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  1. Article ; Online: Alterations of iron homeostasis as a potential druggable driver of long COVID.

    Marques, Oriana / Muckenthaler, Martina U

    Nature immunology

    2024  Volume 25, Issue 3, Page(s) 387–389

    MeSH term(s) Humans ; Post-Acute COVID-19 Syndrome ; COVID-19 ; Iron ; Homeostasis
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-024-01759-3
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5294: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 42: Show issues

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  2. Article ; Online: Iron deficiency anemia.

    Muckenthaler, Martina U

    HemaSphere

    2019  Volume 3, Issue Suppl, Page(s) 99

    Language English
    Publishing date 2019-06-30
    Publishing country United States
    Document type Journal Article
    ISSN 2572-9241
    ISSN (online) 2572-9241
    DOI 10.1097/HS9.0000000000000252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The role of iron in chronic inflammatory diseases: from mechanisms to treatment options in anemia of inflammation.

    Marques, Oriana / Weiss, Günter / Muckenthaler, Martina U

    Blood

    2022  Volume 140, Issue 19, Page(s) 2011–2023

    Abstract: Anemia of inflammation (AI) is a highly prevalent comorbidity in patients affected by chronic inflammatory disorders, such as chronic kidney disease, inflammatory bowel disease, or cancer, that negatively affect disease outcome and quality of life. The ... ...

    Abstract Anemia of inflammation (AI) is a highly prevalent comorbidity in patients affected by chronic inflammatory disorders, such as chronic kidney disease, inflammatory bowel disease, or cancer, that negatively affect disease outcome and quality of life. The pathophysiology of AI is multifactorial, with inflammatory hypoferremia and iron-restricted erythropoiesis playing a major role in the context of disease-specific factors. Here, we review the recent progress in our understanding of the molecular mechanisms contributing to iron dysregulation in AI, the impact of hypoferremia and anemia on the course of the underlying disease, and (novel) therapeutic strategies applied to treat AI.
    MeSH term(s) Humans ; Iron/therapeutic use ; Quality of Life ; Anemia/therapy ; Anemia/drug therapy ; Erythropoiesis/physiology ; Inflammation/therapy ; Chronic Disease
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2022-08-19
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021013472
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.140: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 364: Show issues

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  4. Article ; Online: Iron homeostasis in mice: does liver lobe matter?

    Colucci, Silvia / Carvalho Oliveira, Tiago / Muckenthaler, Martina U / Marques, Oriana

    American journal of physiology. Gastrointestinal and liver physiology

    2023  Volume 325, Issue 5, Page(s) G453–G457

    Abstract: The liver plays a crucial role in maintaining systemic iron homeostasis through iron storage, sensing of systemic iron needs, and production of the iron-regulatory hormone hepcidin. While mice are commonly used as models for studying human iron ... ...

    Abstract The liver plays a crucial role in maintaining systemic iron homeostasis through iron storage, sensing of systemic iron needs, and production of the iron-regulatory hormone hepcidin. While mice are commonly used as models for studying human iron homeostasis, their liver structure differs significantly from humans. Since the mouse liver is structured in six separated lobes, often, the analysis of a single defined lobe is preferred due to concerns over data reproducibility between experimental cohorts. In this study, we compared iron-related parameters in distinct liver lobes of C57BL/6 wild-type mice across different ages. We found that the non-heme iron levels, as well as the mRNA and protein expression of iron storage protein Ferritin and the iron importer Transferrin Receptor 1, were similar between liver lobes. Additionally, the mRNA expression of
    MeSH term(s) Mice ; Humans ; Animals ; Hepcidins/genetics ; Hepcidins/metabolism ; Hemochromatosis Protein/genetics ; Hemochromatosis Protein/metabolism ; Histocompatibility Antigens Class I ; Reproducibility of Results ; Mice, Inbred C57BL ; Liver/metabolism ; Hemochromatosis/metabolism ; Iron/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Mice, Knockout ; Homeostasis
    Chemical Substances Hepcidins ; Hemochromatosis Protein ; Histocompatibility Antigens Class I ; Iron (E1UOL152H7) ; RNA, Messenger
    Language English
    Publishing date 2023-09-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603840-2
    ISSN 1522-1547 ; 0193-1857
    ISSN (online) 1522-1547
    ISSN 0193-1857
    DOI 10.1152/ajpgi.00085.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Cardiac iron metabolism during aging - Role of inflammation and proteolysis.

    Walter, Sophia / Mertens, Christina / Muckenthaler, Martina U / Ott, Christiane

    Mechanisms of ageing and development

    2023  Volume 215, Page(s) 111869

    Abstract: Iron is the most abundant trace element in the human body. Since iron can switch between its 2-valent and 3-valent form it is essential in various physiological processes such as energy production, proliferation or DNA synthesis. Especially high ... ...

    Abstract Iron is the most abundant trace element in the human body. Since iron can switch between its 2-valent and 3-valent form it is essential in various physiological processes such as energy production, proliferation or DNA synthesis. Especially high metabolic organs such as the heart rely on iron-associated iron-sulfur and heme proteins. However, due to switches in iron oxidation state, iron overload exhibits high toxicity through formation of reactive oxygen species, underlining the importance of balanced iron levels. Growing evidence demonstrates disturbance of this balance during aging. While age-associated cardiovascular diseases are often related to iron deficiency, in physiological aging cardiac iron accumulates. To understand these changes, we focused on inflammation and proteolysis, two hallmarks of aging, and their role in iron metabolism. Via the IL-6-hepcidin axis, inflammation and iron status are strongly connected often resulting in anemia accompanied by infiltration of macrophages. This tight connection between anemia and inflammation highlights the importance of the macrophage iron metabolism during inflammation. Age-related decrease in proteolytic activity additionally affects iron balance due to impaired degradation of iron metabolism proteins. Therefore, this review accentuates alterations in iron metabolism during aging with regards to inflammation and proteolysis to draw attention to their implications and associations.
    MeSH term(s) Humans ; Iron/metabolism ; Proteolysis ; Anemia/complications ; Inflammation ; Aging/metabolism
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2023-09-09
    Publishing country Ireland
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 183915-9
    ISSN 1872-6216 ; 0047-6374
    ISSN (online) 1872-6216
    ISSN 0047-6374
    DOI 10.1016/j.mad.2023.111869
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1012: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Interpreting Iron Homeostasis in Congenital and Acquired Disorders.

    Scaramellini, Natalia / Fischer, Dania / Agarvas, Anand R / Motta, Irene / Muckenthaler, Martina U / Mertens, Christina

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 3

    Abstract: Mammalian cells require iron to satisfy their metabolic needs and to accomplish specialized functions, such as hematopoiesis, mitochondrial biogenesis, energy metabolism, or oxygen transport. Iron homeostasis is balanced by the interplay of proteins ... ...

    Abstract Mammalian cells require iron to satisfy their metabolic needs and to accomplish specialized functions, such as hematopoiesis, mitochondrial biogenesis, energy metabolism, or oxygen transport. Iron homeostasis is balanced by the interplay of proteins responsible for iron import, storage, and export. A misbalance of iron homeostasis may cause either iron deficiencies or iron overload diseases. The clinical work-up of iron dysregulation is highly important, as severe symptoms and pathologies may arise. Treating iron overload or iron deficiency is important to avoid cellular damage and severe symptoms and improve patient outcomes. The impressive progress made in the past years in understanding mechanisms that maintain iron homeostasis has already changed clinical practice for treating iron-related diseases and is expected to improve patient management even further in the future.
    Language English
    Publishing date 2023-02-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16030329
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  7. Article ; Online: The Increase in Hemoglobin Concentration With Altitude Differs Between World Regions and Is Less in Children Than in Adults.

    Mairbäurl, Heimo / Kilian, Samuel / Seide, Svenja / Muckenthaler, Martina U / Gassmann, Max / Benedict, Rukundo K

    HemaSphere

    2023  Volume 7, Issue 4, Page(s) e854

    Abstract: To compensate for decreased oxygen partial pressure, high-altitude residents increase hemoglobin concentrations [Hb]. The elevation varies between world regions, posing problems in defining cutoff values for anemia or polycythemia. The currently used ... ...

    Abstract To compensate for decreased oxygen partial pressure, high-altitude residents increase hemoglobin concentrations [Hb]. The elevation varies between world regions, posing problems in defining cutoff values for anemia or polycythemia. The currently used altitude adjustments (World Health Organization [WHO]), however, do not account for regional differences. Data from The Demographic and Health Survey (DHS) Program were analyzed from 32 countries harboring >4% of residents at altitudes above 1000 m. [Hb]-increase, (ΔHb/km altitude) was calculated by linear regression analysis. Tables show 95% reference intervals (RIs) for different altitude ranges, world regions, and age groups. The prevalence of anemia and polycythemia was calculated using regressions in comparison to WHO adjustments. The most pronounced Δ[Hb]/km was found in East Africans and South Americans while [Hb] increased least in South/South-East Asia. In African regions and Middle East, [Hb] was decreased in some altitude regions showing inconsistent changes in different age groups. Of note, in all regions, the Δ[Hb]/km was lower in children than in adults, and in the Middle East, it was even negative. Overall, the Δ[Hb]/km from our analysis differed from the region-independent adjustments currently suggested by the WHO resulting in a lower anemia prevalence at very high altitudes. The distinct patterns of Δ[Hb] with altitude in residents from different world regions imply that one single, region-independent correction factor for altitude is not be applicable for diagnosing abnormal [Hb]. Therefore, we provide regression coefficients and reference-tables that are specific for world regions and altitude ranges to improve diagnosing abnormal [Hb].
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Journal Article
    ISSN 2572-9241
    ISSN (online) 2572-9241
    DOI 10.1097/HS9.0000000000000854
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: miR-148a regulates expression of the transferrin receptor 1 in hepatocellular carcinoma.

    Babu, Kamesh R / Muckenthaler, Martina U

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 1518

    Abstract: Transferrin receptor 1 (TFR1) is a transmembrane glycoprotein that allows for transferrin-bound iron uptake in mammalian cells. It is overexpressed in various cancers to satisfy the high iron demand of fast proliferating cells. Here we show that in ... ...

    Abstract Transferrin receptor 1 (TFR1) is a transmembrane glycoprotein that allows for transferrin-bound iron uptake in mammalian cells. It is overexpressed in various cancers to satisfy the high iron demand of fast proliferating cells. Here we show that in hepatocellular carcinoma (HCC) TFR1 expression is regulated by miR-148a. Within the TFR1 3'UTR we identified and experimentally validated two evolutionarily conserved miRNA response elements (MREs) for miR-148/152 family members, including miR-148a. Interestingly, analyses of RNA sequencing data from patients with liver hepatocellular carcinoma (LIHC) revealed a significant inverse correlation of TFR1 mRNA levels and miR-148a. In addition, TFR1 mRNA levels were significantly increased in the tumor compared to matched normal healthy tissue, while miR-148a levels are decreased. Functional analysis demonstrated post-transcriptional regulation of TFR1 by miR-148a in HCC cells as well as decreased HCC cell proliferation upon either miR-148a overexpression or TFR1 knockdown. We hypothesize that decreased expression of miR-148a in HCC may elevate transferrin-bound iron uptake, increasing cellular iron levels and cell proliferation.
    MeSH term(s) Antigens, CD/genetics ; Antigens, CD/metabolism ; Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Case-Control Studies ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; MicroRNAs/genetics ; Prognosis ; Receptors, Transferrin/genetics ; Receptors, Transferrin/metabolism ; Survival Rate ; Tumor Cells, Cultured
    Chemical Substances Antigens, CD ; Biomarkers, Tumor ; CD71 antigen ; MIRN148 microRNA, human ; MicroRNAs ; Receptors, Transferrin
    Language English
    Publishing date 2019-02-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-35947-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Hfe Is Highly Expressed in Liver Sinusoidal Endothelial Cells But Is Not Needed to Maintain Systemic Iron Homeostasis In Vivo.

    Colucci, Silvia / Müdder, Katja / Muckenthaler, Martina U / Altamura, Sandro

    HemaSphere

    2021  Volume 6, Issue 1, Page(s) e667

    Abstract: Supplemental Digital Content is available in the text. ...

    Abstract Supplemental Digital Content is available in the text.
    Language English
    Publishing date 2021-12-20
    Publishing country United States
    Document type Journal Article
    ISSN 2572-9241
    ISSN (online) 2572-9241
    DOI 10.1097/HS9.0000000000000667
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Interpreting Iron Homeostasis in Congenital and Acquired Disorders

    Natalia Scaramellini / Dania Fischer / Anand R. Agarvas / Irene Motta / Martina U. Muckenthaler / Christina Mertens

    Pharmaceuticals, Vol 16, Iss 329, p

    2023  Volume 329

    Abstract: Mammalian cells require iron to satisfy their metabolic needs and to accomplish specialized functions, such as hematopoiesis, mitochondrial biogenesis, energy metabolism, or oxygen transport. Iron homeostasis is balanced by the interplay of proteins ... ...

    Abstract Mammalian cells require iron to satisfy their metabolic needs and to accomplish specialized functions, such as hematopoiesis, mitochondrial biogenesis, energy metabolism, or oxygen transport. Iron homeostasis is balanced by the interplay of proteins responsible for iron import, storage, and export. A misbalance of iron homeostasis may cause either iron deficiencies or iron overload diseases. The clinical work-up of iron dysregulation is highly important, as severe symptoms and pathologies may arise. Treating iron overload or iron deficiency is important to avoid cellular damage and severe symptoms and improve patient outcomes. The impressive progress made in the past years in understanding mechanisms that maintain iron homeostasis has already changed clinical practice for treating iron-related diseases and is expected to improve patient management even further in the future.
    Keywords iron ; iron metabolism ; rare disease ; hematology ; anemia ; iron overload ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
    Subject code 570
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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