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Article ; Online: Excitation-Inhibition Balance, Neural Criticality, and Activities in Neuronal Circuits.

Liang, Junhao / Yang, Zhuda / Zhou, Changsong

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry

2024 , Page(s) 10738584231221766

Abstract: Neural activities in local circuits exhibit complex and multilevel dynamic features. Individual neurons spike irregularly, which is believed to originate from receiving balanced amounts of excitatory and inhibitory inputs, known as ... ...

Abstract	Neural activities in local circuits exhibit complex and multilevel dynamic features. Individual neurons spike irregularly, which is believed to originate from receiving balanced amounts of excitatory and inhibitory inputs, known as the
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1233753-5
ISSN	1089-4098 ; 1073-8584
ISSN (online)	1089-4098
ISSN	1073-8584
DOI	10.1177/10738584231221766
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Article ; Online: SMRGAT: A traditional Chinese herb recommendation model based on a multi-graph residual attention network and semantic knowledge fusion.

Yang, Xiaoyan / Ding, Changsong

Journal of ethnopharmacology

2023 Volume 315, Page(s) 116693

Abstract: Ethnopharmacological relevance: Traditional Chinese Medicine (TCM) prescriptions are a product of the Chinese medical theory's distinct thinking and clinical experience. TCM practitioners treat diseases by enhancing the efficacy of TCM prescriptions and ...

Abstract	Ethnopharmacological relevance: Traditional Chinese Medicine (TCM) prescriptions are a product of the Chinese medical theory's distinct thinking and clinical experience. TCM practitioners treat diseases by enhancing the efficacy of TCM prescriptions and reducing their poisonous effects. Some TCM herb recommendation methods have been provided for curing the given symptoms to generate a group of herbs according to the TCM principles. However, they ignored the symptoms' semantic characteristics and herbs' different effects on symptoms. Aim of the study: We aim to recommend TCM herbs by considering symptoms' semantic information and the strength of different herbs in curing symptoms. Materials and methods: We propose a herb recommendation model named Multi-Graph Residual Attention Network and Semantic Knowledge Fusion (SMRGAT) to address these problems. Concretely, it uses a multi-head attention mechanism to focus on herbs' different effects on symptoms. Meanwhile, it augments entities' features with a residual network structure while incorporating symptoms' semantic information and external knowledge of herbs. We will verify the effect of SMRGAT on the existing public datasets and the datasets that we have collected and cleaned. Results: Compared with the current best TCM herb recommendation model, on the public dataset, SMRGAT were increased by 15.11%, 20.60%, and 18.25% in Precision@5, Recall@5, and F1 - score@5, respectively; on ours, respectively increased by 9.72%, 9.03%, 9.24%. Conclusions: Our experimental results on two datasets indicate that SMRGAT is capable of recommending herbs with greater precision and outperforms several comparison methods. It can provide a basis for assisting TCM clinical prescriptions.
MeSH term(s)	Humans ; Semantics ; Medicine, Chinese Traditional ; Language ; Traditional Medicine Practitioners ; Drugs, Chinese Herbal/therapeutic use
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2023-05-30
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116693
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Zs.A 1494: Show issues

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Article ; Online: SMRGAT: A traditional Chinese herb recommendation model based on a multi-graph residual attention network and semantic knowledge fusion

Yang, Xiaoyan / Ding, Changsong

Journal of Ethnopharmacology. 2023, p.116693-

2023 , Page(s) 116693–

Abstract: Traditional Chinese Medicine (TCM) prescriptions are a product of the Chinese medical theory's distinct thinking and clinical experience. TCM practitioners treat diseases by enhancing the efficacy of TCM prescriptions and reducing their poisonous effects. ...

Abstract	Traditional Chinese Medicine (TCM) prescriptions are a product of the Chinese medical theory's distinct thinking and clinical experience. TCM practitioners treat diseases by enhancing the efficacy of TCM prescriptions and reducing their poisonous effects. Some TCM herb recommendation methods have been provided for curing the given symptoms to generate a group of herbs according to the TCM principles. However, they ignored the symptoms' semantic characteristics and herbs' different effects on symptoms. We aim to recommend TCM herbs by considering symptoms' semantic information and the strength of different herbs in curing symptoms. We propose a herb recommendation model named Multi-Graph Residual Attention Network and Semantic Knowledge Fusion (SMRGAT) to address these problems. Concretely, it uses a multi-head attention mechanism to focus on herbs' different effects on symptoms. Meanwhile, it augments entities' features with a residual network structure while incorporating symptoms' semantic information and external knowledge of herbs. We will verify the effect of SMRGAT on the existing public datasets and the datasets that we have collected and cleaned. Compared with the current best TCM herb recommendation model, on the public dataset, SMRGAT were increased by 15.11%, 20.60%, and 18.25% in Precision@5, Recall@5, and F1 − score@5, respectively; on ours, respectively increased by 9.72%, 9.03%, 9.24%. Our experimental results on two datasets indicate that SMRGAT is capable of recommending herbs with greater precision and outperforms several comparison methods. It can provide a basis for assisting TCM clinical prescriptions.
Keywords	Oriental traditional medicine ; data collection ; models ; Traditional Chinese medicine ; Herb recommendation ; Attention mechanism ; Semantic knowledge fusion ; Residual structure
Language	English
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116693
Database	NAL-Catalogue (AGRICOLA)

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Article: Dynamics of the Fermentation Products, Residual Non-structural Carbohydrates, and Bacterial Communities of Wilted and Non-wilted Alfalfa Silage With and Without

Yang, Fengyuan / Wang, Yanping / Zhao, Shanshan / Feng, Changsong / Fan, Xiaomiao

Frontiers in microbiology

2022 Volume 12, Page(s) 824229

Abstract: The aim of this study was to investigate effects of wilting ... ...

Abstract	The aim of this study was to investigate effects of wilting and
Language	English
Publishing date	2022-01-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2021.824229
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Article ; Online: Manipulating two-dimensional magnetic states

Bao, Hengxing / Tian, Hao / Li, Xu / Ma, Xingyue / Xu, Changsong / Yang, Yurong / Wu, Di

Physical chemistry chemical physics : PCCP

2023 Volume 25, Issue 33, Page(s) 22244–22249

Abstract: Topological spin configurations have been an intriguing topic due to the exotic transport properties and promising applications in spintronic devices. The discovery of two-dimensional (2D) magnetic materials such as ... ...

Abstract	Topological spin configurations have been an intriguing topic due to the exotic transport properties and promising applications in spintronic devices. The discovery of two-dimensional (2D) magnetic materials such as CrI
Language	English
Publishing date	2023-08-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d3cp02043f
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Article ; Online: Age of Information Minimization for Radio Frequency Energy-Harvesting Cognitive Radio Networks.

Sun, Juan / Zhang, Shubin / Yang, Changsong / Huang, Liang

Entropy (Basel, Switzerland)

2022 Volume 24, Issue 5

Abstract: The Age of Information (AoI) measures the freshness of information and is a critic performance metric for time-sensitive applications. In this paper, we consider a radio frequency energy-harvesting cognitive radio network, where the secondary user ... ...

Abstract	The Age of Information (AoI) measures the freshness of information and is a critic performance metric for time-sensitive applications. In this paper, we consider a radio frequency energy-harvesting cognitive radio network, where the secondary user harvests energy from the primary users' transmissions and opportunistically accesses the primary users' licensed spectrum to deliver the status-update data pack. We aim to minimize the AoI subject to the energy causality and spectrum constraints by optimizing the sensing and update decisions. We formulate the AoI minimization problem as a partially observable Markov decision process and solve it via dynamic programming. Simulation results verify that our proposed policy is significantly superior to the myopic policy under different parameter settings.
Language	English
Publishing date	2022-04-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2014734-X
ISSN	1099-4300 ; 1099-4300
ISSN (online)	1099-4300
ISSN	1099-4300
DOI	10.3390/e24050596
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Article ; Online: Feasibility of sludge deep dewaterability improvement for incineration disposal by combined conditioning of freeze-thaw and sawdust.

Wu, Yajun / Liu, Yang / Zhang, Xudong / Gao, Mengze / Zhang, Changsong / Zang, Xueke / Wu, Linbao

Environmental research

2024 , Page(s) 118987

Abstract: Sludge incineration is the main strategy for sludge reduction in China. The combined conditioning of lime and chemical agents has been proven to achieve sludge dewatering by disrupting the extracellular polymeric substances (EPS) of sludge and reducing ... ...

Abstract	Sludge incineration is the main strategy for sludge reduction in China. The combined conditioning of lime and chemical agents has been proven to achieve sludge dewatering by disrupting the extracellular polymeric substances (EPS) of sludge and reducing its compressibility. However, when incineration is the intended disposal purpose, this method poses challenges such as incomplete combustion, equipment corrosion, secondary pollution, and decreased calorific value of sludge cake. In contrast, freeze-thaw conditioning, coupled with sawdust as a high-calorific-value bio-waste, emerges as an efficient and clean alternative. The research investigates the synergistic effects of freeze-thaw and sawdust co-conditioning on various sludge properties, including dewaterability, compressibility, consolidation, permeability, microscopicity, and calorific value. The study reveals that the combined conditioning significantly reduces water content and compressibility while increasing void ratio, consolidation, permeability, and enhancing the calorific value of the sludge cake. Specifically, sludge cake conditioned with 60% dried solids (DS) sawdust and freeze-thaw achieved a water content (Wc) of 49.07% and a calorific value of 1422.3 kcal/kg, meeting standards for self-sustained incineration. With heat recovery, the combined conditioning generates an economic revenue of 25.1 $/t DS after deducting costs, thereby reducing the overall cost of sludge reduction treatment. This research offers a clean and practical solution for sludge incineration and reduction, demonstrating great economic value and application potential.
Language	English
Publishing date	2024-04-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2024.118987
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Zs.A 726: Show issues

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Article ; Online: Age of Information Minimization for Radio Frequency Energy-Harvesting Cognitive Radio Networks

Juan Sun / Shubin Zhang / Changsong Yang / Liang Huang

Entropy, Vol 24, Iss 596, p

2022 Volume 596

Abstract	The Age of Information (AoI) measures the freshness of information and is a critic performance metric for time-sensitive applications. In this paper, we consider a radio frequency energy-harvesting cognitive radio network, where the secondary user harvests energy from the primary users’ transmissions and opportunistically accesses the primary users’ licensed spectrum to deliver the status-update data pack. We aim to minimize the AoI subject to the energy causality and spectrum constraints by optimizing the sensing and update decisions. We formulate the AoI minimization problem as a partially observable Markov decision process and solve it via dynamic programming. Simulation results verify that our proposed policy is significantly superior to the myopic policy under different parameter settings.
Keywords	Age of Information ; RF energy-harvesting ; cognitive radio network ; dynamic programming ; Science ; Q ; Astrophysics ; QB460-466 ; Physics ; QC1-999
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Claudin 18.2 as a novel therapeutic target.

Nakayama, Izuma / Qi, Changsong / Chen, Yang / Nakamura, Yoshiaki / Shen, Lin / Shitara, Kohei

Nature reviews. Clinical oncology

2024 Volume 21, Issue 5, Page(s) 354–369

Abstract: Claudin 18.2, a tight-junction molecule predominantly found in the nonmalignant gastric epithelium, becomes accessible on the tumour cell surface during malignant transformation, thereby providing an appealing target for cancer therapy. Data from two ... ...

Abstract	Claudin 18.2, a tight-junction molecule predominantly found in the nonmalignant gastric epithelium, becomes accessible on the tumour cell surface during malignant transformation, thereby providing an appealing target for cancer therapy. Data from two phase III trials testing the anti-claudin 18.2 antibody zolbetuximab have established claudin 18.2-positive advanced-stage gastric cancers as an independent therapeutic subset that derives benefit from the addition of this agent to chemotherapy. This development has substantially increased the percentage of patients eligible for targeted therapy. Furthermore, newer treatments, such as high-affinity monoclonal antibodies, bispecific antibodies, chimeric antigen receptor T cells and antibody-drug conjugates capable of bystander killing effects, have shown considerable promise in patients with claudin 18.2-expressing gastric cancers. This new development has resulted from drug developers moving beyond traditional targets, such as driver gene alterations or growth factors. In this Review, we highlight the biological rationale and explore the clinical activity of therapies that target claudin 18.2 in patients with advanced-stage gastric cancer and explore the potential for expansion of claudin 18.2-targeted therapies to patients with other claudin 18.2-positive solid tumours.
MeSH term(s)	Humans ; Claudins/metabolism ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/pathology ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/genetics ; Molecular Targeted Therapy/methods
Chemical Substances	Claudins ; CLDN18 protein, human
Language	English
Publishing date	2024-03-19
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2491410-1
ISSN	1759-4782 ; 1759-4774
ISSN (online)	1759-4782
ISSN	1759-4774
DOI	10.1038/s41571-024-00874-2
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Zs.MG 103: Show issues

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Article: Degradation Mechanism of a Sauce-Glazed Ware of the Song Dynasty Salvaged out of the Water at Dalian Island Wharf: Part I-The Effect of the Surface-Attached Composite Coagula.

Ding, Rao / Li, Weidong / Yang, Zelin / Xu, Changsong / Lu, Xiaoke

Materials (Basel, Switzerland)

2023 Volume 16, Issue 3

Abstract: Dalian Island is located in the sea area near Pingtan County, Fujian, Southeast China. The sea area used to be the junction of the eastern and western ship routes on the Maritime Silk Road, and is also an important region for underwater archaeology in ... ...

Abstract	Dalian Island is located in the sea area near Pingtan County, Fujian, Southeast China. The sea area used to be the junction of the eastern and western ship routes on the Maritime Silk Road, and is also an important region for underwater archaeology in China. This study focused on a sauce-glazed ware of the Song Dynasty, with serious degradation, which was salvaged out of the water at the Dalian Island Wharf. Optical microscopy, scanning electron microscopy, X-ray diffraction analysis, and micro-Raman spectroscopy were used to comprehensively analyze the composition, phase attributes and microstructure of the ware and the surface-attached coagula. The findings revealed that the sea wave-borne debris scoured the surface of the ware, causing mechanical damage to varying degrees and a significant decrease in its degradation resistance. This was the primary factor accounting for the poor preservation state of the salvaged ceramic ware, and the precondition for the subsequent attachment of marine organisms and the deposition of inorganic pollutants. The calcareous skeletons formed on the surface induced by the bio-mineralization of coralline algae (a type of marine plant) could resist the mechanical action caused by the motion of sea waves, thereby slowing down the ware's degradation process. In other words, the calcareous skeletons played a 'bio-protective' role to a certain degree. In addition, inorganic pollutants represented by iron rusts also participated in the corrosion of the glaze. Some pollutants were directly deposited on the pits and cracks on the surface of the ware, which brought stress to the glaze and glaze/body interface, causing the glaze to further crack and spall. Moreover, iron rusts reacted with the glaze, leading to chemical alteration, accompanied by the formation of iron silicate as the alteration product. Anorthite crystals in the interlayer did not participate in the reaction but remained at the original position. The alteration product gradually replaced the original glass phase of the glaze and entered into the body via pores and cracks. In conclusion, the complex degradation morphology of the salvaged sauce-glazed ware could be attributed to the combined action of mechanical damage, marine bio-fouling, and chemical alteration.
Language	English
Publishing date	2023-01-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16031176
Database	MEDical Literature Analysis and Retrieval System OnLINE

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