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  1. Article ; Online: 19th c. tuberculosis probably has nothing to do with current tuberculosis.

    Charlier, P / Deo, S

    Journal of the neurological sciences

    2019  Volume 402, Page(s) 107

    MeSH term(s) Humans ; Tuberculosis
    Language English
    Publishing date 2019-05-17
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2019.05.014
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    In stock of ZB MED Cologne/Königswinter

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  2. Article: Large gap asymptotics on annuli in the random normal matrix model.

    Charlier, Christophe

    Mathematische annalen

    2023  Volume 388, Issue 4, Page(s) 3529–3587

    Abstract: We consider a two-dimensional determinantal point process arising in the random normal matrix model and which is a two-parameter generalization of the complex Ginibre point process. In this paper, we prove that the probability that no points lie on any ... ...

    Abstract We consider a two-dimensional determinantal point process arising in the random normal matrix model and which is a two-parameter generalization of the complex Ginibre point process. In this paper, we prove that the probability that no points lie on any number of annuli centered at 0 satisfies large
    Language English
    Publishing date 2023-03-31
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2161244-4
    ISSN 0025-5831
    ISSN 0025-5831
    DOI 10.1007/s00208-023-02603-z
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  3. Article ; Online: Erosive effects of a posterior mediastinal mass in a 18th to early 19th c. Spanish child mummy.

    Loynes, Robert D / Charlier, Philippe / Perciaccante, Antonio / Gonzalez, Mercedes / Begerock, Anna / Bianucci, Rafaella

    Forensic science, medicine, and pathology

    2018  Volume 14, Issue 4, Page(s) 574–578

    Abstract: During the 2011 restoration works in the central nave of the church of the Assumption of Our Lady, known as "The Piquete", in the village of Quinto (about 50 kms southwest of Zaragoza, Spain), the remains of 70 individuals were uncovered. Of these there ... ...

    Abstract During the 2011 restoration works in the central nave of the church of the Assumption of Our Lady, known as "The Piquete", in the village of Quinto (about 50 kms southwest of Zaragoza, Spain), the remains of 70 individuals were uncovered. Of these there were 32 mummified bodies, four of which have been investigated with CT scans. Here we report on the findings in one such individual, namely a child of between 7 and 8 years of age, whose sex is debatable but may well be female. The main pathological finding is the presence of pressure erosion and distortion of the upper thoracic spine, the cause of which is discussed with the conclusion that this may well represent a neurenteric duplication cyst. The possible consequences of such a lesion are considered.
    MeSH term(s) Child ; Cysts/diagnostic imaging ; Cysts/pathology ; History, 18th Century ; History, 19th Century ; Humans ; Imaging, Three-Dimensional ; Mediastinal Diseases/diagnostic imaging ; Mummies ; Spain ; Thoracic Vertebrae/abnormalities ; Thoracic Vertebrae/diagnostic imaging ; Tomography, X-Ray Computed
    Language English
    Publishing date 2018-08-25
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 2195904-3
    ISSN 1556-2891 ; 1547-769X
    ISSN (online) 1556-2891
    ISSN 1547-769X
    DOI 10.1007/s12024-018-0013-8
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  4. Article: A glimpse into the early origins of medieval anatomy through the oldest conserved human dissection (Western Europe, 13(th) c. A.D.).

    Charlier, Philippe / Huynh-Charlier, Isabelle / Poupon, Joël / Lancelot, Eloïse / Campos, Paula F / Favier, Dominique / Jeannel, Gaël-François / Bonati, Maurizio Rippa / de la Grandmaison, Geoffroy Lorin / Hervé, Christian

    Archives of medical science : AMS

    2013  Volume 10, Issue 2, Page(s) 366–373

    Abstract: Introduction: Medieval autopsy practice is very poorly known in Western Europe, due to a lack of both descriptive medico-surgical texts and conserved dissected human remains. This period is currently considered the dark ages according to a common belief ...

    Abstract Introduction: Medieval autopsy practice is very poorly known in Western Europe, due to a lack of both descriptive medico-surgical texts and conserved dissected human remains. This period is currently considered the dark ages according to a common belief of systematic opposition of Christian religious authorities to the opening of human cadavers.
    Material and methods: The identification in a private collection of an autopsied human individual dated from the 13(th) century A.D. is an opportunity for better knowledge of such practice in this chrono-cultural context, i.e. the early origins of occidental dissections. A complete forensic anthropological procedure was carried out, completed by radiological and elemental analyses.
    Results: The complete procedure of this body opening and internal organs exploration is explained, and compared with historical data about forensic and anatomical autopsies from this period. During the analysis, a red substance filling all arterial cavities, made of mercury sulfide (cinnabar) mixed with vegetal oil (oleic and palmitic acids) was identified; it was presumably used to highlight vascularization by coloring in red such vessels, and help in the preservation of the body.
    Conclusions: Of particular interest for the description of early medical and anatomical knowledge, this "human preparation" is the oldest known yet, and is particularly important for the fields of history of medicine, surgery and anatomical practice.
    Language English
    Publishing date 2013-02-28
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2203781-0
    ISSN 1734-1922
    ISSN 1734-1922
    DOI 10.5114/aoms.2013.33331
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  5. Article ; Online: AGER -429T/C is associated with an increased lung disease severity in cystic fibrosis.

    Beucher, Julie / Boëlle, Pierre-Yves / Busson, Pierre-François / Muselet-Charlier, Céline / Clement, Annick / Corvol, Harriet

    PloS one

    2012  Volume 7, Issue 7, Page(s) e41913

    Abstract: ... severity with the variant AGER -429 T/C, coding for RAGE, a pro-inflammatory protein, in CF patients ... FEV(1) was analyzed as CF-specific percentile adjusted on age, height and mortality. AGER -429T/C ... AGER -429 minor allele (C) was associated with poorer lung function (p = 0.03). In vitro, the promoter ...

    Abstract The clinical course of cystic fibrosis (CF) varies between patients bearing identical CFTR mutations, suggesting the involvement of modifier genes. We assessed the association of lung disease severity with the variant AGER -429 T/C, coding for RAGE, a pro-inflammatory protein, in CF patients from the French CF Gene Modifier Study. We analyzed the lung function of 967 CF patients p.Phe508del homozygous. FEV(1) was analyzed as CF-specific percentile adjusted on age, height and mortality. AGER -429T/C polymorphism was genotyped and its function was evaluated in vitro by measurement of the luciferase activity. AGER -429 minor allele (C) was associated with poorer lung function (p = 0.03). In vitro, the promoter activity was higher in cells transfected with AGER -429C compared to cells transfected with the AGER -429T allele (p = 0.016 in BEAS-2B cells). AGER seems to be a modifier gene of lung disease severity in CF, and could be an interesting biomarker of CF airway inflammation. The functional promoter AGER -429C variant is associated with an increased RAGE expression that can lead to an increased lung inflammation and a more severe lung disease.
    MeSH term(s) Adolescent ; Adult ; Cell Line ; Child ; Cystic Fibrosis/genetics ; Cystic Fibrosis/pathology ; Cystic Fibrosis/physiopathology ; Female ; Gene Expression ; Gene Expression Regulation ; Genes, Reporter ; Genetic Association Studies ; Humans ; Luciferases, Renilla/biosynthesis ; Luciferases, Renilla/genetics ; Lung/pathology ; Lung/physiopathology ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic ; Receptor for Advanced Glycation End Products ; Receptors, Immunologic/genetics ; Receptors, Immunologic/metabolism ; Respiratory Function Tests ; Young Adult
    Chemical Substances Receptor for Advanced Glycation End Products ; Receptors, Immunologic ; Luciferases, Renilla (EC 1.13.12.5)
    Language English
    Publishing date 2012-07-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0041913
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  6. Article: An incomplete fatal trepanation diagnosed on cremation remains (Rome, Italy, 2nd c. AD).

    Charlier, Philippe / Brun, Luc / Pantano, Walter / Catalano, Paola / Augias, Anais / Huynh-Charlier, Isabelle

    Acta medico-historica adriatica : AMHA

    2014  Volume 12, Issue 2, Page(s) 315–320

    Abstract: Background: An original case of incomplete (and reasonably fatal) human trepanation is described in this short paper. The diagnosis was made on the cremated remains of a young adult individual who died in Rome, Italy during the 2nd century AD.: ... ...

    Abstract Background: An original case of incomplete (and reasonably fatal) human trepanation is described in this short paper. The diagnosis was made on the cremated remains of a young adult individual who died in Rome, Italy during the 2nd century AD.
    Clinical presentation: The trepanation was incomplete, as death occurred quickly due to vascular lesions, according to the anatomic analysis of the bone piece. Comparable trepanation from Roman times are described and related to this case.
    Conclusion: Even if archaeological, this case highlights the possibility of such a diagnosis on post-fire fragmented bones. Very suggestive lesions of section are of great interest for the history of such a practice during classical Antiquity. Lastly, from a medical and forensic point of view, such a diagnosis may be of interest during any identification process and research for a cause of death during anthropological analyses.
    MeSH term(s) Archaeology ; Cremation ; History, Ancient ; Humans ; Rome ; Trephining/history
    Language English
    Publishing date 2014
    Publishing country Croatia
    Document type Historical Article ; Journal Article
    ZDB-ID 2195042-8
    ISSN 1334-6253 ; 1334-4366
    ISSN (online) 1334-6253
    ISSN 1334-4366
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  7. Article ; Online: Large gap asymptotics for the generating function of the sine point process.

    Charlier, Christophe

    Proceedings of the London Mathematical Society

    2021  Volume 123, Issue 2, Page(s) 103–152

    Abstract: We consider the generating function of the sine point process ... ...

    Abstract We consider the generating function of the sine point process on
    Language English
    Publishing date 2021-01-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1468238-2
    ISSN 1460-244X ; 0024-6115
    ISSN (online) 1460-244X
    ISSN 0024-6115
    DOI 10.1112/plms.12393
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  8. Article: Crystal structure of a cold-adapted class C beta-lactamase.

    Michaux, Catherine / Massant, Jan / Kerff, Frédéric / Frère, Jean-Marie / Docquier, Jean-Denis / Vandenberghe, Isabel / Samyn, Bart / Pierrard, Annick / Feller, Georges / Charlier, Paulette / Van Beeumen, Jozef / Wouters, Johan

    The FEBS journal

    2008  Volume 275, Issue 8, Page(s) 1687–1697

    Abstract: In this study, the crystal structure of a class C beta-lactamase from a psychrophilic organism ...

    Abstract In this study, the crystal structure of a class C beta-lactamase from a psychrophilic organism, Pseudomonas fluorescens, has been refined to 2.2 A resolution. It is one of the few solved crystal structures of psychrophilic proteins. The structure was compared with those of homologous mesophilic enzymes and of another, modeled, psychrophilic protein. The elucidation of the 3D structure of this enzyme provides additional insights into the features involved in cold adaptation. Structure comparison of the psychrophilic and mesophilic beta-lactamases shows that electrostatics seems to play a major role in low-temperature adaptation, with a lower total number of ionic interactions for cold enzymes. The psychrophilic enzymes are also characterized by a decreased number of hydrogen bonds, a lower content of prolines, and a lower percentage of arginines in comparison with lysines. All these features make the structure more flexible so that the enzyme can behave as an efficient catalyst at low temperatures.
    MeSH term(s) Amino Acid Sequence ; Cold Temperature ; Crystallography, X-Ray ; Enzyme Stability/drug effects ; Kinetics ; Models, Molecular ; Molecular Sequence Data ; Protein Structure, Tertiary ; Pseudomonas fluorescens/enzymology ; Sequence Alignment ; Structural Homology, Protein ; Urea/pharmacology ; beta-Lactamases/chemistry ; beta-Lactamases/classification ; beta-Lactamases/metabolism
    Chemical Substances Urea (8W8T17847W) ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2008-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/j.1742-4658.2008.06324.x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 260: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Lifestyle Behaviours and Plasma Vitamin C and β-Carotene Levels from the ELAN Population (Liège, Belgium).

    Pincemail, Joël / Vanbelle, Sophie / Degrune, Fabien / Cheramy-Bien, Jean-Paul / Charlier, Corinne / Chapelle, Jean-Paul / Giet, Didier / Collette, George / Albert, Adelin / Defraigne, Jean-Olivier

    Journal of nutrition and metabolism

    2011  Volume 2011, Page(s) 494370

    Abstract: ... the plasma concentrations of the two antioxidants vitamin C and β-carotene. Deficiency levels of 6 mg/L (34.2 ... μM) for vitamin C and of 0.22 mg/L (0.4 μM) for β-carotene have been suggested below ... years aimed to examine how modifiable lifestyle factors may be related to vitamin C and/or β-carotene ...

    Abstract Several factors, including fruit and vegetables intakes, have been shown to significantly influence the plasma concentrations of the two antioxidants vitamin C and β-carotene. Deficiency levels of 6 mg/L (34.2 μM) for vitamin C and of 0.22 mg/L (0.4 μM) for β-carotene have been suggested below which cardiovascular risk might be increased. The present study performed on 897 presumably healthy subjects aged 40-60 years aimed to examine how modifiable lifestyle factors may be related to vitamin C and/or β-carotene deficiency. Gender, smoking, lack of regular physical activity and of daily fruit consumption (≥2/day), and social status (in particular, unemployment) were found to be significant risk factors for vitamin C deficiency. For β-carotene deficiency, the same factors were identified except social status; moreover, overweight and OC use in women were also found to have a deleterious effect. For non exposed subjects, the probability of developing vitamin C deficiency was 4% in men and 2.4% in women. This probability increased to 66.3% for men and to 44.3% for women (and even to 50.4% under OC use), when all risk factors were present. For β-carotene deficiency, the corresponding probabilities were equal to 29.7% in men and 13.7% in women (no risk factor present), and to 86.1% for men and 69.9% (91.6% for OC use) for women (all factors present), respectively.
    Language English
    Publishing date 2011-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573563-9
    ISSN 2090-0732 ; 2090-0724
    ISSN (online) 2090-0732
    ISSN 2090-0724
    DOI 10.1155/2011/494370
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  10. Article ; Online: Leprosy combined with vitiligo skin lesions.

    Charlier, C / Canouï, E

    La Revue de medecine interne

    2023  Volume 44, Issue 11, Page(s) 626

    Language English
    Publishing date 2023-10-09
    Publishing country France
    Document type Letter
    ZDB-ID 604679-4
    ISSN 1768-3122 ; 0248-8663
    ISSN (online) 1768-3122
    ISSN 0248-8663
    DOI 10.1016/j.revmed.2023.09.004
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2451: Show issues Location:
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