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  1. Article ; Online: Unlocking consciousness through right median nerve stimulation. Has a potential cure arrived at our doorstep?

    van der Jagt, Mathieu / Robba, Chiara / Skrifvars, Markus B

    Intensive care medicine

    2023  Volume 49, Issue 6, Page(s) 659–661

    MeSH term(s) Humans ; Consciousness ; Median Nerve ; Glasgow Coma Scale
    Language English
    Publishing date 2023-05-21
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07097-6
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  2. Article ; Online: Targeted Temperature Management for Cardiac Arrest.

    van der Jagt, Mathieu

    The New England journal of medicine

    2020  Volume 382, Issue 26, Page(s) e109

    MeSH term(s) Heart Arrest ; Humans ; Hypothermia, Induced
    Language English
    Publishing date 2020-06-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2011066
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  3. Article: Editorial: Crucial Decisions in Severe Traumatic Brain Injury Management: Criteria for Treatment Escalation.

    Robba, Chiara / van der Jagt, Mathieu

    Frontiers in neurology

    2021  Volume 12, Page(s) 740915

    Language English
    Publishing date 2021-09-21
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.740915
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  4. Article ; Online: Fluid Balance and Hemodynamic Monitoring of Traumatic Brain Injured Patients: An International Survey.

    Robba, Chiara / van der Jagt, Mathieu / Taccone, Fabio / Citerio, Giuseppe / Messina, Antonio

    Journal of neurosurgical anesthesiology

    2023  Volume 36, Issue 2, Page(s) 177–179

    MeSH term(s) Humans ; Hemodynamic Monitoring ; Brain ; Water-Electrolyte Balance ; Hemodynamics ; Fluid Therapy
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1018119-2
    ISSN 1537-1921 ; 0898-4921
    ISSN (online) 1537-1921
    ISSN 0898-4921
    DOI 10.1097/ANA.0000000000000925
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  5. Article ; Online: Letter by van der Jagt and Suarez Regarding Article, "Impact of Goal-Directed Therapy on Delayed Ischemia After Aneurysmal Subarachnoid Hemorrhage: Randomized Controlled Trial".

    van der Jagt, Mathieu / Suarez, Jose I

    Stroke

    2020  Volume 52, Issue 1, Page(s) e17–e18

    MeSH term(s) Brain Ischemia/therapy ; Goals ; Humans ; Ischemia ; Subarachnoid Hemorrhage/therapy
    Language English
    Publishing date 2020-12-28
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.120.032082
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    Zs.A 448: Show issues Location:
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  6. Article ; Online: Fluid therapy in the acute brain injured patient.

    Ergezen, Saliha / Wiegers, Eveline J / Klijn, Eva / van der Jagt, Mathieu

    Minerva anestesiologica

    2023  Volume 89, Issue 10, Page(s) 936–944

    Abstract: Adequate fluid therapy in the acute brain injured (ABI) patient is essential for maintaining an adequate brain and systemic physiology and preventing intra- and extracranial complications. The target of euvolemia, implying avoidance of both hypovolemia ... ...

    Abstract Adequate fluid therapy in the acute brain injured (ABI) patient is essential for maintaining an adequate brain and systemic physiology and preventing intra- and extracranial complications. The target of euvolemia, implying avoidance of both hypovolemia and fluid overloading (or "hypervolemia," by definition associated with fluid extravasation leading to tissue edema) is of key importance. Primary brain injury can be aggravated by secondary brain injury and systemic deterioration through diverse pathways which can challenge appropriate fluid management, e.g. neuroendocrine and electrolyte disorders, stress cardiomyopathy (also known as cardiac stunning) and neurogenic pulmonary edema. This is an updated expert opinion aiming to provide a practical overview on fluid therapy in the ABI patient, partly based on more recent work and stressing the fact that intravenous fluids should be regarded as drugs, with their inherent potential for both benefit and (unintended) harm.
    MeSH term(s) Humans ; Fluid Therapy ; Hypovolemia/therapy ; Pulmonary Edema ; Brain Injuries/complications ; Brain Injuries/therapy ; Heart Failure ; Brain
    Language English
    Publishing date 2023-10-11
    Publishing country Italy
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123584-9
    ISSN 1827-1596 ; 0026-4717 ; 0375-9393
    ISSN (online) 1827-1596
    ISSN 0026-4717 ; 0375-9393
    DOI 10.23736/S0375-9393.23.17328-7
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    Zs.MO 192: Show issues

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  7. Article ; Online: Acute ischaemic stroke and its challenges for the intensivist.

    Robba, Chiara / van Dijk, Ewoud J / van der Jagt, Mathieu

    European heart journal. Acute cardiovascular care

    2022  Volume 11, Issue 3, Page(s) 258–268

    Abstract: Acute ischaemic stroke (AIS) is responsible for almost 90% of all strokes and is one of the leading causes of death and disability. Acute ischaemic stroke is caused by a critical alteration in focal cerebral blood flow (ischaemia) from a variety of ... ...

    Abstract Acute ischaemic stroke (AIS) is responsible for almost 90% of all strokes and is one of the leading causes of death and disability. Acute ischaemic stroke is caused by a critical alteration in focal cerebral blood flow (ischaemia) from a variety of causes, resulting in infarction. The primary cerebral injury due to AIS occurs in the first hours, therefore early reperfusion importantly impacts on patient outcome ('Time is brain' concept). Secondary cerebral damage progressively evolves over the following hours and days due to cerebral oedema, haemorrhagic transformation, and cerebral inflammation. Systemic complications, such as pneumonia, sepsis, and deep venous thrombosis, could also affect outcome. The risk of a recurrent ischaemic stroke is in particular high in the first days, which necessitate particular attention. The role of intensive care unit physicians is therefore to avoid or reduce the risk of secondary damage, especially in the areas where the brain is functionally impaired and 'at risk' of further injury. Therapeutic strategies therefore consist of restoration of blood flow and a bundle of medical, endovascular, and surgical strategies, which-when applied in a timely and consistent manner-can prevent secondary deterioration due to cerebral and systemic complications and recurrent stroke and improve short- and long-term outcomes. A multidisciplinary collaboration between neurosurgeons, interventional radiologists, neurologists, and intensivists is necessary to elaborate the best strategy for the treatment of these patients.
    MeSH term(s) Brain ; Brain Ischemia/complications ; Brain Ischemia/drug therapy ; Humans ; Ischemic Stroke ; Reperfusion ; Stroke/etiology ; Stroke/prevention & control
    Language English
    Publishing date 2022-02-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2663340-1
    ISSN 2048-8734 ; 2048-8726
    ISSN (online) 2048-8734
    ISSN 2048-8726
    DOI 10.1093/ehjacc/zuac004
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  8. Article ; Online: Impact of structured care systems on mortality in intensive care units.

    van Steenkiste, Job / Larson, Sarah / Ista, Erwin / van der Jagt, Mathieu / Stevens, Robert D

    Intensive care medicine

    2021  Volume 47, Issue 6, Page(s) 713–715

    MeSH term(s) Hospital Mortality ; Humans ; Intensive Care Units
    Language English
    Publishing date 2021-03-27
    Publishing country United States
    Document type Letter
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-021-06383-5
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    Zs.A 1089: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Treatment-limiting decisions in patients with severe traumatic brain injury in the Netherlands.

    van Erp, Inge A M / van Essen, T A / Kompanje, Erwin J O / van der Jagt, Mathieu / Moojen, Wouter A / Peul, Wilco C / van Dijck, Jeroen T J M

    Brain & spine

    2024  Volume 4, Page(s) 102746

    Abstract: Introduction: Treatment-limiting decisions (TLDs) can be inevitable severe traumatic brain injury (s-TBI) patients, but data on their use remain scarce.: Research question: To investigate the prevalence, timing and considerations of TLDs in s-TBI ... ...

    Abstract Introduction: Treatment-limiting decisions (TLDs) can be inevitable severe traumatic brain injury (s-TBI) patients, but data on their use remain scarce.
    Research question: To investigate the prevalence, timing and considerations of TLDs in s-TBI patients.
    Material and methods: s-TBI patients between 2008 and 2017 were analysed retrospecively. Patient data, timing, location, involvement of proxies, and reasons for TLDs were collected. Baseline characteristics and in-hospital outcomes were compared between s-TBI patients with and without TLDs.
    Results: TLDs were reported in 117 of 270 s-TBI patients (43.3%) and 95.9% of deaths after s-TBI were preceded by a TLD. The majority of TLDs (68.4%) were categorized as withdrawal of therapy, of which withdrawal of organ-support in 64.1%. Neurosurgical intervention was withheld in 29.9%. The median time from admission to TLD was 2 days [IQR, 0-8] and 50.4% of TLDs were made within 3 days of admission. The main reason for a TLD was that the patients were perceived as unsalvageable (66.7%). Nearly all decisions were made multidisciplinary (99.1%) with proxies involvement (75.2%). The predicted mortality (CRASH-score) between patients with and without TLDs were 72.6 vs. 70.6%. The percentage of TLDs in s-TBI patients increased from 20.0% in 2008 to 42.9% in 2012 and 64.3% in 2017.
    Discussion and conclusion: TLDs occurred in almost half of s-TBI patients and were instituted more frequently over time. Half of TLDs were made within 3 days of admission in spite of baseline prognosis between groups being similar. Future research should address whether prognostic nihilism contributes to self-fulfilling prophecies.
    Language English
    Publishing date 2024-01-03
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2772-5294
    ISSN (online) 2772-5294
    DOI 10.1016/j.bas.2024.102746
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  10. Article ; Online: Sustained adherence to a delirium guideline five years after implementation in an intensive care setting: A retrospective cohort study.

    van Bochove-Waardenburg, Marlies / van der Jagt, Mathieu / de Man-van Ginkel, Janneke / Ista, Erwin

    Intensive & critical care nursing

    2023  Volume 76, Page(s) 103398

    Abstract: Objective: To explore the level of sustained adherence to a delirium guideline in a university intensive care unit setting five years after cessation of a multifaceted implementation program conducted between April 2012 and February 2015.: Research ... ...

    Abstract Objective: To explore the level of sustained adherence to a delirium guideline in a university intensive care unit setting five years after cessation of a multifaceted implementation program conducted between April 2012 and February 2015.
    Research methodology/design: A quantitative retrospective cohort study was conducted using the medical records of all eligible patients admitted to the intensive care unit from November 2019 to February 2020.
    Setting: Four adult intensive care units in a university hospital.
    Main outcome measures: Primary outcome is adherence to seven performance indicators indicated in the guideline being: light sedation days, mobilisation, physical therapy, analgesics use, delirium and sedation screening and avoiding benzodiazepines. Clinical patient outcomes such as Intensive care unit stay and prevalence of delirium were also collected. Data were compared with the results of the original implementation study's using descriptive statistics and Kruskal-wallis and Chi-square tests.
    Results: Data of 236 patients were included. The most notable decrease in adherence concerned 'number of light sedation days' (-28 %). Adherence to three indicators had increased: 'number of days receiving out-of-bed mobilisation' (+11 %); 'number of days receiving physical therapy' (+9%); and 'use of analgesics' (+12 %). Comparison of clinical outcomes showed an increased intensive care unit length-of-stay from 3 to 5 days (P < 0.001). Prevalence of delirium increased over five years from 41 % to 43 % of patients while delirium duration decreased from a median of 3 days to a median of 2 days.
    Conclusion: Five years after ceasing of implementation efforts regarding the delirium guideline, partial sustainability has been achieved. The decrease in adherence to 'number of light sedation days' could have contributed to the increased length-of-stay on the intensive care unit.
    Implications for clinical practice: After implementation, routine monitoring of performance indicators is required to evaluate the level of sustainment. Further, revisiting reasons for decrease in guideline adherence when contextual changes occur. Reassessment of the perceived barriers and facilitators can guide adaptations to sustain, or even improve, adherence.
    MeSH term(s) Adult ; Humans ; Retrospective Studies ; Delirium/diagnosis ; Prospective Studies ; Critical Care ; Intensive Care Units ; Analgesics ; Guideline Adherence ; Respiration, Artificial
    Chemical Substances Analgesics
    Language English
    Publishing date 2023-01-31
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1105892-4
    ISSN 1532-4036 ; 0964-3397
    ISSN (online) 1532-4036
    ISSN 0964-3397
    DOI 10.1016/j.iccn.2023.103398
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