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Book: Statistical methods for global health and epidemiology

Chen, Xinguang / Chen, Ding-Geng

principles, methods and applications

(ICSA Book Series in Statistics)

2020

Author's details	edited by Xinguang Chen, (Din) Ding-Geng Chen
Series title	ICSA Book Series in Statistics
Keywords	Statistics ; Biostatistics ; Epidemiology
Subject code	519.5
Language	English
Size	XV, 403 Seiten, Illustrationen
Publisher	Springer
Publishing place	Cham
Publishing country	Switzerland
Document type	Book
HBZ-ID	HT020451375
ISBN	978-3-030-35259-2 ; 9783030352608 ; 3-030-35259-5 ; 3030352609
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2020 A 596	available for loan (reading room)	Lesesaal EG

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Article ; Online: Experiences of surveillance, influential factors, and prevention to end the global coronavirus disease 2019 (COVID-19) pandemic

Chen Xinguang

Global Health Journal, Vol 5, Iss 1, Pp 1-

2021 Volume 3

Keywords	Medicine ; R
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	KeAi Communications Co., Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Experiences of surveillance, influential factors, and prevention to end the global coronavirus disease 2019 (COVID-19) pandemic.

Zhang, Yanjie / Xinguang, Chen

Global health journal (Amsterdam, Netherlands)

2021 Volume 5, Issue 1, Page(s) 1–3

Language	English
Publishing date	2021-04-08
Publishing country	China
Document type	Editorial
ZDB-ID	3008565-2
ISSN	2414-6447 ; 2096-3947
ISSN (online)	2414-6447
ISSN	2096-3947
DOI	10.1016/j.glohj.2021.02.008
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Factors associated with medial meniscal extrusion in non-osteoarthritic knees with medial meniscus tears: A cross-sectional study.

Liu, Xinguang / Yang, Bin / Liu, Chen / Xin, Xing

PM & R : the journal of injury, function, and rehabilitation

2024

Abstract: Background: Medial meniscal extrusion (MME) plays an important role in the progression of knee osteoarthritis. Exploring the factors associated with MME in non-osteoarthritic knees may assist in the prevention of osteoarthritis.: Objective: To ... ...

Abstract	Background: Medial meniscal extrusion (MME) plays an important role in the progression of knee osteoarthritis. Exploring the factors associated with MME in non-osteoarthritic knees may assist in the prevention of osteoarthritis. Objective: To identify the factors associated with pathologic MME in non-osteoarthritic knees with medial meniscus tears (MMTs). Design: A cross-sectional study. Participants: One hundred fifty patients with non-osteoarthritic knees who underwent arthroscopic surgery for MMT. Patients were divided into a pathologic MME group (n = 54) and a control group (n = 96) based on whether a pathologic MME was present on magnetic resonance (MR) images. Setting: Tertiary medical institution. Interventions: Not applicable. Main outcome measures: The MME distance was measured on a coronal MR image obtained at the midpoint of the medial femoral condyle. An MME distance ≥3 mm was considered to indicate pathologic MME. Demographic and clinical data were collected as variables. Multivariable logistic regression analysis was performed to identify factors associated with pathologic MME. Results: After multivariable adjustment, body mass index (BMI) and the type of MMT were associated significantly with pathologic MME in the multivariable logistic regression model. Each unit higher in BMI was associated with a 13% higher risk of pathologic MME (odds ratio [OR] 1.13, 95% confidence interval [CI] 1.01-1.28, p = .04). The odds of pathologic MME were approximately four times and three times higher for radial tears (OR 4.34, 95% CI 1.25-15.03, p = .02) and complex tears (OR 3.07, 95% CI 1.17-8.05, p = .02) than for horizontal and longitudinal tears. Conclusions: BMI and the type of MMT were independent factors associated with pathologic MME in non-osteoarthritic knees with MMT. A higher BMI, radial tears, and complex tears were predisposed to pathologic MME.
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2608988-9
ISSN	1934-1563 ; 1934-1482
ISSN (online)	1934-1563
ISSN	1934-1482
DOI	10.1002/pmrj.13134
Database	MEDical Literature Analysis and Retrieval System OnLINE

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bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

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Article: 3D Printing of a Porous Zn-1Mg-0.1Sr Alloy Scaffold: A Study on Mechanical Properties, Degradability, and Biosafety.

Cao, Xiangyu / Wang, Xinguang / Chen, Jiazheng / Geng, Xiao / Tian, Hua

Journal of functional biomaterials

2024 Volume 15, Issue 4

Abstract: In recent years, the use of zinc (Zn) alloys as degradable metal materials has attracted considerable attention in the field of biomedical bone implant materials. This study investigates the fabrication of porous scaffolds using a Zn-1Mg-0.1Sr alloy ... ...

Abstract	In recent years, the use of zinc (Zn) alloys as degradable metal materials has attracted considerable attention in the field of biomedical bone implant materials. This study investigates the fabrication of porous scaffolds using a Zn-1Mg-0.1Sr alloy through a three-dimensional (3D) printing technique, selective laser melting (SLM). The results showed that the porous Zn-1Mg-0.1Sr alloy scaffold featured a microporous structure and exhibited a compressive strength (CS) of 33.71 ± 2.51 MPa, a yield strength (YS) of 27.88 ± 1.58 MPa, and an elastic modulus (E) of 2.3 ± 0.8 GPa. During the immersion experiments, the immersion solution showed a concentration of 2.14 ± 0.82 mg/L for Zn
Language	English
Publishing date	2024-04-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2648525-4
ISSN	2079-4983
ISSN	2079-4983
DOI	10.3390/jfb15040109
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Progerin Inhibits the Proliferation and Migration of Melanoma Cells by Regulating the Expression of Paxillin.

Liu, Weixian / Huang, Xinxian / Luo, Weizhao / Liu, Xinguang / Chen, Weichun

OncoTargets and therapy

2024 Volume 17, Page(s) 227–242

Abstract: Objective: Progerin, the underlying cause of Hutchinson-Gilford Progeria Syndrome (HGPS), has been extensively studied for its impact on normal cells and premature aging patients. However, there is a lack of research on its specific effects on tumor ... ...

Abstract	Objective: Progerin, the underlying cause of Hutchinson-Gilford Progeria Syndrome (HGPS), has been extensively studied for its impact on normal cells and premature aging patients. However, there is a lack of research on its specific effects on tumor cells. Melanoma is one of the most common malignant tumors with high morbidity and mortality. This study aimed to elucidate the potential therapeutic role of progerin in melanoma. Materials and methods: We constructed the melanoma A375 cell line and M14 cell line with stable expression of progerin. The expression of progerin, paxillin, and epithelial-mesenchymal transition (EMT) marker proteins in each cell group was measured using Western blot. The migration, proliferation, and cell cycle of cancer cells were assessed using the transwell assay, wound healing assay, colony formation assay, CCK 8 assay, and flow cytometry. RT-qPCR technology was used to examine the impact of progerin overexpression on microRNA expression. Finally, we transfected paxillin into the progerin overexpression cell group to verify whether progerin regulates the phenotype of tumor cells through paxillin. Results: Our study demonstrated that overexpression of progerin leads to decreased expression of paxillin and inhibits cancer cell migration, proliferation, EMT process and cell cycle progression. Additionally, rescue experiments revealed that the migration, proliferation ability, and EMT marker protein expression in progerin overexpressing cancer cells could be partially restored by transfecting a plasmid containing the paxillin gene. Mechanistic investigations further revealed that progerin achieves this inhibition of paxillin expression by upregulating miR-212. Conclusion: This study reveals that progerin may inhibit the migration and proliferation of melanoma cells through the miR-212/paxillin axis, which provides a new approach for the future treatment of this disease.
Language	English
Publishing date	2024-03-22
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2495130-4
ISSN	1178-6930
ISSN	1178-6930
DOI	10.2147/OTT.S442504
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Biology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the humoral immunoresponse

Shalini Nair / Xinguang Chen

Global Health Journal, Vol 6, Iss 1, Pp 38-

a systematic review of evidence to support global policy-level actions and research

2022 Volume 43

Abstract: Background: Both population-level epidemiological data and individual-level biological data are needed to control the coronavirus disease 2019 (COVID-19) pandemic. Population-level data are widely available and efforts to combat COVID-19 have generated ... ...

Abstract	Background: Both population-level epidemiological data and individual-level biological data are needed to control the coronavirus disease 2019 (COVID-19) pandemic. Population-level data are widely available and efforts to combat COVID-19 have generated proliferate data on the biology and immunoresponse to the causative pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, there remains a paucity of systemized data on this subject. Objective: In this review, we attempt to extract systemized data on the biology and immuno-response to SARS-CoV-2 from the most up-to-date peer-reviewed studies. We will focus on the biology of the virus and immunological variations that are key for determining long-term immunity, transmission potential, and prognosis. Data Sources and Methods: Peer-reviewed articles were sourced from the PubMed database and by snowballing search of selected publications. Search terms included: “Novel Coronavirus” OR “COVID-19” OR “SARS-CoV-2” OR “2019-nCoV” AND “Immunity” OR “Immune Response” OR “Antibody Response” OR “Immunologic Response”. Studies published from December 31, 2019 to December 31, 2020 were included. To ensure validity, papers in pre-print were excluded. Results: Of 2 889 identified papers, 36 were included. Evidence from these studies suggests early seroconversion in patients infected with SARS-CoV-2. Antibody titers appear to markedly increase two weeks after infection, followed by a plateau. A more robust immune response is seen in patients with severe COVID-19 as opposed to mild or asymptomatic presentations. This trend persists with regard to the length of antibody maintenance. However, overall immunity appears to wane within two to three months post-infection. Conclusion: Findings of this study indicate that immune responses to SARS-CoV-2 follow the general pattern of viral infection. Immunity generated through natural infection appears to be short, suggesting a need for long-term efforts to control the pandemic. Antibody testing will be essential to ...
Keywords	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ; Coronavirus disease 2019 (COVID-19) ; Immunoresponse ; Antibody ; Global health ; Health policy ; Medicine ; R
Subject code	306
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	KeAi Communications Co., Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Saikosaponin A protects against uremic toxin indole‑3 acetic acid‑induced damage to the myocardium.

Chen, Cheng / Hu, Xiaoyuan / Chen, Xinguang

Molecular medicine reports

2023 Volume 28, Issue 3

Abstract: Chronic kidney disease (CKD)‑associated cardiac injury is a common complication in patients with CKD. Indole‑3 acetic acid (IAA) is a uremic toxin that injures the cardiovascular system. Saikosaponin A (SSA) protects against pressure overload‑induced ... ...

Abstract	Chronic kidney disease (CKD)‑associated cardiac injury is a common complication in patients with CKD. Indole‑3 acetic acid (IAA) is a uremic toxin that injures the cardiovascular system. Saikosaponin A (SSA) protects against pressure overload‑induced cardiac fibrosis. However, the role and molecular mechanisms of IAA and SSA in CKD‑associated cardiac injury remain unclear. The present study investigated the effects of IAA and SSA on CKD‑associated cardiac injury in neonatal mouse cardiomyocytes and a mouse model of CKD. The expression of tripartite motif‑containing protein 16 (Trim16), receptor interacting protein kinase 2 (RIP2) and phosphorylated‑p38 were assessed using western blotting. The ubiquitination of RIP2 was measured by coimmunoprecipitation, and mouse cardiac structure and function were evaluated using hematoxylin and eosin staining and echocardiography. The results demonstrated that, SSA inhibited IAA‑induced cardiomyocyte hypertrophy, upregulated Trim16 expression, downregulated RIP2 expression and decreased p38 phosphorylation. Furthermore, Trim16 mediated SSA‑induced degradation of RIP2 by ubiquitination. In a mouse model of IAA‑induced CKD‑associated cardiac injury, SSA upregulated the protein expression levels of Trim16 and downregulated those of RIP2. Moreover, SSA alleviated heart hypertrophy and diastolic dysfunction in IAA‑treated mice. Taken together, these results suggest that SSA is a protective agent against IAA‑induced CKD‑associated cardiac injury and that Trim16‑mediated ubiquitination‑related degradation of RIP2 and p38 phosphorylation may contribute to the development of CKD‑associated cardiac injury.
MeSH term(s)	Mice ; Animals ; Uremic Toxins ; Signal Transduction ; Myocardium ; Myocytes, Cardiac ; Renal Insufficiency, Chronic ; Acetates/pharmacology ; Indoles/pharmacology
Chemical Substances	saikosaponin D (UR635J3F00) ; Uremic Toxins ; Acetates ; Indoles
Language	English
Publishing date	2023-07-07
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2469505-1
ISSN	1791-3004 ; 1791-2997
ISSN (online)	1791-3004
ISSN	1791-2997
DOI	10.3892/mmr.2023.13046
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Global pattern and determinants of coronavirus disease 2019 (COVID-19) vaccine coverage and progression: a global ecological study.

Wang, Huihao / Yu, Bin / Chen, Xinguang / Yan, Hong

Global health journal (Amsterdam, Netherlands)

2023 Volume 7, Issue 1, Page(s) 18–23

Abstract: Background: Understanding and minimizing existing global coronavirus disease 2019 : Methods: COVID-19 vaccination coverage data from 206 countries used in the study were derived from "Our World in Data" website. After obtaining the vaccination ... ...

Abstract	Background: Understanding and minimizing existing global coronavirus disease 2019 Methods: COVID-19 vaccination coverage data from 206 countries used in the study were derived from "Our World in Data" website. After obtaining the vaccination coverage indicators, we fitted the progression indicators for vaccination. Correlation and multiple linear regression analysis were used to examine the effects of gross domestic product (GDP) per capita, Gini index, education, and their interactions on the coverage and progression of the COVID-19 vaccination. Results: The coverage of COVID-19 vaccination ranged from less than 30 doses to more than 150 doses per hundred people, from less than 15% to more than 75% for proportion of people vaccinated, from less than 15% to more than 60% for proportion of people fully vaccinated. Similarly, the progression of vaccination ranged from less than 0.1 to more than 0.6 for progression of total number of doses, from less than 0.1 to more than 0.3 for progression of proportion of people vaccinated, and from less than 0.1 to more than 0.4 for progression of proportion of people fully vaccinated. GDP per capita and education were positively associated with the coverage and progression, while Gini index was negatively associated with the coverage and progression. Negative interaction between GDP per capita and education was also observed for coverage ( Conclusions: Substantial geographic disparities existed for the coverage and progression of COVID-19 vaccination. Economy and education are two important factors contributing to the disparities. Different countries may adopt varied strategies to promote the national distribution and vaccination of COVID-19 vaccines.
Language	English
Publishing date	2023-02-09
Publishing country	China
Document type	Journal Article
ZDB-ID	3008565-2
ISSN	2414-6447 ; 2096-3947
ISSN (online)	2414-6447
ISSN	2096-3947
DOI	10.1016/j.glohj.2023.02.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: First two months of the 2019 Coronavirus Disease (COVID-19) epidemic in China: real-time surveillance and evaluation with a second derivative model

Xinguang Chen, Bin Yu

Global Health Research and Policy

Abstract: Background Similar to outbreaks of many other infectious diseases, success in controlling the novel 2019 coronavirus infection requires a timely and accurate monitoring of the epidemic, particularly during its early period with rather limited data while ... ...

Abstract	Background Similar to outbreaks of many other infectious diseases, success in controlling the novel 2019 coronavirus infection requires a timely and accurate monitoring of the epidemic, particularly during its early period with rather limited data while the need for information increases explosively Methods In this study, we used a second derivative model to characterize the coronavirus epidemic in China with cumulatively diagnosed cases during the first 2 months The analysis was further enhanced by an exponential model with a close-population assumption This model was built with the data and used to assess the detection rate during the study period, considering the differences between the true infections, detectable and detected cases Results Results from the second derivative modeling suggest the coronavirus epidemic as nonlinear and chaotic in nature Although it emerged gradually, the epidemic was highly responsive to massive interventions initiated on January 21, 2020, as indicated by results from both second derivative and exponential modeling analyses The epidemic started to decelerate immediately after the massive actions The results derived from our analysis signaled the decline of the epidemic 14 days before it eventually occurred on February 4, 2020 Study findings further signaled an accelerated decline in the epidemic starting in 14 days on February 18, 2020 Conclusions The coronavirus epidemic appeared to be nonlinear and chaotic, and was responsive to effective interventions The methods used in this study can be applied in surveillance to inform and encourage the general public, public health professionals, clinicians and decision-makers to take coordinative and collaborative efforts to control the epidemic
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #5595
Database	COVID19

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