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  1. Book: Intrinsic immunity

    Cullen, Bryan R.

    (Current topics in microbiology and immunology ; 371)

    2013  

    Author's details Bryan R. Cullen ed
    Series title Current topics in microbiology and immunology ; 371
    Collection
    Keywords Cellular immunity ; Virusinfektion ; Immunität ; Viren ; Replikation ; Inhibition
    Subject Virale Infektion ; Hemmung ; Suppression ; Unterdrückung ; Blockade ; Autoreduplikation ; Reduplikation ; DNS-Replikation ; RNS-Replikation ; DNA-Replikation ; RNA-Replikation ; Virus
    Subject code 571.96
    Language English
    Size VII, 262 S. : Ill., graph. Darst., 24 cm
    Publisher Springer
    Publishing place Heidelberg u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT017672084
    ISBN 978-3-642-37764-8 ; 3-642-37764-5 ; 9783642377655 ; 3642377653
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 A 1322 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: The SMC5/6 complex: An emerging antiviral restriction factor that can silence episomal DNA.

    Irwan, Ishak D / Cullen, Bryan R

    PLoS pathogens

    2023  Volume 19, Issue 3, Page(s) e1011180

    MeSH term(s) DNA ; Plasmids
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2023-03-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1011180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The SMC5/6 complex

    Ishak D. Irwan / Bryan R. Cullen

    PLoS Pathogens, Vol 19, Iss

    An emerging antiviral restriction factor that can silence episomal DNA

    2023  Volume 3

    Keywords Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: The SMC5/6 complex

    Ishak D Irwan / Bryan R Cullen

    PLoS Pathogens, Vol 19, Iss 3, p e

    An emerging antiviral restriction factor that can silence episomal DNA.

    2023  Volume 1011180

    Keywords Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Tax Induces the Recruitment of NF-κB to Unintegrated HIV-1 DNA To Rescue Viral Gene Expression and Replication.

    Irwan, Ishak D / Cullen, Bryan R

    Journal of virology

    2021  Volume 95, Issue 13, Page(s) e0028521

    Abstract: We previously reported that the normally essential step of integration of the HIV-1 proviral DNA intermediate into the host cell genome becomes dispensable in T cells that express the human T cell leukemia virus 1 (HTLV-1) Tax protein, a known activator ... ...

    Abstract We previously reported that the normally essential step of integration of the HIV-1 proviral DNA intermediate into the host cell genome becomes dispensable in T cells that express the human T cell leukemia virus 1 (HTLV-1) Tax protein, a known activator of cellular NF-κB. The rescue of integrase (IN)-deficient HIV-1 replication by Tax results from the strong activation of transcription from the long terminal repeat (LTR) promoter on episomal HIV-1 DNA, an effect that is closely correlated with the recruitment of activating epigenetic marks, such as H3Ac, and depletion of repressive epigenetic marks, such as H3K9me3, from chromatinized unintegrated proviruses. In addition, activation of transcription from unintegrated HIV-1 DNA coincides with the recruitment of NF-κB to the two NF-κB binding sites found in the HIV-1 LTR enhancer. Here, we report that the recruitment of NF-κB to unintegrated viral DNA precedes, and is a prerequisite for, Tax-induced changes in epigenetic marks, so that an IN
    MeSH term(s) Cell Line ; DNA, Viral/genetics ; Enzyme Activation/genetics ; Gene Expression/genetics ; Gene Expression Regulation, Viral/genetics ; Gene Products, tax/metabolism ; HEK293 Cells ; HIV Integrase/deficiency ; HIV Integrase/genetics ; HIV-1/genetics ; Human T-lymphotropic virus 1/metabolism ; Humans ; NF-kappa B/metabolism ; Promoter Regions, Genetic/genetics ; Proviruses/genetics ; Virus Integration/genetics ; Virus Replication/genetics
    Chemical Substances DNA, Viral ; Gene Products, tax ; NF-kappa B ; tax protein, Human T-lymphotrophic virus 1 ; HIV Integrase (EC 2.7.7.-)
    Language English
    Publishing date 2021-06-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.00285-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 609: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Book: Human retroviruses

    Cullen, Bryan R.

    (Frontiers in molecular biology ; [1])

    1993  

    Author's details ed. by Bryan R. Cullen
    Series title Frontiers in molecular biology ; [1]
    Collection
    Keywords Gene Expression Regulation ; HTLV-BLV Infections ; HTLV-BLV Viruses ; Retroviridae ; Retroviren
    Subject Leukoviren ; Retroviridae
    Language English
    Size XVI, 220 S. : Ill., graph. Darst.
    Publisher IRL Pr
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT004982427
    ISBN 0-19-963383-5 ; 0-19-963382-7 ; 978-0-19-963383-8 ; 978-0-19-963382-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1993 A 2638 order for loan Magazin

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  7. Article ; Online: RNA Interference in Mammals: The Virus Strikes Back.

    Cullen, Bryan R

    Immunity

    2017  Volume 46, Issue 6, Page(s) 970–972

    Abstract: The importance of RNA interference (RNAi) as a mammalian antiviral defense mechanism has been controversial. Qiu et al. (2017) now present data suggesting that the difficulty of detecting RNAi in virus-infected mammalian cells reflects the expression of ... ...

    Abstract The importance of RNA interference (RNAi) as a mammalian antiviral defense mechanism has been controversial. Qiu et al. (2017) now present data suggesting that the difficulty of detecting RNAi in virus-infected mammalian cells reflects the expression of highly effective viral suppressors of RNAi.
    MeSH term(s) Animals ; Antiviral Agents ; Humans ; Mammals/genetics ; RNA Interference ; RNA, Small Interfering/genetics ; Viruses/genetics
    Chemical Substances Antiviral Agents ; RNA, Small Interfering
    Language English
    Publishing date 2017-06-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2017.05.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 69: Show issues

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  8. Article ; Online: Epigenetic silencing by the SMC5/6 complex mediates HIV-1 latency.

    Irwan, Ishak D / Bogerd, Hal P / Cullen, Bryan R

    Nature microbiology

    2022  Volume 7, Issue 12, Page(s) 2101–2113

    Abstract: After viral entry and reverse transcription, HIV-1 proviruses that fail to integrate are epigenetically silenced, but the underlying mechanism has remained unclear. Using a genome-wide CRISPR/Cas9 knockout screen, we identified the host SMC5/6 complex as ...

    Abstract After viral entry and reverse transcription, HIV-1 proviruses that fail to integrate are epigenetically silenced, but the underlying mechanism has remained unclear. Using a genome-wide CRISPR/Cas9 knockout screen, we identified the host SMC5/6 complex as essential for this epigenetic silencing. We show that SMC5/6 binds to and then SUMOylates unintegrated chromatinized HIV-1 DNA. Inhibition of SUMOylation, either by point mutagenesis of the SMC5/6 component NSMCE2-a SUMO E3 ligase-or using the SUMOylation inhibitor TAK-981, prevents epigenetic silencing, enables transcription from unintegrated HIV-1 DNA and rescues the replication of integrase-deficient HIV-1. Finally, we show that blocking SMC5/6 complex expression, or inhibiting its SUMOylation activity, suppresses the establishment of latent HIV-1 infections in both CD4+ T cell lines and primary human T cells. Collectively, our data show that the SMC5/6 complex plays a direct role in mediating the establishment of HIV-1 latency by epigenetically silencing integration-competent HIV-1 proviruses before integration.
    MeSH term(s) Humans ; HIV-1/physiology ; HIV Infections/genetics ; Virus Latency/genetics ; Proviruses/genetics ; Proviruses/metabolism ; DNA ; Epigenesis, Genetic ; Chromosomal Proteins, Non-Histone/genetics ; Chromosomal Proteins, Non-Histone/metabolism ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Ligases/genetics
    Chemical Substances DNA (9007-49-2) ; SMC5 protein, human ; Chromosomal Proteins, Non-Histone ; Cell Cycle Proteins ; NSMCE2 protein, human (EC 6.3.2.-) ; Ligases (EC 6.-)
    Language English
    Publishing date 2022-11-14
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2058-5276
    ISSN (online) 2058-5276
    DOI 10.1038/s41564-022-01264-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Mapping RNA Modifications Using Photo-Crosslinking-Assisted Modification Sequencing.

    Cullen, Bryan R / Tsai, Kevin

    Methods in molecular biology (Clifton, N.J.)

    2020  Volume 2298, Page(s) 123–134

    Abstract: Epitranscriptomic RNA modifications function as an important layer of gene regulation that modulates the function of RNA transcripts. A key step in understanding how RNA modifications regulate biological processes is the mapping of their locations, which ...

    Abstract Epitranscriptomic RNA modifications function as an important layer of gene regulation that modulates the function of RNA transcripts. A key step in understanding how RNA modifications regulate biological processes is the mapping of their locations, which is most commonly done by RNA immunoprecipitation (RIP) using modification-specific antibodies. Here, we describe the use of a photoactivatable ribonucleoside-enhanced cross-linking and immunoprecipitation (PAR-CLIP) method, in conjunction with RNA modification-specific antibodies, to map modification sites. First described as photo-crosslinking-assisted m
    MeSH term(s) Gene Expression Profiling/methods ; Humans ; Immunoprecipitation/methods ; RNA/genetics ; RNA Processing, Post-Transcriptional/genetics ; Ribonucleosides/genetics ; Sequence Analysis, RNA/methods ; Transcriptome/genetics
    Chemical Substances Ribonucleosides ; RNA (63231-63-0)
    Language English
    Publishing date 2020-11-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1374-0_8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Epigenetic and epitranscriptomic regulation of viral replication.

    Tsai, Kevin / Cullen, Bryan R

    Nature reviews. Microbiology

    2020  Volume 18, Issue 10, Page(s) 559–570

    Abstract: Eukaryotic gene expression is regulated not only by genomic enhancers and promoters, but also by covalent modifications added to both chromatin and RNAs. Whereas cellular gene expression may be either enhanced or inhibited by specific epigenetic ... ...

    Abstract Eukaryotic gene expression is regulated not only by genomic enhancers and promoters, but also by covalent modifications added to both chromatin and RNAs. Whereas cellular gene expression may be either enhanced or inhibited by specific epigenetic modifications deposited on histones (in particular, histone H3), these epigenetic modifications can also repress viral gene expression, potentially functioning as a potent antiviral innate immune response in DNA virus-infected cells. However, viruses have evolved countermeasures that prevent the epigenetic silencing of their genes during lytic replication, and they can also take advantage of epigenetic silencing to establish latent infections. By contrast, the various covalent modifications added to RNAs, termed epitranscriptomic modifications, can positively regulate mRNA translation and/or stability, and both DNA and RNA viruses have evolved to utilize epitranscriptomic modifications as a means to maximize viral gene expression. As a consequence, both chromatin and RNA modifications could serve as novel targets for the development of antivirals. In this Review, we discuss how host epigenetic and epitranscriptomic processes regulate viral gene expression at the levels of chromatin and RNA function, respectively, and explore how viruses modify, avoid or utilize these processes in order to regulate viral gene expression.
    MeSH term(s) Animals ; Antiviral Agents/pharmacology ; Chromatin/chemistry ; Chromatin/metabolism ; Chromatin/virology ; DNA Viruses/drug effects ; DNA Viruses/genetics ; DNA Viruses/metabolism ; Epigenesis, Genetic ; Eukaryotic Cells/drug effects ; Eukaryotic Cells/metabolism ; Eukaryotic Cells/virology ; Gene Expression Regulation, Viral ; Histones/genetics ; Histones/metabolism ; Host-Pathogen Interactions/genetics ; Humans ; Promoter Regions, Genetic ; Protein Biosynthesis ; RNA Processing, Post-Transcriptional ; RNA Viruses/drug effects ; RNA Viruses/genetics ; RNA Viruses/metabolism ; Transcriptome ; Virus Latency ; Virus Replication
    Chemical Substances Antiviral Agents ; Chromatin ; Histones
    Keywords covid19
    Language English
    Publishing date 2020-06-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2139054-X
    ISSN 1740-1534 ; 1740-1526
    ISSN (online) 1740-1534
    ISSN 1740-1526
    DOI 10.1038/s41579-020-0382-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5865: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MG 74: Show issues

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