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Article: Flavonoids are promising safe therapy against COVID-19

Alzaabi, Moza Mohamed / Hamdy, Rania / Ashmawy, Naglaa S. / Hamoda, Alshaimaa M. / Alkhayat, Fatemah / Khademi, Neda Naser / Al Joud, Sara Mahmoud Abo / El-Keblawy, Ali A. / Soliman, Sameh S. M.

Phytochemistry reviews. 2022 Feb., v. 21, no. 1

2022

Abstract: Flavonoids are a class of phenolic natural products, well-identified in traditional and modern medicines in the treatment of several diseases including viral infection. Flavonoids showed potential inhibitory activity against coronaviruses including the ... ...

Abstract	Flavonoids are a class of phenolic natural products, well-identified in traditional and modern medicines in the treatment of several diseases including viral infection. Flavonoids showed potential inhibitory activity against coronaviruses including the current pandemic outbreak caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and designated as COVID-19. Here, we have collected all data related to the potential inhibitory mechanisms of flavonoids against SARS-CoV-2 infection and their significant immunomodulatory activities. The data were mapped and compared to elect major flavonoids with a promising role in the current pandemic. Further, we have linked the global existence of flavonoids in medicinal plants and their role in protection against COVID-19. Computational analysis predicted that flavonoids can exhibit potential inhibitory activity against SARS-CoV-2 by binding to essential viral targets required in virus entry and/ or replication. Flavonoids also showed excellent immunomodulatory and anti-inflammatory activities including the inhibition of various inflammatory cytokines. Further, flavonoids showed significant ability to reduce the exacerbation of COVID-19 in the case of obesity via promoting lipids metabolism. Moreover, flavonoids exhibit a high safety profile, suitable bioavailability, and no significant adverse effects. For instance, plants rich in flavonoids are globally distributed and can offer great protection from COVID-19. The data described in this study strongly highlighted that flavonoids particularly quercetin and luteolin can exhibit promising multi-target activity against SARS-CoV-2, which promote their use in the current and expected future outbreaks. Therefore, a regimen of flavonoid-rich plants can be recommended to supplement a sufficient amount of flavonoids for the protection and treatment from SARS-CoV-2 infection.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; bioavailability ; cytokines ; luteolin ; obesity ; pandemic ; quercetin ; therapeutics ; viruses
Language	English
Dates of publication	2022-02
Size	p. 291-312.
Publishing place	Springer Netherlands
Document type	Article
Note	Review
ZDB-ID	2065661-0
ISSN	1572-980X ; 1568-7767
ISSN (online)	1572-980X
ISSN	1568-7767
DOI	10.1007/s11101-021-09759-z
Database	NAL-Catalogue (AGRICOLA)

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Article: Flavonoids are promising safe therapy against COVID-19.

Alzaabi, Moza Mohamed / Hamdy, Rania / Ashmawy, Naglaa S / Hamoda, Alshaimaa M / Alkhayat, Fatemah / Khademi, Neda Naser / Al Joud, Sara Mahmoud Abo / El-Keblawy, Ali A / Soliman, Sameh S M

Phytochemistry reviews : proceedings of the Phytochemical Society of Europe

2021 Volume 21, Issue 1, Page(s) 291–312

Abstract	Flavonoids are a class of phenolic natural products, well-identified in traditional and modern medicines in the treatment of several diseases including viral infection. Flavonoids showed potential inhibitory activity against coronaviruses including the current pandemic outbreak caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and designated as COVID-19. Here, we have collected all data related to the potential inhibitory mechanisms of flavonoids against SARS-CoV-2 infection and their significant immunomodulatory activities. The data were mapped and compared to elect major flavonoids with a promising role in the current pandemic. Further, we have linked the global existence of flavonoids in medicinal plants and their role in protection against COVID-19. Computational analysis predicted that flavonoids can exhibit potential inhibitory activity against SARS-CoV-2 by binding to essential viral targets required in virus entry and/ or replication. Flavonoids also showed excellent immunomodulatory and anti-inflammatory activities including the inhibition of various inflammatory cytokines. Further, flavonoids showed significant ability to reduce the exacerbation of COVID-19 in the case of obesity via promoting lipids metabolism. Moreover, flavonoids exhibit a high safety profile, suitable bioavailability, and no significant adverse effects. For instance, plants rich in flavonoids are globally distributed and can offer great protection from COVID-19. The data described in this study strongly highlighted that flavonoids particularly quercetin and luteolin can exhibit promising multi-target activity against SARS-CoV-2, which promote their use in the current and expected future outbreaks. Therefore, a regimen of flavonoid-rich plants can be recommended to supplement a sufficient amount of flavonoids for the protection and treatment from SARS-CoV-2 infection.
Language	English
Publishing date	2021-05-22
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2065661-0
ISSN	1572-980X ; 1568-7767
ISSN (online)	1572-980X
ISSN	1568-7767
DOI	10.1007/s11101-021-09759-z
Database	MEDical Literature Analysis and Retrieval System OnLINE