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Article: Radiation Dose of Contrast-Enhanced Mammography: A Two-Center Prospective Comparison.

Gennaro, Gisella / Cozzi, Andrea / Schiaffino, Simone / Sardanelli, Francesco / Caumo, Francesca

2022 Volume 14, Issue 7

Abstract: The radiation dose associated with contrast-enhanced mammography (CEM) has been investigated only by single-center studies. In this retrospective study, we aimed to compare the radiation dose between two centers performing CEM within two prospective ... ...

Abstract	The radiation dose associated with contrast-enhanced mammography (CEM) has been investigated only by single-center studies. In this retrospective study, we aimed to compare the radiation dose between two centers performing CEM within two prospective studies, using the same type of equipment. The CEM mean glandular dose (MGD) was computed for low energy (LE) and high energy (HE) images and their sum was calculated for each view. MGD and related parameters (entrance dose, breast thickness, compression, and density) were compared between the two centers using the Mann−Whitney test. Finally, per-patient MGD was calculated by pooling the two datasets and determining the contribution of LE and HE images. A total of 348 CEM examinations were analyzed (228 from Center 1 and 120 from Center 2). The median total MGD per view was 2.33 mGy (interquartile range 2.19−2.51 mGy) at Center 1 and 2.46 mGy (interquartile range 2.32−2.70 mGy) at Center 2, with a 0.15 mGy median difference (p < 0.001) equal to 6.2%. LE-images contributed between 64% and 77% to the total patient dose in CEM, with the remaining 23−36% being associated with HE images. The mean radiation dose for a two-view bilateral CEM exam was 4.90 mGy, about 30% higher than for digital mammography.
Language	English
Publishing date	2022-03-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14071774
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Article ; Online: Effect of chronotype on academic achievement in a sample of Italian University students: An update on sex effect.

Castelli, Lucia / Galasso, Letizia / Mulè, Antonino / Caumo, Andrea / Roveda, Eliana / Montaruli, Angela

Chronobiology international

2022 Volume 39, Issue 5, Page(s) 613–615

MeSH term(s)	Academic Success ; Circadian Rhythm ; Educational Status ; Humans ; Students ; Universities
Language	English
Publishing date	2022-01-07
Publishing country	England
Document type	Journal Article
ZDB-ID	998996-1
ISSN	1525-6073 ; 0742-0528
ISSN (online)	1525-6073
ISSN	0742-0528
DOI	10.1080/07420528.2021.2024564
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Article ; Online: Theoretical construct into blocks of actigraphic-derived sleep parameters.

Galasso, Letizia / Calogiuri, Giovanna / Castelli, Lucia / Mulè, Antonino / Esposito, Fabio / Caumo, Andrea / Montaruli, Angela / Roveda, Eliana

Chronobiology international

2022 Volume 40, Issue 2, Page(s) 174–185

Abstract: Actigraphic parameters can provide indication of people's sleep quality during their daily lives. However, there is a need for clear guidelines on the understanding of the different actigraphic parameters. The present study aims to propose a conceptual ... ...

Abstract	Actigraphic parameters can provide indication of people's sleep quality during their daily lives. However, there is a need for clear guidelines on the understanding of the different actigraphic parameters. The present study aims to propose a conceptual and theoretical framework for known actigraphic-derived parameters, which is able to describe the alternation between rest and wake phases during the nocturnal sleep, explaining their main characteristics and interrelations that can be replicated in future studies. Forty Sport Sciences students at the University of Milan (20 males; mean age ± SD, 22 ± 3 y) completed the validated Italian version of Morningness-Eveningness Questionnaire (MEQ) and wore an actigraph (Motion Watch 8®, Cambridge Neurotechnology, Cambridge, UK) for seven days. A framework was developed to depict the interactions between the actigraphic parameters and how they objectively describe sleep, according to which the parameters are organized into three different functional blocks related to different aspects of sleep. Correlations analyses were conducted to explore the relationships among the primary actigraphic parameters within and across the functional blocks. The proposed framework is a purely theoretical construct that provides a simple interpretation of known actigraphic parameters guiding researchers and practitioners in the use of these parameters either for research or clinical purposes.
MeSH term(s)	Male ; Humans ; Circadian Rhythm ; Sleep ; Actigraphy ; Rest ; Surveys and Questionnaires
Language	English
Publishing date	2022-12-19
Publishing country	England
Document type	Journal Article
ZDB-ID	998996-1
ISSN	1525-6073 ; 0742-0528
ISSN (online)	1525-6073
ISSN	0742-0528
DOI	10.1080/07420528.2022.2157737
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Article ; Online: Secondary prevention and treatment innovation of early stage non-small cell lung cancer: Impact on diagnostic-therapeutic pathway from a multidisciplinary perspective.

Pasello, Giulia / Scattolin, Daniela / Bonanno, Laura / Caumo, Francesca / Dell'Amore, Andrea / Scagliori, Elena / Tinè, Mariaenrica / Calabrese, Fiorella / Benati, Gaetano / Sepulcri, Matteo / Baiocchi, Cristina / Milella, Michele / Rea, Federico / Guarneri, Valentina

Cancer treatment reviews

2023 Volume 116, Page(s) 102544

Abstract: Lung cancer (LC) is the leading cause of cancer-related death worldwide, mostly because the lack of a screening program so far. Although smoking cessation has a central role in LC primary prevention, several trials on LC screening through low-dose ... ...

Abstract	Lung cancer (LC) is the leading cause of cancer-related death worldwide, mostly because the lack of a screening program so far. Although smoking cessation has a central role in LC primary prevention, several trials on LC screening through low-dose computed tomography (LDCT) in a high risk population showed a significant reduction of LC related mortality. Most trials showed heterogeneity in terms of selection criteria, comparator arm, detection nodule method, timing and intervals of screening and duration of the follow-up. LC screening programs currently active in Europe as well as around the world will lead to a higher number of early-stage Non Small Cell Lung Cancer (NSCLC) at the diagnosis. Innovative drugs have been recently transposed from the metastatic to the perioperative setting, leading to improvements in terms of resection rates and pathological responses after induction chemoimmunotherapy, and disease free survival with targeted agents and immune checkpoint inhibitors. The present review summarizes available evidence about LC screening, highlighting potential pitfalls and benefits and underlining the impact on the diagnostic therapeutic pathway of NSCLC from a multidisciplinary perspective. Future perspectives in terms of circulating biomarkers under evaluation for patients' risk stratification as well as a focus on recent clinical trials results and ongoing studies in the perioperative setting will be also presented.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/diagnosis ; Carcinoma, Non-Small-Cell Lung/therapy ; Lung Neoplasms/diagnosis ; Lung Neoplasms/prevention & control ; Secondary Prevention ; Small Cell Lung Carcinoma ; Tomography, X-Ray Computed ; Early Detection of Cancer/methods
Language	English
Publishing date	2023-03-17
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	125102-8
ISSN	1532-1967 ; 0305-7372
ISSN (online)	1532-1967
ISSN	0305-7372
DOI	10.1016/j.ctrv.2023.102544
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Zs.A 1022: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 611: Show issues

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Article: Sex Differences in Rest-Activity Circadian Rhythm in Patients With Metabolic Syndrome.

Mulè, Antonino / Bruno, Eleonora / Pasanisi, Patrizia / Galasso, Letizia / Castelli, Lucia / Caumo, Andrea / Esposito, Fabio / Roveda, Eliana / Montaruli, Angela

Frontiers in physiology

2021 Volume 12, Page(s) 641461

Abstract: Rest-Activity circadian Rhythm (RAR) can be used as a marker of the circadian timing system. Recent studies investigated the relationship between irregular circadian rhythms and cardiovascular risk factors such as hypertension, obesity, and dyslipidemia. ...

Abstract	Rest-Activity circadian Rhythm (RAR) can be used as a marker of the circadian timing system. Recent studies investigated the relationship between irregular circadian rhythms and cardiovascular risk factors such as hypertension, obesity, and dyslipidemia. These factors are related to the Metabolic Syndrome (MS), a clustering of metabolic risk factors that increases the risk of several cardiovascular and metabolic diseases. This cross-sectional analysis aimed to explore the RAR characteristics by actigraphy in subjects with MS, particularly in relation to sex and MS parameters, using parametric and non-parametric analyses. Distinguishing the characteristics of RAR based on sex could prove useful as a tool to improve the daily level of activity and set up customized activity programs based on each person's circadian activity profile. This study showed that female participants exhibited higher values than male participants in the Midline Estimating Statistic of Rhythm (MESOR) (243.3 ± 20.0 vs 197.6 ± 17.9 activity count), Amplitude (184.5 ± 18.5 vs 144.2 ± 17.2 activity count), which measures half of the extent of the rhythmic variation in a cycle, and the most active 10-h period (M10) (379.08 ± 16.43 vs 295.13 ± 12.88 activity count). All these parameters are indicative of a higher daily activity level in women. Female participants also had lower Intradaily Variability (IV) than male participants (0.75 ± 0.03 vs 0.85 ± 0.03 activity count), which indicates a more stable and less fragmented RAR. These preliminary data provide the first experimental evidence of a difference in RAR parameters between male and female people with MS.
Language	English
Publishing date	2021-03-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2021.641461
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Article ; Online: Single bout of low-intensity exercise produces modestly favorable changes in glycemic and lipidemic profiles after ingestion of non-isoglucidic breakfasts.

Benedini, Stefano / Codella, Roberto / Caumo, Andrea / Terruzzi, Ileana / Luzi, Livio

Nutrition (Burbank, Los Angeles County, Calif.)

2018 Volume 58, Page(s) 57–64

Abstract: Objectives: The aim of this study was to investigate the acute effects of low-intensity exercise on the postprandial hormonal and metabolic milieu induced by breakfast consumption.: Methods: Exercise began 100 min after the initiation of breakfast ... ...

Abstract	Objectives: The aim of this study was to investigate the acute effects of low-intensity exercise on the postprandial hormonal and metabolic milieu induced by breakfast consumption. Methods: Exercise began 100 min after the initiation of breakfast consumption and consisted of cycling at 40% of maximum oxygen uptake for 20 min. Three different breakfasts were used to elicit the postprandial state: B1 = skimmed milk (125 mL) and 30g corn flakes; B2 = skimmed milk (220 mL), 200 g apple, 30 g cocoa cream-filled sponge cake; B3 = skimmed milk (125 mL), 50 g bread, 150 g apple, and 15 g hazelnut and cocoa spread. Nineteen young healthy participants (8 M/11 F; body mass index 22.7 ± 0.5 kg/m Results: No interaction between the two factors was found for any of the examined variables. Light exercise produced a modest, significant decrease in blood glucose levels (P = 0.004) and a modest, significant increase in free fatty acid levels (P = 0.002) with respect to the resting condition. Conclusions: These findings suggest that short, mild exercise has beneficial effects on postprandial metabolism and this may have direct bearing on the issue of counteracting the epidemic rising of sedentary lifestyle of the general population.
MeSH term(s)	Adult ; Blood Glucose ; Breakfast/physiology ; Cross-Over Studies ; Exercise/physiology ; Fatty Acids, Nonesterified/blood ; Female ; Ghrelin/blood ; Glucose Tolerance Test ; Glycemic Index/physiology ; Humans ; Insulin/blood ; Lipids/blood ; Male ; Reference Values
Chemical Substances	Blood Glucose ; Fatty Acids, Nonesterified ; Ghrelin ; Insulin ; Lipids
Language	English
Publishing date	2018-07-24
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	639259-3
ISSN	1873-1244 ; 0899-9007
ISSN (online)	1873-1244
ISSN	0899-9007
DOI	10.1016/j.nut.2018.06.005
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Article ; Online: Oncoplastic and reconstructive surgery in SENONETWORK Italian breast centers: lights and shadows.

Ghilli, Matteo / Lisa, Andrea Vittorio Emanuele / Salgarello, Marzia / Papa, Giovanni / Rietjens, Mario / Folli, Secondo / Curcio, Annalisa / Ferrari, Guglielmo / Caruso, Francesco / Altomare, Vittorio / Friedman, Daniele / De Santis, Maria Carmen / De Rose, Fiorenza / Meduri, Bruno / De Felice, Francesca / Marino, Lorenza / Cucciarelli, Francesca / Montemezzi, Stefania / Panizza, Pietro /

Belli, Paolo / Caumo, Francesca / Vinci, Valeriano / De Santis, Giorgio / Klinger, Marco / Roncella, Manuela

Breast (Edinburgh, Scotland)

2023 Volume 73, Page(s) 103601

MeSH term(s)	Humans ; Female ; Surgery, Plastic ; Breast Neoplasms/surgery ; Breast ; Mammaplasty ; Italy ; Mastectomy, Segmental
Language	English
Publishing date	2023-11-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1143210-x
ISSN	1532-3080 ; 0960-9776
ISSN (online)	1532-3080
ISSN	0960-9776
DOI	10.1016/j.breast.2023.103601
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Zs.A 3620: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 588: Show issues

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Article ; Online: If the Morning-Evening Questionnaire (MEQ) is able to predict the actigraphy-based acrophase, how does its reduced, five-item version (rMEQ) perform?

Montaruli, Angela / Galasso, Letizia / Carandente, Franca / Vitale, Jacopo A / Roveda, Eliana / Caumo, Andrea

Chronobiology international

2017 Volume 34, Issue 4, Page(s) 443–444

MeSH term(s)	Actigraphy ; Adult ; Circadian Rhythm/physiology ; Humans ; Surveys and Questionnaires ; Time Factors ; Wakefulness/physiology
Language	English
Publishing date	2017-04-20
Publishing country	England
Document type	Letter
ZDB-ID	998996-1
ISSN	1525-6073 ; 0742-0528
ISSN (online)	1525-6073
ISSN	0742-0528
DOI	10.1080/07420528.2017.1306708
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Article ; Online: Predicting the actigraphy-based acrophase using the Morningness-Eveningness Questionnaire (MEQ) in college students of North Italy.

Roveda, Eliana / Vitale, Jacopo / Montaruli, Angela / Galasso, Letizia / Carandente, Franca / Caumo, Andrea

Chronobiology international

2017 Volume 34, Issue 5, Page(s) 551–562

Abstract: Actigraphy is the reference objective method to measure circadian rhythmicity. One simpler subjective approach to assess the circadian typology is the Morningness-Eveningness Questionnaire (MEQ) by Horne and Ostberg. In this study, we compared the MEQ ... ...

Abstract	Actigraphy is the reference objective method to measure circadian rhythmicity. One simpler subjective approach to assess the circadian typology is the Morningness-Eveningness Questionnaire (MEQ) by Horne and Ostberg. In this study, we compared the MEQ score against the actigraphy-based circadian parameters MESOR, amplitude and acrophase in a sample of 54 students of the University of Milan in Northern Italy. MEQ and the acrophase resulted strongly and inversely associated (r = -0.84, p < 0.0001), and their relationship exhibited a clear-cut linear trend. We thus used linear regression to develop an equation enabling us to predict the value of the acrophase from the MEQ score. The parameters of the regression model were precisely estimated, with the slope of the regression line being significantly different from 0 (p < 0.0001). The best-fit linear equation was: acrophase (min) = 1238.7-5.49·MEQ, indicating that each additional point in the MEQ score corresponded to a shortening of the acrophase of approximately 5 min. The coefficient of determination, R
Language	English
Publishing date	2017
Publishing country	England
Document type	Journal Article
ZDB-ID	998996-1
ISSN	1525-6073 ; 0742-0528
ISSN (online)	1525-6073
ISSN	0742-0528
DOI	10.1080/07420528.2016.1276928
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Article ; Online: Rest-activity circadian rhythm in breast cancer survivors at 5 years after the primary diagnosis.

Roveda, Eliana / Bruno, Eleonora / Galasso, Letizia / Mulè, Antonino / Castelli, Lucia / Villarini, Anna / Caumo, Andrea / Esposito, Fabio / Montaruli, Angela / Pasanisi, Patrizia

Chronobiology international

2019 Volume 36, Issue 8, Page(s) 1156–1165

Abstract: Rest-activity circadian rhythm (RAR) is a marker of the circadian timing system. Particular attention has been given to RAR characteristics in cancer diseases. Specifically, alterations of RAR parameters have been found, at different stages of clinical ... ...

Abstract	Rest-activity circadian rhythm (RAR) is a marker of the circadian timing system. Particular attention has been given to RAR characteristics in cancer diseases. Specifically, alterations of RAR parameters have been found, at different stages of clinical pathway, in breast cancer (BC) patients. No studies to date have analyzed RAR alterations in breast cancer survivors several years after the diagnosis. The aim of this study was to determine RAR by actigraphy in a population of BC survivors at 5 years after the primary diagnosis, and to compare their RAR characteristics with healthy controls. The study sample was 28 women: 15 BC survivors at 5 years from the primary diagnosis (BC-group) and 13 healthy controls (Ctrl-group), matched for age and body mass index. All participants have been monitored for 7 days by actigraphy to evaluate RAR. A statistically significant circadian rhythm (T = 24) was found in all 28 subjects (
MeSH term(s)	Actigraphy/methods ; Breast Neoplasms ; Case-Control Studies ; Circadian Clocks/physiology ; Circadian Rhythm ; Exercise ; Female ; Humans ; Rest ; Sleep
Language	English
Publishing date	2019-06-10
Publishing country	England
Document type	Journal Article
ZDB-ID	998996-1
ISSN	1525-6073 ; 0742-0528
ISSN (online)	1525-6073
ISSN	0742-0528
DOI	10.1080/07420528.2019.1621330
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