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  1. Article ; Online: First considerations on the SARS-CoV-2 epidemic in the Dialysis Units of Piedmont and Aosta Valley, Northern Italy.

    Manganaro, Marco / Baldovino, Simone

    Journal of nephrology

    2020  Volume 33, Issue 3, Page(s) 393–395

    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Ambulatory Care Facilities/statistics & numerical data ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/mortality ; Epidemics/statistics & numerical data ; Female ; Health Personnel/statistics & numerical data ; Hospitalization/statistics & numerical data ; Humans ; Italy/epidemiology ; Kidney Transplantation/statistics & numerical data ; Male ; Middle Aged ; Pandemics ; Peritoneal Dialysis/statistics & numerical data ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/mortality ; Preliminary Data ; Prevalence ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/therapy ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-10
    Publishing country Italy
    Document type Editorial
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-020-00732-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: First considerations on the SARS-CoV-2 epidemic in the Dialysis Units of Piedmont and Aosta Valley, Northern Italy

    Manganaro, Marco / Baldovino, Simone

    Journal of Nephrology

    2020  Volume 33, Issue 3, Page(s) 393–395

    Keywords Nephrology ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-020-00732-1
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Spatiotemporal Organic Carbon Distribution in the Capo Peloro Lagoon (Sicily, Italy) in Relation to Environmentally Sustainable Approaches

    Sanfilippo, Marilena / Albano, Marco / Manganaro, Antonio / Capillo, Gioele / Spanò, Nunziacarla / Savoca, Serena

    Water. 2022 Jan. 04, v. 14, no. 1

    2022  

    Abstract: Transitional water environments represent very ecologically interesting areas, which provide various ecosystem services, both concerning biodiversity protection and sustainable fruition of resources. In this way, the evaluation of total carbon and its ... ...

    Abstract Transitional water environments represent very ecologically interesting areas, which provide various ecosystem services, both concerning biodiversity protection and sustainable fruition of resources. In this way, the evaluation of total carbon and its components, chlorophyll, and chemical and physical parameters is of fundamental importance to deepen the dynamics of these peculiar natural areas. Commercial interests linked to the biological resources of these areas are often not well exploited in relation to their sustainability, due to lack of knowledge. In this study, we investigated the distribution of total organic carbon, chlorophyll, and other related physical and chemical parameters in the natural Lagoon of Capo Peloro (Eastern Sicily), to deepen the knowledge on the carbon equilibrium of these transitional basins. Collected data showed different trends for all parameters, mainly related to different seasons and water exchanges with sea. The influences of primary production sources and farmed molluscs were not negligible and deserve to be further investigated in the future. The results obtained reveal good margins for the possibility of environmentally sustainable exploitation of natural resources in both basins, but at the same time, there is a need for a more detailed knowledge of anthropogenic impacts on the area.
    Keywords biodiversity ; chlorophyll ; ecosystems ; primary productivity ; total organic carbon ; water ; Italy ; Sicily
    Language English
    Dates of publication 2022-0104
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2521238-2
    ISSN 2073-4441
    ISSN 2073-4441
    DOI 10.3390/w14010108
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Imaging of Peritoneal Carcinomatosis in Advanced Ovarian Cancer: CT, MRI, Radiomic Features and Resectability Criteria.

    Miceli, Valentina / Gennarini, Marco / Tomao, Federica / Cupertino, Angelica / Lombardo, Dario / Palaia, Innocenza / Curti, Federica / Riccardi, Sandrine / Ninkova, Roberta / Maccioni, Francesca / Ricci, Paolo / Catalano, Carlo / Rizzo, Stefania Maria Rita / Manganaro, Lucia

    Cancers

    2023  Volume 15, Issue 24

    Abstract: PC represents the most striking picture of the loco-regional spread of ovarian cancer, configuring stage III. In the last few years, many papers have evaluated the role of imaging and therapeutic management in patients with ovarian cancer and PC. This ... ...

    Abstract PC represents the most striking picture of the loco-regional spread of ovarian cancer, configuring stage III. In the last few years, many papers have evaluated the role of imaging and therapeutic management in patients with ovarian cancer and PC. This paper summed up the literature on traditional approaches to the imaging of peritoneal carcinomatosis in advanced ovarian cancer, presenting classification systems, most frequent patterns, routes of spread and sites that are difficult to identify. The role of imaging in diagnosis was investigated, with particular attention to the reported sensitivity and specificity data-computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography-CT (PET-CT)-and to the peritoneal cancer index (PCI). In addition, we explored the therapeutic possibilities and radiomics applications that can impact management of patients with ovarian cancer. Careful staging is mandatory, and patient selection is one of the most important factors influencing complete cytoreduction (CCR) outcome: an accurate pre-operative imaging may allow selection of patients that may benefit most from primary cytoreductive surgery.
    Language English
    Publishing date 2023-12-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15245827
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Fetal MRI: what's new? A short review.

    Manganaro, Lucia / Capuani, Silvia / Gennarini, Marco / Miceli, Valentina / Ninkova, Roberta / Balba, Ilaria / Galea, Nicola / Cupertino, Angelica / Maiuro, Alessandra / Ercolani, Giada / Catalano, Carlo

    European radiology experimental

    2023  Volume 7, Issue 1, Page(s) 41

    Abstract: Fetal magnetic resonance imaging (fetal MRI) is usually performed as a second-level examination following routine ultrasound examination, generally exploiting morphological and diffusion MRI sequences. The objective of this review is to describe the ... ...

    Abstract Fetal magnetic resonance imaging (fetal MRI) is usually performed as a second-level examination following routine ultrasound examination, generally exploiting morphological and diffusion MRI sequences. The objective of this review is to describe the novelties and new applications of fetal MRI, focusing on three main aspects: the new sequences with their applications, the transition from 1.5-T to 3-T magnetic field, and the new applications of artificial intelligence software. This review was carried out by consulting the MEDLINE references (PubMed) and including only peer-reviewed articles written in English. Among the most important novelties in fetal MRI, we find the intravoxel incoherent motion model which allow to discriminate the diffusion from the perfusion component in fetal and placenta tissues. The transition from 1.5-T to 3-T magnetic field allowed for higher quality images, thanks to the higher signal-to-noise ratio with a trade-off of more frequent artifacts. The application of motion-correction software makes it possible to overcome movement artifacts by obtaining higher quality images and to generate three-dimensional images useful in preoperative planning.Relevance statementThis review shows the latest developments offered by fetal MRI focusing on new sequences, transition from 1.5-T to 3-T magnetic field and the emerging role of AI software that are paving the way for new diagnostic strategies.Key points• Fetal magnetic resonance imaging (MRI) is a second-line imaging after ultrasound.• Diffusion-weighted imaging and intravoxel incoherent motion sequences provide quantitative biomarkers on fetal microstructure and perfusion.• 3-T MRI improves the detection of cerebral malformations.• 3-T MRI is useful for both body and nervous system indications.• Automatic MRI motion tracking overcomes fetal movement artifacts and improve fetal imaging.
    MeSH term(s) Pregnancy ; Female ; Humans ; Artificial Intelligence ; Magnetic Resonance Imaging/methods ; Diffusion Magnetic Resonance Imaging ; Algorithms ; Software
    Language English
    Publishing date 2023-08-10
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2509-9280
    ISSN (online) 2509-9280
    DOI 10.1186/s41747-023-00358-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Nephrotoxicity in advanced thyroid cancer treated with tyrosine kinase inhibitors: An update.

    Nervo, Alice / Retta, Francesca / Ragni, Alberto / Piovesan, Alessandro / Mella, Alberto / Biancone, Luigi / Manganaro, Marco / Gallo, Marco / Arvat, Emanuela

    Critical reviews in oncology/hematology

    2021  Volume 168, Page(s) 103533

    Abstract: Over the past decade, the prognosis of advanced thyroid cancer (TC) patients has dramatically improved thanks to the introduction of tyrosine kinase inhibitors (TKIs). Despite their effectiveness, these drugs are burdened with several side effects that ... ...

    Abstract Over the past decade, the prognosis of advanced thyroid cancer (TC) patients has dramatically improved thanks to the introduction of tyrosine kinase inhibitors (TKIs). Despite their effectiveness, these drugs are burdened with several side effects that can negatively affect quality of life and compromise therapy continuation. Among renal adverse events (RAEs), proteinuria is the most frequently reported in clinical trials and real-life experiences, especially during treatment with lenvatinib or cabozantinib. This peculiar toxicity is commonly associated with targeted therapies with anti-angiogenic activity, even if the mechanisms underlying its onset and progression are not entirely clear. RAEs should be early recognized and properly managed to avoid renal function worsening and life-threatening consequences. Aiming at providing a comprehensive summary that can help clinicians to identify and manage TKIs-related RAEs in TC patients, we reviewed the current evidence about this topic, from pathogenesis and potential risk factors to diagnosis and treatment.
    MeSH term(s) Antineoplastic Agents/adverse effects ; Drug-Related Side Effects and Adverse Reactions ; Humans ; Protein Kinase Inhibitors/adverse effects ; Quality of Life ; Thyroid Neoplasms/drug therapy
    Chemical Substances Antineoplastic Agents ; Protein Kinase Inhibitors
    Language English
    Publishing date 2021-11-19
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 605680-5
    ISSN 1879-0461 ; 0737-9587 ; 1040-8428
    ISSN (online) 1879-0461
    ISSN 0737-9587 ; 1040-8428
    DOI 10.1016/j.critrevonc.2021.103533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Antibodies, epicenter of SARS-CoV-2 immunology.

    Pecetta, Simone / Pizza, Mariagrazia / Sala, Claudia / Andreano, Emanuele / Pileri, Piero / Troisi, Marco / Pantano, Elisa / Manganaro, Noemi / Rappuoli, Rino

    Cell death and differentiation

    2021  Volume 28, Issue 2, Page(s) 821–824

    MeSH term(s) Antibodies, Neutralizing/immunology ; Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/immunology ; Antibodies, Viral/therapeutic use ; COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19/therapy ; Humans ; Immunization, Passive ; SARS-CoV-2/immunology ; Vaccination ; COVID-19 Serotherapy
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral
    Language English
    Publishing date 2021-01-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1225672-9
    ISSN 1476-5403 ; 1350-9047
    ISSN (online) 1476-5403
    ISSN 1350-9047
    DOI 10.1038/s41418-020-00711-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Adult-onset CblC deficiency: a challenging diagnosis involving different adult clinical specialists.

    Kalantari, Silvia / Brezzi, Brigida / Bracciamà, Valeria / Barreca, Antonella / Nozza, Paolo / Vaisitti, Tiziana / Amoroso, Antonio / Deaglio, Silvia / Manganaro, Marco / Porta, Francesco / Spada, Marco

    Orphanet journal of rare diseases

    2022  Volume 17, Issue 1, Page(s) 33

    Abstract: Background: Methylmalonic aciduria and homocystinuria, CblC type (OMIM #277400) is the most common disorder of cobalamin intracellular metabolism, an autosomal recessive disease, whose biochemical hallmarks are hyperhomocysteinemia, methylmalonic ... ...

    Abstract Background: Methylmalonic aciduria and homocystinuria, CblC type (OMIM #277400) is the most common disorder of cobalamin intracellular metabolism, an autosomal recessive disease, whose biochemical hallmarks are hyperhomocysteinemia, methylmalonic aciduria and low plasma methionine. Despite being a well-recognized disease for pediatricians, there is scarce awareness of its adult presentation. A thorough analysis and discussion of cobalamin C defect presentation in adult patients has never been extensively performed. This article reviews the published data and adds a new case of the latest onset of symptoms ever described for the disease.
    Results: We present the emblematic case of a 45-year-old male, describing the diagnostic odyssey he ventured through to get to the appropriate treatment and molecular diagnosis. Furthermore, available clinical, biochemical and molecular data from 22 reports on cases and case series were collected, resulting in 45 adult-onset CblC cases, including our own. We describe the onset of the disease in adulthood, encompassing neurological, psychiatric, renal, ophthalmic and thromboembolic symptoms. In all cases treatment with intramuscular hydroxycobalamin was effective in reversing symptoms. From a molecular point of view adult patients are usually compound heterozygous carriers of a truncating and a non-truncating variant in the MMACHC gene.
    Conclusion: Adult onset CblC disease is a rare disorder whose diagnosis can be delayed due to poor awareness regarding its presenting insidious symptoms and biochemical hallmarks. To avoid misdiagnosis, we suggest that adult onset CblC deficiency is acknowledged as a separate entity from pediatric late onset cases, and that the disease is considered in the differential diagnosis in adult patients with atypical hemolytic uremic syndromes and/or slow unexplained decline in renal function and/or idiopathic neuropathies, spinal cord degenerations, ataxias and/or recurrent thrombosis and/or visual field defects, maculopathy and optic disc atrophy. Plasma homocysteine measurement should be the first line for differential diagnosis when the disease is suspected. To further aid diagnosis, it is important that genes belonging to the intracellular cobalamin pathway are included within gene panels routinely tested for atypical hemolytic uremic syndrome and chronic kidney disorders.
    MeSH term(s) Amino Acid Metabolism, Inborn Errors/diagnosis ; Amino Acid Metabolism, Inborn Errors/genetics ; Amino Acid Metabolism, Inborn Errors/therapy ; Heterozygote ; Homocystinuria/diagnosis ; Homocystinuria/drug therapy ; Homocystinuria/genetics ; Humans ; Male ; Middle Aged ; Oxidoreductases/genetics ; Oxidoreductases/therapeutic use ; Vitamin B 12/therapeutic use ; Vitamin B 12 Deficiency/diagnosis ; Vitamin B 12 Deficiency/drug therapy ; Vitamin B 12 Deficiency/genetics
    Chemical Substances MMACHC protein, human (EC 1.-) ; Oxidoreductases (EC 1.-) ; Vitamin B 12 (P6YC3EG204)
    Language English
    Publishing date 2022-02-02
    Publishing country England
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2225857-7
    ISSN 1750-1172 ; 1750-1172
    ISSN (online) 1750-1172
    ISSN 1750-1172
    DOI 10.1186/s13023-022-02179-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Growth performance and bioremediation potential of Gracilaria gracilis (Steentoft, L.M. Irvine & Farnham, 1995)

    Spanò, Nunziacarla / Di Paola, Davide / Albano, Marco / Manganaro, Antonio / Sanfilippo, Marilena / D’Iglio, Claudio / Capillo, Gioele / Savoca, Serena

    International journal of environmental studies. 2022 July 04, v. 79, no. 4

    2022  

    Abstract: The rapid development of aquaculture makes it desirable to use environment-friendly methods of purifying the wastewater effluent. Seaweed is often cultured for the dual purpose of useful algal biomass production and its bioremediation potential. This ... ...

    Abstract The rapid development of aquaculture makes it desirable to use environment-friendly methods of purifying the wastewater effluent. Seaweed is often cultured for the dual purpose of useful algal biomass production and its bioremediation potential. This paper offers a survey on growth characters and ecological functions of the macroalgae Gracilaria gracilis (Steentoft, L.M. Irvine & Farnham, 1995), collected from Ganzirri lagoon (Messina, Italy). The results obtained provided promising data in terms of growth rates, biomass and biofiltering potential of G. gracilis. A daily growth rate (DGR) of 0.70%/g and biomass 36,05 g/m³ was obtained using tanks with lower lighting. Its biofiltration efficiency was demonstrated by the strong correlation between the algal growth parameters (Y and DGR) and the concentration decrease of dissolved nutrients. Results provided in this study indicated that G. gracilis can find application in aquaculture systems as a biofilter and that biomass produced offers a valid resource for further biotechnological applications.
    Keywords Gracilaria ; biofilters ; biofiltration ; biomass production ; bioremediation ; growth performance ; lighting ; macroalgae ; surveys ; wastewater ; Italy
    Language English
    Dates of publication 2022-0704
    Size p. 748-760.
    Publishing place Routledge
    Document type Article
    ZDB-ID 2029069-X
    ISSN 1029-0400 ; 0020-7233
    ISSN (online) 1029-0400
    ISSN 0020-7233
    DOI 10.1080/00207233.2021.1954775
    Database NAL-Catalogue (AGRICOLA)

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