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Article: Reply: Correspondence on Fluvoxamine Treatment of Patients with Symptomatic COVID-19.

Seo, Hyeonji / Chong, Yong Pil

2022 Volume 54, Issue 2, Page(s) 370–371

Language	English
Publishing date	2022-07-06
Publishing country	Korea (South)
Document type	Letter
ZDB-ID	2573798-3
ISSN	2093-2340
ISSN	2093-2340
DOI	10.3947/ic.2022.0045
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Article ; Online: Saponarin, a Di-glycosyl Flavone from Barley (

Kantharaj, Vimalraj / Yoon, Young-Eun / Lee, Keum-Ah / Choe, Hyeonji / Chohra, Hadjer / Seo, Woo Duck / Kim, Young-Nam / Lee, Yong Bok

ACS omega

2023 Volume 8, Issue 25, Page(s) 22285–22295

Abstract: Saponarin (SA) is a major di- ...

Abstract	Saponarin (SA) is a major di-
Language	English
Publishing date	2023-06-14
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c00267
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effect of Previous COVID-19 Vaccination on Humoral Immunity 3 Months after SARS-CoV-2 Omicron Infection and Booster Effect of a Fourth COVID-19 Vaccination 2 Months after SARS-CoV-2 Omicron Infection.

Kim, Jinsoo / Seo, Hyeonji / Kim, Han-Wool / Kim, Dongbum / Kwon, Hyung-Joo / Kim, Yong-Kyun

Viruses

2022 Volume 14, Issue 11

Abstract: In this study, we aimed to determine the effect of COVID-19 vaccination on 3-month immune response and durability after natural infection by the Omicron variant and to assess the immune response to a fourth dose of COVID-19 vaccination in patients with ... ...

Abstract	In this study, we aimed to determine the effect of COVID-19 vaccination on 3-month immune response and durability after natural infection by the Omicron variant and to assess the immune response to a fourth dose of COVID-19 vaccination in patients with prior natural infection with the Omicron variant. Overall, 86 patients aged ≥60 years with different vaccination histories and 39 health care workers (HCWs) vaccinated thrice before Omicron infection were enrolled. The sVNT50 titer was significantly lower in patients with incomplete vaccination before SARS-CoV-2 infection with the S clade (
MeSH term(s)	Humans ; Immunity, Humoral ; COVID-19/prevention & control ; COVID-19 Vaccines ; Viral Vaccines ; SARS-CoV-2 ; Vaccination ; Antibodies, Viral
Chemical Substances	COVID-19 Vaccines ; Viral Vaccines ; Antibodies, Viral
Language	English
Publishing date	2022-11-06
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v14112458
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Article: Population Pharmacokinetics and Monte Carlo Simulation of Cefepime in Critically Ill Patients with Hospital-Acquired/Ventilator-Associated Pneumonia.

Seo, Hyeonji / Kim, Yong Kyun / Park, Sunghoon / Kim, Hwan-Il / Lee, Dong-Hwan

Infection & chemotherapy

2022 Volume 55, Issue 1, Page(s) 29–41

Abstract: Background: This study aimed to investigate the population pharmacokinetics (PK) profile and determine the optimal dosage regimen of cefepime in critically ill adult patients with hospital-acquired pneumonia (HAP) or ventilator-associated pneumonia (VAP) ...

Abstract	Background: This study aimed to investigate the population pharmacokinetics (PK) profile and determine the optimal dosage regimen of cefepime in critically ill adult patients with hospital-acquired pneumonia (HAP) or ventilator-associated pneumonia (VAP). Materials and methods: Population-PK models for cefepime were developed using a nonlinear mixed-effect modeling approach. The percentage of time within 24 h in which the free concentration exceeded the minimum inhibitory concentration (MIC) at a steady state (50% Results: Twenty-one patients were prospectively enrolled in this study. Cefepime PK was best described using a two-compartment model in which creatinine clearance (CL Conclusion: Our results suggest that clinicians should consider renal function and potential neurotoxicity when deciding the dosing regimen of cefepime in critically ill patients with HAP or VAP. Therapeutic drug monitoring (TDM) to adjust cefepime trough levels may be useful to improve clinical outcomes and reduce cefepime neurotoxicity.
Language	English
Publishing date	2022-11-11
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2573798-3
ISSN	2093-2340
ISSN	2093-2340
DOI	10.3947/ic.2022.0087
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Article: Measles Virus Neutralizing Antibody Response and Durability Two Years after One or Two Doses of Measles-Mumps-Rubella Vaccine among Young Seronegative Healthcare Workers.

Jang, Byungki / Kim, Han Wool / Kim, Han-Sung / Park, Ji Young / Seo, Hyeonji / Kim, Yong Kyun

Vaccines

2022 Volume 10, Issue 11

Abstract: Although there have been several studies regarding the immunogenicity of one or two booster doses of the measles−mumps−rubella (MMR) vaccine in measles-seronegative young adults, limited data are available about how long the immune response is sustained ... ...

Abstract	Although there have been several studies regarding the immunogenicity of one or two booster doses of the measles−mumps−rubella (MMR) vaccine in measles-seronegative young adults, limited data are available about how long the immune response is sustained compared with natural infection. This study included seronegative healthcare workers (HCWs) (aged 21−38 years) who received one or two doses of the measles−mumps−rubella (MMR) vaccine and HCWs with laboratory-confirmed measles infection during an outbreak in 2019. We compared neutralizing antibody titers measured using the plaque reduction neutralization (PRN) test and measles-specific immunoglobulin G (IgG) using chemiluminescent immunoassays 2 years after vaccination or infection. Among 107 HCWs with seronegative measles IgGs, the overall seroconversion rate of measles IgGs remained 82.2% (88/107), and 45.8% (49/107) of the participants had a medium (121−900) or high (>900) PRN titer after 2 years from one or two booster doses. The measles-neutralizing antibody titers of both PRN titer (ND50) and geometric mean concentration 2 years after natural infection were significantly higher than those of one or two booster doses of the MMR vaccine (p < 0.001 and p < 0.001, respectively). Our results suggest that serologic screening followed by appropriate postexposure prophylaxis can be beneficial for young HCWs without a history of natural infection especially in a measles outbreak setting, because of possible susceptibility to measles despite booster MMR vaccination 2 years ago. Long-term data about sustainable humoral immunity after one or two booster vaccination are needed based on the exact vaccination history.
Language	English
Publishing date	2022-10-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines10111812
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Article: Radiologically Suspected Organizing Pneumonia in a Patient Recovering from COVID-19: A Case Report.

Seo, Hyeonji / Jung, Jiwon / Kim, Min Jae / Jang, Se Jin / Kim, Sung-Han

Infection & chemotherapy

2021 Volume 54, Issue 1, Page(s) 208–212

Abstract: We report a case of coronavirus disease 2019 (COVID-19)-associated radiologically suspected organizing pneumonia with repeated negative Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) results from ... ...

Abstract	We report a case of coronavirus disease 2019 (COVID-19)-associated radiologically suspected organizing pneumonia with repeated negative Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) results from nasopharyngeal swab and sputum samples, but positive result from bronchoalveolar lavage fluid. Performing SARS-CoV-2 RT-PCR in upper respiratory tract samples only could fail to detect COVID-19-associated pneumonia, and SARS-CoV-2 could be an etiology of radiologically suspected organizing pneumonia.
Language	English
Publishing date	2021-02-26
Publishing country	Korea (South)
Document type	Case Reports
ZDB-ID	2573798-3
ISSN	2093-2340
ISSN	2093-2340
DOI	10.3947/ic.2021.0013
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Article: Longitudinal immune kinetics of COVID-19 booster versus primary series vaccination: Insight into the annual vaccination strategy.

Choi, Min Joo / Hyun, Hakjun / Heo, Jung Yeon / Seo, Yu Bin / Noh, Ji Yun / Cheong, Hee Jin / Kim, Woo Joo / Kim, Hwa Jung / Choi, Ju-Yeon / Lee, Young Jae / Chung, Eun Joo / Kim, Su-Hwan / Jeong, Hyeonji / Kim, Byoungguk / Song, Joon Young

Heliyon

2024 Volume 10, Issue 5, Page(s) e27211

Abstract: Background: Data on the durability of booster dose immunity of COVID-19 vaccines are relatively limited.: Methods: Immunogenicity was evaluated for up to 9-12 months after the third dose of vaccination in 94 healthy adults.: Results: Following the ...

Abstract	Background: Data on the durability of booster dose immunity of COVID-19 vaccines are relatively limited. Methods: Immunogenicity was evaluated for up to 9-12 months after the third dose of vaccination in 94 healthy adults. Results: Following the third dose, the anti-spike immunoglobulin G (IgG) antibody response against the wild-type was boosted markedly, which decreased gradually over time. However, even 9-12 months after the booster dose, both the median and geometric mean of anti-spike IgG antibody levels were higher than those measured 4 weeks after the second dose. Breakthrough infection during the Omicron-dominant period boosted neutralizing antibody titers against Omicron sublineages (BA.1 and BA.5) and the ancestral strain. T-cell immune response was efficiently induced and maintained during the study period. Conclusions: mRNA vaccine booster dose elicited durable humoral immunity for up to 1 year after the third dose and T-cell immunity was sustained during the study period, supporting an annual COVID-19 vaccination strategy.
Language	English
Publishing date	2024-02-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e27211
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Article ; Online: Risk and Outcome of Infective Endocarditis in Streptococcal Bloodstream Infections according to Streptococcal Species.

Seo, Hyeonji / Hyun, Junho / Kim, Haein / Park, Sunghee / Chung, Hyemin / Bae, Seongman / Jung, Jiwon / Kim, Min Jae / Kim, Sung-Han / Lee, Sang-Oh / Choi, Sang-Ho / Kim, Yang Soo / Chong, Yong Pil

Microbiology spectrum

2023 Volume 11, Issue 4, Page(s) e0104923

Abstract: This study aimed to identify which streptococcal species are closely associated with infective endocarditis (IE) and to evaluate risk factors for mortality in patients with streptococcal IE. We performed a retrospective cohort study of all patients with ... ...

Abstract	This study aimed to identify which streptococcal species are closely associated with infective endocarditis (IE) and to evaluate risk factors for mortality in patients with streptococcal IE. We performed a retrospective cohort study of all patients with streptococcal bloodstream infection (BSI) from January 2010 to June 2020 in a tertiary hospital in South Korea. We compared clinical and microbiological characteristics of streptococcal BSIs according to the diagnosis of IE. We performed multivariate analysis to evaluate the risk of IE according to streptococcal species and risk factors for mortality in streptococcal IE. A total of 2,737 patients were identified during the study period, and 174 (6.4%) were diagnosed with IE. The highest IE prevalence was in patients with Streptococcus mutans BSI (33% [9/27]) followed by S. sanguinis (31% [20/64]), S. gordonii (23% [5/22]), S. gallolyticus (16% [12/77]), and S. oralis (12% [14/115]). In multivariate analysis, previous IE, high-grade BSI, native valve disease, prosthetic valve, congenital heart disease, and community-onset BSI were independent risk factors for IE. After adjusting for these factors, S. sanguinis (adjusted OR [aOR], 7.75), S. mutans (aOR, 5.50), and S. gallolyticus (aOR, 2.57) were significantly associated with higher risk of IE, whereas S. pneumoniae (aOR, 0.23) and
MeSH term(s)	Humans ; Retrospective Studies ; Streptococcus ; Endocarditis, Bacterial/complications ; Endocarditis, Bacterial/epidemiology ; Endocarditis, Bacterial/diagnosis ; Endocarditis/epidemiology ; Endocarditis/microbiology ; Streptococcal Infections/complications ; Streptococcal Infections/epidemiology ; Streptococcal Infections/diagnosis ; Sepsis
Language	English
Publishing date	2023-06-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.01049-23
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Article ; Online: Measles Virus Neutralizing Antibody Response and Durability Two Years after One or Two Doses of Measles–Mumps–Rubella Vaccine among Young Seronegative Healthcare Workers

Byungki Jang / Han Wool Kim / Han-Sung Kim / Ji Young Park / Hyeonji Seo / Yong Kyun Kim

Vaccines, Vol 10, Iss 1812, p

2022 Volume 1812

Abstract: Although there have been several studies regarding the immunogenicity of one or two booster doses of the measles–mumps–rubella (MMR) vaccine in measles-seronegative young adults, limited data are available about how long the immune response is sustained ... ...

Abstract	Although there have been several studies regarding the immunogenicity of one or two booster doses of the measles–mumps–rubella (MMR) vaccine in measles-seronegative young adults, limited data are available about how long the immune response is sustained compared with natural infection. This study included seronegative healthcare workers (HCWs) (aged 21–38 years) who received one or two doses of the measles–mumps–rubella (MMR) vaccine and HCWs with laboratory-confirmed measles infection during an outbreak in 2019. We compared neutralizing antibody titers measured using the plaque reduction neutralization (PRN) test and measles-specific immunoglobulin G (IgG) using chemiluminescent immunoassays 2 years after vaccination or infection. Among 107 HCWs with seronegative measles IgGs, the overall seroconversion rate of measles IgGs remained 82.2% (88/107), and 45.8% (49/107) of the participants had a medium (121–900) or high (>900) PRN titer after 2 years from one or two booster doses. The measles-neutralizing antibody titers of both PRN titer (ND50) and geometric mean concentration 2 years after natural infection were significantly higher than those of one or two booster doses of the MMR vaccine ( p < 0.001 and p < 0.001, respectively). Our results suggest that serologic screening followed by appropriate postexposure prophylaxis can be beneficial for young HCWs without a history of natural infection especially in a measles outbreak setting, because of possible susceptibility to measles despite booster MMR vaccination 2 years ago. Long-term data about sustainable humoral immunity after one or two booster vaccination are needed based on the exact vaccination history.
Keywords	measles ; measles–mumps–rubella vaccine ; healthcare workers ; immune durability ; plaque reduction neutralization test ; neutralizing antibody ; Medicine ; R
Subject code	570
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Book ; Online: EHRSQL

Lee, Gyubok / Hwang, Hyeonji / Bae, Seongsu / Kwon, Yeonsu / Shin, Woncheol / Yang, Seongjun / Seo, Minjoon / Kim, Jong-Yeup / Choi, Edward

A Practical Text-to-SQL Benchmark for Electronic Health Records

2023

Abstract: We present a new text-to-SQL dataset for electronic health records (EHRs). The utterances were collected from 222 hospital staff members, including physicians, nurses, and insurance review and health records teams. To construct the QA dataset on ... ...

Abstract	We present a new text-to-SQL dataset for electronic health records (EHRs). The utterances were collected from 222 hospital staff members, including physicians, nurses, and insurance review and health records teams. To construct the QA dataset on structured EHR data, we conducted a poll at a university hospital and used the responses to create seed questions. We then manually linked these questions to two open-source EHR databases, MIMIC-III and eICU, and included various time expressions and held-out unanswerable questions in the dataset, which were also collected from the poll. Our dataset poses a unique set of challenges: the model needs to 1) generate SQL queries that reflect a wide range of needs in the hospital, including simple retrieval and complex operations such as calculating survival rate, 2) understand various time expressions to answer time-sensitive questions in healthcare, and 3) distinguish whether a given question is answerable or unanswerable. We believe our dataset, EHRSQL, can serve as a practical benchmark for developing and assessing QA models on structured EHR data and take a step further towards bridging the gap between text-to-SQL research and its real-life deployment in healthcare. EHRSQL is available at https://github.com/glee4810/EHRSQL. Comment: Published as a conference paper at NeurIPS 2022 (Track on Datasets and Benchmarks)
Keywords	Computer Science - Computation and Language ; Computer Science - Artificial Intelligence
Subject code	028
Publishing date	2023-01-16
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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