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  1. Article ; Online: The potential role of acid ceramidase in oral squamous cell carcinoma chemo-resistance by inducing autophagy.

    Norouzi, Ali / Davodabadi, Fatemeh / Noorbakhsh Varnosfaderani, Seyed Mostafa / Zalpoor, Hamidreza

    Human cell

    2023  Volume 36, Issue 6, Page(s) 2273–2275

    Language English
    Publishing date 2023-07-29
    Publishing country Japan
    Document type Letter
    ZDB-ID 1149134-6
    ISSN 1749-0774 ; 0914-7470
    ISSN (online) 1749-0774
    ISSN 0914-7470
    DOI 10.1007/s13577-023-00960-0
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3676: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Breast cancer tumor microenvironment affects Treg/IL-17-producing Treg/Th17 cell axis: Molecular and therapeutic perspectives.

    Seif, Farhad / Torki, Zahra / Zalpoor, Hamidreza / Habibi, Mehran / Pornour, Majid

    Molecular therapy oncolytics

    2023  Volume 28, Page(s) 132–157

    Abstract: The tumor microenvironment (TME) comprises a variety of immune cells, among which T cells exert a prominent axial role in tumor development or anti-tumor responses in patients with breast cancer (BC). High or low levels of anti-inflammatory cytokines, ... ...

    Abstract The tumor microenvironment (TME) comprises a variety of immune cells, among which T cells exert a prominent axial role in tumor development or anti-tumor responses in patients with breast cancer (BC). High or low levels of anti-inflammatory cytokines, such as transforming growth factor β, in the absence or presence of proinflammatory cytokines, such as interleukin-6 (IL-6), delineate the fate of T cells toward either regulatory T (Treg) or T helper 17 (Th17) cells, respectively. The transitional state of RORγt
    Language English
    Publishing date 2023-01-11
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2372-7705
    ISSN 2372-7705
    DOI 10.1016/j.omto.2023.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Ephrin (Eph) receptor and downstream signaling pathways: a promising potential targeted therapy for COVID‑19 and associated cancers and diseases.

    Zalpoor, Hamidreza / Akbari, Abdullatif / Nabi-Afjadi, Mohsen

    Human cell

    2022  Volume 35, Issue 3, Page(s) 952–954

    MeSH term(s) COVID-19 ; Ephrins ; Humans ; Neoplasms/therapy ; Receptor, EphA1/metabolism ; Receptors, Eph Family/metabolism ; Signal Transduction/genetics
    Chemical Substances Ephrins ; Receptor, EphA1 (EC 2.7.10.1) ; Receptors, Eph Family (EC 2.7.10.1)
    Language English
    Publishing date 2022-04-04
    Publishing country Japan
    Document type Letter ; Comment
    ZDB-ID 1149134-6
    ISSN 1749-0774 ; 0914-7470
    ISSN (online) 1749-0774
    ISSN 0914-7470
    DOI 10.1007/s13577-022-00697-2
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3676: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: The promising therapeutic effects of metformin on metabolic reprogramming of cancer-associated fibroblasts in solid tumors.

    Mostafavi, Samaneh / Zalpoor, Hamidreza / Hassan, Zuhair Mohammad

    Cellular & molecular biology letters

    2022  Volume 27, Issue 1, Page(s) 58

    Abstract: Tumor-infiltrated lymphocytes are exposed to many toxic metabolites and molecules in the tumor microenvironment (TME) that suppress their anti-tumor activity. Toxic metabolites, such as lactate and ketone bodies, are produced mainly by catabolic cancer- ... ...

    Abstract Tumor-infiltrated lymphocytes are exposed to many toxic metabolites and molecules in the tumor microenvironment (TME) that suppress their anti-tumor activity. Toxic metabolites, such as lactate and ketone bodies, are produced mainly by catabolic cancer-associated fibroblasts (CAFs) to feed anabolic cancer cells. These catabolic and anabolic cells make a metabolic compartment through which high-energy metabolites like lactate can be transferred via the monocarboxylate transporter channel 4. Moreover, a decrease in molecules, including caveolin-1, has been reported to cause deep metabolic changes in normal fibroblasts toward myofibroblast differentiation. In this context, metformin is a promising drug in cancer therapy due to its effect on oncogenic signal transduction pathways, leading to the inhibition of tumor proliferation and downregulation of key oncometabolites like lactate and succinate. The cross-feeding and metabolic coupling of CAFs and tumor cells are also affected by metformin. Therefore, the importance of metabolic reprogramming of stromal cells and also the pivotal effects of metformin on TME and oncometabolites signaling pathways have been reviewed in this study.
    MeSH term(s) Cancer-Associated Fibroblasts ; Fibroblasts/metabolism ; Glycolysis ; Humans ; Lactates/metabolism ; Metformin/metabolism ; Metformin/pharmacology ; Metformin/therapeutic use ; Neoplasms/metabolism ; Tumor Microenvironment
    Chemical Substances Lactates ; Metformin (9100L32L2N)
    Language English
    Publishing date 2022-07-22
    Publishing country England
    Document type Letter
    ZDB-ID 2108724-6
    ISSN 1689-1392 ; 1689-1392
    ISSN (online) 1689-1392
    ISSN 1689-1392
    DOI 10.1186/s11658-022-00356-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Increased neuropilin-1 expression by COVID-19: a possible cause of long-term neurological complications and progression of primary brain tumors.

    Zalpoor, Hamidreza / Shapourian, Hooriyeh / Akbari, Abdullatif / Shahveh, Shaghayegh / Haghshenas, Leila

    Human cell

    2022  Volume 35, Issue 4, Page(s) 1301–1303

    MeSH term(s) Brain Neoplasms ; COVID-19/complications ; Humans ; Neuropilin-1/genetics ; Vascular Endothelial Growth Factor A/metabolism
    Chemical Substances Vascular Endothelial Growth Factor A ; Neuropilin-1 (144713-63-3)
    Language English
    Publishing date 2022-05-09
    Publishing country Japan
    Document type Letter
    ZDB-ID 1149134-6
    ISSN 1749-0774 ; 0914-7470
    ISSN (online) 1749-0774
    ISSN 0914-7470
    DOI 10.1007/s13577-022-00716-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3676: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Flt3-ITD mutated acute myeloid leukemia patients and COVID-19: potential roles of autophagy and HIF-1α in leukemia progression and mortality.

    Zalpoor, Hamidreza / Rezaei, Mahnaz / Yahyazadeh, Sheida / Ganjalikhani-Hakemi, Mazdak

    Human cell

    2022  Volume 35, Issue 4, Page(s) 1304–1305

    MeSH term(s) Autophagy/genetics ; COVID-19/genetics ; Humans ; Leukemia, Myeloid, Acute/genetics ; Mutation ; Tandem Repeat Sequences ; fms-Like Tyrosine Kinase 3/genetics
    Chemical Substances FLT3 protein, human (EC 2.7.10.1) ; fms-Like Tyrosine Kinase 3 (EC 2.7.10.1)
    Language English
    Publishing date 2022-05-31
    Publishing country Japan
    Document type Letter
    ZDB-ID 1149134-6
    ISSN 1749-0774 ; 0914-7470
    ISSN (online) 1749-0774
    ISSN 0914-7470
    DOI 10.1007/s13577-022-00718-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3676: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Association of MicroRNA-146a with Type 1 and 2 Diabetes and their Related Complications.

    Ghaffari, Mahyar / Razi, Sara / Zalpoor, Hamidreza / Nabi-Afjadi, Mohsen / Mohebichamkhorami, Fariba / Zali, Hakimeh

    Journal of diabetes research

    2023  Volume 2023, Page(s) 2587104

    Abstract: Most medical investigations have found a reduced blood level of miR-146a in type 2 diabetes (T2D) patients, suggesting an important role for miR-146a (microRNA-146a) in the etiology of diabetes mellitus (DM) and its consequences. Furthermore, injection ... ...

    Abstract Most medical investigations have found a reduced blood level of miR-146a in type 2 diabetes (T2D) patients, suggesting an important role for miR-146a (microRNA-146a) in the etiology of diabetes mellitus (DM) and its consequences. Furthermore, injection of miR-146a mimic has been confirmed to alleviate diabetes mellitus in diabetic animal models. In this line, deregulation of miR-146a expression has been linked to the progression of nephropathy, neuropathy, wound healing, olfactory dysfunction, cardiovascular disorders, and retinopathy in diabetic patients. In this review, besides a comprehensive review of the function of miR-146a in DM, we discussed new findings on type 1 (T1MD) and type 2 (T2DM) diabetes mellitus, highlighting the discrepancies between clinical and preclinical investigations and elucidating the biological pathways regulated through miR-146a in DM-affected tissues.
    MeSH term(s) Animals ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 2/complications ; MicroRNAs/metabolism ; Humans
    Chemical Substances MicroRNAs ; MIRN146 microRNA, human
    Language English
    Publishing date 2023-03-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2711897-6
    ISSN 2314-6753 ; 2314-6753
    ISSN (online) 2314-6753
    ISSN 2314-6753
    DOI 10.1155/2023/2587104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: CD147 and cyclophilin A: a promising potential targeted therapy for COVID-19 and associated cancer progression and chemo-resistance.

    Bakhtiyari, Maryam / Haji Aghasi, Ayda / Banihashemi, Sara / Abbassioun, Arian / Tavakol, Chanour / Zalpoor, Hamidreza

    Infectious agents and cancer

    2023  Volume 18, Issue 1, Page(s) 20

    Abstract: Coronavirus disease-2019 (COVID-19), as a worldwide serious issue has been shown to lead to progression and poor outcomes in cancer patients. The underlying mechanisms for SARS-CoV-2 infection's adverse effects on cancer patients have not been fully ... ...

    Abstract Coronavirus disease-2019 (COVID-19), as a worldwide serious issue has been shown to lead to progression and poor outcomes in cancer patients. The underlying mechanisms for SARS-CoV-2 infection's adverse effects on cancer patients have not been fully understood. We hypothesized that CD147 and Cyclophilin A (CyPA) not only can play a significant role in infection severity but also can contribute to cancer progression and chemotherapy resistance in cancer patients with COVID-19. In addition, we hypothesized that the expression of both CD147 and CyPA could be increased by Hypoxia-inducible Factor-1 alpha (HIF-1α) activation during hypoxic conditions that occurred during COVID-19. Therefore, this evidence can open a new window in the management of cancer patients during the pandemic and therapeutic approaches targeting CD147 and CyPA could be a potentially promising therapeutic approach for such patients.
    Language English
    Publishing date 2023-04-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2251117-9
    ISSN 1750-9378
    ISSN 1750-9378
    DOI 10.1186/s13027-023-00501-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The correlation between Flt3-ITD mutation in dendritic cells with TIM-3 expression in acute myeloid leukemia.

    Shapoorian, Hooriyeh / Zalpoor, Hamidreza / Ganjalikhani-Hakemi, Mazdak

    Blood science (Baltimore, Md.)

    2021  Volume 3, Issue 4, Page(s) 132–135

    Abstract: In general, acute myeloid leukemia (AML) is an aggressive and heterogeneous disease that is characterized by rapid cellular proliferation and high mortality. One of the mutations related to AML is the Flt3-ITD mutation, which is found in approximately 25% ...

    Abstract In general, acute myeloid leukemia (AML) is an aggressive and heterogeneous disease that is characterized by rapid cellular proliferation and high mortality. One of the mutations related to AML is the Flt3-ITD mutation, which is found in approximately 25% of patients. In this mini-review, we investigate the function of dendritic cells and T cells based on Flt3-ITD mutation and immune evasion as a result of this abnormality. Finally, we discuss some AML therapeutic strategies, including targeting Flt3 on DCs and TIM-3 on T cells as immune receptors to treat this hematopoietic malignancy.
    Language English
    Publishing date 2021-10-18
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2543-6368
    ISSN (online) 2543-6368
    DOI 10.1097/BS9.0000000000000092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Kaempferol's potential effects against SARS-CoV-2 and COVID-19-associated cancer progression and chemo-resistance.

    Zalpoor, Hamidreza / Liaghat, Mahsa / Bakhtiyari, Maryam / Shapourian, Hooriyeh / Akbari, Abdullatif / Shahveh, Shaghayegh / Nabi-Afjadi, Mohsen / Minaei Beirami, Sohrab / Tarhriz, Vahideh

    Phytotherapy research : PTR

    2023  Volume 37, Issue 5, Page(s) 1731–1739

    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19 ; Kaempferols/pharmacology ; Kaempferols/therapeutic use ; Neoplasms
    Chemical Substances Kaempferols
    Language English
    Publishing date 2023-01-27
    Publishing country England
    Document type Letter
    ZDB-ID 639136-9
    ISSN 1099-1573 ; 0951-418X
    ISSN (online) 1099-1573
    ISSN 0951-418X
    DOI 10.1002/ptr.7706
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