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Article ; Online: Impact of a retrograded starch ingredient obtained from Negro Jamapa beans (Phaseolus vulgaris L. Negro Jamapa) on glucose metabolism and oxidative stress in induced diabetic lab rats model.

Diéguez, Teodoro Suárez / Nájera, Mariza Olvera / Galván, Marcos / Nieto, Juan Antonio

International journal of biological macromolecules

2023 Volume 253, Issue Pt 7, Page(s) 127447

Abstract: A retrograded starch ingredient obtained from Negro Jampa beans (Phaseolus vulgaris L. Negro Jamapa ... 23.6 mmol/L, respectively). Also, significant improvement on weight gain (49.75 ± 34.1 g) compared ...

Abstract	A retrograded starch ingredient obtained from Negro Jampa beans (Phaseolus vulgaris L. Negro Jamapa), applying a debranching process (18 U/g for 12 h) and retrogradation (2 °C for 3 days), was evaluated as a potential functional ingredient to improve glucose homeostasis in a diabetic animal model. The obtained ingredient was reduced in rapid digestible starch amount compared to its related isolated native starch (34.1 % and 53.6 %, respectively) and resistant (33.4 % and 22.3 %, respectively). Therefore, a reduced total digestibility was determined for the obtained ingredient compared to native starch (51.5 % and 79 %, respectively). As consequence, diabetic animals fed with functional ingredient replacement (30 %) showed a lower and attenuated postprandial glucose levels, reducing the hyperglycaemic condition, compared with the non-treated animals (r2 = 0.9775; p ≤ 0.05), reducing the glucose serum levels 73 % compared (17.21 vs 23.6 mmol/L, respectively). Also, significant improvement on weight gain (49.75 ± 34.1 g) compared to non-treated (18.14 ± 45.52 g), as well as lower insulin resistance index and improved oxidative stress status was determined for the treated group. These results highlight the potential of retrograded starch obtained from Negro Jamapa beans as a functional ingredient focus on the improvement of the glucose homeostasis and diabetic condition.
MeSH term(s)	Animals ; Rats ; Diabetes Mellitus ; Glucose ; Oxidative Stress ; Phaseolus ; Starch/metabolism
Chemical Substances	Glucose (IY9XDZ35W2) ; Starch (9005-25-8)
Language	English
Publishing date	2023-10-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.127447
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Article ; Online: Evaluation of the osteoclastogenic process associated with RANK / RANK-L / OPG in odontogenic myxomas.

González-Galván, M-C / Mosqueda-Taylor, A / Bologna-Molina, R / Setien-Olarra, A / Marichalar-Mendia, X / Aguirre-Urizar, J-M

Medicina oral, patologia oral y cirugia bucal

2018 Volume 23, Issue 3, Page(s) e315–e319

Abstract: ... of maxillary neoplasms. RANK (Receptor Activator of Nuclear Factor κappa B) is the signaling receptor of RANK-L (Receptor ... receptor for RANK-L that inhibits pro-osteoclastogenesis. The RANK / RANKL / OPG system participates ... expression of OPG, RANK and RANK-L proteins in odontogenic myxomas (OMs) and their relationship ...

Abstract	Background: Odontogenic myxoma (OM) is a benign intraosseous neoplasm that exhibits local aggressiveness and high recurrence rates. Osteoclastogenesis is an important phenomenon in the tumor growth of maxillary neoplasms. RANK (Receptor Activator of Nuclear Factor κappa B) is the signaling receptor of RANK-L (Receptor activator of nuclear factor kappa-Β ligand) that activates the osteoclasts. OPG (osteoprotegerin) is a decoy receptor for RANK-L that inhibits pro-osteoclastogenesis. The RANK / RANKL / OPG system participates in the regulation of osteolytic activity under normal conditions, and its alteration has been associated with greater bone destruction, and also with tumor growth. Objectives: To analyze the immunohistochemical expression of OPG, RANK and RANK-L proteins in odontogenic myxomas (OMs) and their relationship with the tumor size. Material and methods: Eighteen OMs, 4 small (<3 cm) and 14 large (> 3cm) and 18 dental follicles (DF) that were included as control were studied by means of standard immunohistochemical procedure with RANK, RANKL and OPG antibodies. For the evaluation, 5 fields (40x) of representative areas of OM and DF were selected where the expression of each antibody was determined. Descriptive and comparative statistical analyses were performed with the obtained data. Results: There are significant differences in the expression of RANK in OM samples as compared to DF (p = 0.022) and among the OMSs and OMLs (p = 0.032). Also a strong association is recognized in the expression of RANK-L and OPG in OM samples. Conclusions: Activation of the RANK / RANK-L / OPG triad seems to be involved in the mechanisms of bone balance and destruction, as well as associated with tumor growth in odontogenic myxomas.
MeSH term(s)	Adolescent ; Adult ; Child ; Female ; Humans ; Male ; Middle Aged ; Myxoma/metabolism ; Myxoma/pathology ; Odontogenic Tumors/metabolism ; Odontogenic Tumors/pathology ; Osteogenesis ; RANK Ligand/biosynthesis ; Receptor Activator of Nuclear Factor-kappa B/biosynthesis ; Tumor Burden ; Young Adult
Chemical Substances	RANK Ligand ; Receptor Activator of Nuclear Factor-kappa B
Language	English
Publishing date	2018-05-01
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2171573-7
ISSN	1698-6946 ; 1698-4447
ISSN (online)	1698-6946
ISSN	1698-4447
DOI	10.4317/medoral.22372
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Article ; Online: Nature of Hydrogen Bonds and S···S Interactions in the l-Cystine Crystal.

Flores-Huerta, Anaid G / Tkatchenko, Alexandre / Galván, Marcelo

The journal of physical chemistry. A

2016 Volume 120, Issue 24, Page(s) 4223–4230

Abstract: The intermolecular interactions that govern the stability of the l-cystine crystal were studied ...

Abstract	The intermolecular interactions that govern the stability of the l-cystine crystal were studied. This task is accomplished by using density-functional theory (DFT) with the generalized-gradient approximation (GGA) and including many-body dispersion (MBD) interactions. The strengths of the different interactions within the molecular crystal were obtained by a decomposition of the total interaction energy in two-, three-, and four-body contributions. It was determined that most of the hydrogen bonds formed within the crystal are strong (13, 15, and 19 kcal/mol) and the van der Waals nature of the S···S interaction is fully confirmed. Also, the presence of strong repulsive three-body contributions is determined. The results obtained support the idea of designing crystal growth inhibitors for this system in such a way that, when inserted in the crystal, they maintain the disulfide bridge environment but its capacity of generate hydrogen-bond networks is removed.
Language	English
Publishing date	2016-06-23
Publishing country	United States
Document type	Journal Article
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/acs.jpca.6b03167
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Article ; Online: The 'L' in PLME: A Broad Approach to Medical Education.

Ip, Julianne Y / Aluthge, Dilum / Galvan, Lauren

Rhode Island medical journal (2013)

2015 Volume 98, Issue 7, Page(s) 23–25

MeSH term(s)	Education, Medical, Graduate/ethics ; Humanities ; Humans ; Mental Health ; Mentors ; Music ; Rhode Island
Language	English
Publishing date	2015-07-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2707068-2
ISSN	2327-2228 ; 2327-2228
ISSN (online)	2327-2228
ISSN	2327-2228
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Article: Humidity Restriction, High Night Temperature and their Combination, during Post Flowering on Common Bean (Phaseolus vulgaris L.) Canopy and Pod Senescence

Cayetano-Marcial, M. I. / Peña-Valdivia, C. B. / García Esteva, A. / Jiménez Galindo, J. C. / Galván Escobedo, I. G. / Padilla Chacón, D.

Legume research

2021 Volume 44, Issue 6, Page(s) 634

Document type	Article
ZDB-ID	407856-1
ISSN	0250-5371
Database	Current Contents Nutrition, Environment, Agriculture

In stock of ZB MED Bonn / Germany

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Article ; Online: Evaluation of tolerance to Fusarium oxysporum and Fusarium solani in Virginia-type tobacco (Nicotiana tabacum L.) varieties under controlled conditions in Northwestern Argentina

Lorena A. Berruezo / Eleonora M. Harries / Marta Z. Galván / Sebastian A. Stenglein / Guadalupe Mercado Cárdenas

Revista de la Facultad de Ciencias Agrarias, Vol 53, Iss

2021 Volume 2

Abstract: The production of tobacco (Nicotiana tabacum L.) in Argentina is centered in the northwestern ...

Abstract	The production of tobacco (Nicotiana tabacum L.) in Argentina is centered in the northwestern region (NWA), where the incidence of root rots and stem diseases caused by Fusarium spp. has increased considerably in recent years. This study aimed to evaluate the pathogenicity levels of isolates of the F. oxysporum and F. solani complexes in different varieties of Virginia Type tobacco. The commercial varieties MB47, PVH229, NC71, K346, K326, and K394 were inoculated with six isolates of both complexes. The variables evaluated were the incidence and severity of the symptoms. The area under the disease progress curves (AUDPC) was calculated and subjected to analysis of variance (ANOVA). Also, disease epidemiological models were fitted to the experimental data. The MB47 variety was significantly less infected and the varieties K346, K326, and K394 had the highest AUDPC means, showing susceptibility to the isolates. The disease intensity curves were adequately described by the monomolecular and logistic models. The results provide, for the first time, information about the levels of tolerance to vascular wilt and root rot under controlled conditions for the main varieties of Virginia-type tobacco grown in NWA. Highlights: • FOSC isolates produced mainly wilting, chlorosis, and growth reduction in tobacco plants; in contrast, FSSC isolates caused root rot, with characteristic necrotic lesions and root rot symptoms. • The highest DSI scores were registered for Fo27 and Fo15, while the lowest DSI score was found for Fs98. • The results obtained from the DSI scores were related to the mean AUDPC values of the isolates. • MB47 and NC71 were significantly less infected than the other varieties, which registered low AUDPC values.
Keywords	tolerance ; Nicotiana tabacum L ; FOSC ; FSSC ; soil-borne diseases ; pathogenicity ; Agriculture ; S ; Food processing and manufacture ; TP368-456
Subject code	580
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Facultad de Ciencias Agrarias. Universidad Nacional de Cuyo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluation of tolerance to Fusarium oxysporum and Fusarium solani in Virginia-type tobacco (Nicotiana tabacum L.) varieties under controlled conditions in Northwestern Argentina

Lorena A. Berruezo / Eleonora M. Harries / Marta Z. Galván / Sebastian A. Stenglein / Guadalupe Mercado Cárdenas

Revista de la Facultad de Ciencias Agrarias, Vol 53, Iss

2021 Volume 2

Abstract: The production of tobacco (Nicotiana tabacum L.) in Argentina is centered in the northwestern ...

Abstract	The production of tobacco (Nicotiana tabacum L.) in Argentina is centered in the northwestern region (NWA), where the incidence of root rots and stem diseases caused by Fusarium spp. has increased considerably in recent years. This study aimed to evaluate the pathogenicity levels of isolates of the F. oxysporum and F. solani complexes in different varieties of Virginia Type tobacco. The commercial varieties MB47, PVH229, NC71, K346, K326, and K394 were inoculated with six isolates of both complexes. The variables evaluated were the incidence and severity of the symptoms. The area under the disease progress curves (AUDPC) was calculated and subjected to analysis of variance (ANOVA). Also, disease epidemiological models were fitted to the experimental data. The MB47 variety was significantly less infected and the varieties K346, K326, and K394 had the highest AUDPC means, showing susceptibility to the isolates. The disease intensity curves were adequately described by the monomolecular and logistic models. The results provide, for the first time, information about the levels of tolerance to vascular wilt and root rot under controlled conditions for the main varieties of Virginia-type tobacco grown in NWA. Highlights: • FOSC isolates produced mainly wilting, chlorosis, and growth reduction in tobacco plants; in contrast, FSSC isolates caused root rot, with characteristic necrotic lesions and root rot symptoms. • The highest DSI scores were registered for Fo27 and Fo15, while the lowest DSI score was found for Fs98. • The results obtained from the DSI scores were related to the mean AUDPC values of the isolates. • MB47 and NC71 were significantly less infected than the other varieties, which registered low AUDPC values.
Keywords	tolerance ; Nicotiana tabacum L ; FOSC ; FSSC ; soil-borne diseases ; pathogenicity ; Agriculture ; S ; Food processing and manufacture ; TP368-456
Subject code	580
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Facultad de Ciencias Agrarias. Universidad Nacional de Cuyo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluation of tolerance to Fusarium oxysporum and Fusarium solani in Virginia-type tobacco (Nicotiana tabacum L.) varieties under controlled conditions in Northwestern Argentina

Lorena A. Berruezo / Eleonora M. Harries / Marta Z. Galván / Sebastian A. Stenglein / Guadalupe Mercado Cárdenas

Revista de la Facultad de Ciencias Agrarias, Vol 53, Iss

2021 Volume 2

Abstract: The production of tobacco (Nicotiana tabacum L.) in Argentina is centered in the northwestern ...

Abstract	The production of tobacco (Nicotiana tabacum L.) in Argentina is centered in the northwestern region (NWA), where the incidence of root rots and stem diseases caused by Fusarium spp. has increased considerably in recent years. This study aimed to evaluate the pathogenicity levels of isolates of the F. oxysporum and F. solani complexes in different varieties of Virginia Type tobacco. The commercial varieties MB47, PVH229, NC71, K346, K326, and K394 were inoculated with six isolates of both complexes. The variables evaluated were the incidence and severity of the symptoms. The area under the disease progress curves (AUDPC) was calculated and subjected to analysis of variance (ANOVA). Also, disease epidemiological models were fitted to the experimental data. The MB47 variety was significantly less infected and the varieties K346, K326, and K394 had the highest AUDPC means, showing susceptibility to the isolates. The disease intensity curves were adequately described by the monomolecular and logistic models. The results provide, for the first time, information about the levels of tolerance to vascular wilt and root rot under controlled conditions for the main varieties of Virginia-type tobacco grown in NWA. Highlights: • FOSC isolates produced mainly wilting, chlorosis, and growth reduction in tobacco plants; in contrast, FSSC isolates caused root rot, with characteristic necrotic lesions and root rot symptoms. • The highest DSI scores were registered for Fo27 and Fo15, while the lowest DSI score was found for Fs98. • The results obtained from the DSI scores were related to the mean AUDPC values of the isolates. • MB47 and NC71 were significantly less infected than the other varieties, which registered low AUDPC values.
Keywords	tolerance ; Nicotiana tabacum L ; FOSC ; FSSC ; soil-borne diseases ; pathogenicity ; Agriculture ; S ; Food processing and manufacture ; TP368-456
Subject code	580
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Facultad de Ciencias Agrarias. Universidad Nacional de Cuyo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Poly(L-lactide)/branched β-cyclodextrin blends: Thermal, morphological and mechanical properties.

Lizundia, E / Gómez-Galván, F / Pérez-Álvarez, L / León, L M / Vilas, J L

Carbohydrate polymers

2016 Volume 144, Page(s) 25–32

Abstract: In this work we develop poly(L-lactide)/branched β-cyclodextrin (bβCD) blends in an attempt ...

Abstract	In this work we develop poly(L-lactide)/branched β-cyclodextrin (bβCD) blends in an attempt to obtain new biocompatible and biodegradable materials to be used in the emerging fields of pharmaceutical, biomedicine and food industry. Ionic branched β-cyclodextrin (bβCD) was obtained by polycondensation of the β-CD monomer and it was blended with a commercially available PLLA. Fourier transform infrared spectroscopy (FTIR) has been applied to study the occurring interactions between both partners. Thermal properties of blends have been analyzed by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA), while the phase structure of the blends was analyzed by scanning electron microscopy (SEM). Finally, dynamic mechanical analysis (DMA) has been used to provide further insights into the features controlling miscibility between PLLA and bβCD. Results show the presence of a single phase irrespectively of the blend composition. Overall, this work opens new perspectives for the development of naturally available materials with tunable functional properties for applications in which cyclodextrins emerge as a new class of promising candidates.
MeSH term(s)	Calorimetry, Differential Scanning ; Epichlorohydrin/chemistry ; Hydrophobic and Hydrophilic Interactions ; Mechanical Phenomena ; Microscopy, Electron, Scanning ; Polyesters/chemistry ; Proton Magnetic Resonance Spectroscopy ; Spectroscopy, Fourier Transform Infrared ; Stereoisomerism ; Surface Properties ; Temperature ; beta-Cyclodextrins/chemical synthesis ; beta-Cyclodextrins/chemistry
Chemical Substances	Polyesters ; beta-Cyclodextrins ; Epichlorohydrin (08OOR508C0) ; poly(lactide) (459TN2L5F5)
Language	English
Publishing date	2016-06-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2016.02.043
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Article: Burden of Topical Treatments in Psoriasis and Preferred Criteria of Choice: A Survey-Based Evaluation of Patients in Europe.

Bewley, Anthony / Hiribarne, Lauren / Galván, Jordi / Mburu, Sicily

Dermatology and therapy

2024

Abstract: Introduction: Topical treatments (TT) are widely used in psoriasis management. While psoriasis itself has been associated with diminished quality of life and mental well-being, the impact of TT remains underexplored. This study aimed to evaluate the ... ...

Abstract	Introduction: Topical treatments (TT) are widely used in psoriasis management. While psoriasis itself has been associated with diminished quality of life and mental well-being, the impact of TT remains underexplored. This study aimed to evaluate the burden of TT on the daily lives of patients with psoriasis, the convenience of the TT, and the choice criteria. Methods: Patients were recruited across five countries (France, Germany, Italy, Spain, UK) by Wefight and the International Federation of Psoriasis Associations (IFPA) to complete a 29-item online survey. Results: A total of 766 patients completed the survey (54% female, mean age of 53 years). The mean body surface area covered by psoriasis was 7%, predominantly on the scalp and elbows. Participants had been living with psoriasis for a mean duration of 18 years. Of the respondents, 34% reported feeling affected by their TT in their daily routines and activities. Those feeling affected were more likely to have a more complex disease, be using more treatments, or be diagnosed more recently compared to those less affected. Among those most affected by their TT, 27% reported a strong impact on mental health, 30% on sexual life, and 25% on physical activities, compared to 7%, 6% and 4% in those least affected, respectively. Both cohorts considered tolerability factors such as "does not cause itching/burning" and "good tolerability" as most important when choosing a topical. However, only least affected participants regarded convenience factors such as "does not run off," "ease of application," "does not leave stains" among others equally as important. Conclusion: Overall, one-third of patients report a significant burden of TT on their daily lives. These patients have different criteria of choice, highlighting the importance of communication between physicians and patients to tailor treatment to individual preferences, thereby enhancing adherence and treatment outcomes.
Language	English
Publishing date	2024-03-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2680284-3
ISSN	2190-9172 ; 2193-8210
ISSN (online)	2190-9172
ISSN	2193-8210
DOI	10.1007/s13555-024-01132-0
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