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Article ; Online: Bisphosphonate Use and Risk of Atypical Femoral Fractures: A Danish Case Cohort Study with Blinded Radiographic Review.

Bauer, Douglas C / Black, Dennis M / Dell, Rick / Fan, Bo / Smith, Christopher D / Ernst, Martin T / Jurik, Anne G / Frøkjær, Jens B / Boesen, Mikael / Vittinghoff, Eric / Abrahamsen, Bo

The Journal of clinical endocrinology and metabolism

2024

Abstract: Context: Prolonged bisphosphonate (BP) treatment for osteoporosis prevents hip and other fractures but causes atypical femoral fractures (AFF).: Objective: To establish the relationship between patterns of BP use and the risk of AFF and hip fractures. ...

Abstract	Context: Prolonged bisphosphonate (BP) treatment for osteoporosis prevents hip and other fractures but causes atypical femoral fractures (AFF). Objective: To establish the relationship between patterns of BP use and the risk of AFF and hip fractures. Other potential risk factors for AFF were also examined. Design: Population-based case-cohort study. Setting: The Danish National Healthcare system maintains longitudinal records of medication use, healthcare utilization, and x-ray images. Participants: Among all 1.9 million Danish adults ≥50, those with subtrochanteric or femoral shaft fractures between 2010-2015 (n = 4,973) were identified and compared to a random sample (n = 37,021). Predictors: Bisphosphonate use was collected from 1995-2015. Main outcome measures: Fracture radiographs (n = 4,769) were reviewed by blinded study radiologists to identify AFFs (n = 181) using established criteria. Traditional hip fractures in the random sample (n = 691) were identified by ICD-10. Results: Compared to <1 year of BP use, 5-7 years of use was associated with a 7-fold increase in AFF [adjusted HR = 7.29 (CI: 3.07,17.30)]; the risk of AFF fell quickly after discontinuation. The 5-year number-needed-to-harm for one AFF was 1,424, while the 5-year number-needed-to-treat to prevent one hip fracture was 56. Glucocorticoid and proton pump inhibitor use were independently associated with increased AFF risk. Thirty-one percent of those with AFF had no BP exposure. Conclusions: The risk of AFF increases with duration of BP use but the beneficial effects of BP therapy in adults ≥50 dramatically exceed this increased risk. Nearly one-third of those with AFF have no BP exposure.
Language	English
Publishing date	2024-01-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgae023
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Uh III Zs.134: Show issues

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Article: Association of Premorbid GLP-1RA and SGLT-2i Prescription Alone and in Combination with COVID-19 Severity.

Klein, Klara R / Abrahamsen, Trine J / Kahkoska, Anna R / Alexander, G Caleb / Chute, Christopher G / Haendel, Melissa / Hong, Stephanie S / Mehta, Hemalkumar / Moffitt, Richard / Stürmer, Til / Kvist, Kajsa / Buse, John B

Diabetes therapy : research, treatment and education of diabetes and related disorders

2024 Volume 15, Issue 5, Page(s) 1169–1186

Abstract: Introduction: People with type 2 diabetes are at heightened risk for severe outcomes related to COVID-19 infection, including hospitalization, intensive care unit admission, and mortality. This study was designed to examine the impact of premorbid use ... ...

Abstract	Introduction: People with type 2 diabetes are at heightened risk for severe outcomes related to COVID-19 infection, including hospitalization, intensive care unit admission, and mortality. This study was designed to examine the impact of premorbid use of glucagon-like peptide-1 receptor agonist (GLP-1RA) monotherapy, sodium-glucose cotransporter-2 inhibitor (SGLT-2i) monotherapy, and concomitant GLP1-RA/SGLT-2i therapy on the severity of outcomes in individuals with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods: Utilizing observational data from the National COVID Cohort Collaborative through September 2022, we compared outcomes in 78,806 individuals with a prescription of GLP-1RA and SGLT-2i versus a prescription of dipeptidyl peptidase 4 inhibitors (DPP-4i) within 24 months of a positive SARS-CoV-2 PCR test. We also compared concomitant GLP-1RA/SGLT-2i therapy to GLP-1RA and SGLT-2i monotherapy. The primary outcome was 60-day mortality, measured from the positive test date. Secondary outcomes included emergency room (ER) visits, hospitalization, and mechanical ventilation within 14 days. Using a super learner approach and accounting for baseline characteristics, associations were quantified with odds ratios (OR) estimated with targeted maximum likelihood estimation (TMLE). Results: Use of GLP-1RA (OR 0.64, 95% confidence interval [CI] 0.56-0.72) and SGLT-2i (OR 0.62, 95% CI 0.57-0.68) were associated with lower odds of 60-day mortality compared to DPP-4i use. Additionally, the OR of ER visits and hospitalizations were similarly reduced with GLP1-RA and SGLT-2i use. Concomitant GLP-1RA/SGLT-2i use showed similar odds of 60-day mortality when compared to GLP-1RA or SGLT-2i use alone (OR 0.92, 95% CI 0.81-1.05 and OR 0.88, 95% CI 0.76-1.01, respectively). However, lower OR of all secondary outcomes were associated with concomitant GLP-1RA/SGLT-2i use when compared to SGLT-2i use alone. Conclusion: Among adults who tested positive for SARS-CoV-2, premorbid use of either GLP-1RA or SGLT-2i is associated with lower odds of mortality compared to DPP-4i. Furthermore, concomitant use of GLP-1RA and SGLT-2i is linked to lower odds of other severe COVID-19 outcomes, including ER visits, hospitalizations, and mechanical ventilation, compared to SGLT-2i use alone. Graphical abstract available for this article.
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2566702-6
ISSN	1869-6961 ; 1869-6953
ISSN (online)	1869-6961
ISSN	1869-6953
DOI	10.1007/s13300-024-01562-1
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Article: Thymectomy in Juvenile Myasthenia Gravis Is Safe Regarding Long Term Immunological Effects.

Popperud, Trine H / Gul, Kiran A / Brunborg, Cathrine / Olaussen, Richard W / Abrahamsen, Tore G / Osnes, Liv T / Kerty, Emila

Frontiers in neurology

2021 Volume 12, Page(s) 596859

Abstract: ... the long-term effects of treatment related thymectomy on T cell subsets and T cell receptor rearrangement ... a significant lower number of naïve helper T cells (CD4+CD45RA+) with an increased proportion of memory helper ... T cells (CD4+CD45RO+), and a significant lower number of naïve cytotoxic T cells (CD8+CD27+CD28+ ...

Abstract	Thymectomy is an established treatment in adult MG and also recommended for the treatment of post-pubertal onset juvenile MG. Whether the youngest children should be thymectomized is still debated. Signs of premature aging of the immune system have been shown in studies on early perioperative thymectomy in children with congenital heart defect. In this retrospective cohort study the objective was to investigate the long-term effects of treatment related thymectomy on T cell subsets and T cell receptor rearrangement excision circles (TRECs) in peripheral blood of juvenile myasthenia gravis (MG) patients, as well as clinical occurrence of autoimmune disorders, malignancies and infectious diseases. Forty-seven patients with onset of myasthenia gravis before the age of 19 years were included; 32 (68.1%) had been thymectomized and 15 (31.8%) had not. They were studied at varying times after thymectomy (7-26 years). We found a significant lower number of naïve helper T cells (CD4+CD45RA+) with an increased proportion of memory helper T cells (CD4+CD45RO+), and a significant lower number of naïve cytotoxic T cells (CD8+CD27+CD28+) in the thymectomized patients. In addition they showed a significant reduction in the number of TRECs and proportion of recent thymic emigrants (RTE) compared to non-thymectomized patients. In none of them an increased frequency of malignancies or infections was found. Our findings indicate a premature aging of the immune system after thymectomy in juvenile MG, but associated clinical consequences could not be verified.
Language	English
Publishing date	2021-02-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2021.596859
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Article ; Online: Addition of Anti-thymocyte Globulin in Allogeneic Stem Cell Transplantation With Peripheral Stem Cells From Matched Unrelated Donors Improves Graft-Versus-Host Disease and Relapse Free Survival.

Ali, M M / Grønvold, B / Remberger, M / Abrahamsen, I W / Myhre, A E / Tjønnfjord, G E / Fløisand, Y / Gedde-Dahl, T

Clinical lymphoma, myeloma & leukemia

2021 Volume 21, Issue 9, Page(s) 598–605

Abstract: Anti-thymocyte globulin (ATG) is commonly used to prevent graft-versus-host disease (GvHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). To evaluate the impact of ATG as part of the GvHD prophylaxis in our institution, we report ... ...

Abstract	Anti-thymocyte globulin (ATG) is commonly used to prevent graft-versus-host disease (GvHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). To evaluate the impact of ATG as part of the GvHD prophylaxis in our institution, we report the outcome of 415 patients with matched unrelated donors (MUD) transplanted for hematological malignancies with or without ATG from 2005 to 2019 at Oslo University Hospital, Norway. The following groups were compared: (1) 154 patients transplanted with peripheral blood stem cells (PBSC) without ATG 2005-2014. (2) 137 patients transplanted with bone marrow stem cells (BMSC) 2005-2019. (3) 124 patients transplanted with PBSC and ATG (PBSC + ATG) 2014-2019. Three years survival was similar in the groups, 61% following allografting with PBSC, 54% with BMSC, and 59% with PBSC + ATG. Acute GvHD grade III-IV was 14%, 14%, and 7%; chronic GvHD was 81%, 32, and 26%; and extensive cGvHD 44%, 15%, and 6% in the corresponding groups. Both acute and chronic GvHD were significantly reduced in the PBSC + ATG-versus the PBSC group (p < 0.05 and p < 0.001 respectively).Transplant-related mortality (TRM) was 33%, 25%, and 17% (p = 0.18). Graft versus host disease and relapse free survival (GRFS) at 3 years was 43 %, 43%, and 64% in the groups. Adding ATG to the GvHD prophylaxis regimen of MUD allo-HSCT with PBSC resulted in a substantial reduction of both acute and chronic GvHD without compromising the disease control, reflected in a superior 3 years GRFS.
MeSH term(s)	Adult ; Antilymphocyte Serum/metabolism ; Disease-Free Survival ; Female ; Graft vs Host Disease ; Hematopoietic Stem Cell Transplantation/methods ; Hematopoietic Stem Cell Transplantation/mortality ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Peripheral Blood Stem Cells/metabolism ; Retrospective Studies ; Transplantation Conditioning/methods ; Transplantation Conditioning/mortality ; Transplantation, Homologous/methods ; Transplantation, Homologous/mortality ; Unrelated Donors
Chemical Substances	Antilymphocyte Serum
Language	English
Publishing date	2021-05-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2540992-X
ISSN	2152-2669 ; 2152-2650
ISSN (online)	2152-2669
ISSN	2152-2650
DOI	10.1016/j.clml.2021.05.003
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Zs.A 5903: Show issues

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Article ; Online: Complement Activation in 22q11.2 Deletion Syndrome.

Grinde, Dina / Øverland, Torstein / Lima, Kari / Schjalm, Camilla / Mollnes, Tom Eirik / Abrahamsen, Tore G

Journal of clinical immunology

2020 Volume 40, Issue 3, Page(s) 515–523

Abstract: The 22q11.2 deletion syndrome (22q11.2 del), also known as DiGeorge syndrome, is a genetic disorder with an estimated incidence of 1:3000 to 1:6000 births. These patients may suffer from affection of many organ systems with cardiac malformations, ... ...

Abstract	The 22q11.2 deletion syndrome (22q11.2 del), also known as DiGeorge syndrome, is a genetic disorder with an estimated incidence of 1:3000 to 1:6000 births. These patients may suffer from affection of many organ systems with cardiac malformations, immunodeficiency, hypoparathyroidism, autoimmunity, palate anomalies, and psychiatric disorders being the most frequent. The importance of the complement system in 22q11.2 del has not been investigated. The objective of this study was to evaluate the complement system in relation to clinical and immunological parameters in patients. A national cohort of patients (n = 69) with a proven heterozygous deletion of chromosome 22q11.2 and a group of age and sex matched controls (n = 56) were studied. Functional capacity of the classical, lectin, and alternative pathways of the complement system as well as complement activation products C3bc and terminal complement complex (TCC) were accessed and correlated to clinical features. All patients in our study had normal complement activation in both classical and alternative pathways. The frequency of mannose-binding lectin deficiency was comparable to the normal population. The patients had significantly raised plasma levels of C3bc and a slight, but not significant, increase in TCC compared with controls. This increase was associated with the presence of psychiatric disorders in patients. The present study shows no complement deficiencies in 22q11.2 deletion syndrome. On the contrary, there are signs of increased complement activation in these patients. Complement activation is particularly associated with the presence of psychiatric disorders.
MeSH term(s)	Adolescent ; Child ; Child, Preschool ; Cohort Studies ; Complement Activation/physiology ; Complement C3b ; Complement Membrane Attack Complex/metabolism ; Complement Pathway, Alternative ; DiGeorge Syndrome/epidemiology ; DiGeorge Syndrome/immunology ; Female ; Humans ; Male ; Mental Disorders/epidemiology ; Norway/epidemiology ; Peptide Fragments/blood ; Up-Regulation
Chemical Substances	C3 beta c ; Complement Membrane Attack Complex ; Peptide Fragments ; Complement C3b (80295-43-8)
Language	English
Publishing date	2020-03-09
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	779361-3
ISSN	1573-2592 ; 0271-9142
ISSN (online)	1573-2592
ISSN	0271-9142
DOI	10.1007/s10875-020-00766-x
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Zs.A 1640: Show issues

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Article ; Online: The Laparoscopic Implantation of Neuroprosthesis Procedure Increases Leg Lean Mass in Individuals With Paraplegia Due To Traumatic Spinal Cord Injury.

Løve, Uffe Schou / Kasch, Helge / Severinsen, Kåre Eg / Abrahamsen, Jan / Høyer, Christian / Forman, Axel / Thomsen, Henrik Holm

Neuromodulation : journal of the International Neuromodulation Society

2022 Volume 26, Issue 8, Page(s) 1802–1807

Abstract: ... postoperative follow-up to determine changes in LM, FM, and BMC. Student paired t-test was used to determine ... significance.: Results: The patients gained 2506 ± 565 g of LM in the legs (p < 0.001), which was an 18 ... total increase in leg LM. Total body LM was significantly increased by 3523 ± 1048 g (p < 0.003). FM was ...

Abstract	Objectives: We hypothesized that the laparoscopic implantation of neuroprosthesis (LION) procedure would significantly alter the body composition of patients with chronic traumatic spinal cord injury (SCI). The objectives were to determine the effect of the LION procedure on lean mass (LM), fatty mass (FM), and bone mineral content (BMC) in patients with SCI. Materials and methods: Five consecutive patients underwent dual-energy x-ray absorptiometry scans before the LION procedure and at the one-year postoperative follow-up to determine changes in LM, FM, and BMC. Student paired t-test was used to determine significance. Results: The patients gained 2506 ± 565 g of LM in the legs (p < 0.001), which was an 18% total increase in leg LM. Total body LM was significantly increased by 3523 ± 1048 g (p < 0.003). FM was unaffected, whereas total BMC showed a small but significant increase of 99 ± 42 g (p = 0.009). Conclusions: The LION procedure and subsequent neurostimulation procedures resulted in substantial increases in leg LM in patients with chronic traumatic SCI and paraplegia. A possible incremental effect on total BMC also was observed. Further studies are needed to confirm and expand these promising results.
MeSH term(s)	Humans ; Leg ; Bone Density/physiology ; Spinal Cord Injuries/complications ; Spinal Cord Injuries/diagnostic imaging ; Spinal Cord Injuries/surgery ; Paraplegia/etiology ; Laparoscopy
Language	English
Publishing date	2022-06-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1500372-3
ISSN	1525-1403 ; 1094-7159
ISSN (online)	1525-1403
ISSN	1094-7159
DOI	10.1016/j.neurom.2022.04.044
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Zs.A 5912: Show issues

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Article ; Online: Lymphocyte Apoptosis and FAS Expression in Patients with 22q11.2 Deletion Syndrome.

Aresvik, Dina M / Øverland, Torstein / Lima, Kari / Pettersen, Rolf D / Abrahamsen, Tore G

Journal of clinical immunology

2018 Volume 39, Issue 1, Page(s) 65–74

Abstract: ... circulating T cells to normal T cell counts. It has been hypothesized that the low number of T ... cells may at least in part be due to increased apoptosis of T cells. Increased spontaneous T cell apoptosis has been ...

Abstract	Purpose: Immunodeficiency is one of the key features of 22q11.2 deletion syndrome (del), and it is seen in approximately 75% of the patients. The degree of immunodeficiency varies widely, from no circulating T cells to normal T cell counts. It has been hypothesized that the low number of T cells may at least in part be due to increased apoptosis of T cells. Increased spontaneous T cell apoptosis has been reported in one patient with 22q11.2del, but this has not been further investigated. Methods: A national cohort of patients with a proven heterozygous deletion of chromosome 22q11.2 diagnosed by FISH or MLPA and a group of age and sex matched controls were studied. Spontaneous and activation-induced apoptosis, in addition to FAS expression on lymphocytes, were measured using flow cytometry. Serum levels of FASL were analyzed using ELISA. Results: There was no increased spontaneous apoptosis in patients with 22q11.2del. Upon activation, anti-FAS-induced apoptosis was significantly increased in patients compared to those in controls, while there was no difference in activation induced cell death or activated cell autonomous death. We also found a significant increase in expression of FAS on freshly isolated lymphocytes from patients, while there was no difference in serum levels of FASL. Patients with congenital heart defects (CHD) had significantly higher serum levels of FASL compared to non-CHD patients. Conclusion: We have shown increased FAS expression on lymphocytes from patients with 22q11.2del as well as increased levels of FASL in patients with CHD. Those changes may contribute to the pathophysiology of the 22q11.2del.
MeSH term(s)	Adolescent ; Apoptosis/immunology ; Child ; Child, Preschool ; Chromosomes, Human, Pair 22/genetics ; Chromosomes, Human, Pair 22/immunology ; DiGeorge Syndrome/genetics ; DiGeorge Syndrome/immunology ; Female ; Humans ; Male ; T-Lymphocytes/immunology ; fas Receptor/genetics
Chemical Substances	FAS protein, human ; fas Receptor
Language	English
Publishing date	2018-12-19
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	779361-3
ISSN	1573-2592 ; 0271-9142
ISSN (online)	1573-2592
ISSN	0271-9142
DOI	10.1007/s10875-018-0579-7
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Zs.A 1640: Show issues

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Article ; Online: High-throughput analysis of T cell-monocyte interaction in human tuberculosis.

Habtamu, M / Abrahamsen, G / Aseffa, A / Andargie, E / Ayalew, S / Abebe, M / Spurkland, A

Clinical and experimental immunology

2020 Volume 201, Issue 2, Page(s) 187–199

Abstract: ... in-vitro assay, which assesses multiple aspects of T cell-monocyte interaction. Here, we extended ... our previous work and characterized communication between T cells and monocytes using clinical samples ... from individuals with different TB infection status and healthy controls from a TB endemic setting. To identify T cell-monocyte ...

Abstract	The lack of efficient tools for identifying immunological correlates of tuberculosis (TB) protection or risk of disease progression impedes the development of improved control strategies. To more clearly understand the host response in TB, we recently established an imaging flow cytometer-based in-vitro assay, which assesses multiple aspects of T cell-monocyte interaction. Here, we extended our previous work and characterized communication between T cells and monocytes using clinical samples from individuals with different TB infection status and healthy controls from a TB endemic setting. To identify T cell-monocyte conjugates, peripheral blood mononuclear cells (PBMC) were stimulated with ds-Red-expressing Mycobacterium bovis bacille Calmette-Guérin or 6-kDa early secreted antigenic target (ESAT 6) peptides for 6 h, and analyzed by imaging flow cytometer (IFC). We then enumerated T cell-monocyte conjugates using polarization of T cell receptor (TCR) and F-actin as markers for synapse formation, and nuclear factor kappa B (NF-κB) nuclear translocation in the T cells. We observed a reduced frequency of T cell-monocyte conjugates in cells from patients with active pulmonary tuberculosis (pTB) compared to latent TB-infected (LTBI) and healthy controls. When we monitored NF-κB nuclear translocation in T cells interacting with monocytes, the proportion of responding cells was significantly higher in active pTB compared with LTBI and controls. Overall, these data underscore the need to consider multiple immunological parameters against TB, where IFC could be a valuable tool.
MeSH term(s)	Actins/metabolism ; Adolescent ; Adult ; Antigens, Bacterial ; Bacterial Proteins ; Cell Communication ; Female ; High-Throughput Screening Assays ; Humans ; Male ; Middle Aged ; Monocytes/immunology ; Mycobacterium bovis/immunology ; Mycobacterium tuberculosis/physiology ; NF-kappa B/metabolism ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/metabolism ; T-Lymphocytes/immunology ; Tuberculosis/immunology ; Young Adult
Chemical Substances	Actins ; Antigens, Bacterial ; Bacterial Proteins ; ESAT-6 protein, Mycobacterium tuberculosis ; NF-kappa B ; Receptors, Antigen, T-Cell
Language	English
Publishing date	2020-05-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218531-3
ISSN	1365-2249 ; 0009-9104 ; 0964-2536
ISSN (online)	1365-2249
ISSN	0009-9104 ; 0964-2536
DOI	10.1111/cei.13447
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Zs.B 337: Show issues

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Article ; Online: T-cell Receptor Excision Circles in Newborns with Heart Defects.

Gul, Kiran A / Strand, Janne / Pettersen, Rolf D / Brun, Henrik / Abrahamsen, Tore G

Pediatric cardiology

2020 Volume 41, Issue 4, Page(s) 809–815

Abstract: ... of the heart. In newborn screening for severe T-cell lymphopenia neonates with congenital heart defects may be ... detected. In this study, we investigated the occurrence of T-cell lymphopenia in neonates with or ... 125 patients with heart defects. T-cell receptor excision circles (TRECs), a measure for T-cell ...

Abstract	In the fetus, the cardiac neural crest gives rise to both the thymus and the conotruncus of the heart. In newborn screening for severe T-cell lymphopenia neonates with congenital heart defects may be detected. In this study, we investigated the occurrence of T-cell lymphopenia in neonates with or without 22q11.2 deletion syndrome (del) suffering from heart defects. This retrospective cohort study included 125 patients with heart defects. T-cell receptor excision circles (TRECs), a measure for T-cell lymphopenia, were quantified by RT-PCR using stored newborn screening blood spots. Three patient groups were compared: non-conotruncal defects (n = 57), conotruncal defects (n = 42), and 22q11.2 del with conotruncal defects (n = 26). Significantly lower TREC values were detected in patients with 22q11.2 del and conotruncal heart defects compared to those with non-syndromic conotruncal (p < 0.001) and non-conotruncal (p < 0.001) defects. In contrast, no significant difference was found between patients with non-syndromic conotruncal and non-conotruncal heart defects (p = 0.152). Low TREC levels were obtained in neonates treated with heart surgery/intervention within 2 weeks after birth and in those with a fatal outcome (p = 0.02) independent of patient group. A correlation was found between low TREC numbers and oxygen saturation, SpO
MeSH term(s)	DiGeorge Syndrome/complications ; DiGeorge Syndrome/diagnosis ; DiGeorge Syndrome/genetics ; Female ; Heart Defects, Congenital/complications ; Heart Defects, Congenital/diagnosis ; Heart Defects, Congenital/genetics ; Humans ; Infant, Newborn ; Male ; Neonatal Screening ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/immunology ; Retrospective Studies
Chemical Substances	Receptors, Antigen, T-Cell
Language	English
Publishing date	2020-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	800857-7
ISSN	1432-1971 ; 0172-0643
ISSN (online)	1432-1971
ISSN	0172-0643
DOI	10.1007/s00246-020-02317-y
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Article ; Online: The CD34

Remberger, M / Grønvold, B / Ali, M / Mattsson, J / Egeland, T / Lundin, K U / Myhre, A / Abrahamsen, I / Heldal, D / Dybedal, I / Tjønnfjord, G E / Gedde-Dahl, T / Fløisand, Y

Clinical hematology international

2020 Volume 2, Issue 2, Page(s) 74–81

Abstract: The effect of ... ...

Abstract	The effect of CD34
Language	English
Publishing date	2020-03-04
Publishing country	France
Document type	Journal Article
ISSN	2590-0048
ISSN (online)	2590-0048
DOI	10.2991/chi.d.200221.001
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In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED