:
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  3. Article ; Online: Not myopathic, but autonomic changes in patients with long-COVID syndrome: a case series.

    Bocci, Tommaso / Bertini, Alessandro / Campiglio, Laura / Botta, Stefano / Libelli, Giorgia / Guidetti, Matteo / Priori, Alberto

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2023  Volume 44, Issue 4, Page(s) 1147–1153

    Abstract: Introduction: Neurological sequelae following SARS-CoV-2 infection still represent a serious concern both for neurologists and neuroscientists. In our paper, we investigated pain, myalgia, and fatigue as symptoms in long-COVID patients with an ... ...

    Abstract Introduction: Neurological sequelae following SARS-CoV-2 infection still represent a serious concern both for neurologists and neuroscientists. In our paper, we investigated pain, myalgia, and fatigue as symptoms in long-COVID patients with an electrophysiological approach, comprising the evaluation of sympathetic skin responses (SSRs) and quantitative electromyography (qEMG).
    Materials and methods: Twelve patients were enrolled (mean age, 47.7 ± 11.6 years), referred to our attention because of myalgia, pain, or muscle cramps, which persisted about 6 months after the diagnosis of SARS-CoV-2 infection. They underwent conventional electroneurography (ENG), needle electromyography (EMG), and SSRs; moreover, qEMG was performed by sampling at least 20 motor unit potentials (20-30 MUPs) during weak voluntary contraction in deltoid and tibialis anterior muscles. The mean duration, amplitude, and percentage of polyphasic potentials were assessed and compared with healthy and age-matched volunteers.
    Results: ENG did not disclose significant changes compared to healthy subjects; needle EMG did not reveal denervation activity. In addition, qEMG showed MUPs similar to those recorded in healthy volunteers in terms of polyphasia (deltoid: p = 0.24; TA: p = 0.35), MUP area (deltoid: p = 0.45; TA: p = 0.44), mean duration (deltoid: p = 0.06; TA: p = 0.45), and amplitude (deltoid: p = 0.27; TA: p = 0.63). SSRs were not recordable from lower limbs in seven patients (58%) and from the upper ones in three of them (25%).
    Conclusion: Our data suggest an involvement of the autonomic system, with a focus on cholinergic efferent sympathetic activity, without any evidence of myopathic changes.
    MeSH term(s) Humans ; Adult ; Middle Aged ; Motor Neurons/physiology ; Myalgia ; Post-Acute COVID-19 Syndrome ; COVID-19/complications ; SARS-CoV-2 ; Muscle, Skeletal ; Electromyography
    Language English
    Publishing date 2023-02-03
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-023-06637-8
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1877: Show issues Location:
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  4. Article: The complex inequality-innovation-public investment nexus

    Botta, Alberto

    Forum for social economics volume XLVI , 3 (August), Seite 275-298

    what we (don’t) know, what we should know and what we have to do

    2017  

    Author's details Alberto Botta
    Keywords inequality ; innovation ; financialization ; public investment ; developmental state
    Language English
    Publisher Routledge
    Publishing place Abingdon
    Document type Article
    ZDB-ID 901004x
    ISSN 0736-0932
    Database ECONomics Information System

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  5. Article ; Online: Fighting the COVID-19 Crisis

    Botta, Alberto / Caverzasi, Eugenio / Russo, Alberto

    Intereconomics

    Debt Monétisation and EU Recovery Bonds

    2020  Volume 55, Issue 4, Page(s) 239–244

    Keywords Business, Management and Accounting (miscellaneous) ; Economics, Econometrics and Finance (miscellaneous) ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2066476-X
    ISSN 1613-964X ; 0020-5346
    ISSN (online) 1613-964X
    ISSN 0020-5346
    DOI 10.1007/s10272-020-0907-z
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Structural asymmetries at the roots of the eurozone crisis

    Alberto Botta

    PSL Quarterly Review, Vol 67, Iss 269, Pp 169-

    what’s new for industrial policy in the EU?

    2014  Volume 216

    Abstract: In this paper, we analyze and try to measure productive and technological asymmetries between central and peripheral economies in the eurozone. We assess the effects such asymmetries would likely bring about on center–periphery divergence/convergence ... ...

    Abstract In this paper, we analyze and try to measure productive and technological asymmetries between central and peripheral economies in the eurozone. We assess the effects such asymmetries would likely bring about on center–periphery divergence/convergence patterns, and derive some implications as to the design of future industrial policy at the European level. We stress that future European Union (EU) industrial policy should be regionally focused and specifically target structural changes in the periphery as the main way to favor center–periphery convergence and avoid the reappearance of past external imbalances. To this end, a wide battery of industrial policy tools should be considered ranging from subsidies and fiscal incentives to innovative firms, public financing of R&D efforts, sectoral policies, and public procurements for home-produced goods. All in all, future EU industrial policy should be much more interventionist than it currently is, and dispose of much larger funds with respect to the present setting in order to effectively pursue both short-run stabilization and long-run development goals.
    Keywords Center–Periphery Structural Symmetries ; EU Industrial Policy ; Economic theory. Demography ; HB1-3840 ; Social Sciences ; H
    Subject code 337
    Language English
    Publishing date 2014-06-01T00:00:00Z
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Structural asymmetries at the roots of the eurozone crisis

    Alberto Botta

    PSL Quarterly Review, Vol 67, Iss

    what’s new for industrial policy in the EU?

    2014  Volume 269

    Abstract: In this paper, we analyze and try to measure productive and technological asymmetries between central and peripheral economies in the eurozone. We assess the effects such asymmetries would likely bring about on center–periphery divergence/convergence ... ...

    Abstract In this paper, we analyze and try to measure productive and technological asymmetries between central and peripheral economies in the eurozone. We assess the effects such asymmetries would likely bring about on center–periphery divergence/convergence patterns, and derive some implications as to the design of future industrial policy at the European level. We stress that future European Union (EU) industrial policy should be regionally focused and specifically target structural changes in the periphery as the main way to favor center–periphery convergence and avoid the reappearance of past external imbalances. To this end, a wide battery of industrial policy tools should be considered ranging from subsidies and fiscal incentives to innovative firms, public financing of R&D efforts, sectoral policies, and public procurements for home-produced goods. All in all, future EU industrial policy should be much more interventionist than it currently is, and dispose of much larger funds with respect to the present setting in order to effectively pursue both short-run stabilization and long-run development goals. Keywords: Center–Periphery Structural Symmetries, EU Industrial Policy JEL Codes: E12, F15, O25, O52
    Keywords Center–Periphery Structural Symmetries ; EU Industrial Policy ; Political science ; J ; Economic theory. Demography ; HB1-3840
    Subject code 337
    Language English
    Publishing date 2014-07-01T00:00:00Z
    Publisher Associazione Economia civile
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Book ; Online: The short- and long-run inconsistency of the expansionary austerity theory

    Botta, Alberto

    a post-Keynesian/evolutionist critique

    (Working paper / Levy Economics Institute of Bard College ; no. 878)

    2016  

    Abstract: This paper provides a critical analysis of expansionary austerity theory (EAT). The focus is on the theoretical weaknesses of EAT-the extreme circumstances and fragile assumptions under which expansionary consolidations might actually take place. The ... ...

    Author's details by Alberto Botta (University of Greenwich)
    Series title Working paper / Levy Economics Institute of Bard College ; no. 878
    Abstract This paper provides a critical analysis of expansionary austerity theory (EAT). The focus is on the theoretical weaknesses of EAT-the extreme circumstances and fragile assumptions under which expansionary consolidations might actually take place. The paper presents a simple theoretical model that takes inspiration from both the post-Keynesian and evolutionary/institutionalist traditions. First, it demonstrates that well-designed austerity measures hardly trigger short-run economic expansions in the context of expected long-lasting consolidation plans (i.e., when adjustment plans deal with remarkably high debt-to-GDP ratios), when the so-called "financial channel" is not operative (i.e., in the context of monetarily sovereign economies), or when the degree of export responsiveness to internal devaluation is low. Even in the context of non-monetarily sovereign countries (e.g., members of the eurozone), austerity’s effectiveness crucially depends on its highly disputable capacity to immediately stabilize fiscal variables. The paper then analyzes some possible long-run economic dynamics, emphasizing the high degree of instability that characterizes austerity-based adjustments plans. Path-dependency and cumulativeness make the short-run impulse effects of fiscal consolidation of paramount importance to (hopefully) obtaining any appreciable medium-to-long-run benefit. Should these effects be contractionary at the onset, the short-run costs of austerity measures can breed an endless spiral of recession and ballooning debt in the long run. If so, in the case of non–monetarily sovereign countries debt forgiveness may emerge as the ultimate solution to restore economic soundness. Alternatively, institutional innovations like those adopted since mid-2012 by the European Central Bank are required to stabilize the economy, even though they are unlikely to restore rapid growth in the absence of more active fiscal stimuli.
    Keywords Fiscal Policy ; Expansionary Austerity Theory ; Post-Keynesian Macro Models
    Language English
    Size 1 Online-Ressource (circa 34 Seiten), Illustrationen
    Publisher Levy Economics Institute
    Publishing place Annandale-on-Hudson, NY
    Document type Book ; Online
    Database ECONomics Information System

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  9. Article ; Online: The Prognostic Value of Visceral Adipose Tissue in Patients Undergoing Transcatheter Aortic Valve Replacement.

    Somaschini, Alberto / Casirati, Amanda / Cornara, Stefano / Olivotti, Luca / Giachello, Veronica / Astuti, Matteo / Ghione, Matteo / Botta, Marco / Buscemi, Marialaura / Caccialanza, Riccardo / Bellone, Pietro / Cordone, Stefano

    The American journal of cardiology

    2023  Volume 208, Page(s) 1–3

    Language English
    Publishing date 2023-10-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2023.09.025
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    Ui IV Zs.73: Show issues Location:
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  10. Article: Fighting the COVID-19 Crisis: Debt Monétisation and EU Recovery Bonds

    Botta, Alberto / Caverzasi, Eugenio / Russo, Alberto

    Intereconomics

    Abstract: This paper highlights some peculiar characteristics of the economic crisis induced by the spread of COVID-19. It suggests two intertwined policy measures in order to tackle the emergency phase of the crisis and to support the economy in the subsequent ... ...

    Abstract This paper highlights some peculiar characteristics of the economic crisis induced by the spread of COVID-19. It suggests two intertwined policy measures in order to tackle the emergency phase of the crisis and to support the economy in the subsequent recovery phase. The proposed short-term policy measures offer policy responses in the event of a second wave of coronavirus infections in the coming months. In the aftermath of the emergency phase, the current proposal puts forward the implementation of a massive EU-wide recovery plan addressing the long-lasting technological and environmental challenges of these years, which will be financed by European institutions through the issuance of European Pandemic Recovery Bonds.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #728178
    Database COVID19

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