Article ; Online: Flavonols as potential antiviral drugs targeting SARS-CoV-2 proteases (3CL
European journal of pharmacology
2020 Volume 891, Page(s) 173759
Abstract: The novel coronavirus outbreak (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents the actual greatest global public health crisis. The lack of efficacious drugs and vaccines against this viral infection created a ...
Abstract | The novel coronavirus outbreak (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents the actual greatest global public health crisis. The lack of efficacious drugs and vaccines against this viral infection created a challenge for scientific researchers in order to find effective solutions. One of the promising therapeutic approaches is the search for bioactive molecules with few side effects that display antiviral properties in natural sources like medicinal plants and vegetables. Several computational and experimental studies indicated that flavonoids especially flavonols and their derivatives constitute effective viral enzyme inhibitors and possess interesting antiviral activities. In this context, the present study reviews the efficacy of many dietary flavonols as potential antiviral drugs targeting the SARS-CoV-2 enzymes and proteins including Chymotrypsin-Like Protease (3CL |
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MeSH term(s) | Angiotensin-Converting Enzyme 2/metabolism ; Antiviral Agents/pharmacology ; COVID-19/drug therapy ; COVID-19/metabolism ; Coronavirus 3C Proteases/metabolism ; Coronavirus RNA-Dependent RNA Polymerase/metabolism ; Drug Development ; Flavonols/pharmacology ; Humans ; Phytochemicals/pharmacology ; SARS-CoV-2/drug effects ; SARS-CoV-2/physiology ; Spike Glycoprotein, Coronavirus/metabolism |
Chemical Substances | Antiviral Agents ; Flavonols ; Phytochemicals ; Spike Glycoprotein, Coronavirus ; Coronavirus RNA-Dependent RNA Polymerase (EC 2.7.7.48) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; 3C-like protease, SARS coronavirus (EC 3.4.22.-) ; 3C-like proteinase, SARS-CoV-2 (EC 3.4.22.-) ; Coronavirus 3C Proteases (EC 3.4.22.28) |
Language | English |
Publishing date | 2020-11-27 |
Publishing country | Netherlands |
Document type | Journal Article ; Review |
ZDB-ID | 80121-5 |
ISSN | 1879-0712 ; 0014-2999 |
ISSN (online) | 1879-0712 |
ISSN | 0014-2999 |
DOI | 10.1016/j.ejphar.2020.173759 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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