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  1. Article ; Online: Immune damage in Long Covid.

    Ruf, Wolfram

    Science (New York, N.Y.)

    2024  Volume 383, Issue 6680, Page(s) 262–263

    Abstract: Links between the complement and coagulation systems could lead to Long Covid therapies. ...

    Abstract Links between the complement and coagulation systems could lead to Long Covid therapies.
    MeSH term(s) Humans ; Blood Coagulation/immunology ; Complement System Proteins/analysis ; Complement System Proteins/immunology ; Post-Acute COVID-19 Syndrome/blood ; Post-Acute COVID-19 Syndrome/immunology
    Chemical Substances Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adn1077
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  2. Article ; Online: TRIF turns the switch for DIC in sepsis.

    Ruf, Wolfram

    Blood

    2020  Volume 135, Issue 14, Page(s) 1073–1074

    MeSH term(s) Adaptor Proteins, Vesicular Transport ; Disseminated Intravascular Coagulation ; Gram-Negative Bacteria ; Humans ; Sepsis
    Chemical Substances Adaptor Proteins, Vesicular Transport
    Language English
    Publishing date 2020-01-09
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2020004988
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  3. Article ; Online: Roles of factor Xa beyond coagulation.

    Ruf, Wolfram

    Journal of thrombosis and thrombolysis

    2021  Volume 52, Issue 2, Page(s) 391–396

    Abstract: Oral anticoagulant therapy has changed by clinical evidence that coagulation factor Xa (FXa) can be safely and effectively targeted for thromboprophylaxis. Because thrombotic and thrombo-inflammatory diseases are frequently caused by excessive activation ...

    Abstract Oral anticoagulant therapy has changed by clinical evidence that coagulation factor Xa (FXa) can be safely and effectively targeted for thromboprophylaxis. Because thrombotic and thrombo-inflammatory diseases are frequently caused by excessive activation of the tissue factor (TF) pathway, activation of FX by the TF-FVIIa complex is of central importance for understanding the roles of FXa in thrombosis and hemostasis and functions beyond blood coagulation. Recent data showed that the nascent product FXa associated with TF-FVIIa not only supports hemostatic cofactor VIII activation, but also broadly influences immune reactions in inflammation, cancer, and autoimmunity. These signaling functions of FXa are mediated through protease activated receptor (PAR) cleavage and PAR2 activation occurs in extravascular environments specifically by macrophage synthesized FX. Cell autonomous FXa-PAR2 signaling is a mechanism for tumor-promoting macrophage polarization in the tumor microenvironment and tissue penetrance of oral FXa inhibitors favors the reprogramming of tumor-associated macrophages for non-coagulant therapeutic benefit. It is necessary to decipher the distinct functions of coagulation factors synthesized by the liver for circulation in blood versus those synthesized by extrahepatic immune cells for activity in tissue milieus. This research will lead to a better understanding of the broader roles of FXa as a central regulator of immune and hematopoietic systems.
    MeSH term(s) Anticoagulants ; Blood Coagulation ; Factor VIIa ; Factor Xa ; Humans ; Thromboplastin ; Venous Thromboembolism
    Chemical Substances Anticoagulants ; Thromboplastin (9035-58-9) ; Factor VIIa (EC 3.4.21.21) ; Factor Xa (EC 3.4.21.6)
    Language English
    Publishing date 2021-04-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1230645-9
    ISSN 1573-742X ; 0929-5305
    ISSN (online) 1573-742X
    ISSN 0929-5305
    DOI 10.1007/s11239-021-02458-8
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  4. Article ; Online: Lipid-binding antiphospholipid antibodies: significance for pathophysiology and diagnosis of the antiphospholipid syndrome.

    Müller-Calleja, Nadine / Ruf, Wolfram / Lackner, Karl J

    Critical reviews in clinical laboratory sciences

    2024  , Page(s) 1–18

    Abstract: The antiphospholipid syndrome (APS) is an autoimmune disease characterized by the presence of pathogenic antiphospholipid antibodies (aPL). Since approximately 30 years ago, lipid-binding aPL, which do not require a protein cofactor, have been regarded ... ...

    Abstract The antiphospholipid syndrome (APS) is an autoimmune disease characterized by the presence of pathogenic antiphospholipid antibodies (aPL). Since approximately 30 years ago, lipid-binding aPL, which do not require a protein cofactor, have been regarded as irrelevant for APS pathogenesis even though anticardiolipin are a diagnostic criterion of APS. In this review, we will summarize the available evidence from
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 280641-1
    ISSN 1549-781X ; 1040-8363 ; 0590-8191
    ISSN (online) 1549-781X
    ISSN 1040-8363 ; 0590-8191
    DOI 10.1080/10408363.2024.2305121
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  5. Article ; Online: Translational Research in Thrombosis and Haemostasis.

    Ruf, Wolfram

    Hamostaseologie

    2019  Volume 39, Issue 2, Page(s) 115–116

    MeSH term(s) Administration, Oral ; Anticoagulants/administration & dosage ; Anticoagulants/therapeutic use ; Germany/epidemiology ; Hemostasis/physiology ; Humans ; Practice Patterns, Physicians' ; Prevalence ; Research Design ; Thrombosis/drug therapy ; Thrombosis/epidemiology ; Thrombosis/immunology ; Translational Medical Research/methods
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2019-07-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/s-0039-1691751
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  6. Article ; Online: Is VITT really a HIT.

    Ruggeri, Zaverio M / Ruf, Wolfram

    Nature immunology

    2021  Volume 22, Issue 11, Page(s) 1352–1353

    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-10-22
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-021-01042-9
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  7. Article ; Online: ISTH 2017 Berlin revisited.

    Ruf, Wolfram

    Research and practice in thrombosis and haemostasis

    2017  Volume 2, Issue 1, Page(s) 17–18

    Language English
    Publishing date 2017-12-08
    Publishing country United States
    Document type Editorial
    ISSN 2475-0379
    ISSN (online) 2475-0379
    DOI 10.1002/rth2.12063
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  8. Article: Translational Research in Thrombosis and Haemostasis

    Ruf, Wolfram

    Hämostaseologie

    2019  Volume 39, Issue 02, Page(s) 115–116

    Language English
    Publishing date 2019-06-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/s-0039-1691751
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  9. Article ; Online: Proteases, Protease-Activated Receptors, and Atherosclerosis.

    Ruf, Wolfram

    Arteriosclerosis, thrombosis, and vascular biology

    2018  Volume 38, Issue 6, Page(s) 1252–1254

    MeSH term(s) Animals ; Atherosclerosis ; Endopeptidases ; Mice ; Peptide Hydrolases ; Receptor, PAR-2 ; Receptors, Proteinase-Activated
    Chemical Substances Receptor, PAR-2 ; Receptors, Proteinase-Activated ; Endopeptidases (EC 3.4.-) ; Peptide Hydrolases (EC 3.4.-)
    Language English
    Publishing date 2018-05-21
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.118.311139
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  10. Article ; Online: Regulation of coagulation by tissue factor pathway inhibitor: Implications for hemophilia therapy.

    Mast, Alan E / Ruf, Wolfram

    Journal of thrombosis and haemostasis : JTH

    2022  Volume 20, Issue 6, Page(s) 1290–1300

    Abstract: Tissue factor pathway inhibitor (TFPI) is an alternatively spliced anticoagulant protein that primarily dampens the initiation phase of coagulation before thrombin is generated. As such, TFPI's actions are localized to cells expressing TF and to sites of ...

    Abstract Tissue factor pathway inhibitor (TFPI) is an alternatively spliced anticoagulant protein that primarily dampens the initiation phase of coagulation before thrombin is generated. As such, TFPI's actions are localized to cells expressing TF and to sites of injury, where it is an important regulator of bleeding in hemophilia. The major splice isoforms TFPIα and TFPIβ localize to different sites within and surrounding the vasculature. Both forms directly inhibit factor Xa (FXa) via their Kunitz 2 domain and inhibit TF-FVIIa via their Kunitz 1 domain in a tight complex primarily localized to cells. By forming complexes localized to distinct cellular microenvironments and engaging additional cell surface receptors, TFPI alters cellular trafficking and signaling pathways driven by coagulation proteases of the TF pathway. TFPIα, which circulates in complex with FV and protein S, also serves an inhibitor of FXa independent of the TF initiation complex and prevents the formation of an active prothrombinase. This regulation of thrombin generation in the context of vessel injury is effectively blocked by antibodies to Kunitz 2 domain of TFPI and exploited as a therapy to restore efficient hemostasis in hemophilia.
    MeSH term(s) Blood Coagulation ; Factor Xa/metabolism ; Hemophilia A/drug therapy ; Hemophilia A/genetics ; Humans ; Lipoproteins/metabolism ; Thrombin/metabolism ; Thromboplastin/metabolism
    Chemical Substances Lipoproteins ; lipoprotein-associated coagulation inhibitor ; Thromboplastin (9035-58-9) ; Thrombin (EC 3.4.21.5) ; Factor Xa (EC 3.4.21.6)
    Language English
    Publishing date 2022-03-27
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.15697
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