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Article ; Online: Is oral collagen the elixir of youth?

Khan, Aimen Waqar / Ahmed, Tooba Noor / Shakil, Areej

2023 Volume 23, Issue 2, Page(s) 704–705

MeSH term(s)	Humans ; Adolescent ; Administration, Oral ; Biological Availability
Language	English
Publishing date	2023-10-27
Publishing country	England
Document type	Letter
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.15950
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Article ; Online: HLA gene variations and mycotoxin toxicity: Four case reports.

Saghir, Shakil Ahmed / Ansari, Rais Ahmed

Mycotoxin research

2024 Volume 40, Issue 1, Page(s) 159–173

Abstract: Mycotoxins are produced by certain molds that can cause many health effects. We present four human cases of prolonged consistent mycotoxins exposure linked to genetic variations in human leukocyte antigen (HLA) alleles. The HLA-DR/DQ isotype alleles are ... ...

Abstract	Mycotoxins are produced by certain molds that can cause many health effects. We present four human cases of prolonged consistent mycotoxins exposure linked to genetic variations in human leukocyte antigen (HLA) alleles. The HLA-DR/DQ isotype alleles are linked to mycotoxins susceptibility due to the lack of proper immune response; individuals with these alleles are poor eliminators of mycotoxins from their system. Four subjects with variations in their HLA-DR alleles were exposed to mycotoxins from living in mold-infested houses and experienced persistent mold-related symptoms long after moving out from the mold-infested houses and only exposed to the levels of molds found in the ambient air. From one of the subjects, two urine samples were collected ~ 18 months apart after the cessation of exposure. Urinary elimination rate was extremely slow for two of the mycotoxins (ochratoxin A [OTA] and mycophenolic acid [MPA]) detected in both samples. In 18 months, decline in OTA level was only ~ 3-fold (estimated t
MeSH term(s)	Humans ; Mycotoxins/toxicity ; Mycotoxins/urine ; Fungi ; HLA-DR Antigens
Chemical Substances	Mycotoxins ; HLA-DR Antigens
Language	English
Publishing date	2024-01-10
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	14500-2
ISSN	1867-1632 ; 0178-7888
ISSN (online)	1867-1632
ISSN	0178-7888
DOI	10.1007/s12550-023-00517-y
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Article: The use of acetaminophen in pregnancy: a double whammy.

Shuja, Muhammad H / Shuja, Syed H / Shakil, Firzah / Ahmed, Ilsa

Annals of medicine and surgery (2012)

2023 Volume 85, Issue 4, Page(s) 1346–1347

Abstract: Acetaminophen is the most widely over the counter used analgesic in the world, and the World Health Organization advises using it as first-line treatment for pain issues (WHO).However, various side effects have been documented with its use such as nausea, ...

Abstract	Acetaminophen is the most widely over the counter used analgesic in the world, and the World Health Organization advises using it as first-line treatment for pain issues (WHO).However, various side effects have been documented with its use such as nausea, vomiting, constipation at low doses whereas in large doses, it might even result in hepatoxicity.Recent literature suggests that the use of acetaminophen in pregnancy even in optimal doses could result infant being born with ADHD and autism, so in this short communication we talk about the prevalence of neurodevelopment disorders in infants as a result of its use, as well as shed light to the measures that should be adopted to minimize the adverse effects.
Language	English
Publishing date	2023-03-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1097/MS9.0000000000000303
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Article ; Online: Enhancing Fluorescence in Both Solution and Solid States Induced by Imine Cage Formation.

Bhandari, Pallab / Ahmed, Shakil / Saha, Rajib / Mukherjee, Partha Sarathi

Chemistry (Weinheim an der Bergstrasse, Germany)

2024 Volume 30, Issue 10, Page(s) e202303101

Abstract: Developing luminescent materials that exhibit strong emissions in both solution and solid phases is highly desirable and challenging. Herein, we report imine-bond directed formation of a rigid organic cage (TPE-cage) that was synthesized by [2+4] imine ... ...

Abstract	Developing luminescent materials that exhibit strong emissions in both solution and solid phases is highly desirable and challenging. Herein, we report imine-bond directed formation of a rigid organic cage (TPE-cage) that was synthesized by [2+4] imine condensation of a TPE-cored tetra-aldehyde (TPE-TA) with a clip-like diamine (XA) to illustrate confinement-induced fluorescence enhancement. Compared to the non-emissive TPE-TA (ϕ
Language	English
Publishing date	2024-01-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202303101
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Article: Ensuring competence of essential skills: clinical examination for final year medical students.

Ismail, Faisal Waseem / Ahmed, Rashida / Khan, Sadaf / Shakil, Sara

JPMA. The Journal of the Pakistan Medical Association

2023 Volume 73, Issue 3, Page(s) 520–524

Abstract: Objective: To ensure competence of essential skills of final year medical students in clinical examination by identifying essential skills and by revisiting and practising them before the examination.: Methods: The cross-sectional study was conducted ...

Abstract	Objective: To ensure competence of essential skills of final year medical students in clinical examination by identifying essential skills and by revisiting and practising them before the examination. Methods: The cross-sectional study was conducted at the Aga Khan University, Karachi, from February to November, 2019, and comprised final year medical students and internal examiners from various academic disciplines. An overview of the organisational context, exam structure and process was noted. Results: There were 96 medical students. The four key areas highlighted were development of the list of essential skills across five years of undergraduate medical curriculum with consensus from all disciplines, student motivation for attendance in practice sessions, unfamiliarity of examiners with the assessment tool, and the need for capacity-building. The key areas were based on the feedback received from all the stakeholders, and post-hoc analysis. Conclusion: This form of assessment would enable a thorough analysis of the preparedness of the students to function as independent physicians as undifferentiated doctor at the start of their careers as interns, and improve the quality of subsequent exams based on feedback and suggestions of faculty and students.
MeSH term(s)	Humans ; Students, Medical ; Cross-Sectional Studies ; Education, Medical, Undergraduate ; Curriculum ; Physical Examination ; Clinical Competence
Language	English
Publishing date	2023-03-18
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	603873-6
ISSN	0030-9982
ISSN	0030-9982
DOI	10.47391/JPMA.6336
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Article ; Online: A benzothiadiazole-based Pt(II) coordination polymer as an efficient heterogeneous photocatalyst for visible-light-driven aerobic oxidative coupling of amines.

Ahmed, Shakil / Kumar, Atul / Mukherjee, Partha Sarathi

Chemical communications (Cambridge, England)

2023 Volume 59, Issue 22, Page(s) 3229–3232

Abstract: An emissive Pt(II) coordination polymer (TBP) was synthesized by assembling a benzothiadiazole-based Pt(II) acceptor (A) with a tetraphenylethene (TPE) containing donor (L). Multiple benzothiadiazole units in the polymeric array of the TBP rendered it ... ...

Abstract	An emissive Pt(II) coordination polymer (TBP) was synthesized by assembling a benzothiadiazole-based Pt(II) acceptor (A) with a tetraphenylethene (TPE) containing donor (L). Multiple benzothiadiazole units in the polymeric array of the TBP rendered it with reactive oxygen species generation ability. TBP was found to be an excellent photocatalyst for oxidative coupling of benzylamine under visible light with full conversion within 2 hours at room temperature and reusability for multiple cycles. Such photocatalytic efficiency under ambient conditions, reusability of the catalyst, and easy separation of the product are noteworthy.
Language	English
Publishing date	2023-03-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d3cc00021d
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Article ; Online: Glutathione primed seed improved lead-stress tolerance in

Ahmed, Shakil / Khan, Mawra / Sardar, Rehana

International journal of phytoremediation

2023 Volume 25, Issue 12, Page(s) 1614–1624

Abstract: Heavy metal toxicity is a major environmental issue that affects all life forms, including plants. The accumulation of lead (Pb) in agricultural soils is a significant contributor to reduced crop yields, and it poses serious health risks to people who ... ...

Abstract	Heavy metal toxicity is a major environmental issue that affects all life forms, including plants. The accumulation of lead (Pb) in agricultural soils is a significant contributor to reduced crop yields, and it poses serious health risks to people who consume lead-contaminated agricultural products. The current study was undertaken to investigate the beneficial effects of glutathione (GSH) on the amelioration of stress induced by Pb (300 mg kg
MeSH term(s)	Humans ; Lead/toxicity ; Lead/metabolism ; Brassica rapa/metabolism ; Biodegradation, Environmental ; Glutathione/metabolism ; Glutathione/pharmacology ; Seedlings ; Brassica napus/metabolism ; Soil ; Seeds/metabolism ; Antioxidants/metabolism ; Antioxidants/pharmacology
Chemical Substances	Lead (2P299V784P) ; Glutathione (GAN16C9B8O) ; Soil ; Antioxidants
Language	English
Publishing date	2023-02-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2055357-2
ISSN	1549-7879 ; 1522-6514
ISSN (online)	1549-7879
ISSN	1522-6514
DOI	10.1080/15226514.2023.2178380
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Article ; Online: Optimization, purification and characterization of laccase from Ganoderma leucocontextum along with its phylogenetic relationship

Aisha Umar / Shakil Ahmed

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 14

Abstract: Abstract The aim of this work to study an efficient laccase producing fungus Ganoderma leucocontextum, which was identified by ITS regions of DNA and phylogenetic tree was constructed. This study showed the laccase first-time from G. leucocontextum by ... ...

Abstract	Abstract The aim of this work to study an efficient laccase producing fungus Ganoderma leucocontextum, which was identified by ITS regions of DNA and phylogenetic tree was constructed. This study showed the laccase first-time from G. leucocontextum by using medium containing guaiacol. The growth cultural (pH, temperature, incubation days, rpm) and nutritional (carbon and nitrogen sources) conditions were optimized, which enhanced the enzyme production up to 4.5-folds. Laccase production increased 855 U/L at 40 °C. The pH 5.0 was suitable for laccase secretion (2517 U/L) on the 7th day of incubation at 100 rpm (698.3 U/L). Glucose and sucrose were good carbon source to enhance the laccase synthesis. The 10 g/L beef (4671 U/L) and yeast extract (5776 U/L) were the best nitrogen source for laccase secretion from G. leucocontextum. The laccase was purified from the 80% ammonium sulphate precipitations of protein identified by nucleotides sequence. The molecular weight (65.0 kDa) of purified laccase was identified through SDS and native PAGE entitled as Glacc110. The Glacc110 was characterized under different parameters. It retained > 90% of its activity for 16 min incubation at 60 °C in acidic medium (pH 4.0). This enzyme exerted its optimal activity at pH 3.0 and temperature 70 °C with guaiacol substrate. The catalytic parameters K m and V max was 1.658 (mM) and 2.452 (mM/min), respectively. The thermo stability of the laccase produced by submerged fermentation of G. leucocontextum has potential for industrial and biotechnology applications. The results remarked the G. leucocontextum is a good source for laccase production.
Keywords	Medicine ; R ; Science ; Q
Subject code	660
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
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Article ; Online: Optimization, purification and characterization of laccase from Ganoderma leucocontextum along with its phylogenetic relationship.

Umar, Aisha / Ahmed, Shakil

Scientific reports

2022 Volume 12, Issue 1, Page(s) 2416

Abstract: The aim of this work to study an efficient laccase producing fungus Ganoderma leucocontextum, which was identified by ITS regions of DNA and phylogenetic tree was constructed. This study showed the laccase first-time from G. leucocontextum by using ... ...

Abstract	The aim of this work to study an efficient laccase producing fungus Ganoderma leucocontextum, which was identified by ITS regions of DNA and phylogenetic tree was constructed. This study showed the laccase first-time from G. leucocontextum by using medium containing guaiacol. The growth cultural (pH, temperature, incubation days, rpm) and nutritional (carbon and nitrogen sources) conditions were optimized, which enhanced the enzyme production up to 4.5-folds. Laccase production increased 855 U/L at 40 °C. The pH 5.0 was suitable for laccase secretion (2517 U/L) on the 7th day of incubation at 100 rpm (698.3 U/L). Glucose and sucrose were good carbon source to enhance the laccase synthesis. The 10 g/L beef (4671 U/L) and yeast extract (5776 U/L) were the best nitrogen source for laccase secretion from G. leucocontextum. The laccase was purified from the 80% ammonium sulphate precipitations of protein identified by nucleotides sequence. The molecular weight (65.0 kDa) of purified laccase was identified through SDS and native PAGE entitled as Glacc110. The Glacc110 was characterized under different parameters. It retained > 90% of its activity for 16 min incubation at 60 °C in acidic medium (pH 4.0). This enzyme exerted its optimal activity at pH 3.0 and temperature 70 °C with guaiacol substrate. The catalytic parameters K
MeSH term(s)	Base Sequence ; Chemical Precipitation ; Enzyme Stability ; Fungal Proteins/chemistry ; Fungal Proteins/genetics ; Fungal Proteins/isolation & purification ; Fungal Proteins/metabolism ; Ganoderma/chemistry ; Ganoderma/classification ; Ganoderma/enzymology ; Ganoderma/genetics ; Hot Temperature ; Hydrogen-Ion Concentration ; Kinetics ; Laccase/chemistry ; Laccase/genetics ; Laccase/isolation & purification ; Laccase/metabolism ; Phylogeny
Chemical Substances	Fungal Proteins ; Laccase (EC 1.10.3.2)
Language	English
Publishing date	2022-02-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-06111-z
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Article: Computational insights into the stereo-selectivity of catechins for the inhibition of the cancer therapeutic target EGFR kinase.

Rehan, Mohd / Ahmed, Firoz / Khan, Mohammad Imran / Ansari, Hifzur Rahman / Shakil, Shazi / El-Araby, Moustafa E / Hosawi, Salman / Saleem, Mohammad

Frontiers in pharmacology

2024 Volume 14, Page(s) 1231671

Abstract: The epidermal growth factor receptor (EGFR) plays a crucial role in regulating cellular growth and survival, and its dysregulation is implicated in various cancers, making it a prime target for cancer therapy. Natural compounds known as catechins have ... ...

Abstract	The epidermal growth factor receptor (EGFR) plays a crucial role in regulating cellular growth and survival, and its dysregulation is implicated in various cancers, making it a prime target for cancer therapy. Natural compounds known as catechins have garnered attention as promising anticancer agents. These compounds exert their anticancer effects through diverse mechanisms, primarily by inhibiting receptor tyrosine kinases (RTKs), a protein family that includes the notable member EGFR. Catechins, characterized by two chiral centers and stereoisomerism, demonstrate variations in chemical and physical properties due to differences in the spatial orientation of atoms. Although previous studies have explored the membrane fluidity effects and transport across cellular membranes, the stereo-selectivity of catechins concerning EGFR kinase inhibition remains unexplored. In this study, we investigated the stereo-selectivity of catechins in inhibiting EGFR kinase, both in its wild-type and in the prevalent L858R mutant. Computational analyses indicated that all stereoisomers, including the extensively studied catechin (-)-EGCG, effectively bound within the ATP-binding site, potentially inhibiting EGFR kinase activity. Notably, gallated catechins emerged as superior EGFR inhibitors to their non-gallated counterparts, revealing intriguing binding trends. The top four stereoisomers exhibiting high dock scores and binding energies with wild-type EGFR comprise (-)-CG (-)-GCG (+)-CG, and (-)-EGCG. To assess dynamic behavior and stability, molecular dynamics simulations over 100 ns were conducted for the top-ranked catechin (-)-CG and the widely investigated catechin (-)-EGCG with EGFR kinase. This study enhances our understanding of how the stereoisomeric nature of a drug influences inhibitory potential, providing insights that could guide the selection of specific stereoisomers for improved efficacy inexisting drugs.
Language	English
Publishing date	2024-01-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1231671
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