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Article ; Online: Flotillin-1 palmitoylation is essential for its stability and subsequent tumor promoting capabilities.

McClellan, Bryan / Wilson, Crystal N / Brenner, Andrew J / Jolly, Christopher A / deGraffenried, Linda

2024 Volume 43, Issue 14, Page(s) 1063–1074

Abstract: Flotillin-1 contributes to invasion and metastasis in triple negative breast cancer (TNBC) and is modified post-translationally through palmitoylation. Palmitoylation, the process of conjugating palmitoyl-CoA to proteins, plays an essential role in ... ...

Abstract	Flotillin-1 contributes to invasion and metastasis in triple negative breast cancer (TNBC) and is modified post-translationally through palmitoylation. Palmitoylation, the process of conjugating palmitoyl-CoA to proteins, plays an essential role in protein stability and trafficking. Thus far, there has not been any investigation into the role of flotillin-1 palmitoylation in the context of metastasis in vivo. To address the role of flotillin-1 palmitoylation in metastasis, MDA-MB-231 cells expressing palmitoylation defective flotillin-1 constructs were used as models. Compared to flotillin-1 WT expressing tumors, flotillin-1 palmitoylation defective displayed abrogated tumor progression and lung metastasis in vivo in both spontaneous and experimental models. Further mechanistic investigation led to the identification of zDHHC5 as the main palmitoyl acyltransferase responsible for palmitoylating endogenous flotillin-1. Modulation of flotillin-1 palmitoylation status through mutagenesis, zDHHC5 silencing, and 2-bromopalmitate inhibition all resulted in the proteasomal degradation of flotillin-1 protein. To assess if flotillin-1 palmitoylation can be inhibited for potential clinical relevance, we designed a competitive peptide fused to a cell penetrating peptide sequence, which displayed efficacy in blocking flotillin-1 palmitoylation in vitro without altering palmitoylation of other zDHHC5 substrates, highlighting its specificity. Additionally, TNBC xenograft tumor models expressing a doxycycline inducible flotillin-1 palmitoylation inhibiting peptide displayed attenuated tumor growth and lung metastasis. Collectively, these results reveal a novel palmitoylation dependent mechanism which is essential for the stability of flotillin-1 protein. More specifically, disruption of flotillin-1 palmitoylation through mutagenesis or competitive peptide promoted flotillin-1 protein degradation, subsequently impeding its tumor promoting and metastasis-inducing effects in TNBC tumor models.
MeSH term(s)	Humans ; Cell Line, Tumor ; Lipoylation ; Lung Neoplasms/genetics ; Membrane Proteins/metabolism ; Peptides ; Triple Negative Breast Neoplasms/genetics
Chemical Substances	flotillins ; Membrane Proteins ; Peptides
Language	English
Publishing date	2024-02-19
Publishing country	England
Document type	Journal Article
ZDB-ID	639046-8
ISSN	1476-5594 ; 0950-9232
ISSN (online)	1476-5594
ISSN	0950-9232
DOI	10.1038/s41388-024-02946-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2218: Show issues

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Article ; Online: Titans awake: HMAs for virus-driven ATL.

Jolly, Christopher J / Pimanda, John E

Blood

2020 Volume 136, Issue 7, Page(s) 777–779

MeSH term(s)	DNA ; Human T-lymphotropic virus 1/genetics ; Humans ; Leukemia ; Leukemia-Lymphoma, Adult T-Cell ; Wakefulness
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2020-10-21
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.2020006488
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Uh III Zs.140: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Meta-Analysis of Randomized Trials: Efficacy and Safety of Colchicine for Secondary Prevention of Cardiovascular Disease.

Akl, Elie / Sahami, Nazanin / Labos, Christopher / Genest, Jacques / Zgheib, Ali / Piazza, Nicolo / Jolly, Sanjit

Journal of interventional cardiology

2024 Volume 2024, Page(s) 8646351

Abstract: Background: Colchicine has shown potential cardioprotective effects owing to its broad anti-inflammatory properties. We performed a meta-analysis to assess its safety and efficacy in secondary prevention in patients with established coronary artery ... ...

Abstract	Background: Colchicine has shown potential cardioprotective effects owing to its broad anti-inflammatory properties. We performed a meta-analysis to assess its safety and efficacy in secondary prevention in patients with established coronary artery disease (CAD). Methods: We searched Ovid Healthstar, MEDLINE, and Embase (inception to May 2022) for randomized controlled trials (RCTs) evaluating the cardiovascular effects of colchicine compared with placebo or usual care in patients with CAD. Study-level data on efficacy and safety outcomes were pooled using the Peto method. The primary outcome was the composite of cardiovascular (CV) death, myocardial infarction (MI), or stroke. Results: A total of 8 RCTs were included with a follow-up duration of ≥1 month, comprising a total of 12,151 patients. Compared with placebo or usual care, colchicine was associated with a significant risk reduction in the primary outcome (odds ratio (OR) 0.70, 95% CI 0.60 to 0.83, Conclusions: Colchicine therapy may reduce the risk of future cardiovascular events in patients with established CAD; however, there remains a concern about non-CV mortality. Further trials are underway that will shed light on non-CV mortality and colchicine NCT03048825, and NCT02898610.
MeSH term(s)	Humans ; Cardiovascular Diseases/prevention & control ; Colchicine/adverse effects ; Secondary Prevention ; Randomized Controlled Trials as Topic ; Myocardial Infarction/epidemiology ; Stroke/prevention & control ; Stroke/epidemiology ; Coronary Artery Disease/drug therapy
Chemical Substances	Colchicine (SML2Y3J35T)
Language	English
Publishing date	2024-03-12
Publishing country	United States
Document type	Meta-Analysis ; Journal Article
ZDB-ID	1036325-7
ISSN	1540-8183 ; 0896-4327
ISSN (online)	1540-8183
ISSN	0896-4327
DOI	10.1155/2024/8646351
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Zs.A 2719: Show issues

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Article ; Online: Chaphamaparvovirus antigen and nucleic acids are not detected in kidney tissues from cats with chronic renal disease or immunocompromised cats.

Michel, Adam O / Donovan, Taryn A / Roediger, Ben / Lee, Quintin / Jolly, Christopher J / Monette, Sébastien

Veterinary pathology

2021 Volume 59, Issue 1, Page(s) 120–126

Abstract: Chronic kidney disease (CKD) is a common cause of morbidity and mortality in domestic cats, but the cause is still largely elusive. While some viruses have been associated with this disease, none have been definitively implicated as causative. Recently, ...

Abstract	Chronic kidney disease (CKD) is a common cause of morbidity and mortality in domestic cats, but the cause is still largely elusive. While some viruses have been associated with this disease, none have been definitively implicated as causative. Recently,
MeSH term(s)	Animals ; Cat Diseases ; Cats ; Kidney ; Mice ; Nucleic Acids ; Polymerase Chain Reaction/veterinary ; Renal Insufficiency, Chronic/veterinary ; Retrospective Studies
Chemical Substances	Nucleic Acids
Language	English
Publishing date	2021-10-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	188012-3
ISSN	1544-2217 ; 0300-9858
ISSN (online)	1544-2217
ISSN	0300-9858
DOI	10.1177/03009858211045439
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Article: Viral Biomarker Detection and Validation Using MALDI Mass Spectrometry Imaging (MSI).

O'Rourke, Matthew B / Roediger, Ben R / Jolly, Christopher J / Crossett, Ben / Padula, Matthew P / Hansbro, Phillip M

Proteomes

2022 Volume 10, Issue 3

Abstract: 1) Background: MALDI imaging is a technique that still largely depends on time of flight (TOF)-based instrument such as the Bruker UltrafleXtreme. While capable of performing targeted MS/MS, these instruments are unable to perform fragmentation while ... ...

Abstract	(1) Background: MALDI imaging is a technique that still largely depends on time of flight (TOF)-based instrument such as the Bruker UltrafleXtreme. While capable of performing targeted MS/MS, these instruments are unable to perform fragmentation while imaging a tissue section necessitating the reliance of MS1 values for peptide level identifications. With this premise in mind, we have developed a hybrid bioinformatic/image-based method for the identification and validation of viral biomarkers. (2) Methods: Formalin-Fixed Paraffin-Embedded (FFPE) mouse samples were sectioned, mounted and prepared for mass spectrometry imaging using our well-established methods. Peptide identification was achieved by first extracting confident images corresponding to theoretical viral peptides. Next, those masses were used to perform a Peptide Mmass Fingerprint (PMF) searched against known viral FASTA sequences against a background mouse FASTA database. Finally, a correlational analysis was performed with imaging data to confirm pixel-by-pixel colocalization and intensity of viral peptides. (3) Results: 14 viral peptides were successfully identified with significant PMF Scores and a correlational result of >0.79 confirming the presence of the virus and distinguishing it from the background mouse proteins. (4) Conclusions: this novel approach leverages the power of mass spectrometry imaging and provides confident identifications for viral proteins without requiring MS/MS using simple MALDI Time Of Flight/Time Of Flight (TOF/TOF) instrumentation.
Language	English
Publishing date	2022-09-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720995-7
ISSN	2227-7382
ISSN	2227-7382
DOI	10.3390/proteomes10030033
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Biodegradable, Polymer-Supported Oxygen Atom Transfer Reagent.

Ramey, Erin E / Whitman, Elizabeth L / Buller, Cole E / Tucker, James R / Jolly, Charles S / Oberle, Kjersti G / Becksvoort, Austin J / Turlington, Mark / Turlington, Christopher R

Polymers

2023 Volume 15, Issue 9

Abstract: Biodegradable polymers are desirable to mitigate the environmental impact of plastic waste in the environment. Over the past several decades, the development of organocatalytic ring-opening polymerization (OROP) has made the synthesis of many new types ... ...

Abstract	Biodegradable polymers are desirable to mitigate the environmental impact of plastic waste in the environment. Over the past several decades, the development of organocatalytic ring-opening polymerization (OROP) has made the synthesis of many new types of biodegradable polymers possible. In this research article, the first example of an oxygen atom transfer reagent pendant on a biodegradable polymer backbone is reported. The monomers for the polycarbonate backbone are sourced from the biodegradable 2,2-bis(hydroxymethyl) propionic acid molecule, and an iodoaryl group is installed pendant to the cyclic monomer for post-polymerization modification into an iodosylaryl oxygen atom transfer reagent. The key I-O bond is characterized by XPS spectroscopy, and a test reaction to triphenylphosphine demonstrates the ability of the polymer to engage in an oxygen atom transfer reaction with a substrate.
Language	English
Publishing date	2023-04-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym15092052
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Perceived Barriers to Clinical Cardiovascular Research Involvement in Canada.

Rashid, Mohammed K / Chiang, Christopher / Joza, Jacqueline / Jolly, Umjeet S

CJC open

2021 Volume 3, Issue 8, Page(s) 1089–1090

Language	English
Publishing date	2021-05-01
Publishing country	United States
Document type	Journal Article
ISSN	2589-790X
ISSN (online)	2589-790X
DOI	10.1016/j.cjco.2021.04.011
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Article ; Online: Metal(loid) pollution, not urbanisation nor parasites predicts low body condition in a wetland bioindicator snake.

Lettoof, Damian C / Cornelis, Jari / Jolly, Christopher J / Aubret, Fabien / Gagnon, Marthe Monique / Hyndman, Timothy H / Barton, Diane P / Bateman, Philip W

Environmental pollution (Barking, Essex : 1987)

2021 Volume 295, Page(s) 118674

Abstract: Urban ecosystems and remnant habitat 'islands' therein, provide important strongholds for many wildlife species including those of conservation significance. However, the persistence of these habitats can be undermined if their structure and function are ...

Abstract	Urban ecosystems and remnant habitat 'islands' therein, provide important strongholds for many wildlife species including those of conservation significance. However, the persistence of these habitats can be undermined if their structure and function are too severely disrupted. Urban wetlands, specifically, are usually degraded by a monoculture of invasive vegetation, disrupted hydrology, and chronic-contamination from a suite of anthropogenic pollutants. Top predators-as bioindicators-can be used to assess and monitor the health of these ecosystems. We measured eight health parameters (e.g., parasites, wounds and scars, tail loss and body condition) in a wetland top predator, the western tiger snake, Notechis scutatus occidentalis. For three years, snakes were sampled across four wetlands along an urban gradient. For each site, we used GIS software to measure the area of different landscapes and calculate an urbanisation-landscape score. Previously published research on snake contamination informed our calculations of a metal-pollution index for each site. We used generalised linear mixed models to assess the relationship between all health parameters and site variables. We found the metal-pollution index to have the most significant association with poor body condition. Although parasitism, tail loss and wounds differed among sites, none of these parameters influenced body condition. Additionally, the suite of health parameters suggested differing health status among sites; however, our measure of contemporary landscape urbanisation was never a significant predictor variable. Our results suggest that the health of wetland predators surrounding a rapidly growing city may be offset by higher levels of environmental pollution.
MeSH term(s)	Animals ; Ecosystem ; Environmental Biomarkers ; Environmental Monitoring ; Environmental Pollution ; Parasites ; Snakes ; Urbanization ; Wetlands
Chemical Substances	Environmental Biomarkers
Language	English
Publishing date	2021-12-11
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2021.118674
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Zs.A 2599: Show issues

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Article ; Online: Chaphamaparvovirus antigen and nucleic acids are not detected in kidney tissues from cats with chronic renal disease or immunocompromised cats

Michel, Adam O. / Donovan, Taryn A. / Roediger, Ben / Lee, Quintin / Jolly, Christopher J. / Monette, Sébastien

Veterinary Pathology. 2022 Jan., v. 59, no. 1 p.120-126

2022

Abstract	Chronic kidney disease (CKD) is a common cause of morbidity and mortality in domestic cats, but the cause is still largely elusive. While some viruses have been associated with this disease, none have been definitively implicated as causative. Recently, Rodent chaphamaparvovirus 1 was recognized as the cause of murine inclusion body nephropathy, a disease reported for over 40 years in laboratory mice. A novel virus belonging to the same genus, Carnivore chaphamaparvovirus 2, was recently identified in the feces of cats with diarrhea. The goal of this study was to investigate the possible role of chaphamaparvoviruses including members of Rodent chaphamaparvovirus 1 and Carnivore chaphamaparvovirus 2 in the development of feline CKD. The presence of these viruses was retrospectively investigated in formalin-fixed paraffin-embedded feline kidney samples using polymerase chain reaction, in situ hybridization, and immunohistochemistry. Cats were divided into 3 groups: normal (N = 24), CKD (N = 26), and immunocompromised (N = 25). None of the kidney tissues from any of the 75 cats revealed the presence of chaphamaparvovirus DNA, RNA, or antigen. We conclude that viruses belonging to the chaphamaparvovirus genus are unlikely to contribute to the occurrence of feline CKD.
Keywords	DNA ; RNA ; animal pathology ; antigens ; carnivores ; cats ; diarrhea ; feces ; hybridization ; immunohistochemistry ; kidney diseases ; kidneys ; mice ; morbidity ; mortality ; polymerase chain reaction ; viruses ; chronic kidney disease ; Chaphamaparvovirus ; urinary ; viral
Language	English
Dates of publication	2022-01
Size	p. 120-126.
Publishing place	SAGE Publications
Document type	Article ; Online
ZDB-ID	188012-3
ISSN	1544-2217 ; 0300-9858
ISSN (online)	1544-2217
ISSN	0300-9858
DOI	10.1177/03009858211045439
Database	NAL-Catalogue (AGRICOLA)

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Article: Non-response to Interleukin-1 Antagonist Canakinumab in Two Patients with Refractory Pyoderma Gangrenosum and Hidradenitis Suppurativa.

Sun, Natalie Z / Ro, Teresa / Jolly, Puneet / Sayed, Christopher J

The Journal of clinical and aesthetic dermatology

2017 Volume 10, Issue 9, Page(s) 36–38

Abstract: Pyoderma gangrenosum and hidradenitis suppurativa are skin conditions characterized by an intense neutrophil-mediated inflammatory response that is often difficult to effectively treat. Successful use of interleukin (IL)-1β inhibition using canakinumab ... ...

Abstract	Pyoderma gangrenosum and hidradenitis suppurativa are skin conditions characterized by an intense neutrophil-mediated inflammatory response that is often difficult to effectively treat. Successful use of interleukin (IL)-1β inhibition using canakinumab and anakinra has been reported in patients with concomitant pyoderma gangrenosum and hidradenitis suppurativa. We report two cases where targeted therapy with canakinumab failed to lead to improvement for patients with pyoderma gangrenosum and hidradenitis suppurativa. The reason behind the non-response to IL-1β blockade seen in these patients is unclear. Our report suggests that further controlled studies are warranted to help clinicians predict treatment responses to anti-IL-1 therapies in these challenging patients.
Language	English
Publishing date	2017-09-01
Publishing country	United States
Document type	Case Reports
ISSN	1941-2789
ISSN	1941-2789
Database	MEDical Literature Analysis and Retrieval System OnLINE

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