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Article ; Online: Enhanced Mucoadhesion of Thiolated β-Cyclodextrin by S-Protection with 2-Mercaptoethanesulfonic Acid.

Kali, Gergely / Taha, Ali Magdi Mahmoud Mahmoud / Campanella, Emiliano / Truszkowska, Martyna / Haddadzadegan, Soheil / Denora, Nunzio / Bernkop-Schnürch, Andreas

ACS omega

2024 Volume 9, Issue 5, Page(s) 5819–5828

Abstract: This study aimed at designing an S-protected thiolated β-cyclodextrin (β-CD) exhibiting enhanced ... CD (β-CD-SH) and subsequently S-protected with 2-mercaptoethanesulfonate (MESNA) to form β-CD-SS ...

Abstract	This study aimed at designing an S-protected thiolated β-cyclodextrin (β-CD) exhibiting enhanced mucoadhesive properties. The native β-CD was thiolated with phosphorus pentasulfide resulting in a thiolated β-CD (β-CD-SH) and subsequently S-protected with 2-mercaptoethanesulfonate (MESNA) to form β-CD-SS-MESNA. The structure of the novel excipient was confirmed by
Language	English
Publishing date	2024-01-26
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c08836
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Article: Phylogenetic comparative analysis: Chemical and biological features of caseins (alpha-S-1, alpha-S-2, beta- and kappa-) in domestic dairy animals.

Hassanin, Abdallah A / Osman, Ali / Atallah, Osama Osman / El-Saadony, Mohamed T / Abdelnour, Sameh A / Taha, Heba S A / Awad, Mohamed F / Elkashef, Hany / Ahmed, Ahmed Ezzat / Abd El-Rahim, Ibrahim / Mohamed, Abdullah / Eldomiaty, Ahmed S

Frontiers in veterinary science

2022 Volume 9, Page(s) 952319

Abstract: ... caseins-alpha-S-1, alpha-S-2, beta, and kappa-were analyzed phylogenetically and ...

Abstract	Caseins determine the physicochemical, physiological, and biological characteristics of milk. Four caseins-alpha-S-1, alpha-S-2, beta, and kappa-were analyzed phylogenetically and
Language	English
Publishing date	2022-09-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2022.952319
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Article ; Online: Acute epiglottitis: Analysis of U.S. mortality trends from 1979 to 2017.

Allen, Meredith / Meraj, Taha S / Oska, Sandra / Spillinger, Aviv / Folbe, Adam J / Cramer, John D

American journal of otolaryngology

2021 Volume 42, Issue 2, Page(s) 102882

Abstract: Purpose: Evaluate trends in mortality due to acute epiglottitis before and after adoption of Haemophilus influenza Type b vaccination (Hib) in pediatric and adult populations.: Materials and methods: Patients who died from acute epiglottis from 1979 ... ...

Abstract	Purpose: Evaluate trends in mortality due to acute epiglottitis before and after adoption of Haemophilus influenza Type b vaccination (Hib) in pediatric and adult populations. Materials and methods: Patients who died from acute epiglottis from 1979 to 2017 identified using National Vital Statistics System. Mortality rates calculated using age-adjusted US census data expressed in rate per 100,000 individuals. Trends analyzed using the National Cancer Institute Joinpoint Regression Program (version 4.7.0; Bethesda, Maryland). Results: 1187 epiglottitis-related deaths were identified over thirty-nine years. Total deaths decreased from 65 in 1979 to 15 in 2017. Adult deaths accounted for 63.5% and decreased from 0.015 per 100,000 individuals (24 deaths) in 1979 to 0.006 per 100,000 individuals (14 deaths) in 2017. Best fitting log-liner regression model showed APC of -3.5% (95% CI, -4.2 to -2.7%) from 1979 to 2017. Pediatric and adolescent deaths accounted for 443 (37.3%) deaths, decreasing from 0.064 per 100,000 individuals (41 deaths) in 1979 to 0.001 per 100,000 individuals (1 death) in 2017. APC was -11.1% (95% CI, -13.8% to -8.3%) in 1979 to 1990; 46.5% (95% CI, -16.6% to 157.3%) in 1990 to 1993; -61.6% (95% CI, -88% to 23%) in 1993 to 1996; and 1.1% (95% CI, -2.4% to 4.7%) in 1996 to 2017. Conclusions: Mortality from acute epiglottitis decreased after widespread adoption of Hib vaccination in the US. Adults are now more likely than children to die of acute epiglottitis. Further research including multi-institutional cohort studies must be done to elucidate causative factors contributing to remaining cases of mortality.
MeSH term(s)	Acute Disease ; Adolescent ; Adult ; Child ; Child, Preschool ; Epiglottitis/mortality ; Epiglottitis/prevention & control ; Female ; Haemophilus Vaccines ; Haemophilus influenzae type b ; Humans ; Incidence ; Infant ; Male ; Middle Aged ; Time Factors ; United States/epidemiology ; Vaccination ; Young Adult
Chemical Substances	Haemophilus Vaccines
Language	English
Publishing date	2021-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	604541-8
ISSN	1532-818X ; 0196-0709
ISSN (online)	1532-818X
ISSN	0196-0709
DOI	10.1016/j.amjoto.2020.102882
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Article ; Online: How was the SME’s Performance in Oman during Covid-19?

Atallah Firas Al Taha

International Journal of Economics and Financial Issues, Vol 14, Iss

2024 Volume 1

Abstract: The paper examines the performance and the challenges faced by SMEs in Oman during Covid-19. The data was collected through primary and secondary sources. A questionnaire of 100 respondents was used. Descriptive analysis and chi-squared test have been ... ...

Abstract	The paper examines the performance and the challenges faced by SMEs in Oman during Covid-19. The data was collected through primary and secondary sources. A questionnaire of 100 respondents was used. Descriptive analysis and chi-squared test have been employed in the data analysis. The main findings of the study showed despite the adverse effect of the pandame, the SMEs in Oman have performed well and indicated a resilient and adaptable strategy to cope wth the virus. The reason for this could be attributed to their ability to quickly transition to remote work and online operations. During such a challenging period, some businesses managed to thrive due to their ability to identify opportunities and leverage them. Moreover, the study revealed that financial stability and preparedness are key to navigating the pandemic's uncertainties, as businesses focus on risk management, budget planning, and saving money. In response to unexpected disruptions, businesses have become more cautious and strategic in their financial decisions. SME resilience against future crises is enhanced as a result of SMEs adopting more prudent financial practices. The key challenges faced by SMEs during Covid-19 included delivery delays, reduced income for consumers, and regulation changes. The SMEs in Oman devised severalrisk management strategies, such as maintaining backup plans and setting aside funds, reflect a forward-thinking approach. The findings indicate that businesses in Oman are actively seeking ways to minimize disruptions to their operations and mitigate potential risks. Long-term resilience can be built by such strategic thinking.
Keywords	Business ; HF5001-6182 ; Economics as a science ; HB71-74
Subject code	650
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	EconJournals
Document type	Article ; Online
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Article ; Online: A computational approach to rapidly design peptides that detect SARS-CoV-2 surface protein S.

Hajikarimlou, Maryam / Hooshyar, Mohsen / Moutaoufik, Mohamed Taha / Aly, Khaled A / Azad, Taha / Takallou, Sarah / Jagadeesan, Sasi / Phanse, Sadhna / Said, Kamaledin B / Samanfar, Bahram / Bell, John C / Dehne, Frank / Babu, Mohan / Golshani, Ashkan

NAR genomics and bioinformatics

2022 Volume 4, Issue 3, Page(s) lqac058

Abstract: ... experimentally validate peptides that bind to SARS-CoV-2 spike (S) surface protein. We previously showed ... that two sets of peptides developed using InSiPS method can detect purified SARS-CoV-2 S protein via ELISA ...

Abstract	The coronavirus disease 19 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) prompted the development of diagnostic and therapeutic frameworks for timely containment of this pandemic. Here, we utilized our non-conventional computational algorithm, InSiPS, to rapidly design and experimentally validate peptides that bind to SARS-CoV-2 spike (S) surface protein. We previously showed that this method can be used to develop peptides against yeast proteins, however, the applicability of this method to design peptides against other proteins has not been investigated. In the current study, we demonstrate that two sets of peptides developed using InSiPS method can detect purified SARS-CoV-2 S protein via ELISA and Surface Plasmon Resonance (SPR) approaches, suggesting the utility of our strategy in real time COVID-19 diagnostics. Mass spectrometry-based salivary peptidomics shortlist top SARS-CoV-2 peptides detected in COVID-19 patients' saliva, rendering them attractive SARS-CoV-2 diagnostic targets that, when subjected to our computational platform, can streamline the development of potent peptide diagnostics of SARS-CoV-2 variants of concern. Our approach can be rapidly implicated in diagnosing other communicable diseases of immediate threat.
Language	English
Publishing date	2022-08-22
Publishing country	England
Document type	Journal Article
ISSN	2631-9268
ISSN (online)	2631-9268
DOI	10.1093/nargab/lqac058
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Article ; Online: New poly(ether-phosphoramide)s sulfides based on green resources as sensitive films for the specific impedimetric detection of nickel ions.

Chabbah, Taha / Chatti, Saber / Zouaoui, Fares / Jlalia, Ibtissem / Gaiji, Houda / Abderrazak, Houyem / Casabianca, Hervé / Mercier, Régis / Weidner, Steffen M / Errachid, Abdelhamid / Marestin, Catherine / Jaffrezic-Renault, Nicole

Talanta

2022 Volume 247, Page(s) 123550

Abstract: ... by nucleophilic substitution reaction of P(S)-Cl compound. The resulting polymers were characterized by different ...

Abstract	For the development of selective and sensitive chemical sensors, we have developed a new family of poly(ether-phosphoramide) polymers. These polymers were obtained with satisfactory yields by nucleophilic aromatic polycondensation using isosorbide as green resources, and bisphenol A with two novel difluoro phosphinothioic amide monomers. Unprecedented, the thiophosphorylated aminoheterocycles monomers, functionalized with two heterocyclic amine, N-methylpiperazine and morpholine were successfully obtained by nucleophilic substitution reaction of P(S)-Cl compound. The resulting polymers were characterized by different analytical techniques (NMR, MALDI-ToF MS, GPC, DSC, and ATG). The resulting partially green polymers, having tertiary phosphine sulfide with P-N side chain functionalities along the main chain of polymers are the sensitive film at the surface of a gold electrode for the impedimetric detection of Cd, Ni, Pb and Hg. The bio-based poly(ether-phosphoramide) functionalized with N-methylpiperazine modified sensor showed better analytical performance than petrochemical based polymers for the detection of Ni
MeSH term(s)	Biosensing Techniques/methods ; Electrochemical Techniques/methods ; Electrodes ; Ether ; Ethers ; Limit of Detection ; Nickel/chemistry ; Phosphoramides ; Polymers/chemistry ; Sulfides
Chemical Substances	Ethers ; Phosphoramides ; Polymers ; Sulfides ; Ether (0F5N573A2Y) ; Nickel (7OV03QG267)
Language	English
Publishing date	2022-05-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2022.123550
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Article ; Online: A Response to “Patient’s Perceptions and Attitudes Towards Medical Student’s Involvement in Their Healthcare at a Teaching Hospital in Jordan

Taha HA / Nawaiseh MB

Patient Preference and Adherence, Vol Volume 17, Pp 1159-

A Cross Sectional Study” [Response to Letter]

2023 Volume 1160

Abstract: Hana Ahmad Taha,1–3 Mohammed Bassam Nawaiseh4 1Department of Pharmacology, Public Health, and ... Services, Amman, 11855, JordanCorrespondence: Hana Ahmad Taha, Department of Pharmacology, Public Health ...

Abstract	Hana Ahmad Taha,1–3 Mohammed Bassam Nawaiseh4 1Department of Pharmacology, Public Health, and Clinical Skills, Faculty of Medicine, The Hashemite University, Zarqa, 13133, Jordan; 2Department of Family and Community Medicine, School of Medicine, The University of Jordan, Amman, 11942, Jordan; 3Department of Neurobiology, Caring Science and Society, Karolinska Institutet, Huddinge, 141 52, Sweden; 4Jordanian Royal Medical Services, Amman, 11855, JordanCorrespondence: Hana Ahmad Taha, Department of Pharmacology, Public Health, and Clinical Skills, Faculty of Medicine, The Hashemite University, P. O. Box 330127, Zarqa, 13133, Jordan, Tel +962-5-3903333, Email hanagh@yahoo.com
Keywords	Medicine (General) ; R5-920
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Dove Medical Press
Document type	Article ; Online
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Article: In-hospital outcomes of transapical versus surgical aortic valve replacement: from the U.S. national inpatient sample.

Abugroun, Ashraf / Hallak, Osama / Taha, Ahmed / Sanchez-Nadales, Alejandro / Awadalla, Saria / Daoud, Hussein / Igbinomwanhia, Efehi / Klein, Lloyd W

Journal of geriatric cardiology : JGC

2021 Volume 18, Issue 9, Page(s) 702–710

Abstract: ... and surgical aortic valve replacement (SAVR) using a large US population sample.: Methods: The U.S ...

Abstract	Objective: To compare the outcomes of transapical transcatheter aortic valve replacement (TA-TAVR) and surgical aortic valve replacement (SAVR) using a large US population sample. Methods: The U.S. National Inpatient Sample was queried for all patients who underwent TA-TAVR or SAVR during the years 2016-2017. The primary outcome was all-cause in-hospital mortality. Secondary outcomes were in-hospital stroke, pericardiocentesis, pacemaker insertion, mechanical ventilation, vascular complications, major bleeding, acute kidney injury, length of stay, and cost of hospitalization. Outcomes were modeled using multi-variable logistic regression for binary outcomes and generalized linear models for continuous outcomes. Results: A total of 1560 TA-TAVR and 44,280 SAVR patients were included. Patients who underwent TA-TAVR were older and frailer. Compared to SAVR, TA-TAVR correlated with a higher mortality (4.5% Conclusion: The risk-adjusted analysis showed that TA-TAVR has no advantage over SAVR except for patients with chronic lung disease where TA-TAVR has higher mortality.
Language	English
Publishing date	2021-09-29
Publishing country	China
Document type	Journal Article
ZDB-ID	2421391-3
ISSN	1671-5411
ISSN	1671-5411
DOI	10.11909/j.issn.1671-5411.2021.09.005
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Article ; Online: Nanoluciferase complementation-based bioreporter reveals the importance of N-linked glycosylation of SARS-CoV-2 S for viral entry.

Azad, Taha / Singaravelu, Ragunath / Taha, Zaid / Jamieson, Taylor R / Boulton, Stephen / Crupi, Mathieu J F / Martin, Nikolas T / Fekete, Emily E F / Poutou, Joanna / Ghahremani, Mina / Pelin, Adrian / Nouri, Kazem / Rezaei, Reza / Marshall, Christopher Boyd / Enomoto, Masahiro / Arulanandam, Rozanne / Alluqmani, Nouf / Samson, Reuben / Gingras, Anne-Claude /

Cameron, D William / Greer, Peter A / Ilkow, Carolina S / Diallo, Jean-Simon / Bell, John C

Molecular therapy : the journal of the American Society of Gene Therapy

2021 Volume 29, Issue 6, Page(s) 1984–2000

Abstract: ... bioreporter to interrogate the interaction between the SARS-CoV-2 viral spike (S) protein and its host entry ... reporter, composed of two subunits, large BiT and small BiT, fused to the S receptor-binding domain (RBD ... of the SARS-CoV-2 S protein and ACE2 ectodomain, respectively. Using this bioreporter, we uncovered critical ...

Abstract	The ongoing COVID-19 pandemic has highlighted the immediate need for the development of antiviral therapeutics targeting different stages of the SARS-CoV-2 life cycle. We developed a bioluminescence-based bioreporter to interrogate the interaction between the SARS-CoV-2 viral spike (S) protein and its host entry receptor, angiotensin-converting enzyme 2 (ACE2). The bioreporter assay is based on a nanoluciferase complementation reporter, composed of two subunits, large BiT and small BiT, fused to the S receptor-binding domain (RBD) of the SARS-CoV-2 S protein and ACE2 ectodomain, respectively. Using this bioreporter, we uncovered critical host and viral determinants of the interaction, including a role for glycosylation of asparagine residues within the RBD in mediating successful viral entry. We also demonstrate the importance of N-linked glycosylation to the RBD's antigenicity and immunogenicity. Our study demonstrates the versatility of our bioreporter in mapping key residues mediating viral entry as well as screening inhibitors of the ACE2-RBD interaction. Our findings point toward targeting RBD glycosylation for therapeutic and vaccine strategies against SARS-CoV-2.
MeSH term(s)	Angiotensin-Converting Enzyme 2/antagonists & inhibitors ; Angiotensin-Converting Enzyme 2/chemistry ; Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/immunology ; Antibodies, Neutralizing/pharmacology ; Asparagine/chemistry ; Asparagine/metabolism ; Binding Sites ; Biological Assay ; COVID-19/diagnosis ; COVID-19/immunology ; COVID-19/virology ; Genes, Reporter ; Glycosylation/drug effects ; HEK293 Cells ; Host-Pathogen Interactions/drug effects ; Host-Pathogen Interactions/genetics ; Humans ; Lectins/pharmacology ; Luciferases/genetics ; Luciferases/metabolism ; Luminescent Measurements ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Structure, Secondary ; Receptors, Virus/antagonists & inhibitors ; Receptors, Virus/chemistry ; Receptors, Virus/genetics ; Receptors, Virus/immunology ; SARS-CoV-2/drug effects ; SARS-CoV-2/growth & development ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/antagonists & inhibitors ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology ; Virus Internalization/drug effects ; COVID-19 Drug Treatment
Chemical Substances	Antibodies, Neutralizing ; Lectins ; Receptors, Virus ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Asparagine (7006-34-0) ; Luciferases (EC 1.13.12.-) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Language	English
Publishing date	2021-02-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2010592-7
ISSN	1525-0024 ; 1525-0016
ISSN (online)	1525-0024
ISSN	1525-0016
DOI	10.1016/j.ymthe.2021.02.007
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Article ; Online: Patient’s Perceptions and Attitudes Towards Medical Student’s Involvement in Their Healthcare at a Teaching Hospital in Jordan

Taha HA / Al Saqer JK / Al Harbi NR / Younis RN / Al Dawoud F / Nawaiseh MB / Berggren V

Patient Preference and Adherence, Vol Volume 17, Pp 629-

A Cross Sectional Study

2023 Volume 641

Abstract: ... care varies according to patient’s willingness, as some might consider it a privacy invasion ... Hana Ahmad Taha,1– 3 Jawaher Khaled Al Saqer,2 Noora Rashed Al Harbi,2 Rand Nidal Younis,2 Fatma Al ... Services, Amman, 11855, JordanCorrespondence: Hana Ahmad Taha, Department of Pharmacology, Public Health ...

Abstract	Hana Ahmad Taha,1– 3 Jawaher Khaled Al Saqer,2 Noora Rashed Al Harbi,2 Rand Nidal Younis,2 Fatma Al Dawoud,2 Mohammed Bassam Nawaiseh,4 Vanja Berggren3 1Department of Pharmacology, Public Health, and Clinical Skills, Faculty of Medicine, The Hashemite University, Zarqa, 13133, Jordan; 2Department of Family and Community Medicine, School of Medicine, The University of Jordan, Amman, 11942, Jordan; 3Department of Neurobiology, Caring Science and Society, Karolinska Institutet, Huddinge, 141 52, Sweden; 4Jordanian Royal Medical Services, Amman, 11855, JordanCorrespondence: Hana Ahmad Taha, Department of Pharmacology, Public Health, and Clinical Skills, Faculty of Medicine, The Hashemite University, P.O. Box 330127, Zarqa, 13133, Jordan, Tel +962-5-3903333, Email hanagh@yahoo.comBackground: Medical students’ involvement in patients’ care varies according to patient’s willingness, as some might consider it a privacy invasion. Thus, exploring patients’ perceptions and attitudes towards this interaction should be thoroughly investigated, to better understand it and to provide evidence-based data for improving the training of future doctors.Methods: A cross-sectional study was conducted at Jordan University Hospital. A questionnaire was answered by 420 patients from the out-patients’ clinics.Results: Of the patients interviewed, 94% were aware that they were in a teaching hospital, 92% approved the presence of medical students during their consultation and 80% accepted to be observed and examined by medical students in the presence of a senior doctor. However, this decreased to 30.5% if there was no senior doctor. Almost 83% of the patients believed that their consent should be obtained first. However, only 58% of them indicated that the student asked for consent prior to interacting with them. Patients who were more likely to approve the existence of medical students during consultation and allow students to perform procedures on them, respectively, were those who were asked for consent by students (P = 0.001 and P = ...
Keywords	students ; medical ; education ; undergraduate ; curriculum ; teaching hospital ; patient perception ; Medicine (General) ; R5-920
Subject code	170
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Dove Medical Press
Document type	Article ; Online
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