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  1. Article: Innovative Approaches to Fungal Food Production: Mycelial Pellet Morphology Insights.

    Cheng, Chih-Yu / Wang, Yu-Sheng / Wang, Zhong-Liang / Bibi, Sidra

    Foods (Basel, Switzerland)

    2023  Volume 12, Issue 18

    Abstract: Mycelia products enhance edible mushrooms in alignment with future sustainability trends. To meet forthcoming market demands, the morphology of mycelial pellets was optimized for direct consumption. Among ten commercial edible mushrooms in Taiwan, ...

    Abstract Mycelia products enhance edible mushrooms in alignment with future sustainability trends. To meet forthcoming market demands, the morphology of mycelial pellets was optimized for direct consumption. Among ten commercial edible mushrooms in Taiwan,
    Language English
    Publishing date 2023-09-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12183477
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  2. Article: Two-stage cultivation strategies for optimal production of

    Bibi, Sidra / Wang, Zhong-Liang / Lin, Chitsan / Min, Sheng-Hua / Cheng, Chih-Yu

    Journal of food science and technology

    2023  Volume 60, Issue 6, Page(s) 1793–1802

    Language English
    Publishing date 2023-03-17
    Publishing country India
    Document type Journal Article
    ZDB-ID 242498-8
    ISSN 0975-8402 ; 0022-1155
    ISSN (online) 0975-8402
    ISSN 0022-1155
    DOI 10.1007/s13197-023-05719-x
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    In stock of ZB MED Bonn / Germany

    Z 2636: Show issues

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  3. Article: Characterization of Stimulatory Action on Voltage-Gated Na

    Ting, Chih-Yu / Shih, Chia-Lung / Yu, Meng-Cheng / Wu, Chao-Liang / Wu, Sheng-Nan

    Biomedicines

    2023  Volume 11, Issue 5

    Abstract: Omecamtiv mecarbil (OM, CK-1827452) is recognized as an activator of myosin and has been demonstrated to be beneficial for the treatment of systolic heart failure. However, the mechanisms by which this compound interacts with ionic currents in ... ...

    Abstract Omecamtiv mecarbil (OM, CK-1827452) is recognized as an activator of myosin and has been demonstrated to be beneficial for the treatment of systolic heart failure. However, the mechanisms by which this compound interacts with ionic currents in electrically excitable cells remain largely unknown. The objective of this study was to investigate the effects of OM on ionic currents in GH3 pituitary cells and Neuro-2a neuroblastoma cells. In GH
    Language English
    Publishing date 2023-05-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11051351
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  4. Article ; Online: Survival Benefit of Experience of Liver Resection for Advanced Recurrent Hepatocellular Carcinoma Treated with Sorafenib: A Propensity Score Matching Analysis.

    Hsueh, Kuan-Chun / Lee, Cheng-Chun / Huang, Pi-Teh / Liang, Chih-Yu / Yang, Shun-Fa

    Current oncology (Toronto, Ont.)

    2023  Volume 30, Issue 3, Page(s) 3206–3216

    Abstract: Several studies have shown that liver resection (LR) confers better survival outcomes in intermediate- and advanced-stage hepatocellular carcinoma (HCC) patients. However, the postoperative recurrence rate is high, and little is known about the survival ... ...

    Abstract Several studies have shown that liver resection (LR) confers better survival outcomes in intermediate- and advanced-stage hepatocellular carcinoma (HCC) patients. However, the postoperative recurrence rate is high, and little is known about the survival benefits of LR for recurrent HCC patients who have already received systemic treatment. This study aimed to evaluate the impact of LR on recurrent advanced-stage HCC patients who received sorafenib as a systemic treatment. In this study, 147 advanced HCC patients were enrolled between 1 January 2012 and 31 December 2019. Two study groups were classified, based on whether they underwent LR or not. To reduce the possible selection bias, a propensity score matching (PSM) analysis was performed. The primary study endpoint was set as overall survival (OS), and the secondary endpoint was set as progression-free survival (PFS). Our study results revealed that advanced HCC patients who received sorafenib with LR had a longer OS than did those without LR, whether before or after PSM (15.0 months vs. 6.0 months, HR 0.45, 95% CI 0.31-0.67,
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/surgery ; Sorafenib/therapeutic use ; Liver Neoplasms/drug therapy ; Liver Neoplasms/surgery ; Propensity Score ; Retrospective Studies
    Chemical Substances Sorafenib (9ZOQ3TZI87)
    Language English
    Publishing date 2023-03-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol30030243
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4305: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Transgene-free CRISPR/Cas9-mediated gene editing through protoplast-to-plant regeneration enhances active compounds in Salvia miltiorrhiza.

    Hsu, Chen-Tran / Chiu, Chi-Chou / Hsiao, Pao-Yuan / Lin, Chih-Yu / Cheng, Sychyi / Lin, Yao-Cheng / Yang, Yu-Liang / Wu, Fu-Hui / Harn, Horng-Jyh / Lin, Shinn-Zong / Lin, Choun-Sea

    Plant biotechnology journal

    2024  

    Language English
    Publishing date 2024-01-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2136367-5
    ISSN 1467-7652 ; 1467-7652
    ISSN (online) 1467-7652
    ISSN 1467-7652
    DOI 10.1111/pbi.14285
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  6. Article ; Online: Trick or treat? It's time to rethink the role of placebo in clinical trial.

    Tseng, Ping-Tao / Liang, Chih-Sung / Zeng, Bing-Syuan / Hsu, Chih-Wei / Tu, Yu-Kang

    Psychiatry and clinical neurosciences

    2024  

    Language English
    Publishing date 2024-04-15
    Publishing country Australia
    Document type Letter
    ZDB-ID 1292906-2
    ISSN 1440-1819 ; 1323-1316
    ISSN (online) 1440-1819
    ISSN 1323-1316
    DOI 10.1111/pcn.13668
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    In stock of ZB MED Cologne/Königswinter

    Ui I Zs.238: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Palladium-Catalyzed Chemo- and Regiocontrolled Tandem Cyclization/Cross-Coupling of 2-Benzyl-3-alkynyl Chromones with Aryl Iodides for the Synthesis of 4

    Liang, Yi-En / Kan, Chih-Yu / Barve, Balaji D / Chen, Yen-An / Li, Wen-Tai

    Organic letters

    2022  Volume 24, Issue 37, Page(s) 6728–6733

    Abstract: A novel Pd-catalyzed chemo- and regiocontrolled tandem cyclization/cross-coupling reaction of 3-alkynyl chromone with aryl iodide was developed for the synthesis of ... ...

    Abstract A novel Pd-catalyzed chemo- and regiocontrolled tandem cyclization/cross-coupling reaction of 3-alkynyl chromone with aryl iodide was developed for the synthesis of 4
    MeSH term(s) Alkynes ; Benzopyrans ; Catalysis ; Chromones ; Cyclization ; Iodides ; Ligands ; Palladium ; Xanthones
    Chemical Substances Alkynes ; Benzopyrans ; Chromones ; Iodides ; Ligands ; Xanthones ; Palladium (5TWQ1V240M)
    Language English
    Publishing date 2022-08-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.2c02476
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Regulatory T cells in inflamed liver are dysfunctional in murine primary biliary cholangitis.

    Lin, Chia-I / Wang, Yu-Wen / Liu, Chih-Yu / Chen, Hung-Wen / Liang, Pi-Hui / Chuang, Ya-Hui

    Clinical and experimental immunology

    2023  Volume 215, Issue 3, Page(s) 225–239

    Abstract: Primary biliary cholangitis (PBC) is a chronic autoimmune disease characterized by immune-mediated destruction of intrahepatic small bile ducts. CD8 T cells play a critical role in biliary destruction. However, regulatory T cells (Tregs) have also been ... ...

    Abstract Primary biliary cholangitis (PBC) is a chronic autoimmune disease characterized by immune-mediated destruction of intrahepatic small bile ducts. CD8 T cells play a critical role in biliary destruction. However, regulatory T cells (Tregs) have also been identified in the portal tracts of PBC patients. This study tested the hypothesis that hepatic Tregs in PBC were dysfunctional in suppressing immune responses in disease by using our human PBC-like autoimmune cholangitis (AIC) mouse model induced by 2-octynoic acid-conjugated ovalbumin (2-OA-OVA). Our results showed that female and male mice immunized with 2-OA-OVA developed AIC; however, female AIC mice had more severe liver inflammation and fibrosis than male AIC mice. Levels of functional effector CD8 T cells and their chemoattractants, CXCL9 and CXCL10, in the liver were markedly elevated in female AIC mice than in male AIC mice. These results reinforce that CD8 T cells are the primary effector cells in PBC. The number of hepatic Tregs in AIC mice was also higher than in saline-treated mice, but there was no difference between male and female AIC mice. The suppressive function of AIC Tregs was evident despite a discrepancy in the changes in their co-inhibitory receptors and inhibitory cytokines. However, the expansion of hepatic Tregs by low-dose IL-2 treatment did not reduce immune responses to AIC, which may be due to the dysfunction of Tregs in inhibiting T cells. In conclusion, the function of Tregs in the inflamed liver of PBC was insufficient, and low-dose IL-2 treatment could not restore their function to suppress pathological immune responses. Transferring normal Tregs or directly targeting effector CD8 T cells may be beneficial for treating PBC.
    MeSH term(s) Humans ; Male ; Female ; Mice ; Animals ; Liver Cirrhosis, Biliary ; T-Lymphocytes, Regulatory ; Interleukin-2 ; Liver ; Cholangitis/pathology ; Autoimmune Diseases
    Chemical Substances Interleukin-2
    Language English
    Publishing date 2023-11-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218531-3
    ISSN 1365-2249 ; 0009-9104 ; 0964-2536
    ISSN (online) 1365-2249
    ISSN 0009-9104 ; 0964-2536
    DOI 10.1093/cei/uxad117
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 337: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Immune-stealth VP28-conjugated heparin nanoparticles for enhanced and reversible anticoagulation.

    Hussein, Hussein Reda / Chang, Chia-Yu / Zheng, Yini / Yang, Chih-Yu / Li, Li-Hua / Lee, Yi-Tzu / Chen, Jun-Yi / Liang, Yu-Chaun / Lin, Chuan-Ju / Chang, Yu-Chia / Geo, Hui Nee / Noor, Suzita Mohd / Kiew, Lik Voon / Chen, Fu-Rong / Chang, Chia-Ching

    Nanotechnology

    2024  Volume 35, Issue 17

    Abstract: Heparins are a family of sulfated linear negatively charged polysaccharides that have been widely used for their anticoagulant, antithrombotic, antitumor, anti-inflammatory, and antiviral properties. Additionally, it has been used for acute cerebral ... ...

    Abstract Heparins are a family of sulfated linear negatively charged polysaccharides that have been widely used for their anticoagulant, antithrombotic, antitumor, anti-inflammatory, and antiviral properties. Additionally, it has been used for acute cerebral infarction relief as well as other pharmacological actions. However, heparin's self-aggregated macrocomplex may reduce blood circulation time and induce life-threatening thrombocytopenia (HIT) complicating the use of heparins. Nonetheless, the conjugation of heparin to immuno-stealth biomolecules may overcome these obstacles. An immunostealth recombinant viral capsid protein (VP28) was expressed and conjugated with heparin to form a novel nanoparticle (VP28-heparin). VP28-heparin was characterized and tested to determine its immunogenicity, anticoagulation properties, effects on total platelet count, and risk of inducing HIT in animal models. The synthesized VP28-heparin trimeric nanoparticle was non-immunogenic, possessed an average hydrodynamic size (8.81 ± 0.58 nm) optimal for the evasion renal filtration and reticuloendothelial system uptake (hence prolonging circulating half-life). Additionally, VP28-heparin did not induce mouse death or reduce blood platelet count when administered at a high dose
    MeSH term(s) Animals ; Mice ; Heparin/pharmacology ; Heparin/therapeutic use ; Anticoagulants/pharmacology ; Blood Coagulation ; Thrombocytopenia/drug therapy ; Platelet Count
    Chemical Substances Heparin (9005-49-6) ; Anticoagulants
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362365-5
    ISSN 1361-6528 ; 0957-4484
    ISSN (online) 1361-6528
    ISSN 0957-4484
    DOI 10.1088/1361-6528/ad21a2
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  10. Article ; Online: Thermoresponsive and Conductive Chitosan-Polyurethane Biocompatible Thin Films with Potential Coating Application

    Junpeng Xu / Chih-Yu Fu / Yu-Liang Tsai / Chui-Wei Wong / Shan-hui Hsu

    Polymers, Vol 13, Iss 3, p

    2021  Volume 326

    Abstract: Conductive thin films have great potential for application in the biomedical field. Herein, we designed thermoresponsive and conductive thin films with hydrophilicity, strain sensing, and biocompatibility. The crosslinked dense thin films were ... ...

    Abstract Conductive thin films have great potential for application in the biomedical field. Herein, we designed thermoresponsive and conductive thin films with hydrophilicity, strain sensing, and biocompatibility. The crosslinked dense thin films were synthesized and prepared through a Schiff base reaction and ionic interaction from dialdehyde polyurethane, N-carboxyethyl chitosan, and double-bonded chitosan grafted polypyrrole. The thin films were air-dried under room temperature. These thin films showed hydrophilicity and conductivity (above 2.50 mS/cm) as well as responsiveness to the deformation. The tensile break strength (9.72 MPa to 15.07 MPa) and tensile elongation (5.76% to 12.77%) of conductive thin films were enhanced by heating them from 25 °C to 50 °C. In addition, neural stem cells cultured on the conductive thin films showed cell clustering, proliferation, and differentiation. The application of the materials as a conductive surface coating was verified by different coating strategies. The conductive thin films are potential candidates for surface modification and biocompatible polymer coating.
    Keywords conductive thin film ; thermoresponsive ; polyurethane ; chitosan ; biocompatibility ; polymer coating ; Organic chemistry ; QD241-441
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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