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Article: Antibiothérapies lors d’infections courantes de la sphère ORL.

Kratz, Ben / Boillat Blanco, Noémie / Tschopp, Jonathan

2022 Volume 18, Issue 777, Page(s) 694–699

Abstract: Upper respiratory tract infections are among the most common reasons for medical consultation and the single most frequent cause of antibiotics use in ambulatory care medicine in Switzerland. In this article, we propose an update on the indications, ... ...

Title translation	Antibiotics use for common ENT infections.
Abstract	Upper respiratory tract infections are among the most common reasons for medical consultation and the single most frequent cause of antibiotics use in ambulatory care medicine in Switzerland. In this article, we propose an update on the indications, choice and modalities for antibiotic use in frequent ENT infections, highlighting the Swiss Society for Infectious Diseases guidelines which are freely available on the internet and updated on a regular basis.
MeSH term(s)	Ambulatory Care ; Anti-Bacterial Agents/therapeutic use ; Drug Utilization ; Humans ; Practice Patterns, Physicians' ; Respiratory Tract Infections/drug therapy ; Switzerland
Chemical Substances	Anti-Bacterial Agents
Language	French
Publishing date	2022-04-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
DOI	10.53738/REVMED.2022.18.777.694
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Zs.A 5998: Show issues

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Article ; Online: High False-Positive Rate of (1,3)-β-D-Glucan in Onco-Hematological Patients Receiving Immunoglobulins and Therapeutic Antibodies.

Tschopp, Jonathan / Brunel, Anne Sophie / Spertini, Olivier / Croxatto, Anthony / Lamoth, Frederic / Bochud, Pierre Yves

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2022 Volume 75, Issue 2, Page(s) 330–333

Abstract: Immunoglobulins and/or therapeutic antibody preparations are associated with a high rate of false-positive (1,3)-β-D-glucan (BDG) tests in onco-hematological patients routinely screened for fungal infections. The benefit of BDG monitoring shall be ... ...

Abstract	Immunoglobulins and/or therapeutic antibody preparations are associated with a high rate of false-positive (1,3)-β-D-glucan (BDG) tests in onco-hematological patients routinely screened for fungal infections. The benefit of BDG monitoring shall be balanced against the risk of false-positive tests leading to unnecessary investigations and costs in this population.
MeSH term(s)	Glucans ; Humans ; Immunoglobulins ; Proteoglycans ; Sensitivity and Specificity ; beta-Glucans
Chemical Substances	Glucans ; Immunoglobulins ; Proteoglycans ; beta-Glucans ; polysaccharide-K (3X48A86C8K)
Language	English
Publishing date	2022-01-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciab1028
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Zs.A 1505: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 480: Show issues

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Article: Infectiologie: «less is more ».

Tschopp, Jonathan / Guéry, Benoît / Boillat Blanco, Noémie

Revue medicale suisse

2020 Volume 16, Issue 676-7, Page(s) 55–58

Abstract: Among carefully selected patients, an early oral antibiotic switch is safe and efficient in severe bacterial infections. New data are available on dual antibiotherapy in severe Staphylococcus aureus infections. Neisseria gonorrhoeae strains resistant to ... ...

Title translation	Infectious diseases : « less is more ».
Abstract	Among carefully selected patients, an early oral antibiotic switch is safe and efficient in severe bacterial infections. New data are available on dual antibiotherapy in severe Staphylococcus aureus infections. Neisseria gonorrhoeae strains resistant to ceftriaxone emerge, highlighting the necessity to develop new therapeutic strategies. Alongshan virus is a new tick-borne virus discovered in China. Ebola continues to rage in Democratic Republic of Congo, while Europe and Switzerland face measles outbreaks. North american guidelines for the diagnosis and management of Influenza have been updated, shortly before the FDA approval of baloxavir marboxil, a new antiviral treatment for Influenza infections.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; China ; Communicable Diseases/drug therapy ; Communicable Diseases/epidemiology ; Congo ; Disease Outbreaks ; Europe ; Humans ; Switzerland
Chemical Substances	Anti-Bacterial Agents
Language	French
Publishing date	2020-01-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
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Article ; Online: Direct reprogramming of non-limb fibroblasts to cells with properties of limb progenitors.

Atsuta, Yuji / Lee, ChangHee / Rodrigues, Alan R / Colle, Charlotte / Tomizawa, Reiko R / Lujan, Ernesto G / Tschopp, Patrick / Galan, Laura / Zhu, Meng / Gorham, Joshua M / Vannier, Jean-Pierre / Seidman, Christine E / Seidman, Jonathan G / Ros, Marian A / Pourquié, Olivier / Tabin, Clifford J

Developmental cell

2024 Volume 59, Issue 3, Page(s) 415–430.e8

Abstract: The early limb bud consists of mesenchymal limb progenitors derived from the lateral plate mesoderm (LPM). The LPM also gives rise to the mesodermal components of the flank and neck. However, the cells at these other levels cannot produce the variety of ... ...

Abstract	The early limb bud consists of mesenchymal limb progenitors derived from the lateral plate mesoderm (LPM). The LPM also gives rise to the mesodermal components of the flank and neck. However, the cells at these other levels cannot produce the variety of cell types found in the limb. Taking advantage of a direct reprogramming approach, we find a set of factors (Prdm16, Zbtb16, and Lin28a) normally expressed in the early limb bud and capable of imparting limb progenitor-like properties to mouse non-limb fibroblasts. The reprogrammed cells show similar gene expression profiles and can differentiate into similar cell types as endogenous limb progenitors. The further addition of Lin41 potentiates the proliferation of the reprogrammed cells. These results suggest that these same four factors may play pivotal roles in the specification of endogenous limb progenitors.
MeSH term(s)	Mice ; Animals ; Extremities ; Proteins/metabolism ; Fibroblasts ; Mesoderm/metabolism ; Limb Buds
Chemical Substances	Proteins
Language	English
Publishing date	2024-02-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2054967-2
ISSN	1878-1551 ; 1534-5807
ISSN (online)	1878-1551
ISSN	1534-5807
DOI	10.1016/j.devcel.2023.12.010
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Zs.A 5742: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 76: Show issues

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Article: Invasive

Tschopp, Jonathan / Perentes, Jean Yannis / Beigelman-Aubry, Catherine / Berezowska, Sabina / Lovis, Alban / Spertini, Olivier / Bochud, Pierre-Yves / Lamoth, Frederic

Medical mycology case reports

2021 Volume 32, Page(s) 68–72

Abstract: Hormographiella ... ...

Abstract	Hormographiella aspergillata
Language	English
Publishing date	2021-04-14
Publishing country	Netherlands
Document type	Journal Article
ISSN	2211-7539
ISSN	2211-7539
DOI	10.1016/j.mmcr.2021.03.008
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Article ; Online: Outcome of COVID-19 in Kidney Transplant Recipients Through the SARS-CoV-2 Variants Eras: Role of Anti-SARS-CoV-2 Monoclonal Antibodies.

Papadimitriou-Olivgeris, Matthaios / Cipriano, Ana / Guggisberg, Nicolas / Kroemer, Marie / Tschopp, Jonathan / Manuel, Oriol / Golshayan, Dela

Transplant international : official journal of the European Society for Organ Transplantation

2022 Volume 35, Page(s) 10721

Abstract: Kidney transplant recipients (KTR) are at increased risk for COVID-19-associated complications. We aimed to describe the evolving epidemiology and outcome of PCR-documented SARS-CoV-2 infection in KTR followed at our institution from March 2020 to May ... ...

Abstract	Kidney transplant recipients (KTR) are at increased risk for COVID-19-associated complications. We aimed to describe the evolving epidemiology and outcome of PCR-documented SARS-CoV-2 infection in KTR followed at our institution from March 2020 to May 2022. The primary endpoint was hospitalization for COVID-19-related symptoms or death within 28 days from diagnosis. Overall, 243 cases were included of which 68 (28%) developed the primary outcome. A significant decrease in the incidence of the primary outcome was observed (
MeSH term(s)	Humans ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Viral ; COVID-19 ; Kidney Transplantation ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Transplant Recipients
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Viral ; casirivimab (J0FI6WE1QN) ; imdevimab (2Z3DQD2JHM) ; sotrovimab (1MTK0BPN8V) ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Language	English
Publishing date	2022-10-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	639435-8
ISSN	1432-2277 ; 0934-0874
ISSN (online)	1432-2277
ISSN	0934-0874
DOI	10.3389/ti.2022.10721
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Zs.A 2358: Show issues

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Article ; Online: True prevalence of COPD and its association with peripheral arterial disease in the internal medicine ward of a tertiary care hospital.

Tschopp, Jonathan / Dumont, Philippe / Hayoz, Daniel

Swiss medical weekly

2017 Volume 147, Page(s) w14460

Abstract: Objectives: The primary objective was to determine the prevalence of confirmed chronic obstructive pulmonary disease (COPD) in patients aged 45 years or more who were admitted to the internal medicine ward of our tertiary care hospital (HFR Fribourg, ... ...

Abstract	Objectives: The primary objective was to determine the prevalence of confirmed chronic obstructive pulmonary disease (COPD) in patients aged 45 years or more who were admitted to the internal medicine ward of our tertiary care hospital (HFR Fribourg, Switzerland), and were either "tagged" as having COPD or at risk for COPD. The secondary objective was to determine the prevalence of the association of COPD with peripheral artery disease (PAD) in this population. Methodology: We evaluated all consecutive patients aged 45 years, admitted to our internal medicine ward between November 2013 and March 2014. All patients with a diagnosis of COPD, chronic bronchitis and/or lung emphysema in their electronic medical record ("tagged" as COPD) were evaluated for inclusion, as well as patients with at least one classic symptom and one classic risk factor for COPD identified by them on a check-list (patients at risk for COPD). Spirometry, and measurement of ankle-brachial index (ABI) and toe-brachial index when necessary, were performed in each patient once they were clinically stable. Results: One hundred and seventy-two of 888 consecutive patients were included. COPD was found in 81 patients. Amongst the 75 patients tagged as COPD, 65 (87%) were actually suffering from COPD and 10 (13%) carried a false diagnosis. COPD was diagnosed in 16 (16%) of the 97 at-risk patients. PAD was identified in 35 (43%) of patients suffering from confirmed COPD and in 22 (24%) of patients without COPD. There was a significant association between COPD and PAD (p <0.01). Conclusion: COPD was identified in 9% of the 888 patients evaluated. The majority of patients tagged as COPD were accurately diagnosed and a substantial proportion of at-risk patients were underdiagnosed. A significant association between COPD and PAD was found. In smokers, spirometry showing COPD is a useful test to detect patients at higher cardiovascular risk. Thus, we suggest that screening for PAD using an ABI should be proposed to every smoker with confirmed COPD.
MeSH term(s)	Aged ; Female ; Hospitalization ; Humans ; Internal Medicine ; Male ; Middle Aged ; Peripheral Arterial Disease/complications ; Prevalence ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Risk Factors ; Switzerland/epidemiology ; Tertiary Care Centers
Language	English
Publishing date	2017
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2036179-8
ISSN	1424-3997 ; 1424-7860
ISSN (online)	1424-3997
ISSN	1424-7860
DOI	10.4414/smw.2017.14460
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Article: Invasive Hormographiella aspergillata infection in patients with acute myeloid leukemia: Report of two cases successfully treated and review of the literature

Tschopp, Jonathan / Perentes, Jean Yannis / Beigelman-Aubry, Catherine / Berezowska, Sabina / Lovis, Alban / Spertini, Olivier / Bochud, Pierre-Yves / Lamoth, Frederic

Medical mycology case reports. 2021 June, v. 32

2021

Abstract: Hormographiella aspergillata is a rare cause of invasive mold infection, mostly described in patients with hematological malignancies. We describe two cases of invasive H. aspergillata infections in patients with acute myeloid leukemia, successfully ... ...

Abstract	Hormographiella aspergillata is a rare cause of invasive mold infection, mostly described in patients with hematological malignancies. We describe two cases of invasive H. aspergillata infections in patients with acute myeloid leukemia, successfully managed with complete surgical resection of the lesions and antifungal therapy of voriconazole alone or liposomal amphotericin B, followed by voriconazole, highlighting the key role of a multidisciplinary approach for the treatment of this rare and severe invasive mold infection.
Keywords	amphotericin B ; mycology ; myeloid leukemia ; resection
Language	English
Dates of publication	2021-06
Size	p. 68-72.
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ISSN	2211-7539
DOI	10.1016/j.mmcr.2021.03.008
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Comparison of Traditional Upper Airway Surgery and Upper Airway Stimulation for Obstructive Sleep Apnea.

Huntley, Colin / Boon, Maurits / Tschopp, Samuel / Tschopp, Kurt / Jenks, Carolyn M / Thaler, Erica / Baptista Jardin, Peter / Shah, Janki / Kominsky, Alan / Kezirian, Eric J / Heiser, Clemens / Waxman, Jonathan / Lin, Ho-Sheng

The Annals of otology, rhinology, and laryngology

2020 Volume 130, Issue 4, Page(s) 370–376

Abstract: Objective: To compare patients with moderate-severe obstructive sleep apnea (OSA) undergoing traditional single and multilevel sleep surgery to those undergoing upper airway stimulation (UAS).: Study design: Case control study comparing retrospective ...

Abstract	Objective: To compare patients with moderate-severe obstructive sleep apnea (OSA) undergoing traditional single and multilevel sleep surgery to those undergoing upper airway stimulation (UAS). Study design: Case control study comparing retrospective cohort of patients undergoing traditional sleep surgery to patients undergoing UAS enrolled in the ADHERE registry. Setting: 8 multinational academic medical centers. Subjects and methods: 233 patients undergoing prior single or multilevel traditional sleep surgery and meeting study inclusion criteria were compared to 465 patients from the ADHERE registry who underwent UAS. We compared preoperative and postoperative demographic, quality of life, and polysomnographic data. We also evaluated treatment response rates. Results: The pre and postoperative apnea hypopnea index (AHI) was 33.5 and 15 in the traditional sleep surgery group and 32 and 10 in the UAS group. The postoperative AHI in the UAS group was significantly lower. The pre and postoperative Epworth sleepiness scores (ESS) were 12 and 6 in both the traditional sleep surgery and UAS groups. Subgroup analysis evaluated those patients undergoing single level palate and multilevel palate and tongue base traditional sleep surgeries. The UAS group had a significantly lower postoperive AHI than both traditional sleep surgery subgroups. The UAS group had a higher percentage of patients reaching surgical success, defined as a postoperative AHI <20 with a 50% reduction from preoperative severity. Conclusion: UAS offers significantly better control of AHI severity than traditional sleep surgery. Quality life improvements were similar between groups.
MeSH term(s)	Airway Management/methods ; Case-Control Studies ; Comparative Effectiveness Research ; Electric Stimulation Therapy/adverse effects ; Electric Stimulation Therapy/methods ; Female ; Humans ; Male ; Middle Aged ; Otorhinolaryngologic Surgical Procedures/adverse effects ; Otorhinolaryngologic Surgical Procedures/methods ; Outcome and Process Assessment, Health Care/statistics & numerical data ; Palate/surgery ; Polysomnography/methods ; Polysomnography/statistics & numerical data ; Postoperative Complications/diagnosis ; Postoperative Complications/epidemiology ; Quality of Life ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/physiopathology ; Sleep Apnea, Obstructive/therapy ; Tongue/surgery
Language	English
Publishing date	2020-08-29
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Multicenter Study
ZDB-ID	120642-4
ISSN	1943-572X ; 0003-4894
ISSN (online)	1943-572X
ISSN	0003-4894
DOI	10.1177/0003489420953178
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Ul II Zs.75: Show issues

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Article ; Online: Invasive Hormographiella aspergillata infection in patients with acute myeloid leukemia

Jonathan Tschopp / Jean Yannis Perentes / Catherine Beigelman-Aubry / Sabina Berezowska / Alban Lovis / Olivier Spertini / Pierre-Yves Bochud / Frederic Lamoth

Medical Mycology Case Reports, Vol 32, Iss , Pp 68-

Report of two cases successfully treated and review of the literature

2021 Volume 72

Abstract	Hormographiella aspergillata is a rare cause of invasive mold infection, mostly described in patients with hematological malignancies. We describe two cases of invasive H. aspergillata infections in patients with acute myeloid leukemia, successfully managed with complete surgical resection of the lesions and antifungal therapy of voriconazole alone or liposomal amphotericin B, followed by voriconazole, highlighting the key role of a multidisciplinary approach for the treatment of this rare and severe invasive mold infection.
Keywords	Coprinopsis cinerea ; Hormographiella aspergillata ; Voriconazole ; Amphotericin B ; Fungal PCR ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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