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  1. Article ; Online: Editorial: Role of hypoxia-inducible factors in metabolic immune cell adaptation during sepsis.

    Del Fresno, Carlos / Schulte, Leon Nicolas / López-Collazo, Eduardo

    Frontiers in immunology

    2023  Volume 14, Page(s) 1194504

    MeSH term(s) Humans ; Sepsis ; Inflammation ; Adaptation, Physiological ; Hypoxia
    Language English
    Publishing date 2023-04-18
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1194504
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Myeloid cells in sensing of tissue damage.

    Del Fresno, Carlos / Sancho, David

    Current opinion in immunology

    2020  Volume 68, Page(s) 34–40

    Abstract: Myeloid cells are components of the innate immune system that represent the first line of defense. Tissue damage, associated with pathological conditions such as infection, cancer or autoimmunity, leads to the exposure of the intracellular content to the ...

    Abstract Myeloid cells are components of the innate immune system that represent the first line of defense. Tissue damage, associated with pathological conditions such as infection, cancer or autoimmunity, leads to the exposure of the intracellular content to the extracellular environment. Myeloid cells detect ligands exposed or released by dead cells through specific receptors that signal for a diversity of responses. Inflammatory responses triggered by myeloid cells after sensing tissue injury can contribute to resolution of the damage. The signaling response following dead-cell sensing by myeloid cells can contribute either to an inflammatory or a regulatory response. We review herein some representative examples of how myeloid cells react to the recognition of cell death during specific tissue damage contexts. A deep understanding of the cellular and molecular mechanisms underlying these processes would allow to improve therapeutical interventions in pathologies associated with tissue damage.
    MeSH term(s) Animals ; Cell Death/immunology ; Humans ; Immunity, Innate/immunology ; Myeloid Cells/immunology ; Myeloid Cells/pathology ; Signal Transduction/immunology
    Keywords covid19
    Language English
    Publishing date 2020-10-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2020.08.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2773: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 13: Show issues

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  3. Article ; Online: cDC1s: New Orchestrators of Tissue Innate Immunity.

    Del Fresno, Carlos / Sancho, David

    Trends in immunology

    2019  Volume 40, Issue 7, Page(s) 559–561

    Abstract: Type-I conventional dendritic cells (cDC1s) are key in inducing adaptive immunity. Using single-cell sequencing, Ginhoux and colleagues (Immunity 2019;50:1069-1083.e8) find that a subset of activated cDC1s in bacteria-infected skin is critical for ... ...

    Abstract Type-I conventional dendritic cells (cDC1s) are key in inducing adaptive immunity. Using single-cell sequencing, Ginhoux and colleagues (Immunity 2019;50:1069-1083.e8) find that a subset of activated cDC1s in bacteria-infected skin is critical for neutrophil recruitment via the production of VEGF-α. These results reveal a crucial function for cDC1s beyond antigen presentation.
    MeSH term(s) Antigen Presentation ; Bacterial Infections ; Dendritic Cells ; Humans ; Immunity, Innate ; Neutrophils
    Language English
    Publishing date 2019-05-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2019.05.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1601: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 2: Show issues

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  4. Article ; Online: Clec2d Joins the Cell Death Sensor Ranks.

    Del Fresno, Carlos / Sancho, David

    Immunity

    2019  Volume 52, Issue 1, Page(s) 6–8

    Abstract: Sensing tissue damage is an ancient function of immune cells that is central to the regulation of inflammation, tissue repair, and immunity. In this issue of Immunity, Lai et al. (2020) uncover a role for the C-type lectin receptor Clec2d as a sensor of ... ...

    Abstract Sensing tissue damage is an ancient function of immune cells that is central to the regulation of inflammation, tissue repair, and immunity. In this issue of Immunity, Lai et al. (2020) uncover a role for the C-type lectin receptor Clec2d as a sensor of cell death, which directly detects histones released during necrosis and thus contributes to inflammation and immunopathology.
    MeSH term(s) Cell Death ; Histones ; Humans ; Inflammation ; Lectins, C-Type ; Necrosis ; Receptors, Cell Surface
    Chemical Substances CLEC2D protein, human ; Histones ; Lectins, C-Type ; Receptors, Cell Surface
    Language English
    Publishing date 2019-12-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2019.12.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 69: Show issues

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  5. Article ; Online: Dectin-1 Signaling Update: New Perspectives for Trained Immunity.

    Mata-Martínez, Pablo / Bergón-Gutiérrez, Marta / Del Fresno, Carlos

    Frontiers in immunology

    2022  Volume 13, Page(s) 812148

    Abstract: The C-type lectin receptor Dectin-1 was originally described as the β-glucan receptor expressed in myeloid cells, with crucial functions in antifungal responses. However, over time, different ligands both of microbial-derived and endogenous origin have ... ...

    Abstract The C-type lectin receptor Dectin-1 was originally described as the β-glucan receptor expressed in myeloid cells, with crucial functions in antifungal responses. However, over time, different ligands both of microbial-derived and endogenous origin have been shown to be recognized by Dectin-1. The outcomes of this recognition are diverse, including pro-inflammatory responses such as cytokine production, reactive oxygen species generation and phagocytosis. Nonetheless, tolerant responses have been also attributed to Dectin-1, depending on the specific ligand engaged. Dectin-1 recognition of their ligands triggers a plethora of downstream signaling pathways, with complex interrelationships. These signaling routes can be modulated by diverse factors such as phosphatases or tetraspanins, resulting either in pro-inflammatory or regulatory responses. Since its first depiction, Dectin-1 has recently gained a renewed attention due to its role in the induction of trained immunity. This process of long-term memory of innate immune cells can be triggered by β-glucans, and Dectin-1 is crucial for its initiation. The main signaling pathways involved in this process have been described, although the understanding of the above-mentioned complexity in the β-glucan-induced trained immunity is still scarce. In here, we have reviewed and updated all these factors related to the biology of Dectin-1, highlighting the gaps that deserve further research. We believe on the relevance to fully understand how this receptor works, and therefore, how we could harness it in different pathological conditions as diverse as fungal infections, autoimmunity, or cancer.
    MeSH term(s) Lectins, C-Type/metabolism ; Ligands ; Phagocytosis ; Signal Transduction ; beta-Glucans
    Chemical Substances Lectins, C-Type ; Ligands ; beta-Glucans ; dectin 1
    Language English
    Publishing date 2022-02-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.812148
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Candida albicans triggers a differential profile of microRNAs depending on its growing form.

    Del Fresno Sánchez, Carlos

    Virulence

    2017  Volume 8, Issue 1, Page(s) 8–10

    Language English
    Publishing date 2017-01-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2657572-3
    ISSN 2150-5608 ; 2150-5594
    ISSN (online) 2150-5608
    ISSN 2150-5594
    DOI 10.1080/21505594.2016.1214794
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: DNGR-1, a Dendritic Cell-Specific Sensor of Tissue Damage That Dually Modulates Immunity and Inflammation.

    Cueto, Francisco J / Del Fresno, Carlos / Sancho, David

    Frontiers in immunology

    2020  Volume 10, Page(s) 3146

    Abstract: DNGR-1 (encoded ... ...

    Abstract DNGR-1 (encoded by
    MeSH term(s) Animals ; Cross-Priming/immunology ; Dendritic Cells/immunology ; Humans ; Immune Tolerance/immunology ; Inflammation/immunology ; Lectins, C-Type/immunology ; Receptors, Immunologic/immunology
    Chemical Substances Lectins, C-Type ; Receptors, Immunologic
    Language English
    Publishing date 2020-02-07
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.03146
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Heat-killed

    Minute, Luna / Bergón-Gutiérrez, Marta / Mata-Martínez, Pablo / Fernández-Pascual, Jaime / Terrón, Verónica / Bravo-Robles, Laura / Bıçakcıoğlu, Gülce / Zapata-Fernández, Gabriela / Aguiló, Nacho / López-Collazo, Eduardo / Del Fresno, Carlos

    iScience

    2024  Volume 27, Issue 2, Page(s) 108869

    Abstract: Trained immunity (TI) represents a memory-like process of innate immune cells. TI can be initiated with various compounds such as fungal β-glucan or the tuberculosis vaccine, Bacillus Calmette-Guérin. Nevertheless, considering the clinical applications ... ...

    Abstract Trained immunity (TI) represents a memory-like process of innate immune cells. TI can be initiated with various compounds such as fungal β-glucan or the tuberculosis vaccine, Bacillus Calmette-Guérin. Nevertheless, considering the clinical applications of harnessing TI against infections and cancer, there is a growing need for new, simple, and easy-to-use TI inducers. Here, we demonstrate that heat-killed
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.108869
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Dectin-1 embraces Candida glabrata.

    Del Fresno Sánchez, Carlos

    Virulence

    2017  Volume 8, Issue 8, Page(s) 1478–1480

    MeSH term(s) Candida ; Candida glabrata ; Candidiasis ; Humans ; Lectins, C-Type
    Chemical Substances Lectins, C-Type ; dectin 1
    Language English
    Publishing date 2017-08-24
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2657572-3
    ISSN 2150-5608 ; 2150-5594
    ISSN (online) 2150-5608
    ISSN 2150-5594
    DOI 10.1080/21505594.2017.1358350
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Sensing Tissue Damage by Myeloid C-Type Lectin Receptors.

    Del Fresno, Carlos / Cueto, Francisco J / Sancho, David

    Current topics in microbiology and immunology

    2020  Volume 429, Page(s) 117–145

    Abstract: After both sterile and infectious insults, damage is inflicted on tissues leading to accidental or programmed cell death. In addition, events of programmed cell death also take place under homeostatic conditions, such as in embryo development or in the ... ...

    Abstract After both sterile and infectious insults, damage is inflicted on tissues leading to accidental or programmed cell death. In addition, events of programmed cell death also take place under homeostatic conditions, such as in embryo development or in the turnover of hematopoietic cells. Mammalian tissues are seeded with myeloid immune cells, which harbor a plethora of receptors that allow the detection of cell death, modulating immune responses. The myeloid C-type lectin receptors (CLRs) are one of the most prominent families of receptors involved in tailoring immunity after sensing dead cells. In this chapter, we will cover a diversity of signals arising from different forms of cell death and how they are recognized by myeloid CLRs. We will also explore how myeloid cells develop their sentinel function, exploring how some of these CLRs identify cell death and the type of responses triggered thereof. In particular, we will focus on DNGR-1 (CLEC9A), Mincle (CLEC4E), CLL-1 (CLEC12A), LOX-1 (OLR1), CD301 (CLEC10A) and DEC-205 (LY75) as paradigmatic death-sensing CLRs expressed by myeloid cells. The molecular processes triggered after cell death recognition by myeloid CLRs contribute to the regulation of immune responses in pathologies associated with tissue damage, such as infection, autoimmunity and cancer. A better understanding of these processes may help to improve the current approaches for therapeutic intervention.
    MeSH term(s) Animals ; Apoptosis ; Homeostasis ; Lectins, C-Type/genetics ; Myeloid Cells
    Chemical Substances Lectins, C-Type
    Language English
    Publishing date 2020-01-23
    Publishing country Germany
    Document type Journal Article
    ISSN 0070-217X
    ISSN 0070-217X
    DOI 10.1007/82_2019_194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Einzelsignatur: Show issues

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