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Article ; Online: Effect of pulse methylprednisolone on prognosis in SARS-CoV-2 patients with severe pneumonia.

Eraslan, B Z / Fidan, A / Baysal, T / Cömert, S S / Kıral, N / Parmaksız, E T

European review for medical and pharmacological sciences

2024 Volume 28, Issue 3, Page(s) 1234–1240

Abstract: Objective: This study aimed to evaluate the effect of pulse methylprednisolone treatment on prognosis in severe COVID-19 pneumonia.: Patients and methods: This retrospective cohort study included 128 patients hospitalized in our clinic for severe ... ...

Abstract	Objective: This study aimed to evaluate the effect of pulse methylprednisolone treatment on prognosis in severe COVID-19 pneumonia. Patients and methods: This retrospective cohort study included 128 patients hospitalized in our clinic for severe COVID-19 between March 2020 and February 2021. Standard treatment (plaquenil, favipravir, low molecular weight heparin, and antibiotics when necessary) was given to the patients in accordance with the Turkish Ministry of Health guidelines. After steroid treatment was included in the guidelines, dexamethasone 6 mg/day was administered along with standard treatment. In patients whose clinical condition did not improve despite this treatment, 250 mg/day methylprednisolone (pulse steroid therapy) was administered intravenous (i.v.) for 3 days, followed by a 40 mg/day maintenance dose. The group receiving methylprednisolone 250 mg/day for 3 days and the group receiving standard treatment without steroids were compared in terms of symptoms, comorbidities, laboratory and radiological findings, length of hospitalization, prognosis, intensive care unit (ICU) admission, and intubation. Results: Of the 128 patients included in the study, 85 (66.4%) were male, and the mean age was 61.7 ± 13.2 years (min: 25; max: 88). A total of 50 (39.1%) patients were transferred to the ICU, while the number of intubated patients was 37 (28.9%). Pulse methylprednisolone treatment was given to 98 (76.6%) patients, compared to the 30 (23.4%) patients who received only standard treatment. In total, 37 patients (28.9%) died. The presence of comorbid diseases (34.3% vs. 1.5%, p = 0.012), advanced age (67.7 vs. 59.3, p = 0.001), and not receiving steroid treatment (p = 0.046) significantly increased mortality. The mortality rate was 24.4% (24/98 patients) in the steroid therapy group and 43.3% (13/30 patients) in patients not receiving steroid therapy, and the difference was statistically significant (p = 0.046). Pulse steroid therapy also significantly decreased the rate of intubation (p = 0.014) and ICU admission (p = 0.007). In the logistic regression analysis that included comorbidity, advanced age, and pulse steroid therapy, advanced age (p = 0.022) and pulse steroid therapy (p = 0.048) were found to be effective independent variables of mortality. Conclusions: The results showed that pulse i.v. methylprednisolone significantly reduced mortality in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients with severe pneumonia requiring hospitalization, in addition to significantly reducing the need for intensive care and intubation. In SARS-CoV-2 patients with severe pneumonia, pulse i.v. methylprednisolone may be useful as a standard treatment in patients who do not respond to dexamethasone.
MeSH term(s)	Humans ; Male ; Middle Aged ; Aged ; Female ; SARS-CoV-2 ; COVID-19 ; Methylprednisolone/therapeutic use ; Retrospective Studies ; Prognosis ; Dexamethasone
Chemical Substances	Methylprednisolone (X4W7ZR7023) ; Dexamethasone (7S5I7G3JQL)
Language	English
Publishing date	2024-02-20
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202402_35362
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Article ; Online: Midterm Donor Site Morbidity After Vascularized Free Fibula Flap Harvesting.

Büyüktopçu, Ömer / Baysal, Özgür / Ağırdil, Yücel / Şahbat, Yavuz / Shammadli, Ziya / Şirin, Evrim / Erol, Bülent

Foot & ankle international

2024 Volume 45, Issue 4, Page(s) 364–372

Abstract: Background: Vascularized fibula grafts (VFGs) have become one of the most preferred grafts for the reconstruction of bone defects. However, despite the many advantages over other graft options, recipient and donor site morbidities are also common. Donor ...

Abstract	Background: Vascularized fibula grafts (VFGs) have become one of the most preferred grafts for the reconstruction of bone defects. However, despite the many advantages over other graft options, recipient and donor site morbidities are also common. Donor site morbidity has been reported at rates ranging from 5% to 67%. The aim of this study was to present a single-center series examining the clinical, functional, and radiologic aspects of donor site morbidity following VFG harvesting. Methods: The study included 69 patients who underwent biological reconstruction with VFG for bone tumors, avascular necrosis of the femoral head, or bone defects after trauma. Patients were evaluated functionally, clinically, and radiologically for donor site morbidity. Results: Donor site morbidity was observed in 33 of 69 patients (48%). The most complications were sensation deficits around the feet and ankles (20 of 69; 29%). Knee laxity was more common in patients who underwent osteoarticular fibular resection ( Conclusion: We found VFG to be an effective method for the reconstruction of large bone defects, but associated with a relatively high rate of complications. Complications requiring surgical intervention were rare and the majority of patients did not have long-term functional limitations. Level of evidence: Level IV, retrospective case series.
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1183283-6
ISSN	1944-7876 ; 1071-1007
ISSN (online)	1944-7876
ISSN	1071-1007
DOI	10.1177/10711007241226620
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Article: Real-Time and Rapid Detection of

Ghimire, Bhawana / Avin, Farhat A / Waliullah, Sumyya / Ali, Emran / Baysal-Gurel, Fulya

Plant disease

2023 Volume 107, Issue 11, Page(s) 3394–3402

Abstract: Phytopythium ... ...

Abstract	Phytopythium vexans
MeSH term(s)	Nucleic Acid Amplification Techniques/methods ; Polymerase Chain Reaction/methods ; DNA ; Oomycetes
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2023-11-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS-08-22-1944-RE
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Article: Staged Management of Infection with Adjustable Spacers After Megaprosthesis Implantation in Primary Sarcoma Patients.

Şirin, Evrim / Sofulu, Ömer / Baysal, Özgür / Akgülle, Ahmet Hamdi / Erol, Bülent

Indian journal of orthopaedics

2023 Volume 57, Issue 6, Page(s) 938–947

Abstract: Background: While periprosthetic joint infection has always been a significant concern for orthopaedic surgeons, the rate of infection is five to ten times higher after tumor prosthesis implantation. With the growing use of mega-implants, the number of ... ...

Abstract	Background: While periprosthetic joint infection has always been a significant concern for orthopaedic surgeons, the rate of infection is five to ten times higher after tumor prosthesis implantation. With the growing use of mega-implants, the number of these infections has also increased. We aimed to investigate the results of our patients with a primary malignant musculoskeletal tumor, who underwent two-stage revision surgery for an infected mega-prosthesis. We also presented the emerging complicatons and required soft tissue reconstruction procedures. Methods: The study included 32 primary bone and soft tissue sarcoma patients who underwent a two-stage revision procedure for infection. After a rigorous bone and soft tissue debridement procedure at the first stage, antibiotic-loaded bone cement was wrapped around a cloverleaf type intramedullary nail and inserted into the forming gap. After a minimum of 6 weeks of antibiotic therapy, depending on patients' clinical signs and serum infection markers, the reimplantation stage was undertaken. Results: The mean oncologic follow-up period was 28 months (range 5-96 months). During this period, 11 patients died because of non-infection related causes, 12 patients were alive with their disease, whereas 9 patients were totally free of their oncologic condition. The infection was eradicated in all survivors except one patient, where a high-level transfemoral amputation became necessary. Conclusion: Periprosthetic infection after tumor proshesis implantation in cancer patients can be managed with same principles as conventional arthroplaty procedures, taking care that they are immunocompromised and vulnerable patients and their bone stock loss is significant which makes surgical options more challenging.
Language	English
Publishing date	2023-03-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	603194-8
ISSN	0019-5413
ISSN	0019-5413
DOI	10.1007/s43465-023-00876-9
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Article ; Online: Comparison of Magnetic Resonance Imaging With Positron Emission Tomography/Computed Tomography in the Evaluation of Response to Neoadjuvant Therapy of Breast Cancer.

Baysal, Hakan / Serdaroglu, Ahmet Yusuf / Ozemir, Ibrahim Ali / Baysal, Begumhan / Gungor, Serkan / Erol, Cem Ilgin / Ozsoy, Mehmet Sait / Ekinci, Ozgur / Alimoglu, Orhan

The Journal of surgical research

2022 Volume 278, Page(s) 223–232

Abstract: ... staining intensity and a loss of E-cadherin expression, whereas PET-CT was found to be more sensitive ... in patients with HER-2 overexpression, Luminal B, or Ki-67 proliferation >14% (P = 0.01). ...

Abstract	Introduction: The present study aims to determine the diagnostic accuracy of magnetic resonance imaging (MRI) and positron emission tomography-computed tomography (PET-CT) in predicting a pathological response of molecular subtypes of breast cancer to neoadjuvant chemotherapy (NAC). Materials and methods: We retrospectively analyzed patients with breast cancer who were operated after NAC between January 2018 and May 2020. Radiological responses were evaluated as per the Response Evaluation Criteria in Solid Tumors (RECIST) and changes in contrast enhancement patterns on MRI and the classification of PET Response Criteria in Solid Tumors (PERCIST) on PET-CT. The presence of a pathological response was evaluated based on the Sataloff classification. The agreement between the radiological response determined through imaging modalities before and after the NAC and the postoperative pathological complete response (pCR) was evaluated and compared statistically. Among the patients diagnosed with breast cancer between the ages of 18 and 80 y, those with N (+) at the time of diagnosis, those with T2 and advanced tumors, and those who were planned for breast conserving surgery were included in our study. Male patients, patients with distant metastases at the time of diagnosis, and patients with other system malignancies were excluded. Results: The study included 88 patients who had undergone surgery for breast cancer after NAC between January 2018 and May 2020. The study was conducted retrospectively in a single center. The tumor diameters and standard uptake values significantly decreased after NAC (P < 0.001). Estrogen receptor (ER) and progesterone receptor (PR) positivity were negatively associated with pCR (P = 0.03 and P = 0.03, respectively), whereas there was a significant positive association between HER-2 positivity and pCR (P = 0.004). There was a moderate agreement between the RECIST criteria used with MRI and pCR (k: 0.46). Moreover, a good agreement between PET-CT-PERCIST and pCR was detected (k: 0.61). In predicting pCR after NAC, MRI showed a selectivity of 80.7%, a sensitivity of 65.2%, a positive predictive value (PPV) of 75%, and a negative predictive value (NPV) of 72.4%. The corresponding rates for PET-CT were 75.7%, 100%, 57.9%, and 100%. Conclusions: When evaluating pCR after NAC, MRI was found to be more sensitive in patients with ER-positive cancer cell nuclei with weak to medium staining intensity and a loss of E-cadherin expression, whereas PET-CT was found to be more sensitive in patients with HER-2 overexpression, Luminal B, or Ki-67 proliferation >14% (P = 0.01).
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/drug therapy ; Fluorodeoxyglucose F18/therapeutic use ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Neoadjuvant Therapy/methods ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography ; Retrospective Studies ; Treatment Outcome ; Young Adult
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2022-05-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	80170-7
ISSN	1095-8673 ; 0022-4804
ISSN (online)	1095-8673
ISSN	0022-4804
DOI	10.1016/j.jss.2022.04.063
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Article ; Online: Efficacy of siRNA-loaded nanoparticles in the treatment of K-RAS mutant lung cancer

Gencer, Ayse / Baysal, Ipek / Nemutlu, Emirhan / Yabanoglu-Ciftci, Samiye / Arica, Betul

Journal of microencapsulation

2022 Volume 39, Issue 3, Page(s) 261–275

Abstract: To design and develop K-RAS silencing small interfering RNA (siRNA)-loaded poly (D, L-lactic-co-glycolic acid) nanoparticles and evaluate their efficacy in the treatment of K-RAS mutant lung cancer. The nanoparticles prepared by the double emulsion ... ...

Abstract	To design and develop K-RAS silencing small interfering RNA (siRNA)-loaded poly (D, L-lactic-co-glycolic acid) nanoparticles and evaluate their efficacy in the treatment of K-RAS mutant lung cancer. The nanoparticles prepared by the double emulsion solvent evaporation method were characterized by TEM, FTIR and XPS analyzes and evaluated
MeSH term(s)	Humans ; Lactic Acid ; Lung Neoplasms/genetics ; Lung Neoplasms/therapy ; Nanoparticles ; Particle Size ; Polylactic Acid-Polyglycolic Acid Copolymer ; RNA, Small Interfering/genetics
Chemical Substances	RNA, Small Interfering ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; Lactic Acid (33X04XA5AT)
Language	English
Publishing date	2022-04-18
Publishing country	England
Document type	Journal Article
ZDB-ID	843632-0
ISSN	1464-5246 ; 0265-2048
ISSN (online)	1464-5246
ISSN	0265-2048
DOI	10.1080/02652048.2022.2061058
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Article ; Online: An unusual injury pattern: arm wrestling injury, treatment modalities, clinical outcomes, and return to sport.

Şahbat, Yavuz / Kütük, Emir / Çat, Görkem / Ünsalan, Oğulcan / Kart, Hayati / Topkar, Osman Mert / Baysal, Özgür / Erol, Bülent

Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES

2023 Volume 29, Issue 6, Page(s) 733–740

Abstract: Background: In the sport of arm wrestling, the great rotational force is applied to the upper extremity, which can result in muscle and tendon injuries in the shoulder, elbow, and wrist joints, and even bone fractures. The aim of this study was to ... ...

Title translation	Farklı bir yaralanma şekli: Bilek güreşi yaralanması; tedavi şekilleri, klinik sonuçlar ve spora dönüş.
Abstract	Background: In the sport of arm wrestling, the great rotational force is applied to the upper extremity, which can result in muscle and tendon injuries in the shoulder, elbow, and wrist joints, and even bone fractures. The aim of this study was to present the treatment modalities, functional outcomes, and return to sport after arm wrestling injuries. Methods: A retrospective evaluation was made of the trauma mechanisms, treatment modalities, clinical outcomes, and time of return to sports of patients admitted to our hospital with an arm wrestling injury between 2008 and 2020. At the final follow-up examination, the functional scores (DASH score and constant score) of the patients were evaluated. Results: Evaluation was made of 22 patients comprising 18 (82%) males and 4 (18%) females with a mean age of 20±6.1 years (range, 12-33 years). Two (10%) patients were professional arm wrestlers. The DASH scores at the final follow-up (mean 4 years) examination were 0.57 (min: 0 and max: 1.7) for the patients with humerus shaft fracture. All the patients with isolated soft-tissue injuries returned to sports within 1 month. Patients with humeral shaft fractures returned to sports later and had a lower functional score (P<0.05). There was no disability in any patient during long-term follow-up. Patients with soft-tissue injuries continued arm wrestling more than patients with bone injuries (P<0.001). Conclusion: This study constitutes the largest patient series evaluating patients presenting at a health-care institution with any complaint after arm wrestling. Arm wrestling is not a sport that only results in bone pathologies. Therefore, providing the participants in this sport with information that they may be injured in arm wrestling but there will be a full recovery, may reassure and encourage them.
MeSH term(s)	Adolescent ; Adult ; Female ; Humans ; Male ; Young Adult ; Arm ; Arm Injuries/etiology ; Arm Injuries/therapy ; Humeral Fractures ; Retrospective Studies ; Return to Sport ; Wrestling/injuries ; Child
Language	English
Publishing date	2023-06-05
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2253739-9
ISSN	1307-7945 ; 1306-696X
ISSN (online)	1307-7945
ISSN	1306-696X
DOI	10.14744/tjtes.2023.34247
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Article ; Online: Synthesis and characterization of antibacterial bio-nano films for food packaging.

Baysal, Gülay / Çelik, Burç Yilmaz

Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes

2018 Volume 54, Issue 2, Page(s) 79–88

Abstract: ... activity of CS nanofilms against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) bacteria ...

Abstract	This study prepared antibacterial nanocomposite films for food packaging from Montmorillonite, which was modified by quaternary ammonium salts such as cetyltrimethylammonium bromide (CT), hexadecyl-tributyl phosphonium bromide (HD) and corn starch (CS). After this, it determined the antimicrobial activity of CS nanofilms against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) bacteria. Dispersion of silicate layers and starch nanocomposite films was analyzed by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM), and the results indicated that presence of quaternary ammonium salts enhanced clay dispersion, and the starch films incorporated with quaternary ammonium salts would provide potential use in food packaging as nanostructural materials. The nanofilms that were obtained based on the results of the antibacterial analysis were confirmed to have much stronger antibacterial properties than those in similar studies in the literature.
MeSH term(s)	Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Bentonite/chemistry ; Cetrimonium/chemistry ; Escherichia coli/drug effects ; Food Packaging/instrumentation ; Food Packaging/methods ; Microbial Sensitivity Tests ; Microscopy, Electron, Scanning ; Nanocomposites/chemistry ; Organophosphorus Compounds/chemistry ; Spectroscopy, Fourier Transform Infrared ; Staphylococcus aureus/drug effects ; Starch/chemistry ; X-Ray Diffraction
Chemical Substances	Anti-Bacterial Agents ; Organophosphorus Compounds ; tributylhexadecylphosphonium bromide ; Bentonite (1302-78-9) ; Starch (9005-25-8) ; Cetrimonium (Z7FF1XKL7A)
Language	English
Publishing date	2018-11-08
Publishing country	England
Document type	Journal Article
ZDB-ID	197072-0
ISSN	1532-4109 ; 0360-1234
ISSN (online)	1532-4109
ISSN	0360-1234
DOI	10.1080/03601234.2018.1530546
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Article ; Online: Evaluation of prognosis and nephrotoxicity in patients treated with colistin in intensive care unit.

Gunay, Emrah / Kaya, Safak / Baysal, Birol / Yuksel, Enver / Arac, Esref

Renal failure

2020 Volume 42, Issue 1, Page(s) 704–709

Abstract: Introduction: Nephrotoxicity is the most important adverse effect of colistin therapy. We investigated the frequency of nephrotoxicity, risk factors related to nephrotoxicity, and its relationship with mortality in patients who received intravenous ... ...

Abstract	Introduction: Nephrotoxicity is the most important adverse effect of colistin therapy. We investigated the frequency of nephrotoxicity, risk factors related to nephrotoxicity, and its relationship with mortality in patients who received intravenous colistin in intensive care units (ICUs). Materials and methods: We retrospectively reviewed the data of patients who received intravenous colistin in ICUs between 2011 and 2017. Acute kidney injury (AKI) diagnosis and staging were made based on the Kidney Disease Improving Global Outcome criteria. Results: There were 149 patients included in the study with 61% being male. The mean age was 58.7 ± 20.3 years. AKI was detected in 96 (64.4%) patients. There were 25 patients with AKI stage 1 (16.8%) and 71 patients with AKI stage 2 or 3 (47.7%). Advanced age (65.0 vs. 47.4 years; Discussion: Higher AKI and mortality rates are observed in patients with diabetes, heart failure, advanced age and the hemodynamically impaired. However, it is a fact that there are no alternative therapies other than colistin in the treatment of multidrug-resistant Gram-negative bacterial infections. Therefore, the development of AKI in this patient group should not be considered a sufficient reason for discontinuing colistin treatment. Understanding the risk factors in this potential nephrotoxic treatment can provide a more careful patient follow-up.
MeSH term(s)	APACHE ; Acute Kidney Injury/chemically induced ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/mortality ; Administration, Intravenous ; Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/adverse effects ; Colistin/administration & dosage ; Colistin/adverse effects ; Critical Illness/therapy ; Female ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Risk Factors ; Time Factors ; Turkey/epidemiology
Chemical Substances	Anti-Bacterial Agents ; Colistin (Z67X93HJG1)
Language	English
Publishing date	2020-08-07
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	632949-4
ISSN	1525-6049 ; 0886-022X
ISSN (online)	1525-6049
ISSN	0886-022X
DOI	10.1080/0886022X.2020.1795878
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Article ; Online: Clinical follow-up of patients with HBeAg positive chronic hepatitis B infection: A long-term observational study.

Arslan, Ferhat / Batirel, Ayse / Betul Baysal, Naciye / Vahaboglu, Haluk / Mert, Ali

Hepatology forum

2022 Volume 3, Issue 2, Page(s) 57–60

Abstract: ... of patients with HBeAg positive chronic hepatitis B infection in tertiary care centers in Istanbul ... chronic hepatitis B infection, who were followed up in three tertiary care centers in Istanbul between ... The Ethical Committee of Istanbul Medipol University approved this study (Protocol no: 10840098-604.01.01-E.44136 ...

Abstract	Background and aim: We aimed to analyze the demographic, laboratory, and clinical characteristics of patients with HBeAg positive chronic hepatitis B infection in tertiary care centers in Istanbul. Materials and methods: We conducted an observational cohort with ≥18-year-old patients with HBeAg positive chronic hepatitis B infection, who were followed up in three tertiary care centers in Istanbul between January 2000 and August 2018, were evaluated by reviewing electronic and recorded files. The Ethical Committee of Istanbul Medipol University approved this study (Protocol no: 10840098-604.01.01-E.44136). During the polyclinic interview, consent was obtained from patients for analysis and publication. Results: The mean age of the 64 patients was 30 (range 18-39) years, and 50% (32) of them were males. The mean follow-up period of the patients was 67 (18-180) months. Twenty-four patients were treated with at least one antiviral in their follow-up, and only 2 (3.1%) of these patients developed HBeAg seroconversion without antiviral treatment. HBeAg (+) chronic hepatitis B developed in 4 of the patients after the immune-active period. None of the patients and first-degree relatives had hepatocellular carcinoma (HCC). Conclusion: The rationality of antiviral treatment and HCC development risk in these patients still remains elusive.
Language	English
Publishing date	2022-04-26
Publishing country	Turkey
Document type	Journal Article
ISSN	2757-7392
ISSN (online)	2757-7392
DOI	10.14744/hf.2021.2021.0011
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