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Article ; Online: Demographic and clinical risk factors for diagnosis of sleep disorders in ESRD patients.

Smaha, Katlyn / Mixson, Andrew / Waller, Jennifer L / Bollag, Wendy B / Taskar, Varsha / Padala, Sandeep Anand / Baer, Stephanie L / Healy, William J

The American journal of the medical sciences

2023 Volume 366, Issue 4, Page(s) 270–277

Abstract: Background: Sleep disturbances in patients with end-stage renal disease (ESRD) are common and more prevalent than in the general population. This study aims to assess the demographic and clinical risk factors for the diagnosis of sleep disorders in ESRD ...

Abstract	Background: Sleep disturbances in patients with end-stage renal disease (ESRD) are common and more prevalent than in the general population. This study aims to assess the demographic and clinical risk factors for the diagnosis of sleep disorders in ESRD patients. Methods: This study is a retrospective analysis of the United States Renal Data System (USRDS) to evaluate risk factors for the diagnosis of sleep disorders, including hypersomnolence, insomnia, restless leg syndrome (RLS), or obstructive or central sleep apnea (OSA/CSA). All ESRD subjects enrolled in the USRDS between 2004-2015 were eligible for inclusion. The risk factors analyzed were age, race, sex, ethnicity, access type, dialysis modality, and the Charlson Comorbidity Index (CCI). All statistical analysis was performed using SAS 9.4, and statistical significance was assessed using an alpha level of 0.05. Descriptive statistics on all variables overall and by each sleep diagnosis were determined. Results: Increasing age, black race, other race, and Hispanic ethnicity were associated with decreased risk of each sleep diagnosis while CCI was associated with increased risk. Females were at increased risk of RLS and insomnia while males were at increased risk of OSA/CSA. Catheter and graft access decreased risk of RLS but increased risk of insomnia compared to AVF access. Catheter access increased risk of OSA/CSA compared to graft access. Hemodialysis increased risk of OSA/CSA compared to peritoneal dialysis. Conclusions: Some ESRD patients are at an increased risk for diagnosis of sleep disorders based on age, race, sex, comorbid health conditions, and dialysis modality.
Language	English
Publishing date	2023-07-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	82078-7
ISSN	1538-2990 ; 0002-9629
ISSN (online)	1538-2990
ISSN	0002-9629
DOI	10.1016/j.amjms.2023.07.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Rare Presentation of Choledochoduodenal Fistula Due to Ovarian Cancer Metastasis.

Misra, Deeksha / Mirza, Usman / Vakiti, Anusha / Padala, Sandeep Anand

Journal of investigative medicine high impact case reports

2020 Volume 8, Page(s) 2324709620934680

Abstract: Choledochoduodenal fistula (CDF) is an abnormal communication between the common bile duct and the duodenum. It accounts for about 5% to 25% of the total biliary fistulas and is usually due to a perforated duodenal ulcer, choledocholithiasis, and ... ...

Abstract	Choledochoduodenal fistula (CDF) is an abnormal communication between the common bile duct and the duodenum. It accounts for about 5% to 25% of the total biliary fistulas and is usually due to a perforated duodenal ulcer, choledocholithiasis, and complications secondary to tuberculosis or could be iatrogenic. Primary intrabilliary tumors usually cause obstructive jaundice and rarely biliary metastasis arising from other organs like colon, breast, and lungs can cause obstructive jaundice. There has been a case report of metastasis from ovarian cancer to the major papilla of the duodenum but no reported cases of it causing a CDF. We report a rare case of an 83-year-old female with ovarian cancer who developed a metastatic lesion to the duodenum eventually resulting in a CDF.
MeSH term(s)	Aged, 80 and over ; Ampulla of Vater/pathology ; Biliary Fistula/etiology ; Cholangiopancreatography, Endoscopic Retrograde ; Cholangiopancreatography, Magnetic Resonance ; Common Bile Duct/pathology ; Duodenal Neoplasms/physiopathology ; Duodenal Neoplasms/secondary ; Endoscopy, Digestive System ; Female ; Humans ; Intestinal Fistula/etiology ; Ovarian Neoplasms/pathology ; Tomography, X-Ray Computed
Language	English
Publishing date	2020-06-15
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2710326-2
ISSN	2324-7096 ; 2324-7096
ISSN (online)	2324-7096
ISSN	2324-7096
DOI	10.1177/2324709620934680
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Epidemiology of Non-Hodgkin's Lymphoma.

Thandra, Krishna C / Barsouk, Adam / Saginala, Kalyan / Padala, Sandeep Anand / Barsouk, Alexander / Rawla, Prashanth

Medical sciences (Basel, Switzerland)

2021 Volume 9, Issue 1

Abstract: Non-Hodgins's lymphoma (NHL) is the most common hematological malignancy worldwide, accounting for nearly 3% of cancer diagnoses and deaths. NHL is the seventh most prevalent cancer and has the sixth highest mortality among cancers in the US. NHL ... ...

Abstract	Non-Hodgins's lymphoma (NHL) is the most common hematological malignancy worldwide, accounting for nearly 3% of cancer diagnoses and deaths. NHL is the seventh most prevalent cancer and has the sixth highest mortality among cancers in the US. NHL accounts for 4% of US cancer diagnoses, and incidence has increased 168% since 1975 (while survival has improved 158%). NHL is more common among men, those >65 years old, and those with autoimmune disease or a family history of hematological malignancies. NHL is a heterogenous disease, with each subtype associated with different risk factors. Marginal zone lymphoma (MZL) is strongly associated with Sjogren's syndrome (SS) and Hashimoto's thyroiditis, while peripheral T-cell lymphoma (PTCL) is most associated with celiac disease. Occupational exposures among farm workers or painters increases the risk of most of the common subtypes. Prior radiation treatment, obesity, and smoking are most highly associated with diffuse large B-cell lymphoma (DLBCL), while breast implants have been rarely associated with anaplastic large cell lymphoma (ALCL). Infection with Epstein-Barr Virus (EBV) is strongly associated with endemic Burkitts lymphoma. HIV and human herpes virus 8 (HHV-8), is predisposed to several subtypes of DLBCL, and human T-cell lymphoma virus (HTLV-1) is a causative agent of T-cell lymphomas. Obesity and vitamin D deficiency worsen NHL survival. Atopic diseases and alcohol consumption seem to be protective against NHL.
MeSH term(s)	Aged ; Epstein-Barr Virus Infections ; Female ; Herpesvirus 4, Human ; Humans ; Lymphoma, B-Cell, Marginal Zone ; Lymphoma, Large B-Cell, Diffuse ; Lymphoma, Non-Hodgkin/epidemiology ; Lymphoma, T-Cell ; Male ; Obesity/complications
Language	English
Publishing date	2021-01-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2754473-4
ISSN	2076-3271 ; 2076-3271
ISSN (online)	2076-3271
ISSN	2076-3271
DOI	10.3390/medsci9010005
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Article ; Online: A Rare Case of Drug-Resistant

Kapoor, Rajan / Adapa, Sreedhar / Vakiti, Anusha / Gani, Imran Yaseen / Mulloy, Laura / Padala, Sandeep Anand

Journal of investigative medicine high impact case reports

2020 Volume 8, Page(s) 2324709620909243

Abstract: ... Nocardia ... ...

Abstract	Nocardia transvalensis
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Drug Resistance, Multiple, Bacterial ; Humans ; Immunocompromised Host ; Kidney Transplantation ; Nocardia/isolation & purification ; Nocardia Infections/drug therapy ; Nocardia Infections/microbiology ; Opportunistic Infections/complications
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2020-02-15
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2710326-2
ISSN	2324-7096 ; 2324-7096
ISSN (online)	2324-7096
ISSN	2324-7096
DOI	10.1177/2324709620909243
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Article: Collapsing focal segmental sclerosis in an HIV-negative patient.

Padala, Sandeep Anand / Birkelo, Bethany / Mohammed, Azeem / Kapoor, Rajan / Mulloy, Laura / Rawla, Prashanth

Clinical case reports

2020 Volume 8, Issue 11, Page(s) 2166–2171

Abstract: Collapsing focal segmental glomerulosclerosis (FSGS) is classically seen in HIV-infected patients and carries a dismal prognosis. It can also occur in HIV-negative patients in which case, early aggressive treatment with glucocorticoids may be helpful ... ...

Abstract	Collapsing focal segmental glomerulosclerosis (FSGS) is classically seen in HIV-infected patients and carries a dismal prognosis. It can also occur in HIV-negative patients in which case, early aggressive treatment with glucocorticoids may be helpful with improvement in both proteinuria and renal function.
Language	English
Publishing date	2020-07-03
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.3078
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Article: First Reported Use of Highly Adsorptive Hemofilter in Critically Ill COVID-19 Patients in the USA.

Padala, Sandeep Anand / Vakiti, Anusha / White, John Jason / Mulloy, Laura / Mohammed, Azeem

Journal of clinical medicine research

2020 Volume 12, Issue 7, Page(s) 454–457

Abstract: Critically ill patients with coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develop respiratory failure and septic shock. Extracorporeal blood purification is proposed as an adjuvant therapy for ...

Abstract	Critically ill patients with coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develop respiratory failure and septic shock. Extracorporeal blood purification is proposed as an adjuvant therapy for sepsis and aims at controlling the dysregulated autoimmune system. We describe our experience in treating COVID-19 patients with the oXiris
Keywords	covid19
Language	English
Publishing date	2020-06-25
Publishing country	Canada
Document type	Case Reports
ZDB-ID	2548987-2
ISSN	1918-3011 ; 1918-3003
ISSN (online)	1918-3011
ISSN	1918-3003
DOI	10.14740/jocmr4228
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Article ; Online: Epidemiology of Non-Hodgkin’s Lymphoma

Krishna C. Thandra / Adam Barsouk / Kalyan Saginala / Sandeep Anand Padala / Alexander Barsouk / Prashanth Rawla

Medical Sciences, Vol 9, Iss 1, p

2021 Volume 5

Abstract: Non-Hodgins’s lymphoma (NHL) is the most common hematological malignancy worldwide, accounting for nearly 3% of cancer diagnoses and deaths. NHL is the seventh most prevalent cancer and has the sixth highest mortality among cancers in the US. NHL ... ...

Abstract	Non-Hodgins’s lymphoma (NHL) is the most common hematological malignancy worldwide, accounting for nearly 3% of cancer diagnoses and deaths. NHL is the seventh most prevalent cancer and has the sixth highest mortality among cancers in the US. NHL accounts for 4% of US cancer diagnoses, and incidence has increased 168% since 1975 (while survival has improved 158%). NHL is more common among men, those >65 years old, and those with autoimmune disease or a family history of hematological malignancies. NHL is a heterogenous disease, with each subtype associated with different risk factors. Marginal zone lymphoma (MZL) is strongly associated with Sjogren’s syndrome (SS) and Hashimoto’s thyroiditis, while peripheral T-cell lymphoma (PTCL) is most associated with celiac disease. Occupational exposures among farm workers or painters increases the risk of most of the common subtypes. Prior radiation treatment, obesity, and smoking are most highly associated with diffuse large B-cell lymphoma (DLBCL), while breast implants have been rarely associated with anaplastic large cell lymphoma (ALCL). Infection with Epstein–Barr Virus (EBV) is strongly associated with endemic Burkitts lymphoma. HIV and human herpes virus 8 (HHV-8), is predisposed to several subtypes of DLBCL, and human T-cell lymphoma virus (HTLV-1) is a causative agent of T-cell lymphomas. Obesity and vitamin D deficiency worsen NHL survival. Atopic diseases and alcohol consumption seem to be protective against NHL.
Keywords	NHL ; non-Hodgkin’s lymphoma ; epidemiology ; incidence ; prevalence ; mortality ; Medicine ; R
Subject code	610 ; 616
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Rectovaginal Fistula as a Complication of Fecal Management System.

Butts, Emily / Padala, Sandeep Anand / Vakiti, Anusha / Kota, Vamsi

Journal of investigative medicine high impact case reports

2019 Volume 7, Page(s) 2324709619869368

Abstract: We report a rare complication of the use of an intrarectal catheter. An 18-year-old female with T-cell acute lymphoblastic leukemia post-matched unrelated donor allogeneic stem cell transplantation (auto-SCT) developed hepatic encephalopathy secondary to ...

Abstract	We report a rare complication of the use of an intrarectal catheter. An 18-year-old female with T-cell acute lymphoblastic leukemia post-matched unrelated donor allogeneic stem cell transplantation (auto-SCT) developed hepatic encephalopathy secondary to hepatic sinusoidal obstructive disease. A fecal management system was used to contain and divert fecal matter in this immobilized patient. Approximately 1 month after placement of an intrarectal catheter, stool was noted in the vaginal vault. Speculum examination confirmed development of a rectovaginal fistula.
MeSH term(s)	Adolescent ; Catheterization/adverse effects ; Catheters/adverse effects ; Fatal Outcome ; Female ; Graft Rejection/complications ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Multiple Organ Failure/etiology ; Multiple Organ Failure/therapy ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/complications ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Rectovaginal Fistula/etiology ; Rectum
Language	English
Publishing date	2019-08-18
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2710326-2
ISSN	2324-7096 ; 2324-7096
ISSN (online)	2324-7096
ISSN	2324-7096
DOI	10.1177/2324709619869368
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Tumor-Induced Osteomalacia and the Importance of Plasma Fibroblast Growth Factor 23 as an Indicator: Diagnostic Delay Leads to a Suicide Attempt.

Seemann, LaRae / Padala, Sandeep Anand / Mohammed, Azeem / Belayneh, Nardos

Journal of investigative medicine high impact case reports

2019 Volume 7, Page(s) 2324709619895162

Abstract: Tumor-induced osteomalacia is a rare hypophosphatemic disease caused by unregulated production of fibroblast growth factor 23 by a tumor, thereby inducing renal phosphate wasting and inhibiting appropriate increase of calcitriol production. Symptoms of ... ...

Abstract	Tumor-induced osteomalacia is a rare hypophosphatemic disease caused by unregulated production of fibroblast growth factor 23 by a tumor, thereby inducing renal phosphate wasting and inhibiting appropriate increase of calcitriol production. Symptoms of tumor-induced osteomalacia, including muscle weakness, bone pain, and pathologic fractures, are nonspecific and warrant further workup. We report the case of a 50-year-old African American female with no known psychiatric illness who was admitted after a failed suicide attempt provoked by severe bone pain. She had been treated for fibromyalgia and hypophosphatemic rickets at other facilities with no improvement. The findings of profound renal phosphate wasting initiated further evaluation, which revealed an elevated fibroblast growth factor 23 level and a right proximal fibular mesenchymal tumor on octreotide scintigraphy. Magnetic resonance imaging confirmed the findings of a solid intramuscular tumor corresponding to the octreotide avid lesion. After wide excision of the tumor, serum phosphate and parathyroid hormone levels began to normalize. This case highlights the importance of extensively investigating the cause of bone pain, weakness, and fatigue in patients without a family history of hypophosphatemia or bone disorders. The aforementioned symptoms may precede recurrent pathological fractures, and a thorough workup ensures that a diagnosis of tumor is not delayed or overlooked, as tumor resection confers a favorable prognosis and dramatic increase in the quality of life for patients.
MeSH term(s)	Delayed Diagnosis/psychology ; Female ; Fibroblast Growth Factors/blood ; Fibromyalgia/etiology ; Humans ; Hypophosphatemia/etiology ; Magnetic Resonance Imaging ; Middle Aged ; Neoplasms, Connective Tissue/blood ; Neoplasms, Connective Tissue/complications ; Neoplasms, Connective Tissue/diagnosis ; Pain/etiology ; Paraneoplastic Syndromes/blood ; Paraneoplastic Syndromes/complications ; Paraneoplastic Syndromes/diagnosis ; Phosphates/blood ; Radionuclide Imaging ; Rickets, Hypophosphatemic/etiology ; Suicide, Attempted/psychology
Chemical Substances	Phosphates ; Fibroblast Growth Factors (62031-54-3) ; fibroblast growth factor 23 (7Q7P4S7RRE)
Language	English
Publishing date	2019-12-18
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2710326-2
ISSN	2324-7096 ; 2324-7096
ISSN (online)	2324-7096
ISSN	2324-7096
DOI	10.1177/2324709619895162
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Article ; Online: Epidemiology of Bladder Cancer.

Saginala, Kalyan / Barsouk, Adam / Aluru, John Sukumar / Rawla, Prashanth / Padala, Sandeep Anand / Barsouk, Alexander

Medical sciences (Basel, Switzerland)

2020 Volume 8, Issue 1

Abstract: Based on the latest GLOBOCAN data, bladder cancer accounts for 3% of global cancer diagnoses and is especially prevalent in the developed world. In the United States, bladder cancer is the sixth most incident neoplasm. A total of 90% of bladder cancer ... ...

Abstract	Based on the latest GLOBOCAN data, bladder cancer accounts for 3% of global cancer diagnoses and is especially prevalent in the developed world. In the United States, bladder cancer is the sixth most incident neoplasm. A total of 90% of bladder cancer diagnoses are made in those 55 years of age and older, and the disease is four times more common in men than women. While the average 5-year survival in the US is 77%, the 5-year survival for those with metastatic disease is a measly 5%. The strongest risk factor for bladder cancer is tobacco smoking, which accounts for 50-65% of all cases. Occupational or environmental toxins likewise greatly contribute to disease burden (accounting for an estimated 20% of all cases), though the precise proportion can be obscured by the fact bladder cancer develops decades after exposure, even if the exposure only lasted several years. Schistosomiasis infection is the common cause of bladder cancer in regions of Africa and the Middle East and is considered the second most onerous tropical pathogen after malaria. With 81% of cases attributable to known risk factors (and only 7% to heritable mutations), bladder cancer is a prime candidate for prevention strategies. Smoking cessation, workplace safety practices, weight loss, exercise and schistosomiasis prevention (via water disinfection and mass drug administration) have all been shown to significantly decrease the risk of bladder cancer, which poses a growing burden around the world.
Language	English
Publishing date	2020-03-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2754473-4
ISSN	2076-3271 ; 2076-3271
ISSN (online)	2076-3271
ISSN	2076-3271
DOI	10.3390/medsci8010015
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